Peter S Sever

Peter S Sever

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Peter S Sever

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Efficacy and Safety of Evolocumab in Chronic Kidney Disease in the FOURIER Trial.

J Am Coll Cardiol 2019 Jun;73(23):2961-2970

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; TIMI Study Group, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: https://twitter.com/rgiugliano.

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http://dx.doi.org/10.1016/j.jacc.2019.03.513DOI Listing
June 2019

The importance of a valid assessment of salt intake in individuals and populations. A scientific statement of the British and Irish Hypertension Society.

J Hum Hypertens 2019 May 26;33(5):345-348. Epub 2019 Apr 26.

Imperial College London, National Heart & Lung Institute, London, UK.

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http://dx.doi.org/10.1038/s41371-019-0203-1DOI Listing
May 2019

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Authors:
Mary F Feitosa Aldi T Kraja Daniel I Chasman Yun J Sung Thomas W Winkler Ioanna Ntalla Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jonathan Marten Solomon K Musani Changwei Li Amy R Bentley Michael R Brown Karen Schwander Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Rajkumar Dorajoo Virginia Fisher Fernando P Hartwig Andrea R V R Horimoto Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Mary K Wojczynski Maris Alver Mathilde Boissel Qiuyin Cai Archie Campbell Jin Fang Chai Xu Chen Jasmin Divers Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Meian He Fang-Chi Hsu Anne U Jackson Mika Kähönen Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Jian'an Luan Nana Matoba Ilja M Nolte Sandosh Padmanabhan Muhammad Riaz Rico Rueedi Antonietta Robino M Abdullah Said Robert A Scott Tamar Sofer Alena Stančáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Veronique Vitart Yajuan Wang Erin B Ware Helen R Warren Stefan Weiss Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Eric Boerwinkle Ingrid Borecki Ulrich Broeckel Morris Brown Marco Brumat Gregory L Burke Mickaël Canouil Aravinda Chakravarti Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Adolfo Correa Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Xuan Deng Jingzhong Ding Qing Duan Charles B Eaton Georg Ehret Ruben N Eppinga Evangelos Evangelou Jessica D Faul Stephan B Felix Nita G Forouhi Terrence Forrester Oscar H Franco Yechiel Friedlander Ilaria Gandin He Gao Mohsen Ghanbari Bruna Gigante C Charles Gu Dongfeng Gu Saskia P Hagenaars Göran Hallmans Tamara B Harris Jiang He Sami Heikkinen Chew-Kiat Heng Makoto Hirata Barbara V Howard M Arfan Ikram Ulrich John Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh José E Krieger Stephen B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Cora E Lewis Yize Li Shiow Lin Jianjun Liu Jingmin Liu Marie Loh Tin Louie Reedik Mägi Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Yukihide Momozawa Mike A Nalls Christopher P Nelson Nona Sotoodehnia Jill M Norris Jeff R O'Connell Nicholette D Palmer Thomas Perls Nancy L Pedersen Annette Peters Patricia A Peyser Neil Poulter Leslie J Raffel Olli T Raitakari Kathryn Roll Lynda M Rose Frits R Rosendaal Jerome I Rotter Carsten O Schmidt Pamela J Schreiner Nicole Schupf William R Scott Peter S Sever Yuan Shi Stephen Sidney Mario Sims Colleen M Sitlani Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Heather M Stringham Nicholas Y Q Tan Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham Stephen T Turner André G Uitterlinden Peter Vollenweider Melanie Waldenberger Lihua Wang Ya Xing Wang Wen Bin Wei Christine Williams Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Jost Bruno Jonas Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Zoltán Kutalik Markku Laakso Cathy C Laurie Karin Leander Terho Lehtimäki Lifelines Cohort Study Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Ozren Polasek David J Porteous Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Tangchun Wu Wei Zheng Claude Bouchard Kaare Christensen Michele K Evans Vilmundur Gudnason Bernardo L Horta Sharon L R Kardia Yongmei Liu Alexandre C Pereira Bruce M Psaty Paul M Ridker Rob M van Dam W James Gauderman Xiaofeng Zhu Dennis O Mook-Kanamori Myriam Fornage Charles N Rotimi L Adrienne Cupples Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Charles Kooperberg Walter Palmas Kenneth Rice Alanna C Morrison Paul Elliott Mark J Caulfield Patricia B Munroe Dabeeru C Rao Michael A Province Daniel Levy

PLoS One 2018 18;13(6):e0198166. Epub 2018 Jun 18.

