Peter Pickkers

Peter Pickkers

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Peter Pickkers

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Noradrenaline drives immunosuppression in sepsis: clinical consequences.

Intensive Care Med 2020 Apr 8. Epub 2020 Apr 8.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00134-020-06025-2DOI Listing
April 2020

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes.

Crit Care 2020 03 20;24(1):110. Epub 2020 Mar 20.

Pathophysiology of Injury-Induced Immunosuppression, Université Claude Bernard Lyon 1, Hospices Civils de Lyon, bioMérieux, Edouard Herriot Hospital, 5 place d'Arsonval, 69437, Lyon Cedex 03, France.

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http://dx.doi.org/10.1186/s13054-020-2830-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082984PMC
March 2020

Effect of Vasopressors on the Macro- and Microcirculation During Systemic Inflammation in Humans In Vivo.

Shock 2020 Feb;53(2):171-174

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001357DOI Listing
February 2020

Influence of sedation on delirium recognition in critically ill patients: A multinational cohort study.

Aust Crit Care 2020 Feb 5. Epub 2020 Feb 5.

School of Pharmacy, Northeastern University, Boston, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aucc.2019.12.002DOI Listing
February 2020

The influence of hypoxia on platelet function and plasmatic coagulation during systemic inflammation in humans .

Platelets 2019 25;30(7):927-930. Epub 2018 Dec 25.

Department of Intensive Care Medicine, Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/09537104.2018.1557617DOI Listing
January 2020

Differentiation and activation of eosinophils in the human bone marrow during experimental human endotoxemia.

J Leukoc Biol 2020 Jan 10. Epub 2020 Jan 10.

Department of Respiratory Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/JLB.1AB1219-493RDOI Listing
January 2020

Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients.

Shock 2020 Jan 21. Epub 2020 Jan 21.

Department of Intensive Care Medicine, Radboud university medical center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001510DOI Listing
January 2020

Multicentric experience with interferon gamma therapy in sepsis induced immunosuppression. A case series.

BMC Infect Dis 2019 Nov 5;19(1):931. Epub 2019 Nov 5.

Groupe Hospitalier Saint-Louis Lariboisière, AP-HP, Université Paris 7 Denis Diderot, 2 rue Ambroise Paré, 75010, Paris, France.

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http://dx.doi.org/10.1186/s12879-019-4526-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833157PMC
November 2019

Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study.

J Crit Care 2019 Oct 11;53:120-124. Epub 2019 Jun 11.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Institute of Health Sciences, Radboud university medical center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2019.06.007DOI Listing
October 2019

Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230.

Nephron 2018 6;140(2):148-151. Epub 2018 Jul 6.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1159/000490772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214607PMC
September 2019

Precision Immunotherapy for Sepsis.

Front Immunol 2018 5;9:1926. Epub 2018 Sep 5.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.01926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133985PMC
September 2019

The Human Chorionic Gonadotropin Derivate EA-230 Modulates the Immune Response and Exerts Renal Protective Properties: Therapeutic Potential in Humans.

Semin Nephrol 2019 09;39(5):496-504

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Institute for Molecular Life Sciences, Radboud Center for Infectious Diseases (RCI), Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.semnephrol.2019.06.009DOI Listing
September 2019

Development and daily use of a numeric rating score to assess sleep quality in ICU patients.

J Crit Care 2019 Aug 6;52:68-74. Epub 2019 Apr 6.

Radboud University Medical Center, Department of Intensive Care Medicine, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183169
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http://dx.doi.org/10.1016/j.jcrc.2019.04.009DOI Listing
August 2019

Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium: Results of the REDUCE Study.

Anesthesiology 2019 08;131(2):328-335

From the Department of Intensive Care Medicine, Radboud Institute Health Science, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands (P.J.T.R., M.Z., J.G.v.d.H., P.P., M.v.d.B.) the Department of Intensive Care Medicine and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands (A.J.C.S.) the Department of Intensive Care Medicine, Medical Spectrum Twente, Enschede, The Netherlands (A.B.) the Department of Intensive Care Medicine, Jeroen Bosch Hospital Den-Bosch, The Netherlands (K.S.S.) the Department of Intensive Care Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (P.H.J.v.d.V.) the Tilburg Institute for Academical Studies School for Business and Society, Tilburg University, Tilburg, The Netherlands (P.H.J.v.d.V.) the Department Intensive Care Medicine, Zuyderland Medical Center, Heerlen, The Netherlands (M.C.E.v.d.W.) the Department Intensive Care Medicine, Gelre Hospital, Apeldoorn, The Netherlands (P.E.S.).

