Peter Paul De Deyn

Peter Paul De Deyn

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Peter Paul De Deyn

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Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits.

Behav Brain Res 2019 Nov 17;373:112089. Epub 2019 Jul 17.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk (Antwerp), Belgium; Department of Neurology and Alzheimer Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, the Netherlands; Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2019.112089DOI Listing
November 2019

The retinal nerve fiber layer as a window to the glymphatic system.

Clin Neurol Neurosurg 2019 Nov 10;188:105593. Epub 2019 Nov 10.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, the Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.clineuro.2019.105593DOI Listing
November 2019

Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy.

Neuroscience 2019 Nov 27;425:112-122. Epub 2019 Nov 27.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk (Antwerp), Belgium; Department of Neurology and Alzheimer Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands; Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2019.11.007DOI Listing
November 2019

Alzheimer's disease: Neurotransmitters of the sleep-wake cycle.

Neurosci Biobehav Rev 2019 Oct 1;105:72-80. Epub 2019 Aug 1.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk (Antwerp), Belgium; Department of Neurology and Alzheimer Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands; Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2019.07.019DOI Listing
October 2019

How does a researcher choose the best rodent model for their Alzheimer's disease drug discovery study?

Expert Opin Drug Discov 2019 Oct 8:1-3. Epub 2019 Oct 8.

Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp , Wilrijk (Antwerp) , Belgium.

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http://dx.doi.org/10.1080/17460441.2020.1676719DOI Listing
October 2019

Added Diagnostic Value of Cerebrospinal Fluid Biomarkers for Differential Dementia Diagnosis in an Autopsy-Confirmed Cohort.

J Alzheimers Dis 2018 ;63(1):373-381

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3233/JAD-170927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900550PMC
August 2019

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation.

Neuron 2019 08 18;103(4):702-718.e5. Epub 2019 Jun 18.

Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.05.034DOI Listing
August 2019

The buffering capacity of the brain and optic nerve against spaceflight-associated neuro-ocular syndrome.

Proc Natl Acad Sci U S A 2019 Aug 30;116(32):15770-15771. Epub 2019 Jul 30.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.1073/pnas.1908865116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689895PMC
August 2019

PTZ-induced seizures in mice require a revised Racine scale.

Epilepsy Behav 2019 Jun 24;95:51-55. Epub 2019 Apr 24.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Neurology and Alzheimer Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, the Netherlands; Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2019.02.029DOI Listing
June 2019

Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits.

Behav Brain Res 2019 Nov 17;373:112089. Epub 2019 Jul 17.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk (Antwerp), Belgium; Department of Neurology and Alzheimer Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, the Netherlands; Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2019.112089DOI Listing
November 2019

Alzheimer's disease and glaucoma: Look-alike neurodegenerative diseases.

Alzheimers Dement 2019 04 31;15(4):600-601. Epub 2019 Jan 31.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.jalz.2018.12.012DOI Listing
April 2019

Brief cognitive screening instruments for early detection of Alzheimer's disease: a systematic review.

Alzheimers Res Ther 2019 02 28;11(1):21. Epub 2019 Feb 28.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1186/s13195-019-0474-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396539PMC
February 2019

Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer's disease.

Med Hypotheses 2019 01 22;122:57. Epub 2018 Oct 22.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.mehy.2018.10.020DOI Listing
January 2019

Validation of the Erlangen Score Algorithm for Differential Dementia Diagnosis in Autopsy-Confirmed Subjects.

J Alzheimers Dis 2019 ;68(3):1151-1159

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3233/JAD-180563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484252PMC
January 2019

Episodic memory in mild cognitive impairment inversely correlates with the global modularity of the cerebral blood flow network.

Psychiatry Res Neuroimaging 2018 12 3;282:73-81. Epub 2018 Nov 3.

Cuban Neuroscience Center, Ave. 25, No. 15007, Playa, La Habana 11600, Cuba; Laboratoire de Recherche en Neuroimagerie (LREN), Centre Hospitalier Universitaire Vaudois (CHUV), Mont-Paisible 16, Lausanne CH-1011, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S09254927183021
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http://dx.doi.org/10.1016/j.pscychresns.2018.11.003DOI Listing
December 2018

Can cerebrospinal fluid diversion be beneficial in the treatment of chronic fatigue syndrome?

