Peter Penzes

Peter Penzes

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Peter Penzes

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Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.

Authors:
Brett V Johnson Raman Kumar Sabrina Oishi Suzy Alexander Maria Kasherman Michelle Sanchez Vega Atma Ivancevic Alison Gardner Deepti Domingo Mark Corbett Euan Parnell Sehyoun Yoon Tracey Oh Matthew Lines Henrietta Lefroy Usha Kini Margot Van Allen Sabine Grønborg Sandra Mercier Sébastien Küry Stéphane Bézieau Laurent Pasquier Martine Raynaud Alexandra Afenjar Thierry Billette de Villemeur Boris Keren Julie Désir Lionel Van Maldergem Martina Marangoni Nicola Dikow David A Koolen Peter M VanHasselt Marjan Weiss Petra Zwijnenburg Joaquim Sa Claudia Falcao Reis Carlos López-Otín Olaya Santiago-Fernández Alberto Fernández-Jaén Anita Rauch Katharina Steindl Pascal Joset Amy Goldstein Suneeta Madan-Khetarpal Elena Infante Elaine Zackai Carey Mcdougall Vinodh Narayanan Keri Ramsey Saadet Mercimek-Andrews Loren Pena Vandana Shashi Kelly Schoch Jennifer A Sullivan Filippo Pinto E Vairo Pavel N Pichurin Sarah A Ewing Sarah S Barnett Eric W Klee M Scott Perry Mary Kay Koenig Catherine E Keegan Jane L Schuette Stephanie Asher Yezmin Perilla-Young Laurie D Smith Jill A Rosenfeld Elizabeth Bhoj Paige Kaplan Dong Li Renske Oegema Ellen van Binsbergen Bert van der Zwaag Marie Falkenberg Smeland Ioana Cutcutache Matthew Page Martin Armstrong Angela E Lin Marcie A Steeves Nicolette den Hollander Mariëtte J V Hoffer Margot R F Reijnders Serwet Demirdas Daniel C Koboldt Dennis Bartholomew Theresa Mihalic Mosher Scott E Hickey Christine Shieh Pedro A Sanchez-Lara John M Graham Kamer Tezcan G B Schaefer Noelle R Danylchuk Alexander Asamoah Kelly E Jackson Naomi Yachelevich Margaret Au Luis A Pérez-Jurado Tjitske Kleefstra Peter Penzes Stephen A Wood Thomas Burne Tyler Mark Pierson Michael Piper Jozef Gécz Lachlan A Jolly

Biol Psychiatry 2020 Jan 29;87(2):100-112. Epub 2019 Jun 29.

University of Adelaide and Robinson Research Institute, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925349PMC
January 2020

CNTNAP2 is targeted to endosomes by the polarity protein PAR3.

Eur J Neurosci 2019 Nov 15. Epub 2019 Nov 15.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1111/ejn.14620DOI Listing
November 2019

Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development.

Neuron 2019 Nov 19. Epub 2019 Nov 19.

Department of Physiology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.11.003DOI Listing
November 2019

Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss.

Eur J Neurosci 2019 Oct 9;50(7):3108-3114. Epub 2019 Jul 9.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1111/ejn.14487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821562PMC
October 2019

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density.

Mol Cell Neurosci 2019 07 4;98:19-31. Epub 2019 May 4.

Department of Physiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 125 Coldharbour Lane, London SE5 8NU, UK; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639166PMC
July 2019

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.

Eur J Neurosci 2019 May 20;49(9):1091-1101. Epub 2019 Jan 20.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1111/ejn.14311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559832PMC
May 2019

The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons.

Neurosci Lett 2019 05 16;701:92-99. Epub 2019 Feb 16.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Northwestern University Center for Autism and Neurodevelopment, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508520PMC
May 2019

Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

Am J Psychiatry 2018 10 19;175(10):999-1009. Epub 2018 Jul 19.

From the Departments of Psychiatry, Cell Biology, Neurology, and Pathology, University of Pittsburgh School of Medicine, Pittsburgh; the Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh; the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago; the Geriatric Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh.

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http://dx.doi.org/10.1176/appi.ajp.2018.17080858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167138PMC
October 2018

CNTNAP2 stabilizes interneuron dendritic arbors through CASK.

Mol Psychiatry 2018 09 9;23(9):1832-1850. Epub 2018 Apr 9.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1038/s41380-018-0027-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168441PMC
September 2018

Ankyrins: Roles in synaptic biology and pathology.

Mol Cell Neurosci 2018 09 3;91:131-139. Epub 2018 May 3.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA; Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128775PMC
September 2018

A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.

Biol Psychiatry 2018 03 7;83(6):499-508. Epub 2017 Nov 7.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809265PMC
March 2018

Dendritic structural plasticity and neuropsychiatric disease.

