Publications by authors named "Peter S Nelson"

100Publications

FOXA2 promotes prostate cancer growth in the bone.

Am J Transl Res 2020 15;12(9):5619-5629. Epub 2020 Sep 15.

Department of Biochemistry and Molecular Biology, LSU Health Shreveport, LA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540102PMC
September 2020

Two Steps Forward and One Step Back for Precision in Prostate Cancer Treatment.

J Clin Oncol 2020 Sep 8:JCO2001755. Epub 2020 Sep 8.

Division of Oncology, Department of Medicine, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.20.01755DOI Listing
September 2020

Imaging Fibroblast Activation Protein Alpha Improves Diagnosis of Metastatic Prostate Cancer with Positron Emission Tomography.

Clin Cancer Res 2020 Sep 7;26(18):4882-4891. Epub 2020 Jul 7.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-1358DOI Listing
September 2020

Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress.

Cell Rep 2020 May;31(8):107669

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Urology, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453577PMC
May 2020

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4.

Neoplasia 2020 06 11;22(6):253-262. Epub 2020 May 11.

Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA; Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2020.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218227PMC
June 2020

and COVID-19: Serendipity or Opportunity for Intervention?

Cancer Discov 2020 06 10;10(6):779-782. Epub 2020 Apr 10.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-20-0451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437472PMC
June 2020

Comparison of four next generation sequencing platforms for fusion detection: Oncomine by ThermoFisher, AmpliSeq by illumina, FusionPlex by ArcherDX, and QIAseq by QIAGEN.

Cancer Genet 2020 05 7;243:11-18. Epub 2020 Mar 7.

Cytogenetics Laboratory, Seattle Cancer Care Alliance, United States; Clinical Research Division, Fred Hutchinson Cancer Research Center (FHCRC), 825 Eastlake Ave. E., MS: BL103, Seattle, WA 98109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2020.02.007DOI Listing
May 2020

Exploitation of CD133 for the Targeted Imaging of Lethal Prostate Cancer.

Clin Cancer Res 2020 03 15;26(5):1054-1064. Epub 2019 Nov 15.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056526PMC
March 2020

PEG10 Promoter-Driven Expression of Reporter Genes Enables Molecular Imaging of Lethal Prostate Cancer.

Cancer Res 2019 11 17;79(21):5668-5680. Epub 2019 Sep 17.

Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825593PMC
November 2019

Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion.

Prostate 2019 09 2;79(13):1530-1542. Epub 2019 Aug 2.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/pros.23874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783279PMC
September 2019

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer.

Prostate 2019 08 18;79(11):1326-1337. Epub 2019 Jun 18.

Department of Anatomy and Developmental Biology, Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute, Prostate Cancer Research Group, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1002/pros.23839DOI Listing
August 2019

Downregulation of Accelerates Progression to Castration-Resistant Prostate Cancer.

Cancer Res 2018 11 21;78(22):6354-6362. Epub 2018 Sep 21.

Department of Medicine and Cancer Center, Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239953PMC
November 2018

The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells.

Mol Cancer Res 2019 01 17;17(1):321-331. Epub 2018 Sep 17.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0522DOI Listing
January 2019

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models.

Neoplasia 2018 08 4;20(8):789-799. Epub 2018 Jul 4.

Molecular Oncology and Biomarkers Program, Georgia Cancer Center; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA; MetCure Therapeutics LLC, Atlanta, GA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034581PMC
August 2018

Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.

Cell 2018 06;173(7):1770-1782.e14

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.04.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084431PMC
June 2018

Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice.

J Biol Chem 2018 05 22;293(18):6996-7007. Epub 2018 Mar 22.

From the Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294,

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http://dx.doi.org/10.1074/jbc.RA117.001646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936824PMC
May 2018

Polyclonal Reversion Mutations Detected in Circulating Tumor DNA After Platinum Chemotherapy in a Patient With Metastatic Prostate Cancer.

JCO Precis Oncol 2018 14;2. Epub 2018 Feb 14.

All authors, University of Washington; and , Fred Hutchinson Cancer Research Center; and , Veterans Affairs Puget Sound Health Care System, Seattle, WA.

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http://dx.doi.org/10.1200/PO.17.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446371PMC
February 2018

Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms.

J Urol 2018 06 12;199(6):1494-1501. Epub 2018 Jan 12.

The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.juro.2018.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964005PMC
June 2018

loss is associated with prostate cancer recurrence and alterations in tumor DNA methylation profiles.

Oncotarget 2017 Oct 15;8(48):84338-84348. Epub 2017 Sep 15.

Division of Public Health Sciences, Fred Hutchison Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.18632/oncotarget.20940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663600PMC
October 2017

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.

Cancer Cell 2017 10;32(4):474-489.e6

Department of Medicine, University of Washington, Seattle, WA, USA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Mailstop D4-100, 1100 Fairview Avenue N, Seattle, WA 98109-1024, USA; Department of Urology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750052PMC
October 2017

Prostate Cancer Screening in a New Era of Genetics.

Clin Genitourin Cancer 2017 12 31;15(6):625-628. Epub 2017 May 31.

Department of Medicine, University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA.

