Peter Peschke

Peter Peschke

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Peter Peschke

Peter Peschke

Publications by authors named "Peter Peschke"

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Intrinsic and extrinsic tumor characteristics are of minor relevance for the efficacy of split-dose carbon ion irradiation in three experimental prostate tumors.

Radiother Oncol 2019 04 24;133:120-124. Epub 2019 Jan 24.

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.12.017DOI Listing
April 2019

Examining correlations of oxygen sensitive MRI (BOLD/TOLD) with [F]FMISO PET in rat prostate tumors.

Am J Nucl Med Mol Imaging 2019 15;9(2):156-167. Epub 2019 Apr 15.

Department of Radiology, UT Southwestern Medical Center Dallas, TX 75390-9058, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526364PMC
April 2019

Determination of the proton RBE in the rat spinal cord: Is there an increase towards the end of the spread-out Bragg peak?

Radiother Oncol 2018 07 21;128(1):115-120. Epub 2018 Mar 21.

Dept. of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.radonc.2018.03.002DOI Listing
July 2018

Late normal tissue response in the rat spinal cord after carbon ion irradiation.

Radiat Oncol 2018 Jan 11;13(1). Epub 2018 Jan 11.

Department of Medical Physics in Radiation Oncology (E040), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13014-017-0950-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765675PMC
January 2018

RBE and related modeling in carbon-ion therapy.

Phys Med Biol 2017 12 19;63(1):01TR02. Epub 2017 Dec 19.

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany. Author to whom any correspondence should be addressed.

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http://stacks.iop.org/0031-9155/63/i=1/a=01TR02?key=crossref
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http://dx.doi.org/10.1088/1361-6560/aa9102DOI Listing
December 2017

Carbon ion radiotherapy: impact of tumor differentiation on local control in experimental prostate carcinomas.

Radiat Oncol 2017 Nov 9;12(1):174. Epub 2017 Nov 9.

Department of Medical Physics in Radiation Oncology (E040), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13014-017-0914-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679331PMC
November 2017

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm.

Acta Oncol 2016 Dec 9;55(12):1512-1515. Epub 2016 Nov 9.

b Department of Medical Physics in Radiation Oncology , German Cancer Research Center (DKFZ) , Heidelberg , Germany.

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http://dx.doi.org/10.1080/0284186X.2016.1250947DOI Listing
December 2016

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response.

Cancer Lett 2016 09 3;380(1):69-77. Epub 2016 Jun 3.

Department of Radiology, UT Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967391PMC
September 2016

Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors.

Cancer Lett 2016 08 17;378(2):97-103. Epub 2016 May 17.

National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany; Department of Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.canlet.2016.05.013DOI Listing
August 2016

A role for dynamic contrast-enhanced magnetic resonance imaging in predicting tumour radiation response.

Br J Cancer 2016 05 3;114(11):1206-11. Epub 2016 May 3.

Department of Radiology, UT Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1038/bjc.2016.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891499PMC
May 2016

Biological intercomparison using gut crypt survivals for proton and carbon-ion beams.

J Radiat Res 2007 ;48 Suppl A:A75-80

Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences.

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http://dx.doi.org/10.1269/jrr.48.a75DOI Listing
April 2016

Split dose carbon ion irradiation of the rat spinal cord: Dependence of the relative biological effectiveness on dose and linear energy transfer.

Radiother Oncol 2015 Nov 18;117(2):358-63. Epub 2015 Jul 18.

Dept. of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.radonc.2015.07.006DOI Listing
November 2015

Dynamic oxygen challenge evaluated by NMR T1 and T2*--insights into tumor oxygenation.

NMR Biomed 2015 Aug 8;28(8):937-947. Epub 2015 Jun 8.

Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA 75390.

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http://cds.ismrm.org/ismrm-2008/files/00450.pdf
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http://doi.wiley.com/10.1002/nbm.3325
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http://dx.doi.org/10.1002/nbm.3325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506740PMC
August 2015

Measurement of hypoxia-related parameters in three sublines of a rat prostate carcinoma using dynamic (18)F-FMISO-Pet-Ct and quantitative histology.

Am J Nucl Med Mol Imaging 2015 15;5(4):348-62. Epub 2015 Jun 15.

Department of Medical Physics in Radiation Oncology, German Cancer Research Center Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529589PMC
August 2015

Carbon ion irradiation of the rat spinal cord: dependence of the relative biological effectiveness on linear energy transfer.

Int J Radiat Oncol Biol Phys 2014 Sep 3;90(1):63-70. Epub 2014 Jul 3.

Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2014.05.008DOI Listing
September 2014

Photon and carbon ion irradiation of a rat prostate carcinoma: does a higher fraction number increase the metastatic rate?

Radiat Res 2014 Jun 20;181(6):623-8. Epub 2014 May 20.

a  Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany;

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http://dx.doi.org/10.1667/RR13611.1DOI Listing
June 2014

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response.

Magn Reson Med 2014 May 27;71(5):1863-73. Epub 2013 Jun 27.

Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1002/mrm.24846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883977PMC
May 2014

A noninvasive tumor oxygenation imaging strategy using magnetic resonance imaging of endogenous blood and tissue water.

Magn Reson Med 2014 Feb;71(2):561-9

Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1002/mrm.24691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718873PMC
February 2014

Flow cytometric characterization of tumor subpopulations in three sublines of the Dunning R3327 rat prostate tumor model.

Prostate 2013 Nov 12;73(15):1710-20. Epub 2013 Jul 12.

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Clinical Radiology, University of Heidelberg, Germany.

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http://dx.doi.org/10.1002/pros.22710DOI Listing
November 2013

A model to simulate the oxygen distribution in hypoxic tumors for different vascular architectures.

Med Phys 2013 Aug;40(8):081703

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

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http://dx.doi.org/10.1118/1.4812431DOI Listing
August 2013

Relative biological effectiveness of carbon ions in a rat prostate carcinoma in vivo: comparison of 1, 2, and 6 fractions.

Int J Radiat Oncol Biol Phys 2013 Jul 6;86(3):450-5. Epub 2013 Mar 6.

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2013.01.019DOI Listing
July 2013

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma.

Cancer Res 2011 Dec 17;71(23):7155-67. Epub 2011 Oct 17.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1212DOI Listing
December 2011

Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat.

Int J Radiat Oncol Biol Phys 2011 Jan 8;79(1):239-46. Epub 2010 Oct 8.

Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2010.07.1976DOI Listing
January 2011

HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations.

Nanomedicine (Lond) 2010 Dec;5(10):1501-23

Department of Experimental Molecular Imaging, RWTH-Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany.

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http://dx.doi.org/10.2217/nnm.10.130DOI Listing
December 2010

Computer simulation of tumour control probabilities after irradiation for varying intrinsic radio-sensitivity using a single cell based model.

Acta Oncol 2010 Nov 15;49(8):1354-62. Epub 2010 Sep 15.

German Cancer Research Center, Department of Medical Physics in Radiation Oncology, Heidelberg, Germany.

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http://dx.doi.org/10.3109/0284186X.2010.485208DOI Listing
November 2010

Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers.

Biomaterials 2009 Jul 21;30(20):3466-75. Epub 2009 Mar 21.

Department of Innovative Cancer Diagnosis and Therapy, DKFZ Heidelberg, German Cancer Research Center, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612090023
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http://dx.doi.org/10.1016/j.biomaterials.2009.02.040DOI Listing
July 2009

Comparison of biological effectiveness of carbon-ion beams in Japan and Germany.

Int J Radiat Oncol Biol Phys 2009 Apr;73(5):1545-51

Heavy-Ion Radiobiology Research Group, Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.

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http://dx.doi.org/10.1016/j.ijrobp.2008.12.021DOI Listing
April 2009

Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity.

Mol Cancer 2007 Oct 17;6:65. Epub 2007 Oct 17.

Department of Innovative Cancer Diagnosis and Therapy, Clinical Cooperation Unit Radiotherapeutic Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/1476-4598-6-65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100065PMC
October 2007

Retrospective motion gating in small animal CT of mice and rats.

Invest Radiol 2007 Oct;42(10):704-14

Junior Group Molecular Imaging, Department of Medical Physics in Radiology, German Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1097/RLI.0b013e318070dcadDOI Listing
October 2007

Single-cell-based computer simulation of the oxygen-dependent tumour response to irradiation.

Phys Med Biol 2007 Aug 24;52(16):4775-89. Epub 2007 Jul 24.

German Cancer Research Center (DKFZ), Department of Medical Physics in Radiation Oncology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1088/0031-9155/52/16/005DOI Listing
August 2007

Transcriptional network governing the angiogenic switch in human pancreatic cancer.

Proc Natl Acad Sci U S A 2007 Jul 24;104(31):12890-5. Epub 2007 Jul 24.

Department of Radiation Oncology, German Cancer Research Center (DKFZ) and University of Heidelberg Medical School, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1073/pnas.0705505104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1931565PMC
July 2007

Absence of tissue reaction after focal high-dose irradiation of rabbit liver.

