Publications by authors named "Peter Penzes"

81Publications

Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome.

Authors:
Sehyoun Yoon Nicolas H Piguel Natalia Khalatyan Leonardo E Dionisio Jeffrey N Savas Peter Penzes

Mol Psychiatry 2021 Jan 4. Epub 2021 Jan 4.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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January 2021

Autism Genetics: Over 100 Risk Genes and Counting.

Authors:
Marc P Forrest Peter Penzes

Pediatr Neurol Briefs 2020 Dec 4;34:13. Epub 2020 Dec 4.

Department of Physiology, Northwestern University, Chicago, IL.

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December 2020

Missense variant contribution to USP9X-female syndrome.

Authors:
Lachlan A Jolly Euan Parnell Alison E Gardner Mark A Corbett Luis A Pérez-Jurado Marie Shaw Gaetan Lesca Catherine Keegan Michael C Schneider Emily Griffin Felicitas Maier Courtney Kiss Andrea Guerin Kathleen Crosby Kenneth Rosenbaum Pranoot Tanpaiboon Sandra Whalen Boris Keren Julie McCarrier Donald Basel Simon Sadedin Susan M White Martin B Delatycki Tjitske Kleefstra Sébastien Küry Alfredo Brusco Elena Sukarova-Angelovska Slavica Trajkova Sehoun Yoon Stephen A Wood Michael Piper Peter Penzes Jozef Gecz

NPJ Genom Med 2020 Dec 9;5(1):53. Epub 2020 Dec 9.

University of Adelaide and Robinson Research Institute, Adelaide, SA, 5005, Australia.

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December 2020

KALRN: A central regulator of synaptic function and synaptopathies.

Authors:
Euan Parnell Lauren P Shapiro Roos A Voorn Marc P Forrest Hiba A Jalloul Daniel D Loizzo Peter Penzes

Gene 2021 Feb 13;768:145306. Epub 2020 Nov 13.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Northwestern University Center for Autism and Neurodevelopment, Chicago, IL 60611, USA. Electronic address:

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February 2021

Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and Function.

Authors:
Colleen R Zaccard Lauren Shapiro Maria D Martin-de-Saavedra Christopher Pratt Kristoffer Myczek Amy Song Marc P Forrest Peter Penzes

Neuron 2020 08 27;107(3):522-537.e6. Epub 2020 May 27.

Department of Physiology, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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August 2020

TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance.

Authors:
Sehyoun Yoon Euan Parnell Peter Penzes

Cell Rep 2020 05;31(8):107685

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Northwestern University, Center for Autism and Neurodevelopment, Chicago, IL 60611, USA. Electronic address:

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May 2020

Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD.

Authors:
Lorenza Culotta Peter Penzes

Mol Autism 2020 05 11;11(1):32. Epub 2020 May 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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May 2020

Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders.

Authors:
Filippo Erli Alish B Palmos Pooja Raval Jayanta Mukherjee Katherine J Sellers Nicholas J F Gatford Stephen J Moss Nicholas J Brandon Peter Penzes Deepak P Srivastava

Transl Psychiatry 2020 01 21;10(1):16. Epub 2020 Jan 21.

Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RT, UK.

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January 2020

Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development.

Authors:
James Fraser Alexandra Essebier Alexander S Brown Raul Ayala Davila Danyon Harkins Oressia Zalucki Lauren P Shapiro Peter Penzes Brandon J Wainwright Matthew P Scott Richard M Gronostajski Mikael Bodén Michael Piper Tracey J Harvey

Cerebellum 2020 Feb;19(1):89-101

The School of Biomedical Sciences, The University of Queensland, Brisbane, 4072, Australia.

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February 2020

Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development.

Authors:
Sehyoun Yoon Euan Parnell Maria Kasherman Marc P Forrest Kristoffer Myczek Susitha Premarathne Michelle C Sanchez Vega Michael Piper Thomas H J Burne Lachlan A Jolly Stephen A Wood Peter Penzes

Neuron 2020 02 5;105(3):506-521.e7. Epub 2019 Dec 5.

Department of Physiology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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February 2020

CNTNAP2 is targeted to endosomes by the polarity protein PAR3.

Authors:
Ruoqi Gao Christopher P Pratt Sehyoun Yoon Maria Dolores Martin-de-Saavedra Marc P Forrest Peter Penzes

Eur J Neurosci 2020 02 2;51(4):1074-1086. Epub 2019 Dec 2.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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February 2020

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.