The Framingham Heart Study, Framingham, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005576PMC
January 2019

Inflammatory and Cholesterol Risk in the FOURIER Trial.

Circulation 2018 Jul 12;138(2):131-140. Epub 2018 Mar 12.

TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.B., R.P.G., J.-G.P., S.A.M., M.S.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034032DOI Listing
July 2018

Clinical benefits of evolocumab appear less than hoped - Authors' reply.

Lancet 2018 03;391(10124):934-935

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S0140-6736(18)30529-4DOI Listing
March 2018

Cognitive Function in a Randomized Trial of Evolocumab.

N Engl J Med 2017 08;377(7):633-643

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Brigham and Women's Hospital, Boston (R.P.G., K.I., E.K., M.S.S.); Hôpital Cantonal, Hopitaux Universitaires de Genève, Geneva (F.M.); Cambridge Cognition, Cambridge (K.Z.), and International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London (P.S.S.) - both in the United Kingdom; Amgen, Thousand Oaks, CA (C.K., J.S., H.W., N.H., S.M.W.); Sydney Medical School, NHMRC Clinical Trials Centre, University of Sydney, Sydney (A.K.); Oslo University Hospital, Ullevål, and Medical Faculty, University of Oslo - both in Oslo (T.R.P.); University of Iowa, Iowa City (J.G.R.); and Rhode Island Hospital, Department of Neurology, Alpert Medical School of Brown University, Providence (B.R.O.).

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http://www.nejm.org/doi/10.1056/NEJMoa1701131
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http://dx.doi.org/10.1056/NEJMoa1701131DOI Listing
August 2017

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.

N Engl J Med 2017 05 17;376(18):1713-1722. Epub 2017 Mar 17.

From the Thrombolysis in Myocardial Infarction (TIMI) Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (M.S.S., R.P.G., S.D.W., S.A.M., J.F.K.); Sydney Medical School, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney (A.C.K.); Amgen, Thousand Oaks, CA (N.H., H.W., T.L., S.M.W.); International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London (P.S.S.); and Oslo University Hospital, Ullevål and Medical Faculty, University of Oslo, Oslo (T.R.P.).

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http://dx.doi.org/10.1056/NEJMoa1615664DOI Listing
May 2017

Development and Validation of a Model to Predict Absolute Vascular Risk Reduction by Moderate-Intensity Statin Therapy in Individual Patients With Type 2 Diabetes Mellitus: The Anglo Scandinavian Cardiac Outcomes Trial, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, and Collaborative Atorvastatin Diabetes Study.

Circ Cardiovasc Qual Outcomes 2016 05 11;9(3):213-21. Epub 2016 May 11.

From the Department of Vascular Medicine (L.K., F.L.J.V.) and Julius Centre for Health Sciences and Primary Care (Y.v.d.G.), University Medical Centre Utrecht, Utrecht, The Netherlands; ICCH, Imperial College London, London, United Kingdom (N.R.P., P.S.S.); Biomedical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom (H.M.C., S.J.L.); Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands (S.M.B.); and University of Texas Health Science Center, Houston (S.L.P., B.R.D.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.115.001980DOI Listing
May 2016

Rationale and design of the Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk trial.

Am Heart J 2016 Mar 17;173:94-101. Epub 2015 Dec 17.