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http://dx.doi.org/10.1016/j.clgc.2017.05.024DOI Listing
December 2017

The Path of Most Resistance: Transdifferentiation Underlies Exceptional Nonresponses to Androgen Receptor Pathway Inhibition in Prostate Cancer.

Cancer Discov 2017 07;7(7):673-674

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0481DOI Listing
July 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675034PMC
June 2017

Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance.

Cold Spring Harb Perspect Med 2018 08 1;8(8). Epub 2018 Aug 1.

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

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http://dx.doi.org/10.1101/cshperspect.a030510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681439PMC
August 2018

DNA Damage Induces a Secretory Program in the Quiescent TME that Fosters Adverse Cancer Phenotypes.

Mol Cancer Res 2017 07 29;15(7):842-851. Epub 2017 Mar 29.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859576PMC
July 2017

Anti-Depressant Therapy Brightens the Outlook for Prostate Cancer Bone Metastases.

Cancer Cell 2017 03;31(3):303-305

Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.02.012DOI Listing
March 2017

Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors.

Oncotarget 2017 Jan;8(4):6179-6192

Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Department of Veterans Affairs Medical Center Baylor College of Medicine, Houston, 77030, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.14049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351622PMC
January 2017

A proteolytic modification of AIM promotes its renal excretion.

Sci Rep 2016 12 8;6:38762. Epub 2016 Dec 8.

Laboratory of Molecular Biomedicine for Pathogenesis, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1038/srep38762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144010PMC
December 2016

Timing of Adverse Prostate Cancer Reclassification on First Surveillance Biopsy: Results from the Canary Prostate Cancer Active Surveillance Study.

J Urol 2017 04 1;197(4):1026-1033. Epub 2016 Nov 1.

University of Washington School of Medicine, Seattle, Washington; Seattle Puget Sound Health Care System, Veterans Affairs Hospital, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2016.10.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571762PMC
April 2017

DNA-Repair Gene Mutations in Metastatic Prostate Cancer.

N Engl J Med 2016 11;375(18):1804-5

Fred Hutchinson Cancer Research Center, Seattle, WA

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http://dx.doi.org/10.1056/NEJMc1611137DOI Listing
November 2016

Histologic Grading of Prostatic Adenocarcinoma Can Be Further Optimized: Analysis of the Relative Prognostic Strength of Individual Architectural Patterns in 1275 Patients From the Canary Retrospective Cohort.

Am J Surg Pathol 2016 11;40(11):1439-1456

*Cleveland Clinic, Cleveland, OH †University of Texas MD Anderson Cancer Center, Houston ††University of Texas Health Sciences Center San Antonio, San Antonio, TX ‡Canary Foundation, Palo Alto #University of California- San Francisco, San Francisco ‡‡Stanford University Medical Center, Stanford, CA §Fred Hutchinson Cancer Research Center ∥University of Washington Medical Center, Seattle, WA **Eastern Virginia Medical School, Norfolk, VA ¶University of British Columbia, Vancouver, BC, Canada.

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http://pdfs.journals.lww.com/ajsp/2016/11000/Histologic_Grad
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http://dx.doi.org/10.1097/PAS.0000000000000736DOI Listing
November 2016

Screening Men at Increased Risk for Prostate Cancer Diagnosis: Model Estimates of Benefits and Harms.

Cancer Epidemiol Biomarkers Prev 2017 02 14;26(2):222-227. Epub 2016 Oct 14.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296376PMC
February 2017

Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy.

Clin Epigenetics 2016;8:97. Epub 2016 Sep 15.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024 USA ; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA USA.

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http://dx.doi.org/10.1186/s13148-016-0260-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024414PMC
April 2017

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

N Engl J Med 2016 Aug 6;375(5):443-53. Epub 2016 Jul 6.

From the University of Washington (C.C.P., M. Beightol, C.M., B.N., H.H.C., B.M., T.W., S. Casadei, P.S.N.) and Fred Hutchinson Cancer Research Center (N.D.S., R.G., P.S.N.) - both in Seattle; the Institute of Cancer Research and Royal Marsden Hospital, London (J.M., S. Carreira, R.E., J.B.); Memorial Sloan Kettering Cancer Center (M.F.W., W.A., M. Berger, L.Z., A.Z., J. Vijai, H.I.S., C.S., N.S., P.W.K., D.S., M.R., K.O.), Weill Cornell Medical College (H.B., O.E., M.A.R.), and the Prostate Cancer Clinical Trials Consortium (J. Vinson, J.F.) - all in New York; the University of Michigan, Ann Arbor (D.R., R.L., M.H., A.C.); Howard Hughes Medical Institute, Chevy Chase, MD (A.C., C.S.); and Dana-Farber Cancer Institute, Boston (A.G., L.G., M.-E.T., S.A., G.C.H., E.M.V.A.).

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http://dx.doi.org/10.1056/NEJMoa1603144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986616PMC
August 2016

Expression of STAT3 in Prostate Cancer Metastases.

Eur Urol 2017 03 22;71(3):313-316. Epub 2016 Jun 22.

Department of Translational Medicine, Division of Urological Cancers, Lund University, Malmö, Sweden; Department of Urology, Skåne University Hospital, Lund University, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624794PMC
March 2017