Authors:
Brett V Johnson Raman Kumar Sabrina Oishi Suzy Alexander Maria Kasherman Michelle Sanchez Vega Atma Ivancevic Alison Gardner Deepti Domingo Mark Corbett Euan Parnell Sehyoun Yoon Tracey Oh Matthew Lines Henrietta Lefroy Usha Kini Margot Van Allen Sabine Grønborg Sandra Mercier Sébastien Küry Stéphane Bézieau Laurent Pasquier Martine Raynaud Alexandra Afenjar Thierry Billette de Villemeur Boris Keren Julie Désir Lionel Van Maldergem Martina Marangoni Nicola Dikow David A Koolen Peter M VanHasselt Marjan Weiss Petra Zwijnenburg Joaquim Sa Claudia Falcao Reis Carlos López-Otín Olaya Santiago-Fernández Alberto Fernández-Jaén Anita Rauch Katharina Steindl Pascal Joset Amy Goldstein Suneeta Madan-Khetarpal Elena Infante Elaine Zackai Carey Mcdougall Vinodh Narayanan Keri Ramsey Saadet Mercimek-Andrews Loren Pena Vandana Shashi Kelly Schoch Jennifer A Sullivan Filippo Pinto E Vairo Pavel N Pichurin Sarah A Ewing Sarah S Barnett Eric W Klee M Scott Perry Mary Kay Koenig Catherine E Keegan Jane L Schuette Stephanie Asher Yezmin Perilla-Young Laurie D Smith Jill A Rosenfeld Elizabeth Bhoj Paige Kaplan Dong Li Renske Oegema Ellen van Binsbergen Bert van der Zwaag Marie Falkenberg Smeland Ioana Cutcutache Matthew Page Martin Armstrong Angela E Lin Marcie A Steeves Nicolette den Hollander Mariëtte J V Hoffer Margot R F Reijnders Serwet Demirdas Daniel C Koboldt Dennis Bartholomew Theresa Mihalic Mosher Scott E Hickey Christine Shieh Pedro A Sanchez-Lara John M Graham Kamer Tezcan G B Schaefer Noelle R Danylchuk Alexander Asamoah Kelly E Jackson Naomi Yachelevich Margaret Au Luis A Pérez-Jurado Tjitske Kleefstra Peter Penzes Stephen A Wood Thomas Burne Tyler Mark Pierson Michael Piper Jozef Gécz Lachlan A Jolly

Biol Psychiatry 2020 01 29;87(2):100-112. Epub 2019 Jun 29.

University of Adelaide and Robinson Research Institute, Adelaide, Australia. Electronic address:

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January 2020

Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss.

Authors:
Zhong Xie Peter Penzes Deepak P Srivastava

Eur J Neurosci 2019 10 9;50(7):3108-3114. Epub 2019 Jul 9.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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October 2019

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density.

Authors:
Kelly A Jones Michiko Sumiya Kevin M Woolfrey Deepak P Srivastava Peter Penzes

Mol Cell Neurosci 2019 07 4;98:19-31. Epub 2019 May 4.

Department of Physiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane, London SE5 8NU, UK; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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July 2019

A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling.

Authors:
Britta Schürmann Daniel P Bermingham Katherine J Kopeikina Kristoffer Myczek Sehyoun Yoon Katherine E Horan Crystle J Kelly Maria Dolores Martin-de-Saavedra Marc P Forrest Jessica M Fawcett-Patel Katharine R Smith Ruoqi Gao Anthony Bach Alain C Burette Joshua Z Rappoport Richard J Weinberg Marco Martina Peter Penzes

Mol Psychiatry 2020 09 9;25(9):2000-2016. Epub 2019 Apr 9.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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September 2020

The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons.

Authors:
Ruoqi Gao Colleen R Zaccard Lauren P Shapiro Leonardo E Dionisio Maria Dolores Martin-de-Saavedra Nicolas H Piguel Christopher P Pratt Katherine E Horan Peter Penzes

Neurosci Lett 2019 05 16;701:92-99. Epub 2019 Feb 16.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Northwestern University Center for Autism and Neurodevelopment, Chicago, IL 60611, USA. Electronic address:

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May 2019

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.

