Peter Spégel

Peter Spégel

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Peter Spégel

Peter Spégel

Publications by authors named "Peter Spégel"

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Metabolomics Analysis of Nutrient Metabolism in β-Cells.

J Mol Biol 2019 Jul 17. Epub 2019 Jul 17.

Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, at Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Sweden.

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http://dx.doi.org/10.1016/j.jmb.2019.07.020DOI Listing
July 2019

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Cell Metab 2019 Feb 8;29(2):430-442.e4. Epub 2018 Nov 8.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Metabolic Research, Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Göteborg, Box 433, Göteborg 405 30, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370947PMC
February 2019

Alterations in levels of intermediate-chained acylcarnitines associate with weight-gain following reestablishment of euthyroidism in Graves' disease.

Endocrine 2019 01 3;63(1):164-166. Epub 2018 Sep 3.

Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1007/s12020-018-1735-9DOI Listing
January 2019

Identification of lignin oligomers in Kraft lignin using ultra-high-performance liquid chromatography/high-resolution multiple-stage tandem mass spectrometry (UHPLC/HRMS).

Anal Bioanal Chem 2018 Nov 10;410(29):7803-7814. Epub 2018 Oct 10.

Department of Chemistry, Centre for Analysis and Synthesis, Lund University, P.O. Box 124, 22100, Lund, Sweden.

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http://link.springer.com/10.1007/s00216-018-1400-4
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http://dx.doi.org/10.1007/s00216-018-1400-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244760PMC
November 2018

Population-Level Analysis to Determine Parameters That Drive Variation in the Plasma Metabolite Profiles.

Metabolites 2018 Nov 15;8(4). Epub 2018 Nov 15.

Centre for Analysis and Synthesis, Department of Chemistry, Lund University, 223 62 Lund, Sweden.

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http://www.mdpi.com/2218-1989/8/4/78
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http://dx.doi.org/10.3390/metabo8040078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316279PMC
November 2018

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.

Lancet Diabetes Endocrinol 2018 05 5;6(5):361-369. Epub 2018 Mar 5.

Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(18)30051-2DOI Listing
May 2018

Screening of stationary phase selectivities for global lipid profiling by ultrahigh performance supercritical fluid chromatography.

J Chromatogr A 2018 May 14;1548:76-82. Epub 2018 Mar 14.

Department of Chemistry, Centre for Analysis and Synthesis, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2018.03.024DOI Listing
May 2018

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Diabetes 2018 03 11;67(3):372-384. Epub 2017 Dec 11.

Unit of Molecular Metabolism, Department of Clinical Sciences, Lund University Diabetes Centre, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden

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http://dx.doi.org/10.2337/db16-1441DOI Listing
March 2018

The pathogenetic role of β-cell mitochondria in type 2 diabetes.

J Endocrinol 2018 03;236(3):R145-R159

Department of Clinical Sciences in MalmöUnit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmö University Hospital, Lund University, Malmö, Sweden

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http://dx.doi.org/10.1530/JOE-17-0367DOI Listing
March 2018

Ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for analysis of lignin-derived monomeric compounds in processed lignin samples.

Anal Bioanal Chem 2017 Dec 13;409(30):7049-7061. Epub 2017 Oct 13.

Department of Chemistry, Centre for Analysis and Synthesis, Lund University, P.O. Box 124, SE-22100, Lund, Sweden.

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http://dx.doi.org/10.1007/s00216-017-0663-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717129PMC
December 2017

Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels.

Thyroid 2017 09 18;27(9):1109-1117. Epub 2017 Aug 18.

1 Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö Lund University , Malmö, Sweden .

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http://dx.doi.org/10.1089/thy.2017.0218DOI Listing
September 2017

Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence.

PLoS One 2016 20;11(10):e0164962. Epub 2016 Oct 20.

Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malmö, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164962PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072741PMC
June 2017

NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells.

Mol Metab 2017 06 21;6(6):535-547. Epub 2017 Apr 21.

Université catholique de Louvain, Institute of Experimental and Clinical Research, Pole of Endocrinology, Diabetes and Nutrition, Brussels, B-1200, Belgium.

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http://dx.doi.org/10.1016/j.molmet.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444111PMC
June 2017

Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype.

Diabetes 2017 04 2;66(4):806-814. Epub 2016 Dec 2.

Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

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http://dx.doi.org/10.2337/db16-0779DOI Listing
April 2017

Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets.

Mol Nutr Food Res 2017 03 5;61(3). Epub 2016 Dec 5.