Oslo University Hospital, Ullevål and Medical Faculty, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1016/j.ahj.2015.11.015DOI Listing
March 2016

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Authors:
Daniel I Swerdlow David Preiss Karoline B Kuchenbaecker Michael V Holmes Jorgen E L Engmann Tina Shah Reecha Sofat Stefan Stender Paul C D Johnson Robert A Scott Maarten Leusink Niek Verweij Stephen J Sharp Yiran Guo Claudia Giambartolomei Christina Chung Anne Peasey Antoinette Amuzu KaWah Li Jutta Palmen Philip Howard Jackie A Cooper Fotios Drenos Yun R Li Gordon Lowe John Gallacher Marlene C W Stewart Ioanna Tzoulaki Sarah G Buxbaum Daphne L van der A Nita G Forouhi N Charlotte Onland-Moret Yvonne T van der Schouw Renate B Schnabel Jaroslav A Hubacek Ruzena Kubinova Migle Baceviciene Abdonas Tamosiunas Andrzej Pajak Roman Topor-Madry Urszula Stepaniak Sofia Malyutina Damiano Baldassarre Bengt Sennblad Elena Tremoli Ulf de Faire Fabrizio Veglia Ian Ford J Wouter Jukema Rudi G J Westendorp Gert Jan de Borst Pim A de Jong Ale Algra Wilko Spiering Anke H Maitland-van der Zee Olaf H Klungel Anthonius de Boer Pieter A Doevendans Charles B Eaton Jennifer G Robinson David Duggan John Kjekshus John R Downs Antonio M Gotto Anthony C Keech Roberto Marchioli Gianni Tognoni Peter S Sever Neil R Poulter David D Waters Terje R Pedersen Pierre Amarenco Haruo Nakamura John J V McMurray James D Lewsey Daniel I Chasman Paul M Ridker Aldo P Maggioni Luigi Tavazzi Kausik K Ray Sreenivasa Rao Kondapally Seshasai JoAnn E Manson Jackie F Price Peter H Whincup Richard W Morris Debbie A Lawlor George Davey Smith Yoav Ben-Shlomo Pamela J Schreiner Myriam Fornage David S Siscovick Mary Cushman Meena Kumari Nick J Wareham W M Monique Verschuren Susan Redline Sanjay R Patel John C Whittaker Anders Hamsten Joseph A Delaney Caroline Dale Tom R Gaunt Andrew Wong Diana Kuh Rebecca Hardy Sekar Kathiresan Berta A Castillo Pim van der Harst Eric J Brunner Anne Tybjaerg-Hansen Michael G Marmot Ronald M Krauss Michael Tsai Josef Coresh Ronald C Hoogeveen Bruce M Psaty Leslie A Lange Hakon Hakonarson Frank Dudbridge Steve E Humphries Philippa J Talmud Mika Kivimäki Nicholas J Timpson Claudia Langenberg Folkert W Asselbergs Mikhail Voevoda Martin Bobak Hynek Pikhart James G Wilson Alex P Reiner Brendan J Keating Aroon D Hingorani Naveed Sattar

Lancet 2015 Jan 24;385(9965):351-61. Epub 2014 Sep 24.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/S0140-6736(14)61183-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322187PMC
January 2015

The value of N-terminal pro-B-type natriuretic peptide in determining antihypertensive benefit: observations from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).

Hypertension 2014 Mar 9;63(3):507-13. Epub 2013 Dec 9.

BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Pl, Glasgow G12 8TA, United Kingdom. or

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02204DOI Listing
March 2014

Evaluation of C-reactive protein before and on-treatment as a predictor of benefit of atorvastatin: a cohort analysis from the Anglo-Scandinavian Cardiac Outcomes Trial lipid-lowering arm.

J Am Coll Cardiol 2013 Aug;62(8):717-29

International Centre for Circulatory Health, National Heart & Lung Institute, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2013.02.098DOI Listing
August 2013