Authors:
Zhong Xie Lauren P Shapiro Michael E Cahill Theron A Russell Pascale N Lacor William L Klein Peter Penzes

Eur J Neurosci 2019 05 20;49(9):1091-1101. Epub 2019 Jan 20.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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May 2019

Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure.

Authors:
Kelly A Jones Yue Luo Lynn Dukes-Rimsky Deepak P Srivastava Richa Koul-Tewari Theron A Russell Lauren P Shapiro Anand K Srivastava Peter Penzes

PLoS One 2018 3;13(10):e0203760. Epub 2018 Oct 3.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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March 2019

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.

Authors:
Jacob C Garza Xiaoli Qi Klaudio Gjeluci Melanie P Leussis Himanish Basu Surya A Reis Wen Ning Zhao Nicolas H Piguel Peter Penzes Stephen J Haggarty Gerard J Martens Geert Poelmans Tracey L Petryshen

Transl Psychiatry 2018 07 25;8(1):135. Epub 2018 Jul 25.

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

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July 2018

Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

Authors:
Josh M Krivinko Susan L Erickson Ying Ding Zhe Sun Peter Penzes Matthew L MacDonald Nathan A Yates Milos D Ikonomovic Oscar L Lopez Robert A Sweet Julia Kofler

Am J Psychiatry 2018 10 19;175(10):999-1009. Epub 2018 Jul 19.

From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh.

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October 2018

Ankyrins: Roles in synaptic biology and pathology.

Authors:
Katharine R Smith Peter Penzes

Mol Cell Neurosci 2018 09 3;91:131-139. Epub 2018 May 3.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA; Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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September 2018

CNTNAP2 stabilizes interneuron dendritic arbors through CASK.

Authors:
Ruoqi Gao Nicolas H Piguel Alexandria E Melendez-Zaidi Maria Dolores Martin-de-Saavedra Sehyoun Yoon Marc P Forrest Kristoffer Myczek Gefei Zhang Theron A Russell John G Csernansky D James Surmeier Peter Penzes

Mol Psychiatry 2018 09 9;23(9):1832-1850. Epub 2018 Apr 9.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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September 2018

Dendritic structural plasticity and neuropsychiatric disease.

Authors:
Marc P Forrest Euan Parnell Peter Penzes

Nat Rev Neurosci 2018 03;19(4):215-234

Department of Physiology, Northwestern University, Chicago, IL, USA.

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March 2018

A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.

Authors:
Theron A Russell Melanie J Grubisha Christine L Remmers Seok Kyu Kang Marc P Forrest Katharine R Smith Katherine J Kopeikina Ruoqi Gao Robert A Sweet Peter Penzes

Biol Psychiatry 2018 03 7;83(6):499-508. Epub 2017 Nov 7.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

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March 2018

Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.

Authors:
Katharine R Smith Kelly A Jones Katherine J Kopeikina Alain C Burette Bryan A Copits Sehyoun Yoon Marc P Forrest Jessica M Fawcett-Patel Jonathan G Hanley Richard J Weinberg Geoffrey T Swanson Peter Penzes

J Neurosci 2017 11 13;37(46):11127-11139. Epub 2017 Oct 13.

Departments of Physiology,

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November 2017

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Authors:
Marc P Forrest Hanwen Zhang Winton Moy Heather McGowan Catherine Leites Leonardo E Dionisio Zihui Xu Jianxin Shi Alan R Sanders William J Greenleaf Chad A Cowan Zhiping P Pang Pablo V Gejman Peter Penzes Jubao Duan

Cell Stem Cell 2017 09 10;21(3):305-318.e8. Epub 2017 Aug 10.

Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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September 2017

Selective Loss of Smaller Spines in Schizophrenia.

Authors:
Matthew L MacDonald Jamil Alhassan Jason T Newman Michelle Richard Hong Gu Ryan M Kelly Alan R Sampson Kenneth N Fish Peter Penzes Zachary P Wills David A Lewis Robert A Sweet

Am J Psychiatry 2017 06 31;174(6):586-594. Epub 2017 Mar 31.

From the Departments of Psychiatry, Neurology, Statistics, and Neurobiology, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh; the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Departments of Physiology and of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago.

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June 2017

Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.

Authors:
Josh M Krivinko Susan L Erickson Eric E Abrahamson Zachary P Wills Milos D Ikonomovic Peter Penzes Robert A Sweet

Neurobiol Aging 2017 06 16;54:59-70. Epub 2017 Feb 16.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. Electronic address:

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June 2017

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex.