Med Hypotheses 2018 09 24;118:174. Epub 2018 Apr 24.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.mehy.2018.04.020DOI Listing
September 2018

The putative glymphatic signature of chronic fatigue syndrome: A new view on the disease pathogenesis and therapy.

Med Hypotheses 2018 Sep 6;118:142-145. Epub 2018 Jul 6.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183054
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http://dx.doi.org/10.1016/j.mehy.2018.07.007DOI Listing
September 2018

Intracranial pressure and glaucoma: Is there a new therapeutic perspective on the horizon?

Med Hypotheses 2018 Sep 28;118:98-102. Epub 2018 Jun 28.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.mehy.2018.06.026DOI Listing
September 2018

Sleep and Alzheimer's disease: A pivotal role for the suprachiasmatic nucleus.

Sleep Med Rev 2018 08 28;40:17-27. Epub 2017 Jul 28.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands; Department of Neurology, Memory Clinic of Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.smrv.2017.07.005DOI Listing
August 2018

CFAI-Plus: Adding cognitive frailty as a new domain to the comprehensive frailty assessment instrument.

Int J Geriatr Psychiatry 2018 07 10;33(7):941-947. Epub 2018 Apr 10.

Department of Clinical and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium.

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http://dx.doi.org/10.1002/gps.4875DOI Listing
July 2018

Fibromyalgia as a glymphatic overload syndrome.

Med Hypotheses 2018 06 26;115:17-18. Epub 2018 Mar 26.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183019
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http://dx.doi.org/10.1016/j.mehy.2018.03.014DOI Listing
June 2018

The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease.

Biomed Res Int 2017 29;2017:5123148. Epub 2017 Aug 29.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium.

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https://www.hindawi.com/journals/bmri/2017/5123148/
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http://dx.doi.org/10.1155/2017/5123148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602488PMC
May 2018

Why Space Flight-Associated Neuro-ocular Syndrome May Differ From Idiopathic Intracranial Hypertension.

JAMA Ophthalmol 2018 04;136(4):451-452

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1001/jamaophthalmol.2018.0316DOI Listing
April 2018

The First Histologic Evidence of a Paravascular Pathway Within the Optic Nerve.

Invest Ophthalmol Vis Sci 2018 04;59(5):1717

Department of Ophthalmology, Kantonsspital Aarau, Aarau, Switzerland.

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http://dx.doi.org/10.1167/iovs.17-23119DOI Listing
April 2018

The "Ocular Glymphatic System": An Important Missing Piece in the Puzzle of Optic Disc Edema in Astronauts?

Invest Ophthalmol Vis Sci 2018 04;59(5):2090-2091

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium.

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http://dx.doi.org/10.1167/iovs.17-23263DOI Listing
April 2018

Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration.

Alzheimers Res Ther 2018 03 20;10(1):31. Epub 2018 Mar 20.

Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.

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http://dx.doi.org/10.1186/s13195-018-0364-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859717PMC
March 2018

Why a One-Way Ticket to Mars May Result in a One-Way Directional Glymphatic Flow to the Eye.

J Neuroophthalmol 2017 12;37(4):462-463

Department of Psychiatry, PC Sint-Amandus, Beernem, Belgium Department of Ophthalmology, Kantonsspital Aarau, Aarau, Switzerland Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Antwerp, Belgium.

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http://dx.doi.org/10.1097/WNO.0000000000000578DOI Listing
December 2017

Intracranial pressure-induced optic nerve sheath response as a predictive biomarker for optic disc edema in astronauts.

Biomark Med 2017 Nov 4;11(11):1003-1008. Epub 2017 Sep 4.

Laboratory of Neurochemistry & Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.2217/bmm-2017-0218DOI Listing
November 2017

Adapted Morris Water Maze protocol to prevent interference from confounding motor deficits on cognitive functioning.

Somatosens Mot Res 2017 09 10;34(3):172-178. Epub 2017 Sep 10.

a Laboratory for Neurochemistry and Behaviour , Institute Born-Bunge, University of Antwerp , Wilrijk , Belgium.