Department of Chemistry, Centre for Analysis and Synthesis, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/mnfr.201600442DOI Listing
March 2017

Glycogen metabolism in the glucose-sensing and supply-driven β-cell.

FEBS Lett 2016 Dec 5;590(23):4242-4251. Epub 2016 Nov 5.

Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malmö, Sweden.

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http://dx.doi.org/10.1002/1873-3468.12460DOI Listing
December 2016

Changes in glucose-elicited blood metabolite responses following weight loss and long term weight maintenance in obese individuals with impaired glucose tolerance.

Diabetes Res Clin Pract 2016 Mar 15;113:187-97. Epub 2016 Jan 15.

Department of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Sweden; Steno Diabetes Center A/S, Gentofte, Denmark.

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http://dx.doi.org/10.1016/j.diabres.2015.12.024DOI Listing
March 2016

Deletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice.

Physiol Rep 2015 Sep;3(9)

Department of Health Science and Technology, Aalborg University, Aalborg, Denmark Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden

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http://dx.doi.org/10.14814/phy2.12538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600382PMC
September 2015

Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis.

Endocrinology 2015 Jun 16;156(6):1995-2005. Epub 2015 Mar 16.

Unit of Molecular Metabolism (P.S., L.E.A., V.S., I.G., H.M.), Lund University Diabetes Centre, Clinical Research Center, Skåne University Hospital, and Lund University Diabetes Centre (P.S., A.H.R.), Clinical Research Center, Skåne University Hospital, 205 02 Malmö, Sweden.

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http://dx.doi.org/10.1210/en.2014-1391DOI Listing
June 2015

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.

Biochem J 2015 May;468(1):49-63

*Unit of Molecular Metabolism, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, CRC, Lund University, Skåne University Hospital, Malmö 205 02, Sweden.

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http://dx.doi.org/10.1042/BJ20140697DOI Listing
May 2015

Short- and long-term hormonal and metabolic consequences of reversing gastric bypass to normal anatomy in a type 2 diabetes patient.

Obes Surg 2015 Jan;25(1):180-5

Clinical Research Centre, Neuroendocrine Cell Biology, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Skåne University Hospital, Jan Waldenströms gata 35, Malmö, Sweden,

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http://dx.doi.org/10.1007/s11695-014-1459-8DOI Listing
January 2015

Metabolite profile deviations in an oral glucose tolerance test-a comparison between lean and obese individuals.

Obesity (Silver Spring) 2014 Nov 11;22(11):2388-95. Epub 2014 Aug 11.

Department of Clinical Sciences, Malmö, Clinical Obesity, Lund University Diabetes Centre, Lund University, Sweden.

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http://dx.doi.org/10.1002/oby.20868DOI Listing
November 2014

Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.

Sci Transl Med 2014 Oct;6(257):257ra139

Department of Clinical Sciences, Lund University, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.1126/scitranslmed.3009934DOI Listing
October 2014

Gastric bypass improves β-cell function and increases β-cell mass in a porcine model.

Diabetes 2014 May 31;63(5):1665-71. Epub 2014 Jan 31.

Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

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http://dx.doi.org/10.2337/db13-0969DOI Listing
May 2014

Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells.

J Biol Chem 2014 Feb 19;289(6):3786-98. Epub 2013 Dec 19.

From the Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, 20502 Malmö, Sweden and.

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http://dx.doi.org/10.1074/jbc.M113.507335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916575PMC
February 2014

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Regul Pept 2014 Feb 8;189:11-6. Epub 2014 Jan 8.

Neuroendocrine Cell Biology, Lund University Diabetes Centre, Malmö Sweden.

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http://dx.doi.org/10.1016/j.regpep.2013.12.009DOI Listing
February 2014

Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans.

J Clin Endocrinol Metab 2013 May 30;98(5):E856-61. Epub 2013 Apr 30.

Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, SE-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1210/jc.2012-3996DOI Listing
May 2013

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.

Biochem J 2013 Mar;450(3):595-605

Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Scania University Hospital, 205 02 Malmö, Sweden.

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http://dx.doi.org/10.1042/BJ20121349DOI Listing
March 2013

Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2).

Diabetes 2013 Feb 8;62(2):653-61. Epub 2012 Nov 8.

Unit of Molecular Metabolism, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Malmö, Sweden.

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http://dx.doi.org/10.2337/db12-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554352PMC
February 2013

NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice.

Gastroenterology 2012 Nov 27;143(5):1352-1360.e7. Epub 2012 Jul 27.

Department of Clinical Sciences, Section of Surgery, Skåne University Hospital, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.07.098DOI Listing
November 2012

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.

