Peter S Nelson

Peter S Nelson

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Peter S Nelson

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Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.

Prostate 2019 Sep 2;79(13):1530-1542. Epub 2019 Aug 2.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/pros.23874DOI Listing
September 2019

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Prostate 2019 Aug 18;79(11):1326-1337. Epub 2019 Jun 18.

Department of Anatomy and Developmental Biology, Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1002/pros.23839DOI Listing
August 2019

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

Nat Cell Biol 2019 02 21;21(2):238-250. Epub 2019 Jan 21.

Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41556-018-0267-0
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http://dx.doi.org/10.1038/s41556-018-0267-0DOI Listing
February 2019

The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells.

Mol Cancer Res 2019 01 17;17(1):321-331. Epub 2018 Sep 17.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0522DOI Listing
January 2019

Downregulation of Accelerates Progression to Castration-Resistant Prostate Cancer.

Cancer Res 2018 11 21;78(22):6354-6362. Epub 2018 Sep 21.

Department of Medicine and Cancer Center, Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239953PMC
November 2018

Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance.

Cold Spring Harb Perspect Med 2018 08 1;8(8). Epub 2018 Aug 1.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

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http://dx.doi.org/10.1101/cshperspect.a030510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681439PMC
August 2018

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models.

Neoplasia 2018 08 4;20(8):789-799. Epub 2018 Jul 4.

Molecular Oncology and Biomarkers Program, Georgia Cancer Center; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; MetCure Therapeutics LLC, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034581PMC
August 2018

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms.

J Urol 2018 06 12;199(6):1494-1501. Epub 2018 Jan 12.

The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.juro.2018.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964005PMC
June 2018

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.

Cell 2018 06;173(7):1770-1782.e14

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084431PMC
June 2018

Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice.

J Biol Chem 2018 05 22;293(18):6996-7007. Epub 2018 Mar 22.

From the Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294,

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http://dx.doi.org/10.1074/jbc.RA117.001646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936824PMC
May 2018

Prostate Cancer Screening in a New Era of Genetics.

Clin Genitourin Cancer 2017 12 31;15(6):625-628. Epub 2017 May 31.

Department of Medicine, University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA.

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http://dx.doi.org/10.1016/j.clgc.2017.05.024DOI Listing
December 2017

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Cancer Cell 2017 10;32(4):474-489.e6

Department of Medicine, University of Washington, Seattle, WA, USA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Mailstop D4-100, 1100 Fairview Avenue N, Seattle, WA 98109-1024, USA; Department of Urology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750052PMC
October 2017

loss is associated with prostate cancer recurrence and alterations in tumor DNA methylation profiles.

Oncotarget 2017 Oct 15;8(48):84338-84348. Epub 2017 Sep 15.

Division of Public Health Sciences, Fred Hutchison Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.18632/oncotarget.20940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663600PMC
October 2017

DNA Damage Induces a Secretory Program in the Quiescent TME that Fosters Adverse Cancer Phenotypes.

Mol Cancer Res 2017 07 29;15(7):842-851. Epub 2017 Mar 29.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859576PMC
July 2017

The Path of Most Resistance: Transdifferentiation Underlies Exceptional Nonresponses to Androgen Receptor Pathway Inhibition in Prostate Cancer.

Cancer Discov 2017 07;7(7):673-674

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0481DOI Listing
July 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675034PMC
June 2017

Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy.

Clin Epigenetics 2016;8:97. Epub 2016 Sep 15.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024 USA ; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA USA.

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http://dx.doi.org/10.1186/s13148-016-0260-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024414PMC
April 2017

Timing of Adverse Prostate Cancer Reclassification on First Surveillance Biopsy: Results from the Canary Prostate Cancer Active Surveillance Study.

J Urol 2017 04 1;197(4):1026-1033. Epub 2016 Nov 1.

University of Washington School of Medicine, Seattle, Washington; Seattle Puget Sound Health Care System, Veterans Affairs Hospital, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.10.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571762PMC
April 2017

Expression of STAT3 in Prostate Cancer Metastases.

Eur Urol 2017 03 22;71(3):313-316. Epub 2016 Jun 22.

Department of Translational Medicine, Division of Urological Cancers, Lund University, Malmö, Sweden; Department of Urology, Skåne University Hospital, Lund University, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624794PMC
March 2017

Anti-Depressant Therapy Brightens the Outlook for Prostate Cancer Bone Metastases.

Cancer Cell 2017 03;31(3):303-305

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.02.012DOI Listing
March 2017

Screening Men at Increased Risk for Prostate Cancer Diagnosis: Model Estimates of Benefits and Harms.

Cancer Epidemiol Biomarkers Prev 2017 02 14;26(2):222-227. Epub 2016 Oct 14.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296376PMC
February 2017

Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors.

Oncotarget 2017 Jan;8(4):6179-6192

Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center Baylor College of Medicine, Houston, 77030, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.14049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351622PMC
January 2017

A proteolytic modification of AIM promotes its renal excretion.

Sci Rep 2016 12 8;6:38762. Epub 2016 Dec 8.

Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/srep38762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144010PMC
December 2016

Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort.

Am J Surg Pathol 2016 11;40(11):1439-1456

*Cleveland Clinic, Cleveland, OH †University of Texas MD Anderson Cancer Center, Houston ††University of Texas Health Sciences Center San Antonio, San Antonio, TX ‡Canary Foundation, Palo Alto #University of California- San Francisco, San Francisco ‡‡Stanford University Medical Center, Stanford, CA §Fred Hutchinson Cancer Research Center ∥University of Washington Medical Center, Seattle, WA **Eastern Virginia Medical School, Norfolk, VA ¶University of British Columbia, Vancouver, BC, Canada.

