Peter T C So

Peter T C So

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Peter T C So

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Studying nucleic envelope and plasma membrane mechanics of eukaryotic cells using confocal reflectance interferometric microscopy.

Nat Commun 2019 Aug 13;10(1):3652. Epub 2019 Aug 13.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-019-11645-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692322PMC
August 2019

Self-assembling amyloid-like peptides as exogenous second harmonic probes for bioimaging applications.

J Biophotonics 2019 Jun 4:e201900065. Epub 2019 Jun 4.

Laboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering, King Abdullah University of Science and Technology, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1002/jbio.201900065DOI Listing
June 2019

Low-coherent optical diffraction tomography by angle-scanning illumination.

J Biophotonics 2019 May 28;12(5):e201800289. Epub 2019 Jan 28.

Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1002/jbio.201800289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470054PMC
May 2019

Functional imaging of visual cortical layers and subplate in awake mice with optimized three-photon microscopy.

Nat Commun 2019 01 11;10(1):177. Epub 2019 Jan 11.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-018-08179-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329792PMC
January 2019

Scattering reduction by structured light illumination in line-scanning temporal focusing microscopy.

Biomed Opt Express 2018 Nov 22;9(11):5654-5666. Epub 2018 Oct 22.

Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1364/BOE.9.005654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238912PMC
November 2018

Reflection phase microscopy using spatio-temporal coherence of light.

Optica 2018 Nov 15;5(11):1468-1473. Epub 2018 Nov 15.

Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1364/OPTICA.5.001468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472928PMC
November 2018

Evaluation of accuracy dependence of Raman spectroscopic models on the ratio of calibration and validation points for non-invasive glucose sensing.

Anal Bioanal Chem 2018 Oct 25;410(25):6469-6475. Epub 2018 Jul 25.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://link.springer.com/10.1007/s00216-018-1244-y
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http://dx.doi.org/10.1007/s00216-018-1244-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128756PMC
October 2018

Deep learning enables automated scoring of liver fibrosis stages.

Sci Rep 2018 10 30;8(1):16016. Epub 2018 Oct 30.

Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore, 138669, Singapore.

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http://www.nature.com/articles/s41598-018-34300-2
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http://dx.doi.org/10.1038/s41598-018-34300-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207665PMC
October 2018

Absorption by water increases fluorescence image contrast of biological tissue in the shortwave infrared.

Proc Natl Acad Sci U S A 2018 09 27;115(37):9080-9085. Epub 2018 Aug 27.

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1803210115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140498PMC
September 2018

Single-Shot Optical Anisotropy Imaging with Quantitative Polarization Interference Microscopy.

Laser Photon Rev 2018 Aug 10;12(8). Epub 2018 Jun 10.

Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge, MA 02139, USA, Department of Biological Engineering Massachusetts Institute of Technology Cambridge, MA 02139, USA, Laser Biomedical Research Center Massachusetts Institute of Technology Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1002/lpor.201800070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424346PMC
August 2018

Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales.

Curr Opin Biomed Eng 2018 Jun;6:1-7

Department of Mechanical Engineering Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cobme.2017.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788464PMC
June 2018

Single-shot dual-wavelength interferometric microscopy.

Methods 2018 03 25;136:35-39. Epub 2017 Oct 25.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

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http://dx.doi.org/10.1016/j.ymeth.2017.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857408PMC
March 2018

Eleven quick tips for running an interdisciplinary short course for new graduate students.

PLoS Comput Biol 2018 03 29;14(3):e1006039. Epub 2018 Mar 29.

Singapore MIT Alliance for Research and Technology Centre, Singapore.

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http://dx.doi.org/10.1371/journal.pcbi.1006039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875739PMC
March 2018

Development of a classification model for non-alcoholic steatohepatitis (NASH) using confocal Raman micro-spectroscopy.

J Biophotonics 2017 Dec 21;10(12):1703-1713. Epub 2017 Jun 21.

Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A*STAR), Singapore, 138669.

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http://dx.doi.org/10.1002/jbio.201600303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902180PMC
December 2017

Large population cell characterization using quantitative phase cytometer.

Cytometry A 2017 05 26;91(5):450-459. Epub 2017 Apr 26.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.