Authors:
Melanie J Grubisha Chien-Wei Lin George C Tseng Peter Penzes Etienne Sibille Robert A Sweet

Eur J Neurosci 2016 10 18;44(7):2483-2492. Epub 2016 Aug 18.

Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Rm W-1645, 3811 O'Hara Street, Pittsburgh, PA, 15213-2593, USA.

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October 2016

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub.

Authors:
Katherine D Blizinsky Blanca Diaz-Castro Marc P Forrest Britta Schürmann Anthony P Bach Maria Dolores Martin-de-Saavedra Lei Wang John G Csernansky Jubao Duan Peter Penzes

Proc Natl Acad Sci U S A 2016 07 11;113(30):8520-5. Epub 2016 Jul 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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July 2016

Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.

Authors:
Xiaojie Liu Yao Chen Jiaqing Tong Ashley M Reynolds Sarah C Proudfoot Jinshun Qi Peter Penzes Youming Lu Qing-Song Liu

J Neurosci 2016 04;36(17):4802-15

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226,

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April 2016

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.

Authors:
Olga Varea Maria Dolores Martin-de-Saavedra Katherine J Kopeikina Britta Schürmann Hunter J Fleming Jessica M Fawcett-Patel Anthony Bach Seil Jang Elior Peles Eunjoon Kim Peter Penzes

Proc Natl Acad Sci U S A 2015 May 27;112(19):6176-81. Epub 2015 Apr 27.

Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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May 2015

Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

Authors:
Micah A Shelton Jason T Newman Hong Gu Allan R Sampson Kenneth N Fish Matthew L MacDonald Caitlin E Moyer James V DiBitetto Karl-Anton Dorph-Petersen Peter Penzes David A Lewis Robert A Sweet

Biol Psychiatry 2015 Sep 30;78(6):374-85. Epub 2015 Jan 30.

Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. Electronic address:

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September 2015

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice.

Authors:
Caitlin E Moyer Susan L Erickson Kenneth N Fish Edda Thiels Peter Penzes Robert A Sweet

Cereb Cortex 2016 May 10;26(5):2115-26. Epub 2015 Mar 10.

Center for Neuroscience Translational Neuroscience Program, Department of Psychiatry Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

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May 2016

Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

Authors:
Matthew L MacDonald Ying Ding Jason Newman Scott Hemby Peter Penzes David A Lewis Nathan A Yates Robert A Sweet

Biol Psychiatry 2015 Jun 26;77(11):959-68. Epub 2014 Nov 26.

Departments of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania; Veterans Integrated Service Network 4 Mental Illness Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.. Electronic address:

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June 2015

Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.

Authors:
Kelly A Jones Andrew G Eng Pooja Raval Deepak P Srivastava Peter Penzes

J Biol Chem 2014 Dec 5;289(51):35517-29. Epub 2014 Nov 5.

From the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611,

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December 2014

Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.

Authors:
Katharine R Smith Katherine J Kopeikina Jessica M Fawcett-Patel Katherine Leaderbrand Ruoqi Gao Britta Schürmann Kristoffer Myczek Jelena Radulovic Geoffrey T Swanson Peter Penzes

Neuron 2014 Oct 22;84(2):399-415. Epub 2014 Oct 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611 USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611 USA. Electronic address:

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October 2014

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness.

Authors:
Theron A Russell Katherine D Blizinsky Derin J Cobia Michael E Cahill Zhong Xie Robert A Sweet Jubao Duan Pablo V Gejman Lei Wang John G Csernansky Peter Penzes

Nat Commun 2014 Sep 16;5:4858. Epub 2014 Sep 16.

1] Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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September 2014

Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications.

Authors:
Jon-Eric VanLeeuwen Igor Rafalovich Katherine Sellers Kelly A Jones Theanne N Griffith Rafiq Huda Richard J Miller Deepak P Srivastava Peter Penzes

J Biol Chem 2014 Apr 24;289(15):10831-42. Epub 2014 Feb 24.

From the Departments of Physiology and.

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April 2014

Abnormal kalirin signaling in neuropsychiatric disorders.

Authors:
Christine Remmers Robert A Sweet Peter Penzes

Brain Res Bull 2014 Apr 12;103:29-38. Epub 2013 Dec 12.