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http://pdfs.journals.lww.com/ajsp/2016/11000/Histologic_Grad
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http://dx.doi.org/10.1097/PAS.0000000000000736DOI Listing
November 2016

DNA-Repair Gene Mutations in Metastatic Prostate Cancer.

N Engl J Med 2016 11;375(18):1804-5

Fred Hutchinson Cancer Research Center, Seattle, WA

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http://dx.doi.org/10.1056/NEJMc1611137DOI Listing
November 2016

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

N Engl J Med 2016 Aug 6;375(5):443-53. Epub 2016 Jul 6.

From the University of Washington (C.C.P., M. Beightol, C.M., B.N., H.H.C., B.M., T.W., S. Casadei, P.S.N.) and Fred Hutchinson Cancer Research Center (N.D.S., R.G., P.S.N.) - both in Seattle; the Institute of Cancer Research and Royal Marsden Hospital, London (J.M., S. Carreira, R.E., J.B.); Memorial Sloan Kettering Cancer Center (M.F.W., W.A., M. Berger, L.Z., A.Z., J. Vijai, H.I.S., C.S., N.S., P.W.K., D.S., M.R., K.O.), Weill Cornell Medical College (H.B., O.E., M.A.R.), and the Prostate Cancer Clinical Trials Consortium (J. Vinson, J.F.) - all in New York; the University of Michigan, Ann Arbor (D.R., R.L., M.H., A.C.); Howard Hughes Medical Institute, Chevy Chase, MD (A.C., C.S.); and Dana-Farber Cancer Institute, Boston (A.G., L.G., M.-E.T., S.A., G.C.H., E.M.V.A.).

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http://dx.doi.org/10.1056/NEJMoa1603144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986616PMC
August 2016

ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer.

Clin Cancer Res 2016 07 2;22(14):3672-82. Epub 2016 Mar 2.

Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, Massachusetts. Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947432PMC
July 2016

Docetaxel-related toxicity in metastatic hormone-sensitive and metastatic castration-resistant prostate cancer.

Med Oncol 2016 Jul 14;33(7):77. Epub 2016 Jun 14.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s12032-016-0793-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298886PMC
July 2016

Biallelic Inactivation of BRCA2 in Platinum-sensitive Metastatic Castration-resistant Prostate Cancer.

Eur Urol 2016 06 24;69(6):992-5. Epub 2015 Dec 24.

Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909531PMC
June 2016

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.

Mol Cancer Res 2016 Apr 11;14(4):374-84. Epub 2016 Jan 11.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington. Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Pathology, University of Washington, Seattle, Washington. Department of Urology, University of Washington, Seattle, Washington. Department of Medicine, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582956PMC
April 2016

Trial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3.

J Clin Oncol 2016 Apr 22;34(12):1402-18. Epub 2016 Feb 22.

Howard I. Scher, Michael J. Morris, Dana E. Rathkopf, and Susan F. Slovin, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College; David Nanus, NewYork Presbyterian Weill Cornell Medical Center; Lawrence W. Schwartz, NewYork Presbyterian Columbia University Medical Center, New York, NY; Walter M. Stadler, University of Chicago Medicine, Chicago, IL; Celestina Higano and Peter S. Nelson, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA; Ethan Basch, University of North Carolina at Chapel Hill, Chapel Hill, NC; Emmanual S. Antonarakis and Michael A. Carducci, Johns Hopkins University School of Medicine, Baltimore, MD; Tomasz M. Beer, Oregon Health and Science University, Portland, OR; Paul G. Corn and Christopher Logothetis, MD Anderson Cancer Center, Houston, TX; Robert Dreicer, University of Virginia School of Medicine, Charlottesville, VA; Daniel J. George, Susan Halabi, and Andrew J. Armstrong, Duke University and Duke Cancer Institute, Durham, NC; Elisabeth I. Heath, Wayne State University Karmanos Cancer Institute, Detroit; and Maha Hussain, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; Wm. Kevin Kelly, Sidney Kimmel School of Medicine at Thomas Jefferson University, Philadelphia, PA; Glenn Liu and George Wilding, University of Wisconsin Carbone Cancer Center, Madison, WI; Mark N. Stein, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ; Charles S. Ryan and Eric J. Small, University of California Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Oliver Sartor, Tulane School of Medicine, New Orleans, LA; Matthew Raymond Smith, Massachusetts General Hospital Cancer Center and Harvard Medical School; Mary-Ellen Taplin and Philip W. Kantoff, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; Karim Fizazi, Institut Gustave Roussy, University of Paris Sud, Villejuif, Franc

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http://dx.doi.org/10.1200/JCO.2015.64.2702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872347PMC
April 2016

Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence.

J Mol Diagn 2016 Mar 2;18(2):215-24. Epub 2016 Jan 2.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Seattle Cancer Care Alliance, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816705PMC
March 2016

High-Resolution Genomic Profiling of Disseminated Tumor Cells in Prostate Cancer.

J Mol Diagn 2016 Jan 20;18(1):131-43. Epub 2015 Nov 20.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Urology, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715223PMC
January 2016

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors.

Cancer Cell 2015 Jun;27(6):797-808

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461839PMC
June 2015

Integrative clinical genomics of advanced prostate cancer.

Cell 2015 May;161(5):1215-1228

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484602PMC
May 2015