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http://dx.doi.org/10.1080/08990220.2017.1372740DOI Listing
September 2017

Optic Nerve Sheath Distention as a Protective Mechanism Against the Visual Impairment and Intracranial Pressure Syndrome in Astronauts.

Invest Ophthalmol Vis Sci 2017 09;58(11):4601-4602

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.17-22600DOI Listing
September 2017

Evidence for the existence of a communication between the eye and the brain?

Acta Neurochir (Wien) 2017 08 17;159(8):1413-1414. Epub 2017 May 17.

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00701-017-3218-9DOI Listing
August 2017

Eagle syndrome: A comprehensive review.

Clin Neurol Neurosurg 2017 Aug 6;159:34-38. Epub 2017 May 6.

Department of Otolaryngology-Head and Neck Surgery, The New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.clineuro.2017.04.021DOI Listing
August 2017

Glymphatic stasis at the site of the lamina cribrosa as a potential mechanism underlying open-angle glaucoma.

Clin Exp Ophthalmol 2017 Jul 27;45(5):539-547. Epub 2017 Feb 27.

Laboratory of Neurochemistry and Behavior. Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1111/ceo.12915DOI Listing
July 2017

Alzheimer's disease and glaucoma: can glymphatic system dysfunction underlie their comorbidity?

Acta Ophthalmol 2017 05 29;95(3):e244-e245. Epub 2016 Apr 29.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1111/aos.13068DOI Listing
May 2017

Acute Ischemic Stroke Severity, Progression, and Outcome Relate to Changes in Dipeptidyl Peptidase IV and Fibroblast Activation Protein Activity.

Transl Stroke Res 2017 04 26;8(2):157-164. Epub 2016 Aug 26.

Laboratory of Medical Biochemistry, University of Antwerp, Universiteitsplein 1, Building S, room D.S.513, 2610, Wilrijk-Antwerp, Belgium.

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http://dx.doi.org/10.1007/s12975-016-0493-3DOI Listing
April 2017

Accelerated high-frequency repetitive transcranial magnetic stimulation enhances motor activity in rats.

Neuroscience 2017 04 9;347:103-110. Epub 2017 Feb 9.

Molecular Imaging Center Antwerp (MICA), Universiteitsplein 1, 2610 Wilrijk, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.01.045DOI Listing
April 2017

Non human primate models for Alzheimer's disease-related research and drug discovery.

Expert Opin Drug Discov 2017 Feb 25;12(2):187-200. Epub 2016 Dec 25.

a Laboratory of Neurochemistry and Behavior, Institute Born-Bunge , University of Antwerp , Antwerp , Belgium.

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http://dx.doi.org/10.1080/17460441.2017.1271320DOI Listing
February 2017

Do repetitive Valsalva maneuvers reduce glymphatic clearance?

Ann Neurol 2017 02 27;81(2):322. Epub 2017 Jan 27.

Laboratory of Neurochemistry and Behavior, Born-Bunge Institute, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/ana.24851DOI Listing
February 2017

"Hypodense Holes" and the Ocular Glymphatic System: Author Response: "Black Holes" and the Ocular Glymphatic System.

Invest Ophthalmol Vis Sci 2017 02;58(2):1132-1133

Department of Ophthalmology, Kantonsspital Aarau, Aarau, Switzerland.

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http://dx.doi.org/10.1167/iovs.16-21143DOI Listing
February 2017

The two faces of the translaminar pressure difference: the biomechanical one and the biochemical one.

Clin Exp Optom 2017 01 25;100(1):102-103. Epub 2016 Oct 25.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1111/cxo.12494DOI Listing
January 2017

Diagnostic Impact of Cerebrospinal Fluid Biomarker (Pre-)Analytical Variability in Alzheimer's Disease.

J Alzheimers Dis 2016 ;51(1):97-106

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.3233/JAD-150953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927863PMC
December 2016

Age-related macular degeneration, glaucoma and Alzheimer's disease: amyloidogenic diseases with the same glymphatic background?

Cell Mol Life Sci 2016 11 29;73(22):4299-4301. Epub 2016 Aug 29.

Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00018-016-2348-1DOI Listing
November 2016

The Glymphatic System: A New Player in Ocular Diseases?