Department of Physiology, 303 E. Chicago Avenue, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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April 2014

Insights into rapid modulation of neuroplasticity by brain estrogens.

Authors:
Deepak P Srivastava Kevin M Woolfrey Peter Penzes

Pharmacol Rev 2013 27;65(4):1318-50. Epub 2013 Sep 27.

Department of Neuroscience & Centre for the Cellular Basis of Behaviour, 125 Coldharbour Lane, The James Black Centre, Institute of Psychiatry, King's College London, London, SE5 9NU, UK.

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February 2014

Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization.

Authors:
Xiaoting Wang Michael E Cahill Craig T Werner Daniel J Christoffel Sam A Golden Zhong Xie Jessica A Loweth Michela Marinelli Scott J Russo Peter Penzes Marina E Wolf

J Neurosci 2013 Jul;33(27):11012-22

Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA.

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July 2013

Neuregulin1 signaling promotes dendritic spine growth through kalirin.

Authors:
Michael E Cahill Christine Remmers Kelly A Jones Zhong Xie Robert A Sweet Peter Penzes

J Neurochem 2013 Sep 27;126(5):625-35. Epub 2013 Jun 27.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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September 2013

PAK1 protein expression in the auditory cortex of schizophrenia subjects.

Authors:
Anthony J Deo Isaac M Goldszer Siyu Li James V DiBitetto Ruth Henteleff Allan Sampson David A Lewis Peter Penzes Robert A Sweet

PLoS One 2013 22;8(4):e59458. Epub 2013 Apr 22.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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November 2013

Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.

Authors:
Peter Penzes Andres Buonanno Maria Passafaro Carlo Sala Robert A Sweet

J Neurochem 2013 Jul 22;126(2):165-82. Epub 2013 May 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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July 2013

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.

Authors:
Maria V Barbolina Yiuying Liu Hilal Gurler Mijung Kim Andre A Kajdacsy-Balla Lisa Rooper Jaclyn Shepard Michael Weiss Lonnie D Shea Peter Penzes Matthew J Ravosa M Sharon Stack

J Biol Chem 2013 Jan 14;288(1):141-51. Epub 2012 Nov 14.

Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois 60622, USA.

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January 2013

Afadin is required for maintenance of dendritic structure and excitatory tone.

Authors:
Deepak P Srivastava Bryan A Copits Zhong Xie Rafiq Huda Kelly A Jones Srishti Mukherji Michael E Cahill Jon-Eric VanLeeuwen Kevin M Woolfrey Igor Rafalovich Geoffrey T Swanson Peter Penzes

J Biol Chem 2012 Oct 4;287(43):35964-74. Epub 2012 Sep 4.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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October 2012

Social, communication, and cortical structural impairments in Epac2-deficient mice.

Authors:
Deepak P Srivastava Kelly A Jones Kevin M Woolfrey Jeffrey Burgdorf Theron A Russell Abigail Kalmbach Hyerin Lee Connie Yang Mazdak M Bradberry David Wokosin Joseph R Moskal Manuel F Casanova Jack Waters Peter Penzes

J Neurosci 2012 Aug;32(34):11864-78

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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August 2012

Long-term perturbation of spine plasticity results in distinct impairments of cognitive function.

Authors:
Jon-Eric Vanleeuwen Peter Penzes

J Neurochem 2012 Dec 11;123(5):781-9. Epub 2012 Oct 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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December 2012

An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice.

Authors:
Deepak P Srivastava Kevin M Woolfrey Kelly A Jones Charles T Anderson Katharine R Smith Theron A Russell Hyerin Lee Marina V Yasvoina David L Wokosin P Hande Ozdinler Gordon M G Shepherd Peter Penzes

PLoS Biol 2012 26;10(6):e1001350. Epub 2012 Jun 26.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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October 2012

Spatially restricted actin-regulatory signaling contributes to synapse morphology.

Authors:
Daniel A Nicholson Michael E Cahill Christopher T Tulisiak Yuri Geinisman Peter Penzes

J Neurochem 2012 Jun 27;121(6):852-60. Epub 2012 Apr 27.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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June 2012

β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.