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Authors:
Marcel den Hoed Mark Eijgelsheim Tõnu Esko Bianca J J M Brundel David S Peal David M Evans Ilja M Nolte Ayellet V Segrè Hilma Holm Robert E Handsaker Harm-Jan Westra Toby Johnson Aaron Isaacs Jian Yang Alicia Lundby Jing Hua Zhao Young Jin Kim Min Jin Go Peter Almgren Murielle Bochud Gabrielle Boucher Marilyn C Cornelis Daniel Gudbjartsson David Hadley Pim van der Harst Caroline Hayward Martin den Heijer Wilmar Igl Anne U Jackson Zoltán Kutalik Jian'an Luan John P Kemp Kati Kristiansson Claes Ladenvall Mattias Lorentzon May E Montasser Omer T Njajou Paul F O'Reilly Sandosh Padmanabhan Beate St Pourcain Tuomo Rankinen Perttu Salo Toshiko Tanaka Nicholas J Timpson Veronique Vitart Lindsay Waite William Wheeler Weihua Zhang Harmen H M Draisma Mary F Feitosa Kathleen F Kerr Penelope A Lind Evelin Mihailov N Charlotte Onland-Moret Ci Song Michael N Weedon Weijia Xie Loic Yengo Devin Absher Christine M Albert Alvaro Alonso Dan E Arking Paul I W de Bakker Beverley Balkau Cristina Barlassina Paola Benaglio Joshua C Bis Nabila Bouatia-Naji Søren Brage Stephen J Chanock Peter S Chines Mina Chung Dawood Darbar Christian Dina Marcus Dörr Paul Elliott Stephan B Felix Krista Fischer Christian Fuchsberger Eco J C de Geus Philippe Goyette Vilmundur Gudnason Tamara B Harris Anna-Liisa Hartikainen Aki S Havulinna Susan R Heckbert Andrew A Hicks Albert Hofman Suzanne Holewijn Femke Hoogstra-Berends Jouke-Jan Hottenga Majken K Jensen Asa Johansson Juhani Junttila Stefan Kääb Bart Kanon Shamika Ketkar Kay-Tee Khaw Joshua W Knowles Angrad S Kooner Jan A Kors Meena Kumari Lili Milani Päivi Laiho Edward G Lakatta Claudia Langenberg Maarten Leusink Yongmei Liu Robert N Luben Kathryn L Lunetta Stacey N Lynch Marcello R P Markus Pedro Marques-Vidal Irene Mateo Leach Wendy L McArdle Steven A McCarroll Sarah E Medland Kathryn A Miller Grant W Montgomery Alanna C Morrison Martina Müller-Nurasyid Pau Navarro Mari Nelis Jeffrey R O'Connell Christopher J O'Donnell Ken K Ong Anne B Newman Annette Peters Ozren Polasek Anneli Pouta Peter P Pramstaller Bruce M Psaty Dabeeru C Rao Susan M Ring Elizabeth J Rossin Diana Rudan Serena Sanna Robert A Scott Jaban S Sehmi Stephen Sharp Jordan T Shin Andrew B Singleton Albert V Smith Nicole Soranzo Tim D Spector Chip Stewart Heather M Stringham Kirill V Tarasov André G Uitterlinden Liesbeth Vandenput Shih-Jen Hwang John B Whitfield Cisca Wijmenga Sarah H Wild Gonneke Willemsen James F Wilson Jacqueline C M Witteman Andrew Wong Quenna Wong Yalda Jamshidi Paavo Zitting Jolanda M A Boer Dorret I Boomsma Ingrid B Borecki Cornelia M van Duijn Ulf Ekelund Nita G Forouhi Philippe Froguel Aroon Hingorani Erik Ingelsson Mika Kivimaki Richard A Kronmal Diana Kuh Lars Lind Nicholas G Martin Ben A Oostra Nancy L Pedersen Thomas Quertermous Jerome I Rotter Yvonne T van der Schouw W M Monique Verschuren Mark Walker Demetrius Albanes David O Arnar Themistocles L Assimes Stefania Bandinelli Michael Boehnke Rudolf A de Boer Claude Bouchard W L Mark Caulfield John C Chambers Gary Curhan Daniele Cusi Johan Eriksson Luigi Ferrucci Wiek H van Gilst Nicola Glorioso Jacqueline de Graaf Leif Groop Ulf Gyllensten Wen-Chi Hsueh Frank B Hu Heikki V Huikuri David J Hunter Carlos Iribarren Bo Isomaa Marjo-Riitta Jarvelin Antti Jula Mika Kähönen Lambertus A Kiemeney Melanie M van der Klauw Jaspal S Kooner Peter Kraft Licia Iacoviello Terho Lehtimäki Marja-Liisa L Lokki Braxton D Mitchell Gerjan Navis Markku S Nieminen Claes Ohlsson Neil R Poulter Lu Qi Olli T Raitakari Eric B Rimm John D Rioux Federica Rizzi Igor Rudan Veikko Salomaa Peter S Sever Denis C Shields Alan R Shuldiner Juha Sinisalo Alice V Stanton Ronald P Stolk David P Strachan Jean-Claude Tardif Unnur Thorsteinsdottir Jaako Tuomilehto Dirk J van Veldhuisen Jarmo Virtamo Jorma Viikari Peter Vollenweider Gérard Waeber Elisabeth Widen Yoon Shin Cho Jesper V Olsen Peter M Visscher Cristen Willer Lude Franke Jeanette Erdmann John R Thompson Arne Pfeufer Nona Sotoodehnia Christopher Newton-Cheh Patrick T Ellinor Bruno H Ch Stricker Andres Metspalu Markus Perola Jacques S Beckmann George Davey Smith Kari Stefansson Nicholas J Wareham Patricia B Munroe Ody C M Sibon David J Milan Harold Snieder Nilesh J Samani Ruth J F Loos