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http://dx.doi.org/10.1097/ALN.0000000000002812DOI Listing
August 2019

Innovative Drugs to Target Renal Inflammation in Sepsis: Alkaline Phosphatase.

Front Pharmacol 2019 23;10:919. Epub 2019 Aug 23.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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https://www.frontiersin.org/article/10.3389/fphar.2019.00919
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http://dx.doi.org/10.3389/fphar.2019.00919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716471PMC
August 2019

Fever in Sepsis: Still a Hot Topic.

Am J Respir Crit Care Med 2019 07;200(2):263-264

1 Radboud University Medical Center Nijmegen, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201903-0484LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635785PMC
July 2019

Pharmacokinetics, safety and tolerability of the novel β-hCG derived immunomodulatory compound, EA-230.

Br J Clin Pharmacol 2019 07 2;85(7):1572-1584. Epub 2019 Jun 2.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/bcp.13942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595371PMC
July 2019

Long-Term Effects of Experimental Human Endotoxemia on Immune Cell Function: Similarities and Differences With Sepsis.

Shock 2019 06;51(6):678-689

Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001222DOI Listing
June 2019

Obesity in the critically ill: a narrative review.

Intensive Care Med 2019 06 19;45(6):757-769. Epub 2019 Mar 19.

Anesthesia and Critical Care Department (DAR-B), Saint Eloi, University of Montpellier, Research Unit: PhyMedExp, INSERM U-1046, CNRS, 34295, Montpellier Cedex 5, France.

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http://link.springer.com/10.1007/s00134-019-05594-1
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http://dx.doi.org/10.1007/s00134-019-05594-1DOI Listing
June 2019

Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.

Front Immunol 2018 19;9:292. Epub 2018 Feb 19.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.00292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827550PMC
April 2019

Experimental human endotoxemia as a model of systemic inflammation.

Biochimie 2019 Apr 22;159:99-106. Epub 2018 Jun 22.

Dept. of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2018.06.014DOI Listing
April 2019

Preclinical safety evaluation of the adrenomedullin-binding antibody Adrecizumab in rodents, dogs and non-human primates.

Toxicol Appl Pharmacol 2019 04 27;369:1-16. Epub 2019 Feb 27.

Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.02.014DOI Listing
April 2019

New frontiers in precision medicine for sepsis-induced immunoparalysis.

Expert Rev Clin Immunol 2019 03 7;15(3):251-263. Epub 2019 Jan 7.

a Department of Intensive Care Medicine , Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/1744666X.2019.1562336DOI Listing
March 2019

Treatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?

Intensive Care Med 2019 02 3;45(2):282-283. Epub 2018 Dec 3.

Centre for Heart Lung Innovation, and Division of Critical Care Medicine, St. Paul's Hospital and University of British Columbia, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.

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http://link.springer.com/10.1007/s00134-018-5481-5
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http://dx.doi.org/10.1007/s00134-018-5481-5DOI Listing
February 2019

Mitochondrial DNA: Innocent in Plasma, but Guilty in Urine?

Shock 2019 02;51(2):266

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001142DOI Listing
February 2019

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Cell Metab 2019 01 4;29(1):211-220.e5. Epub 2018 Oct 4.

Department of Internal Medicine (463) and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183056
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http://dx.doi.org/10.1016/j.cmet.2018.09.003DOI Listing
January 2019

What's new in immunostimulating strategies in the ICU.

Intensive Care Med 2019 01 19;45(1):110-112. Epub 2018 Nov 19.

Division of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-018-5462-8DOI Listing
January 2019

Correction to: What's new in immunostimulating strategies in the ICU.

Intensive Care Med 2019 01;45(1):137

Division of Infectious Diseases and Center of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-018-5482-4DOI Listing
January 2019

Effects of the Humanized Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) on Vascular Barrier Function and Survival in Rodent Models of Systemic Inflammation and Sepsis.

Shock 2018 12;50(6):648-654

Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001102DOI Listing
December 2018

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation.

Ann Rheum Dis 2018 12 17;77(12):1790-1798. Epub 2018 Aug 17.

Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2018-213223DOI Listing
December 2018

Haloperidol serum concentrations in critically ill patients included in the REDUCE study.

Intensive Care Med 2018 10 24;44(10):1774-1775. Epub 2018 Aug 24.

Department of Intensive Care, OLVG Hospital, 95500, 1090, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00134-018-5348-9DOI Listing
October 2018

Moderate correlation between systemic IL-6 responses and CRP with trough concentrations of voriconazole.