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http://dx.doi.org/10.1002/cyto.a.23106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730079PMC
May 2017

Near-common-path interferometer for imaging Fourier-transform spectroscopy in wide-field microscopy.

Optica 2017 May;4(5):546-556

Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1364/OPTICA.4.000546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788042PMC
May 2017

Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation.

Wound Repair Regen 2017 04 27;25(2):177-191. Epub 2017 Apr 27.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1111/wrr.12516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520812PMC
April 2017

Quantification of labile heme in live malaria parasites using a genetically encoded biosensor.

Proc Natl Acad Sci U S A 2017 03 27;114(11):E2068-E2076. Epub 2017 Feb 27.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1615195114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358388PMC
March 2017

Enhanced Axial Resolution of Wide-Field Two-Photon Excitation Microscopy by Line Scanning Using a Digital Micromirror Device.

Micromachines (Basel) 2017 9;8(3). Epub 2017 Mar 9.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.3390/mi8030085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788041PMC
March 2017

Fluorescent probes for nanoscopy: four categories and multiple possibilities.

J Biophotonics 2017 01 25;10(1):11-23. Epub 2016 May 25.

Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.

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http://dx.doi.org/10.1002/jbio.201600042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775479PMC
January 2017

Tomographic phase microscopy: principles and applications in bioimaging [Invited].

J Opt Soc Am B 2017;34(5):B64-B77

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788179PMC
January 2017

Investigating Effects of Proteasome Inhibitor on Multiple Myeloma Cells Using Confocal Raman Microscopy.

Sensors (Basel) 2016 Dec 14;16(12). Epub 2016 Dec 14.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.3390/s16122133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191113PMC
December 2016

Superpixel-based segmentation of muscle fibers in multi-channel microscopy.

BMC Syst Biol 2016 Dec 5;10(Suppl 5):124. Epub 2016 Dec 5.

Centre for Computational Biology, and Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1186/s12918-016-0372-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249035PMC
December 2016

Raman Spectroscopy Differentiates Each Tissue from the Skin to the Spinal Cord: A Novel Method for Epidural Needle Placement?

Anesthesiology 2016 10;125(4):793-804

From the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts (T.A.A.); and Departments of Chemistry (J.W.K., R.R.D.), Mechanical Engineering (T.G.), and Mechanical and Biological Engineering (P.T.C.S.), Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1097/ALN.0000000000001249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030194PMC
October 2016

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units.

Sci Adv 2016 08 3;2(8):e1501429. Epub 2016 Aug 3.

Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.

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http://dx.doi.org/10.1126/sciadv.1501429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972469PMC
August 2016

Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease.

Proc Natl Acad Sci U S A 2016 08 10;113(34):9527-32. Epub 2016 Aug 10.

Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1610435113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003247PMC
August 2016

Virtual k-Space Modulation Optical Microscopy.

Phys Rev Lett 2016 Jul 6;117(2):028102. Epub 2016 Jul 6.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1103/PhysRevLett.117.028102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548665PMC
July 2016

Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging.

Sci Rep 2016 06 10;6:27142. Epub 2016 Jun 10.

Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Rep. of Korea.

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http://dx.doi.org/10.1038/srep27142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901393PMC
June 2016

In Situ Quantification of Surface Chemistry in Porous Collagen Biomaterials.

Ann Biomed Eng 2016 Mar 14;44(3):803-15. Epub 2015 Sep 14.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1007/s10439-015-1445-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791220PMC
March 2016

Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform.

Small 2016 Feb 30;12(5):612-22. Epub 2015 Nov 30.

Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1002/smll.201501905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752442PMC
February 2016

Inhibitory Synapses Are Repeatedly Assembled and Removed at Persistent Sites In Vivo.

Neuron 2016 02 4;89(4):756-69. Epub 2016 Feb 4.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760889PMC
February 2016

Differential remodeling of extracellular matrices by breast cancer initiating cells.

J Biophotonics 2015 Oct 19;8(10):804-15. Epub 2015 Jan 19.

Institute of Bioengineering and Nanotechnology, A*STAR, Singapore, 138669.