Nat Genet 2013 Jun 14;45(6):621-31. Epub 2013 Apr 14.

Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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http://www.nature.com/protocolexchange/system/uploads/2514/o
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http://www.nature.com/doifinder/10.1038/ng.2610
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http://dx.doi.org/10.1038/ng.2610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696959PMC
June 2013

First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study.

Int J Cardiol 2013 Jan 29;162(3):189-92. Epub 2012 Sep 29.

National Heart and Lung Institute, International Centre for Circulatory Health, Imperial College London & Imperial College Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.1016/j.ijcard.2012.09.019DOI Listing
January 2013

Is plasma renin activity a biomarker for the prediction of renal and cardiovascular outcomes in treated hypertensive patients? Observations from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).

Eur Heart J 2012 Dec 31;33(23):2970-9. Epub 2012 Aug 31.

Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, 59 North Wharf Road, London W2 1LA, UK.

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http://dx.doi.org/10.1093/eurheartj/ehs241DOI Listing
December 2012

The Anglo-Scandinavian Cardiac Outcomes Trial: implications and further outcomes.

Authors:
Peter S Sever

Hypertension 2012 Aug 2;60(2):248-59. Epub 2012 Jul 2.

International Centre for Circulatory Health, Imperial College London, 59 North Wharf Rd, London W2 1LA, United Kingdom.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.111.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.187070DOI Listing
August 2012

Hypertension management 2011: optimal combination therapy.

Eur Heart J 2011 Oct 22;32(20):2499-506. Epub 2011 Jun 22.

International Centre for Circulatory Health, Imperial College London, 59 North Wharf Road, London W2 1LA, UK.

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http://dx.doi.org/10.1093/eurheartj/ehr177DOI Listing
October 2011

The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K.

Eur Heart J 2011 Oct 28;32(20):2525-32. Epub 2011 Aug 28.

Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, 59 North Wharf Road, London W2 1PG, UK.

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http://dx.doi.org/10.1093/eurheartj/ehr333DOI Listing
October 2011

Ethnic variations in lipid-lowering in response to a statin (EVIREST): a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).

Ethn Dis 2011 ;21(2):150-7

International Centre for Circulatory Health, Imperial College, London, UK.

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September 2011

Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke.

Lancet Neurol 2010 May 11;9(5):469-80. Epub 2010 Mar 11.

Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/S1474-4422(10)70066-1DOI Listing
May 2010

Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.

J Am Coll Cardiol 2010 Apr;55(17):1875-81

International Centre for Circulatory Health, NHLI, St. Mary's Hospital and Imperial College London, St. Mary'sCampus, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2009.11.084DOI Listing
April 2010

Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy.

Eur Heart J 2010 Mar 26;31(6):747-52. Epub 2009 Nov 26.

Department of Cardiology, International Centre for Circulatory Health, St Mary's Hospital and Imperial College London, 59-61 North Wharf Road, Paddington, London W2 1LA, UK.

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http://dx.doi.org/10.1093/eurheartj/ehp498DOI Listing
March 2010

Aspirin and primary prevention. BHS reaffirms its guidance.

Authors:
Peter S Sever

BMJ 2010 Mar 2;340:c1183. Epub 2010 Mar 2.