Authors:
Patrick S Murray Caitlin M Kirkwood Megan C Gray Milos D Ikonomovic William R Paljug Eric E Abrahamson Ruth A Henteleff Ronald L Hamilton Julia K Kofler William E Klunk Oscar L Lopez Peter Penzes Robert A Sweet

Neurobiol Aging 2012 Dec 17;33(12):2807-16. Epub 2012 Mar 17.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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December 2012

Regulation of the actin cytoskeleton in dendritic spines.

Authors:
Peter Penzes Igor Rafalovich

Adv Exp Med Biol 2012 ;970:81-95

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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June 2012

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines.

Authors:
Peter Penzes Michael E Cahill

Cytoskeleton (Hoboken) 2012 Jul 12;69(7):426-41. Epub 2012 Mar 12.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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July 2012

Kalirin signaling: implications for synaptic pathology.

Authors:
Peter Penzes Christine Remmers

Mol Neurobiol 2012 Feb 23;45(1):109-18. Epub 2011 Dec 23.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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February 2012

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.

Authors:
Anthony J Deo Michael E Cahill Siyu Li Isaac Goldszer Ruth Henteleff Jon-Eric Vanleeuwen Igor Rafalovich Ruoqi Gao Erin K Stachowski Allan R Sampson David A Lewis Peter Penzes Robert A Sweet

Neurobiol Dis 2012 Feb 13;45(2):796-803. Epub 2011 Nov 13.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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February 2012

Analysis of dendritic spine morphology in cultured CNS neurons.

Authors:
Deepak P Srivastava Kevin M Woolfrey Peter Penzes

J Vis Exp 2011 Jul 13(53):e2794. Epub 2011 Jul 13.

Department of Physiology, Northwestern University Feinberg School of Medicine, USA.

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July 2011

Dendritic spine pathology in neuropsychiatric disorders.

Authors:
Peter Penzes Michael E Cahill Kelly A Jones Jon-Eric VanLeeuwen Kevin M Woolfrey

Nat Neurosci 2011 Mar;14(3):285-93

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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March 2011

Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease.

Authors:
Peter Penzes Jon-Eric Vanleeuwen

Brain Res Rev 2011 Jun 26;67(1-2):184-92. Epub 2011 Jan 26.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Ward 7-174, Chicago, IL 60611, USA.

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June 2011

Rapid estradiol modulation of neuronal connectivity and its implications for disease.

Authors:
Deepak P Srivastava Peter Penzes

Front Endocrinol (Lausanne) 2011 22;2:77. Epub 2011 Nov 22.

Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.

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August 2012

Epac2-mediated dendritic spine remodeling: implications for disease.

Authors:
Peter Penzes Kevin M Woolfrey Deepak P Srivastava

Mol Cell Neurosci 2011 Feb 27;46(2):368-80. Epub 2010 Nov 27.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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February 2011

Estrogen receptor ß activity modulates synaptic signaling and structure.

Authors:
Deepak P Srivastava Kevin M Woolfrey Feng Liu Nicholas J Brandon Peter Penzes

J Neurosci 2010 Oct;30(40):13454-60

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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October 2010

Hippocampal phenotypes in kalirin-deficient mice.

Authors:
Zhong Xie Michael E Cahill Jelena Radulovic Jing Wang Susan L Campbell Courtney A Miller J David Sweatt Peter Penzes

Mol Cell Neurosci 2011 Jan 11;46(1):45-54. Epub 2010 Aug 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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January 2011

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.

Authors:
Akiko Hayashi-Takagi Manabu Takaki Nick Graziane Saurav Seshadri Hannah Murdoch Allan J Dunlop Yuichi Makino Anupamaa J Seshadri Koko Ishizuka Deepak P Srivastava Zhong Xie Jay M Baraban Miles D Houslay Toshifumi Tomoda Nicholas J Brandon Atsushi Kamiya Zhen Yan Peter Penzes Akira Sawa

Nat Neurosci 2010 Mar 7;13(3):327-32. Epub 2010 Feb 7.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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March 2010

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.

Authors:
Kelly A Jones Deepak P Srivastava John A Allen Ryan T Strachan Bryan L Roth Peter Penzes

Proc Natl Acad Sci U S A 2009 Nov 4;106(46):19575-80. Epub 2009 Nov 4.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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November 2009

Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling.

Authors:
Marie-France Lisé Deepak P Srivastava Pamela Arstikaitis Robyn L Lett Razan Sheta Vijay Viswanathan Peter Penzes Timothy P O'Connor Alaa El-Husseini

J Cell Sci 2009 Oct;122(Pt 20):3810-21

Department of Psychiatry and Brain Research Center, University of British Columbia, Vancouver, BC, Canada.