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http://dx.doi.org/10.1002/jbio.201400079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761427PMC
October 2015

Non-descanned multifocal multiphoton microscopy with a multianode photomultiplier tube.

AIP Adv 2015 Aug 23;5(8):084802. Epub 2015 Mar 23.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology , Cambridge, MA, USA.

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http://dx.doi.org/10.1063/1.4916040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387602PMC
August 2015

Objective, comparative assessment of the penetration depth of temporal-focusing microscopy for imaging various organs.

J Biomed Opt 2015 Jun;20(6):61107

Massachusetts Institute of Technology, Department of Biological Engineering, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United StatescMassachusetts Institute of Technology, Department of Mechanical Engineering, 77 Massachusetts Avenue, Cambr.

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http://dx.doi.org/10.1117/1.JBO.20.6.061107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450320PMC
June 2015

High resolution live cell Raman imaging using subcellular organelle-targeting SERS-sensitive gold nanoparticles with highly narrow intra-nanogap.

Nano Lett 2015 Mar 11;15(3):1766-72. Epub 2015 Feb 11.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, and ‡Department of Mechanical and Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.

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http://pubs.acs.org/doi/10.1021/nl504444w
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http://dx.doi.org/10.1021/nl504444wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356631PMC
March 2015

Three-dimensional image cytometer based on widefield structured light microscopy and high-speed remote depth scanning.

Cytometry A 2015 Jan 28;87(1):49-60. Epub 2014 Oct 28.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139.

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http://dx.doi.org/10.1002/cyto.a.22584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280269PMC
January 2015

In vivo label-free quantification of liver microcirculation using dual-modality microscopy.

J Biomed Opt 2014 ;19(11):116006

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, #04-13/14 Enterprise Wing, 138602 Singapore, SingaporebInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, #04-01, 138669 Singapore, Singapor.

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http://biomedicaloptics.spiedigitallibrary.org/data/Journals
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http://hanrylab.med.nus.edu.sg/Publications/PUB134-JBO19(201
Web Search
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
Publisher Site
http://dx.doi.org/10.1117/1.JBO.19.11.116006DOI Listing
January 2015

Depth-selective microscopic observation of a photomobile liquid crystal polymer under UV illumination.

Phys Chem Chem Phys 2014 Dec;16(48):27074-7

Department of Applied Chemistry, Chuo University, 1-13-27, Kasuga, Bunkyo, Tokyo 112-8551, Japan.

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http://dx.doi.org/10.1039/c4cp04602aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291456PMC
December 2014

3D-resolved targeting of photodynamic therapy using temporal focusing.

Laser Phys Lett 2014 Nov;11(11)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA ; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1088/1612-2011/11/11/115605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301304PMC
November 2014

Improving femtosecond laser pulse delivery through a hollow core photonic crystal fiber for temporally focused two-photon endomicroscopy.

Sci Rep 2014 Oct 15;4:6626. Epub 2014 Oct 15.

1] Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA [2] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA [3] BioSym, Singapore-MIT Alliance for Research and Technology, Singapore 138602, Singapore [4] Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep06626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894416PMC
October 2014

Depth resolved hyperspectral imaging spectrometer based on structured light illumination and Fourier transform interferometry.

Biomed Opt Express 2014 Oct 9;5(10):3494-507. Epub 2014 Sep 9.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA ; BioSym, Singapore-MIT Alliance for Research and Technology, Singapore 138602, Singapore ; Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1364/BOE.5.003494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206319PMC
October 2014

Talbot holographic illumination nonscanning (THIN) fluorescence microscopy.

Laser Photon Rev 2014 Sep 8;8(5):L71-L75. Epub 2014 Aug 8.

Singapore-MIT Alliance for Research and Technology (SMART) Centre, 1 CREATE Way, #10-01 CREATE Tower, 138602, Singapore.

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http://dx.doi.org/10.1002/lpor.201400053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321697PMC
September 2014

Reassignment of scattered emission photons in multifocal multiphoton microscopy.

Sci Rep 2014 Jun 5;4:5153. Epub 2014 Jun 5.

1] Massachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, MA 02139 [2] Singapore-MIT Alliance for Research and Technology (SMART), BioSyM, Singapore 138602 [3] Massachusetts Institute of Technology, Department of Biomedical Engineering, Cambridge, MA 02139.

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http://dx.doi.org/10.1038/srep05153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046171PMC
June 2014

Thermomechanical Actuator-Based Three-Axis Optical Scanner for High-Speed Two-Photon Endomicroscope Imaging.

J Microelectromech Syst 2014 May;23(3):570-578

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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http://dx.doi.org/10.1109/JMEMS.2013.2287708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321806PMC
May 2014

Experimenting liver fibrosis diagnostic by two photon excitation microscopy and Bag-of-Features image classification.

Sci Rep 2014 Apr 10;4:4636. Epub 2014 Apr 10.

1] Computation and System Biology Program, Singapore MIT Alliance, Singapore, Singapore [2] Biosystems and Micromechanics IRG, Singapore MIT Alliance for Research and Technology, Singapore, Singapore [3] Institute of Bioengineering and Nanotechnology, Singapore, Singapore [4] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA [5] Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore [6] The Mechanobiology Institute, Singapore, Singapore.

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http://dx.doi.org/10.1038/srep04636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982167PMC
April 2014

Quantifying intracellular protein binding thermodynamics during mechanotransduction based on FRET spectroscopy.

Methods 2014 Mar 31;66(2):208-21. Epub 2013 Oct 31.

Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Mass Ave., Cambridge, MA 02139, United states; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Mass Ave., Cambridge, MA 02139, United States.

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http://dx.doi.org/10.1016/j.ymeth.2013.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094350PMC
March 2014

Application of Multiphoton Microscopy in Dermatological Studies: a Mini-Review.

J Innov Opt Health Sci 2014 Jan;7(5):1330010

Singapore-MIT Alliance for Research and Technology (SMART), 1 CREATE Way CREATE Tower, Singapore 138602 ; Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge MA 02139, USA ; Department of Mechanical Engineering Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge MA 02139, USA ; GR Harrison Spectroscopy Laboratory 77 Massachusetts Ave, Cambridge MA 02139, USA.

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http://dx.doi.org/10.1142/S1793545813300103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112132PMC
January 2014

High-throughput nonlinear optical microscopy.

Biophys J 2013 Dec;105(12):2641-54

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; Laser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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https://linkinghub.elsevier.com/retrieve/pii/S00063495130114
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http://dx.doi.org/10.1016/j.bpj.2013.08.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882500PMC
December 2013

Measurement of the time-resolved reflection matrix for enhancing light energy delivery into a scattering medium.

Phys Rev Lett 2013 Dec 9;111(24):243901. Epub 2013 Dec 9.

Laser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092257PMC
http://dx.doi.org/10.1103/PhysRevLett.111.243901DOI Listing
December 2013

Parallel super-resolution imaging.

Nat Methods 2013 Aug;10(8):709-10

Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.2567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280568PMC
August 2013

Improvement of axial resolution and contrast in temporally focused widefield two-photon microscopy with structured light illumination.

Biomed Opt Express 2013 Jul 3;4(7):995-1005. Epub 2013 Jun 3.

Department of Mechanical Engineering Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1364/BOE.4.000995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704103PMC
July 2013

Temporally focused wide-field two-photon microscopy: paraxial to vectorial.

Opt Express 2013 May;21(10):12951-63

Singapore MIT Alliance for Research and Technology, 1 CREATE Way, #10-01 CREATE Tower, Singapore 138602, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686358PMC
http://dx.doi.org/10.1364/OE.21.012951DOI Listing
May 2013

On the correction of errors in some multiple particle tracking experiments.

Appl Phys Lett 2013 Jan 17;102(2):21913. Epub 2013 Jan 17.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1063/1.4776738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562246PMC
January 2013

Coupled and uncoupled dipole models of nonlinear scattering.

Opt Express 2012 Nov;20(23):25834-42

Computation and Systems Biology Program, Singapore MIT Alliance, E4-04-10, 4 Engineering Drive 3, National University of Singapore, 117576 Singapore.

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http://dx.doi.org/10.1364/OE.20.025834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802241PMC
November 2012

Common features of optimal collagen scaffolds that disrupt wound contraction and enhance regeneration both in peripheral nerves and in skin.