Nat Rev Neurosci 2018 03;19(4):215-234

Department of Physiology, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/nrn.2018.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442683PMC
March 2018

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Cell Stem Cell 2017 09 10;21(3):305-318.e8. Epub 2017 Aug 10.

Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL 60201, USA; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909173028
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http://dx.doi.org/10.1016/j.stem.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591074PMC
September 2017

Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.

Neurobiol Aging 2017 06 16;54:59-70. Epub 2017 Feb 16.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502748PMC
June 2017

Selective Loss of Smaller Spines in Schizophrenia.

Am J Psychiatry 2017 06 31;174(6):586-594. Epub 2017 Mar 31.

From the Departments of Psychiatry, Neurology, Statistics, and Neurobiology, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh; the Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh; and the Departments of Physiology and of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago.

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http://dx.doi.org/10.1176/appi.ajp.2017.16070814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800878PMC
June 2017

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex.

Eur J Neurosci 2016 10 18;44(7):2483-2492. Epub 2016 Aug 18.

Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Rm W-1645, 3811 O'Hara Street, Pittsburgh, PA, 15213-2593, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048532PMC
http://dx.doi.org/10.1111/ejn.13351DOI Listing
October 2016

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub.

Proc Natl Acad Sci U S A 2016 07 11;113(30):8520-5. Epub 2016 Jul 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1607014113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968749PMC
July 2016

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice.

Cereb Cortex 2016 May 10;26(5):2115-26. Epub 2015 Mar 10.

Center for Neuroscience Translational Neuroscience Program, Department of Psychiatry Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1093/cercor/bhv040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830289PMC
May 2016

Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

Biol Psychiatry 2015 Sep 30;78(6):374-85. Epub 2015 Jan 30.

Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2014.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520801PMC
September 2015

Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

Biol Psychiatry 2015 Jun 26;77(11):959-68. Epub 2014 Nov 26.

Departments of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania; Veterans Integrated Service Network 4 Mental Illness Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223140070
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http://dx.doi.org/10.1016/j.biopsych.2014.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428927PMC
June 2015

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.

Proc Natl Acad Sci U S A 2015 May 27;112(19):6176-81. Epub 2015 Apr 27.

Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611;

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http://dx.doi.org/10.1073/pnas.1423205112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434727PMC
May 2015

Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.

J Biol Chem 2014 Dec 5;289(51):35517-29. Epub 2014 Nov 5.

From the Departments of Physiology and Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611,

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http://dx.doi.org/10.1074/jbc.M114.587709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271236PMC
December 2014

Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.

Neuron 2014 Oct 22;84(2):399-415. Epub 2014 Oct 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611 USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611 USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223651PMC
October 2014

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness.

Nat Commun 2014 Sep 16;5:4858. Epub 2014 Sep 16.

1] Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/ncomms5858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166532PMC
September 2014

Abnormal kalirin signaling in neuropsychiatric disorders.

Brain Res Bull 2014 Apr 12;103:29-38. Epub 2013 Dec 12.

Department of Physiology, 303 E. Chicago Avenue, Chicago, IL 60611, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989394PMC
April 2014

Insights into rapid modulation of neuroplasticity by brain estrogens.

Pharmacol Rev 2013 27;65(4):1318-50. Epub 2013 Sep 27.

Department of Neuroscience & Centre for the Cellular Basis of Behaviour, 125 Coldharbour Lane, The James Black Centre, Institute of Psychiatry, King's College London, London, SE5 9NU, UK.

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http://dx.doi.org/10.1124/pr.111.005272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799233PMC
February 2014

PAK1 protein expression in the auditory cortex of schizophrenia subjects.

PLoS One 2013 22;8(4):e59458. Epub 2013 Apr 22.

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059458PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632562PMC
November 2013

Neuregulin1 signaling promotes dendritic spine growth through kalirin.

J Neurochem 2013 Sep 27;126(5):625-35. Epub 2013 Jun 27.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/jnc.12330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752328PMC
September 2013

Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.

J Neurochem 2013 Jul 22;126(2):165-82. Epub 2013 May 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1111/jnc.12261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700683PMC
July 2013

Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization.

J Neurosci 2013 Jul;33(27):11012-22

Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1097-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718375PMC
July 2013

Long-term perturbation of spine plasticity results in distinct impairments of cognitive function.

J Neurochem 2012 Dec 11;123(5):781-9. Epub 2012 Oct 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07899.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493825PMC
December 2012

Afadin is required for maintenance of dendritic structure and excitatory tone.

J Biol Chem 2012 Oct 4;287(43):35964-74. Epub 2012 Sep 4.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1074/jbc.M112.363358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476264PMC
October 2012

Rapid estradiol modulation of neuronal connectivity and its implications for disease.

Front Endocrinol (Lausanne) 2011 22;2:77. Epub 2011 Nov 22.

Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, IL, USA.