Br J Clin Pharmacol 2018 09 19;84(9):1980-1988. Epub 2018 Jun 19.

Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/bcp.13627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089823PMC
September 2018

Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.

Br J Clin Pharmacol 2018 09 3;84(9):2129-2141. Epub 2018 Jul 3.

Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, HP: 710, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1111/bcp.13655
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http://dx.doi.org/10.1111/bcp.13655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089825PMC
September 2018

Crew Resource Management in the trauma room: a prospective 3-year cohort study.

Eur J Emerg Med 2018 Aug;25(4):281-287

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen.

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http://Insights.ovid.com/crossref?an=00063110-201808000-0001
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http://dx.doi.org/10.1097/MEJ.0000000000000458DOI Listing
August 2018

Vascular Effects of Adrenomedullin and the Anti-Adrenomedullin Antibody Adrecizumab in Sepsis.

Shock 2018 08;50(2):132-140

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000001103DOI Listing
August 2018

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

EBioMedicine 2018 Jul 4;33:144-156. Epub 2018 Jul 4.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085583PMC
July 2018

Prophylactic Haloperidol for Critically Ill Adults-Reply.

JAMA 2018 07;320(3):304-305

Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1001/jama.2018.6049DOI Listing
July 2018

Monocyte Subsets Are Differentially Lost from the Circulation during Acute Inflammation Induced by Human Experimental Endotoxemia.

J Innate Immun 2017 23;9(5):464-474. Epub 2017 Jun 23.

Department of Respiratory Medicine and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1159/000475665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738874PMC
June 2018

The mechanism of action of the adrenomedullin-binding antibody adrecizumab.

Crit Care 2018 06 13;22(1):159. Epub 2018 Jun 13.

Department of Intensive Care Medicine, Radboud University Medical Center, PO Box 9101, Internal Mail 710, Nijmegen, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1186/s13054-018-2074-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998508PMC
June 2018

Effect of organisational factors on the variation in incidence of delirium in intensive care unit patients: A systematic review and meta-regression analysis.

Aust Crit Care 2018 05 12;31(3):180-187. Epub 2018 Mar 12.

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.aucc.2018.02.002DOI Listing
May 2018

Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study.

Crit Care 2018 05 25;22(1):137. Epub 2018 May 25.

Department of Intensive Care Medicine, Jeroen Bosch Hospital, Henri Dunantstraat 1, 5200 ME, 's-Hertogenbosch, The Netherlands.

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http://dx.doi.org/10.1186/s13054-018-2054-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970442PMC
May 2018

Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans.

Neuropsychopharmacology 2018 04 26;43(5):1107-1118. Epub 2017 Sep 26.

Donders Institute for Brain, Centre for Cognitive Neuroimaging, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

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http://www.nature.com/doifinder/10.1038/npp.2017.231
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http://dx.doi.org/10.1038/npp.2017.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854801PMC
April 2018

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP).

Intensive Care Med 2018 03 15;44(3):337-344. Epub 2018 Feb 15.

Department of Anesthesiology and Intensive Care, Uniklinikum Jena, Jena, Germany.

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http://dx.doi.org/10.1007/s00134-017-5043-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861160PMC
March 2018

Feasibility of Cognitive Training in Critically Ill Patients: A Pilot Study.

Am J Crit Care 2018 03;27(2):124-135

Annelies Wassenaar and Paul Rood are PhD students, Department of Intensive Care Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Danielle Boelen is a clinical neuropsychologist, Department of Medical Psychology, Radboud Expert Center for Psychology and Medicine, Radboud University Medical Center, and Klimmendaal Rehabilitation Centre, Arnhem, the Netherlands. Lisette Schoonhoven is professor of nursing, IQ Healthcare, Radboud Institute for Health Sciences, Radboud University Medical Center, and Faculty of Health Sciences, University of Southampton, Southampton, United Kingdom. Peter Pickkers is a professor of experimental intensive care medicine, and Mark van den Boogaard is an assistant professor, Department of Intensive Care Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center.

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http://dx.doi.org/10.4037/ajcc2018467DOI Listing
March 2018

Norepinephrine Contributes to Enterocyte Damage in Septic Shock Patients: A Prospective Cohort Study.

Shock 2018 02;49(2):137-143

Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboudumc, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000000955DOI Listing
February 2018

Parenteral bilirubin in healthy volunteers: a reintroduction in translational research.

Br J Clin Pharmacol 2018 02 15;84(2):268-279. Epub 2017 Dec 15.

Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/bcp.13458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777445PMC
February 2018

Man flu: less inflammation but more consequences in men than women.

BMJ 2018 02 7;360:k439. Epub 2018 Feb 7.

Department of Intensive Care Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/bmj.k439DOI Listing
February 2018

Development and Validation of an Abbreviated Questionnaire to Easily Measure Cognitive Failure in ICU Survivors: A Multicenter Study.

Crit Care Med 2018 01;46(1):79-84

Department of Intensive Care Medicine, Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/CCM.0000000000002806DOI Listing
January 2018

Development and implementation of a clinical pathway for cardiac surgery in the intensive care unit: Effects on protocol adherence.

J Eval Clin Pract 2017 Dec 18;23(6):1289-1298. Epub 2017 Jul 18.

Department of Intensive Care Medicine, Radboud University Medical Centre, Radboud Institute for Health Science, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/jep.12778DOI Listing
December 2017

Spleen-derived IFN-γ induces generation of PD-L1-suppressive neutrophils during endotoxemia.

J Leukoc Biol 2017 12 3;102(6):1401-1409. Epub 2017 Oct 3.

Radboud Center for Infectious Diseases (RCI), Nijmegen, The Netherlands; and

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http://doi.wiley.com/10.1189/jlb.3A0217-051RR
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http://dx.doi.org/10.1189/jlb.3A0217-051RRDOI Listing
December 2017

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Cell Rep 2017 Oct;21(5):1160-1168

INSERM LNC UMR 1231, 21000 Dijon, France; University Bourgogne Franche-Comté, LNC UMR 1231, 21000 Dijon, France; LipSTIC LabEx, Fondation de Coopération Scientifique Bourgogne Franche-Comté, 21000 Dijon, France; AgroSup Dijon, 21000 Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.008DOI Listing
October 2017

Implementation and Evaluation of a Clinical Pathway for Pancreaticoduodenectomy Procedures: a Prospective Cohort Study.

J Gastrointest Surg 2017 Sep 6;21(9):1428-1441. Epub 2017 Jun 6.

Department of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s11605-017-3459-1DOI Listing
September 2017

Release of Danger-Associated Molecular Patterns following Chemotherapy Does Not Induce Immunoparalysis in Leukemia Patients.

Acta Haematol 2017 20;138(1):39-43. Epub 2017 Jul 20.

Department of Intensive Care Medicine, Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1159/000477530DOI Listing
September 2017

A randomised trial on the effect of anti-platelet therapy on the systemic inflammatory response in human endotoxaemia.

Thromb Haemost 2017 08 6;117(9):1798-1807. Epub 2017 Jul 6.

Prof. N. P. Riksen, Dept. of Internal Medicine 463, Radboud University Medical Center, PO Box 9101, 6500HB Nijmegen, The Netherlands, Tel.: +31 24 3618819, Fax: +31 24 3616519, E-mail:

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http://dx.doi.org/10.1160/TH16-10-0799DOI Listing
August 2017

Simultaneously Mounted Pro- and Anti-inflammatory Host Response Relates to the Development of Secondary Infections in Patients with Sepsis.

Authors:
Peter Pickkers

Am J Respir Crit Care Med 2017 08;196(4):406-407

1 Department of Intensive Care Medicine Radboud University Medical Center Nijmegen, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201701-0253EDDOI Listing
August 2017

Reduced glial activity after surgery: A sign of immunoparalysis of the brain?

Ann Neurol 2017 07;82(1):152

Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1002/ana.24966DOI Listing
July 2017

Ethylene, an early marker of systemic inflammation in humans.

Sci Rep 2017 07 31;7(1):6889. Epub 2017 Jul 31.

Department of Molecular and Laser Physics, Institute of Molecules and Materials, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-05930-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537290PMC
July 2017

Adjuvant interferon-gamma immunotherapy in a patient with progressive cerebral Nocardia abscesses.

Int J Infect Dis 2017 Jun 22;59:25-28. Epub 2017 Mar 22.

Department of Internal Medicine, Radboud university medical center, Radboud Institute for Molecular Life Sciences (RILMS), Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2017.03.013DOI Listing
June 2017

Markers of Intestinal Damage and their Relation to Cytokine Levels in Cardiac Surgery Patients.

Shock 2017 06;47(6):709-714

*Department of Intensive Care Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands†Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/SHK.0000000000000803DOI Listing
June 2017

Human CD62L neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling.

Blood 2017 06 17;129(26):3476-3485. Epub 2017 May 17.

Department of Respiratory Medicine and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1182/blood-2016-07-727669DOI Listing
June 2017