Biomaterials 2012 Jun 6;33(19):4783-91. Epub 2012 Apr 6.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612120036
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http://dx.doi.org/10.1016/j.biomaterials.2012.03.068DOI Listing
June 2012

Clustered dynamics of inhibitory synapses and dendritic spines in the adult neocortex.

Neuron 2012 Apr;74(2):361-73

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340582PMC
April 2012

Predicting in vivo anti-hepatofibrotic drug efficacy based on in vitro high-content analysis.

PLoS One 2011 2;6(11):e26230. Epub 2011 Nov 2.

Computation and Systems Biology Program, Singapore-MIT Alliance, National University of Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026230PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206809PMC
March 2012

Methodological considerations for global analysis of cellular FLIM/FRET measurements.

J Biomed Opt 2012 Feb;17(2):026013

Massachusetts Institute of Technology, Department of Mechanical Engineering, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1117/1.JBO.17.2.026013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382354PMC
February 2012

Improving signal-to-noise ratio of structured light microscopy based on photon reassignment.

Biomed Opt Express 2012 Jan 22;3(1):206-14. Epub 2011 Dec 22.

BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology (SMART) centre, 3 Science Drive 2, 117543, Singapore.

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http://lbrc.mit.edu/wp-content/uploads/2014/05/PMID_22254180
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https://www.osapublishing.org/boe/abstract.cfm?uri=boe-3-1-2
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http://dx.doi.org/10.1364/BOE.3.000206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255338PMC
January 2012

Toward surface quantification of liver fibrosis progression.

J Biomed Opt 2010 Sep-Oct;15(5):056007

Singapore-MIT Alliance, E4-04-10, 4 Engineering Drive 3, Singapore 117576.

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http://dx.doi.org/10.1117/1.3490414DOI Listing
March 2011

Shack-Hartmann wavefront-sensor-based adaptive optics system for multiphoton microscopy.

J Biomed Opt 2010 Jul-Aug;15(4):046022

Massachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1117/1.3475954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937046PMC
January 2011

An optical method to quantify the density of ligands for cell adhesion receptors in three-dimensional matrices.

J R Soc Interface 2010 Oct 29;7 Suppl 5:S649-61. Epub 2010 Jul 29.

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1098/rsif.2010.0321.focusDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024575PMC
October 2010

Second harmonic scattering from small particles using Discrete Dipole Approximation.

Opt Express 2010 Oct;18(21):21603-11

Computation and Systems Biology Program, Singapore MIT Alliance, E4-04-10, 4 Engineering Drive 3, National University of Singapore, 117576 Singapore.

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http://dx.doi.org/10.1364/OE.18.021603DOI Listing
October 2010

An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.

FASEB J 2010 May 7;24(5):1604-15. Epub 2010 Jan 7.

Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.09-145367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879944PMC
May 2010

High-throughput three-dimensional lithographic microfabrication.

Opt Lett 2010 May;35(10):1602-4

Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue,Cambridge, Massachusetts 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775475PMC
http://dx.doi.org/10.1364/OL.35.001602DOI Listing
May 2010

Depth resolved wide field illumination for biomedical imaging and fabrication.

Conf Proc IEEE Eng Med Biol Soc 2009 ;2009:3234-5

Department of Mechanical Engineering in the Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1109/IEMBS.2009.5333601DOI Listing
March 2010

Surface-plasmon-coupled emission microscopy with a spiral phase plate.

Opt Lett 2010 Feb;35(4):517-9

Computation and Systems Biology, Singapore-MIT Alliance, National University of Singapore, 4 Engineering Drive 3,Singapore 117576, Singapore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775480PMC
http://dx.doi.org/10.1364/OL.35.000517DOI Listing
February 2010

Single-wavelength reflected confocal and multiphoton microscopy for tissue imaging.

J Biomed Opt 2009 Sep-Oct;14(5):054026

National Taiwan University, Department of Physics, No. 1 Section 4 Roosevelt Road, Taipei 10617, Taiwan.

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http://dx.doi.org/10.1117/1.3247157DOI Listing
January 2010