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October 2009

Kalirin loss results in cortical morphological alterations.

Authors:
Zhong Xie Michael E Cahill Peter Penzes

Mol Cell Neurosci 2010 Jan 30;43(1):81-9. Epub 2009 Sep 30.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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January 2010

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines.

Authors:
Kevin M Woolfrey Deepak P Srivastava Huzefa Photowala Megumi Yamashita Maria V Barbolina Michael E Cahill Zhong Xie Kelly A Jones Lawrence A Quilliam Murali Prakriya Peter Penzes

Nat Neurosci 2009 Oct 6;12(10):1275-84. Epub 2009 Sep 6.

Department of Physiology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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October 2009

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.

Authors:
Michael E Cahill Zhong Xie Michelle Day Huzefa Photowala Maria V Barbolina Courtney A Miller Craig Weiss Jelena Radulovic J David Sweatt John F Disterhoft D James Surmeier Peter Penzes

Proc Natl Acad Sci U S A 2009 Aug 22;106(31):13058-63. Epub 2009 Jul 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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August 2009

Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.

Authors:
Maria V Barbolina Brian P Adley David L Kelly Jaclyn Shepard Angela J Fought Denise Scholtens Peter Penzes Lonnie D Shea M Sharon Stack

Int J Cancer 2009 Aug;125(4):816-25

Department of Chemical and Biological Engineering, Northwestern University, Chicago, IL, USA.

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August 2009

Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear.

Authors:
Natalie C Tronson Christina Schrick Yomayra F Guzman Kyu Hwan Huh Deepak P Srivastava Peter Penzes Anita L Guedea Can Gao Jelena Radulovic

J Neurosci 2009 Mar;29(11):3387-94

Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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March 2009

Not just actin? A role for dynamic microtubules in dendritic spines.

Authors:
Peter Penzes Deepak P Srivastava Kevin M Woolfrey

Neuron 2009 Jan;61(1):3-5

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.

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January 2009

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity.

Authors:
Deepak P Srivastava Kevin M Woolfrey Kevin Woolfrey Kelly A Jones Cassandra Y Shum L Leanne Lash Geoffrey T Swanson Peter Penzes

Proc Natl Acad Sci U S A 2008 Sep 18;105(38):14650-5. Epub 2008 Sep 18.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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September 2008

Convergent CaMK and RacGEF signals control dendritic structure and function.

Authors:
Peter Penzes Michael E Cahill Kelly A Jones Deepak P Srivastava

Trends Cell Biol 2008 Sep 11;18(9):405-13. Epub 2008 Aug 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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September 2008

Dendritic spine dynamics--a key role for kalirin-7.

Authors:
Peter Penzes Kelly A Jones

Trends Neurosci 2008 Aug 1;31(8):419-27. Epub 2008 Jul 1.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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August 2008

Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7.

Authors:
Zhong Xie Huzefa Photowala Michael E Cahill Deepak P Srivastava Kevin M Woolfrey Cassandra Y Shum Richard L Huganir Peter Penzes

J Neurosci 2008 Jun;28(24):6079-91

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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June 2008

Pumping up the synapse.

Authors:
Peter Penzes

Neuron 2007 Dec;56(6):942-4

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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December 2007

Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines.

Authors:
Zhong Xie Deepak P Srivastava Huzefa Photowala Li Kai Michael E Cahill Kevin M Woolfrey Cassandra Y Shum D James Surmeier Peter Penzes

Neuron 2007 Nov;56(4):640-56

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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November 2007

N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation.

Authors:
Christina Schrick Andre Fischer Deepak P Srivastava Natalie C Tronson Peter Penzes Jelena Radulovic

Neuron 2007 Sep;55(5):786-98

Department of Psychiatry and Behavioral Sciences, The Asher Center for Depressive Disorders, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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September 2007

Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6.

Authors:
Zhong Xie Richard L Huganir Peter Penzes

Neuron 2005 Nov;48(4):605-18

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611.

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November 2005

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.

Authors:
Peter Penzes Alexander Beeser Jonathan Chernoff Martin R Schiller Betty A Eipper Richard E Mains Richard L Huganir

Neuron 2003 Jan;37(2):263-74

Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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January 2003