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http://dx.doi.org/10.3389/fendo.2011.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356153PMC
August 2012

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines.

Cytoskeleton (Hoboken) 2012 Jul 12;69(7):426-41. Epub 2012 Mar 12.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/cm.21015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576145PMC
July 2012

Regulation of the actin cytoskeleton in dendritic spines.

Adv Exp Med Biol 2012 ;970:81-95

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://link.springer.com/10.1007/978-3-7091-0932-8_4
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http://dx.doi.org/10.1007/978-3-7091-0932-8_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576144PMC
June 2012

Spatially restricted actin-regulatory signaling contributes to synapse morphology.

J Neurochem 2012 Jun 27;121(6):852-60. Epub 2012 Apr 27.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07743.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371164PMC
June 2012

Kalirin signaling: implications for synaptic pathology.

Mol Neurobiol 2012 Feb 23;45(1):109-18. Epub 2011 Dec 23.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/s12035-011-8223-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303189PMC
February 2012

Analysis of dendritic spine morphology in cultured CNS neurons.

J Vis Exp 2011 Jul 13(53):e2794. Epub 2011 Jul 13.

Department of Physiology, Northwestern University Feinberg School of Medicine, USA.

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http://dx.doi.org/10.3791/2794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196192PMC
July 2011

Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease.

Brain Res Rev 2011 Jun 26;67(1-2):184-92. Epub 2011 Jan 26.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Ward 7-174, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.brainresrev.2011.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109125PMC
June 2011

Dendritic spine pathology in neuropsychiatric disorders.

Nat Neurosci 2011 Mar;14(3):285-93

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nn.2741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530413PMC
March 2011

Epac2-mediated dendritic spine remodeling: implications for disease.

Mol Cell Neurosci 2011 Feb 27;46(2):368-80. Epub 2010 Nov 27.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.mcn.2010.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031158PMC
February 2011

Hippocampal phenotypes in kalirin-deficient mice.

Mol Cell Neurosci 2011 Jan 11;46(1):45-54. Epub 2010 Aug 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10447431100019
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http://dx.doi.org/10.1016/j.mcn.2010.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576140PMC
January 2011

Estrogen receptor ß activity modulates synaptic signaling and structure.

J Neurosci 2010 Oct;30(40):13454-60

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3264-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956485PMC
October 2010

Kalirin loss results in cortical morphological alterations.

Mol Cell Neurosci 2010 Jan 30;43(1):81-9. Epub 2009 Sep 30.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104474310900211
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http://dx.doi.org/10.1016/j.mcn.2009.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818244PMC
January 2010

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling.

Proc Natl Acad Sci U S A 2009 Nov 4;106(46):19575-80. Epub 2009 Nov 4.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.0905884106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780750PMC
November 2009

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines.

Nat Neurosci 2009 Oct 6;12(10):1275-84. Epub 2009 Sep 6.

Department of Physiology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nn.2386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754861PMC
October 2009

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.

Proc Natl Acad Sci U S A 2009 Aug 22;106(31):13058-63. Epub 2009 Jul 22.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.0904636106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722269PMC
August 2009

Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear.

J Neurosci 2009 Mar;29(11):3387-94

Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5619-08.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892108PMC
March 2009

Not just actin? A role for dynamic microtubules in dendritic spines.

Neuron 2009 Jan;61(1):3-5

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.neuron.2008.12.018DOI Listing
January 2009

Convergent CaMK and RacGEF signals control dendritic structure and function.

Trends Cell Biol 2008 Sep 11;18(9):405-13. Epub 2008 Aug 11.

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.tcb.2008.07.002DOI Listing
September 2008

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity.

Proc Natl Acad Sci U S A 2008 Sep 18;105(38):14650-5. Epub 2008 Sep 18.

Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1073/pnas.0801581105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567160PMC
September 2008

Dendritic spine dynamics--a key role for kalirin-7.

Trends Neurosci 2008 Aug 1;31(8):419-27. Epub 2008 Jul 1.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.tins.2008.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973420PMC
August 2008

Coordination of synaptic adhesion with dendritic spine remodeling by AF-6 and kalirin-7.

J Neurosci 2008 Jun;28(24):6079-91

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1170-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727754PMC
June 2008

Pumping up the synapse.

Authors:
Peter Penzes

Neuron 2007 Dec;56(6):942-4

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.12.006DOI Listing
December 2007

N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation.

Neuron 2007 Sep;55(5):786-98

Department of Psychiatry and Behavioral Sciences, The Asher Center for Depressive Disorders, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.neuron.2007.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064867PMC
September 2007

Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6.

Neuron 2005 Nov;48(4):605-18

Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611.

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http://dx.doi.org/10.1016/j.neuron.2005.09.027DOI Listing
November 2005

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.

Neuron 2003 Jan;37(2):263-74

Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

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January 2003