Acta Oncol 2006 ;45(7):865-9

Department Radiation Oncology, University of Heidelberg, Germany.

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http://dx.doi.org/10.1080/02841860600904847DOI Listing
February 2007

Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems.

J Control Release 2007 Feb 25;117(3):333-41. Epub 2006 Nov 25.

Department of Innovative Cancer Diagnosis and Therapy, Clinical Cooperation Unit Radiotherapeutic Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.jconrel.2006.10.032DOI Listing
February 2007

Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: experimental results and clinical implications.

Int J Radiat Oncol Biol Phys 2006 Dec;66(5):1488-97

Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ijrobp.2006.08.045DOI Listing
December 2006

Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury.

Int J Exp Pathol 2006 Oct;87(5):343-59

Division of Radiooncology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1365-2613.2006.00485.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517380PMC
October 2006

Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems.

Neoplasia 2006 Oct;8(10):788-95

Clinical Cooperation Unit Radiotherapeutic Oncology, Department of Innovative Cancer Diagnosis and Therapy, German Cancer Research Center, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1593/neo.06436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715923PMC
October 2006

Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec).

Strahlenther Onkol 2006 Jul;182(7):400-7

Department of Radiation Oncology, German Cancer Research Center, and University of Heidelberg, Medical School, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00066-006-1445-8DOI Listing
July 2006

Differential effects of CLDR and PDR brachytherapy on cell cycle progression in a syngeneic rat prostate tumour model.

Int J Radiat Biol 2006 Mar;82(3):191-6

Department of Radio Oncology, University of Heidelberg, Germany.

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http://dx.doi.org/10.1080/09553000600632279DOI Listing
March 2006

Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.

J Control Release 2005 Dec 7;110(1):103-18. Epub 2005 Nov 7.

Department of Innovative Cancer Diagnosis and Therapy, Clinical Cooperation Unit Radiotherapeutic Oncology, German Cancer Research Center, Heidelberg.

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http://dx.doi.org/10.1016/j.jconrel.2005.09.010DOI Listing
December 2005

Biodistribution and pharmacokinetics of the (19)F-labeled radiosensitizer 3-aminobenzamide: assessment by (19)F MR imaging.

Magn Reson Imaging 2005 Nov 26;23(9):967-76. Epub 2005 Oct 26.

Research Program 'Innovative Diagnosis and Therapy,' German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.mri.2005.09.003DOI Listing
November 2005

Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy.

Cancer Res 2005 May;65(9):3643-55

Department of Radiation Oncology, German Cancer Research Center, University of Heidelberg Medical School, Heidelberg Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1668DOI Listing
May 2005

Computed tomography monitoring of radiation-induced lung fibrosis in mice.

Invest Radiol 2004 Oct;39(10):600-9

Department of Radiology, Deutsches Krebsforschungszentrum Heidelberg, Germany.

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http://dx.doi.org/10.1097/01.rli.0000138134.89050.a5DOI Listing
October 2004

Modeling and computer simulations of tumor growth and tumor response to radiotherapy.

Radiat Res 2004 Jul;162(1):71-83

Department of Medical Physics, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

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http://dx.doi.org/10.1667/rr3193DOI Listing
July 2004

Tumor oximetry: comparison of 19F MR EPI and electrodes.

Adv Exp Med Biol 2003 ;530:19-27

U.T. Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1007/978-1-4615-0075-9_3DOI Listing
November 2003

Radiation tolerance of the rat spinal cord after single and split doses of photons and carbon ions.

Radiat Res 2003 Nov;160(5):536-42

Department of Clinical Radiology, University of Heidelberg, Germany.

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http://dx.doi.org/10.1667/3063DOI Listing
November 2003

High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculature.

J Magn Reson Imaging 2003 Jul;18(1):59-65

Division Oncological Diagnostics and Therapy (E010), Research Program Radiological Diagnostics and Therapy, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1002/jmri.10318DOI Listing
July 2003

Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma.

J Nucl Med 2003 Jun;44(6):973-80

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany.

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June 2003

Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA.

Eur J Nucl Med Mol Imaging 2002 Aug 25;29(8):1055-62. Epub 2002 May 25.

Department of Radiation Oncology, E0505, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00259-002-0835-0DOI Listing
August 2002

A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells.

J Mol Biol 2002 Apr;318(2):237-43

Division of Radiooncology, Klinische Kooperationseinheit Strahlentherapeutische Onkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360200031
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http://dx.doi.org/10.1016/S0022-2836(02)00031-1DOI Listing
April 2002