Biochem J 2011 Apr;435(1):277-84

Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Scania University Hospital, 205 02 Malmö, Sweden.

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http://dx.doi.org/10.1042/BJ20100655DOI Listing
April 2011

Continuous full filling capillary electrochromatography-electrospraying chromatographic nanoparticles.

Electrophoresis 2011 Jan 17;32(2):261-7. Epub 2010 Dec 17.

Department of Physical and Analytical Chemistry, Analytical Chemistry, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/elps.201000261DOI Listing
January 2011

Development and optimization of a metabolomic method for analysis of adherent cell cultures.

Anal Biochem 2010 Sep 22;404(1):30-9. Epub 2010 Apr 22.

Department of Clinical Sciences, Lund University Diabetes Centre, Malmö University Hospital, Sweden.

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http://dx.doi.org/10.1016/j.ab.2010.04.013DOI Listing
September 2010

Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.

Biochem J 2010 Jul;429(1):205-13

Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, Malmö University Hospital, 20502 Malmö, Sweden.

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http://biochemj.org/lookup/doi/10.1042/BJ20100142
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http://dx.doi.org/10.1042/BJ20100142DOI Listing
July 2010

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

J Proteome Res 2008 Jan 7;7(1):400-11. Epub 2007 Dec 7.

Unit of Molecular Endocrinology, Department of Experimental Medical Science, Lund University, Sweden.

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http://dx.doi.org/10.1021/pr070547dDOI Listing
January 2008

Continuous full filling capillary electrochromatography: chromatographic performance and reproducibility.

J Chromatogr A 2007 Jun 24;1154(1-2):386-9. Epub 2007 Feb 24.

Analytical Chemistry, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.

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http://dx.doi.org/10.1016/j.chroma.2007.02.059DOI Listing
June 2007

Continuous full filling capillary electrochromatography: nanoparticle synthesis and evaluation.

J Chromatogr A 2007 Jun 2;1154(1-2):379-85. Epub 2007 Mar 2.

Analytical Chemistry, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.

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http://dx.doi.org/10.1016/j.chroma.2007.02.092DOI Listing
June 2007

Nanoparticle-based continuous full filling capillary electrochromatography/electrospray ionization-mass spectrometry for separation of neutral compounds.

Anal Chem 2006 Sep;78(17):6088-95

Pure and Applied Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, 221 00 Lund, Sweden.

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http://dx.doi.org/10.1021/ac060526nDOI Listing
September 2006

Chiral separations by HPLC using molecularly imprinted polymers.

Methods Mol Biol 2004 ;243:217-29

Departmento f Technical Analytical Chemistry, Lund Univerity, Sweden.

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http://dx.doi.org/10.1385/1-59259-648-7:217DOI Listing
June 2004

Chiral separations by capillary electrochromatography using molecularly imprinted polymers.

Methods Mol Biol 2004 ;243:411-24

Department of Technical Analytical Chemistry, Lund University, Sweden.

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http://dx.doi.org/10.1385/1-59259-648-7:411DOI Listing
June 2004

Molecularly imprinted polymer formats for capillary electrochromatography.

J Chromatogr B Analyt Technol Biomed Life Sci 2004 May;804(1):3-12

Technical Analytical Chemistry, Lund Institute of Technology, Lund University, PO Box 124, SE-221 00 Lund, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S157002320400021
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http://dx.doi.org/10.1016/j.jchromb.2003.12.036DOI Listing
May 2004

Molecularly imprinted polymers in capillary electrochromatography: recent developments and future trends.

Electrophoresis 2003 Dec;24(22-23):3892-9

Technical Analytical Chemistry, Lund Institute of Technology, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1002/elps.200305665DOI Listing
December 2003

Selectivity toward multiple predetermined targets in nanoparticle capillary electrochromatography.

Anal Chem 2003 Dec;75(23):6608-13

Technical Analytical Chemistry, Lund Institute of Technology, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.

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http://dx.doi.org/10.1021/ac034732wDOI Listing
December 2003

Nanoparticles as pseudostationary phase in capillary electrochromatography/ESI-MS.

Anal Chem 2002 Sep;74(18):4595-601

Center for Chemistry and Chemical Engineering, Lund University, Sweden.

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http://dx.doi.org/10.1021/ac0204045DOI Listing
September 2002

Molecularly imprinted polymers.

Anal Bioanal Chem 2002 Jan 12;372(1):37-8. Epub 2001 Dec 12.

Technical Analytical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, Sweden.

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http://dx.doi.org/10.1007/s00216-001-1155-0DOI Listing
January 2002