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http://dx.doi.org/10.1136/bmj.c1183DOI Listing
March 2010

Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension.

Lancet 2010 Mar;375(9718):895-905

Stroke Prevention Research Unit, University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(10)60308-XDOI Listing
March 2010

Atorvastatin treatment is associated with less augmentation of the carotid pressure waveform in hypertension: a substudy of the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT).

Hypertension 2009 Nov 31;54(5):1009-13. Epub 2009 Aug 31.

International Centre for Circulatory Health, Imperial College London & Imperial College Healthcare NHS Trust, London W2 1LA, UK.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.130914DOI Listing
November 2009

Coronary heart disease benefits from blood pressure and lipid-lowering.

Int J Cardiol 2009 Jun 20;135(2):218-22. Epub 2009 Feb 20.

Clinical Pharmacology and Therapeutics, Imperial College London, International Centre for Circulatory Health, London, UK.

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http://dx.doi.org/10.1016/j.ijcard.2009.01.036DOI Listing
June 2009

Managing cardiovascular and renal risk: the potential of direct renin inhibition.

J Renin Angiotensin Aldosterone Syst 2009 Jun;10(2):65-76

International Centre for Circulatory Health, Imperial College London, UK.

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http://dx.doi.org/10.1177/1470320309104662DOI Listing
June 2009

Antihypertensive therapy and the benefits of atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial: lipid-lowering arm extension.

J Hypertens 2009 May;27(5):947-54

Imperial College London, International Centre for Circulatory Health, London, UK.

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http://dx.doi.org/10.1097/HJH.0b013e328326cb1aDOI Listing
May 2009

Ethnicity and left ventricular diastolic function in hypertension an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.

J Am Coll Cardiol 2008 Sep;52(12):1015-21

International Centre for Circulatory Health, St Mary's Hospital and Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jacc.2008.04.065DOI Listing
September 2008

Effect of doxazosin gastrointestinal therapeutic system as third-line antihypertensive therapy on blood pressure and lipids in the Anglo-Scandinavian Cardiac Outcomes Trial.

Circulation 2008 Jul 16;118(1):42-8. Epub 2008 Jun 16.

International Centre for Circulatory Health, Imperial College London, 59 N Wharf Rd, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.737957DOI Listing
July 2008

The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure.

Eur Heart J 2008 Feb 5;29(4):499-508. Epub 2008 Jan 5.

International Centre for Circulatory Health, Imperial College London, 59 North Wharf Road, London W2 1PG, UK.

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http://dx.doi.org/10.1093/eurheartj/ehm583DOI Listing
February 2008

Effect of spironolactone on blood pressure in subjects with resistant hypertension.

Hypertension 2007 Apr 19;49(4):839-45. Epub 2007 Feb 19.

International Centre for Circulatory Health, Imperial College London, 59 North Wharf Rd, London W2 1PG, United Kingdom.

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http://dx.doi.org/10.1161/01.HYP.0000259805.18468.8cDOI Listing
April 2007

Blood pressure reduction is not the only determinant of outcome.

Circulation 2006 Jun;113(23):2754-72; discussion 2773-4

International Centre for Circulatory Health, Imperial College London, 59 N. Wharf Rd, London, W2 1PG, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.588020DOI Listing
June 2006

Lipid-lowering therapy and the patient with multiple risk factors: what have we learned from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)?

Authors:
Peter S Sever

Am J Med 2005 Dec;118 Suppl 12A:3-9

International Centre for Circulatory Health, Imperial College London, London, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S000293430500796
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http://dx.doi.org/10.1016/j.amjmed.2005.09.002DOI Listing
December 2005

British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary.

BMJ 2004 Mar;328(7440):634-40

Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester.

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http://dx.doi.org/10.1136/bmj.328.7440.634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381142PMC
March 2004

Improving Antihypertensive Efficacy while Maintaining Placebo-like Tolerability.

Authors:
Peter S Sever

Blood Press 2000 ;9(sup1):19-22

a Queen Elizabeth The Queen Mother Wing, St. Mary's Hospital School of Medicine, Norfolk Place, London, W2 1PG UK.

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http://dx.doi.org/10.1080/080370500439173DOI Listing
January 2000