Invest Ophthalmol Vis Sci 2016 10;57(13):5426-5427

Department of Ophthalmology, Kantonsspital Aarau, Aarau, Switzerland.

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http://dx.doi.org/10.1167/iovs.16-20262DOI Listing
October 2016

A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Belgium.

J Alzheimers Dis 2016 08;54(1):383-95

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3233/JAD-151097DOI Listing
August 2016

Dilated Virchow-Robin spaces in primary open-angle glaucoma: a biomarker of glymphatic waste clearance dysfunction?

Acta Radiol Open 2016 Aug 10;5(8):2058460116653630. Epub 2016 Aug 10.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Antwerp, Belgium.

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http://dx.doi.org/10.1177/2058460116653630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984313PMC
August 2016

Are depressive symptoms in mild cognitive impairment predictive of conversion to dementia?

Int Psychogeriatr 2016 06 18;28(6):921-8. Epub 2016 Jan 18.

Developmental and Lifespan Psychology,Vrije Universiteit Brussel,Brussels,Belgium.

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http://www.journals.cambridge.org/abstract_S1041610215002409
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http://dx.doi.org/10.1017/S1041610215002409DOI Listing
June 2016

Fast circulation of cerebrospinal fluid: an alternative perspective on the protective role of high intracranial pressure in ocular hypertension.

Clin Exp Optom 2016 May 21;99(3):213-8. Epub 2015 Dec 21.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium.

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http://dx.doi.org/10.1111/cxo.12332DOI Listing
May 2016

A general decline in cerebrospinal fluid flow and optic nerve compartmentation: are these sequential steps leading to toxicity in normal-tension glaucoma?

Acta Ophthalmol 2016 May 4;94(3):e242-3. Epub 2016 Feb 4.

Laboratory of Neurochemistry and Behavior, Department of Biomedical Sciences, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1111/aos.12979DOI Listing
May 2016

A New Look at Glaucoma.

J Ophthalmic Vis Res 2015 Oct-Dec;10(4):502-3

Department of Biomedical Sciences, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.4103/2008-322X.176901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795406PMC
April 2016

Overdiagnosing Vascular Dementia using Structural Brain Imaging for Dementia Work-Up.

J Alzheimers Dis 2015 ;45(4):1039-43

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium Department of Neurology and Memory Clinic, Hospital Network Antwerp, Middelheim and Hoge Beuken, Antwerp, Belgium.

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http://dx.doi.org/10.3233/JAD-142103DOI Listing
March 2016

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42.

Alzheimers Dement 2015 Dec 15;11(12):1452-1460. Epub 2015 Jun 15.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.02.013DOI Listing
December 2015

Dementia: Cerebrospinal fluid biomarkers in dementias.

Nat Rev Neurol 2015 Oct 15;11(10):549-50. Epub 2015 Sep 15.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk, Belgium.

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http://dx.doi.org/10.1038/nrneurol.2015.175DOI Listing
October 2015

Glaucoma and the Role of Cerebrospinal Fluid Dynamics.

Invest Ophthalmol Vis Sci 2015 Oct;56(11):6630-1

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium 6Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Antwerp, Belgium 7Department of Neur.

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http://dx.doi.org/10.1167/iovs.15-18016DOI Listing
October 2015

Validation of the AD-CSF-index in autopsy-confirmed Alzheimer's disease patients and healthy controls.

J Alzheimers Dis 2014 ;41(3):903-9

Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.

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http://dx.doi.org/10.3233/JAD-131085DOI Listing
September 2015

Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis.

Int J Geriatr Psychiatry 2015 Aug 3;30(8):864-9. Epub 2014 Nov 3.

Reference Center for Biological Markers of Dementia (BIODEM), and Biobank, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/gps.4229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657469PMC
August 2015

Initial cognitive response to cholinesterase inhibitors and subsequent long-term course in patients with mild Alzheimer's disease.

Int Psychogeriatr 2015 Aug 17;27(8):1323-33. Epub 2015 Mar 17.

Department of Neurology and Alzheimer Research Center,University Medical Center Groningen,University of Groningen,Groningen,the Netherlands.

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http://dx.doi.org/10.1017/S1041610215000289DOI Listing
August 2015

A new glaucoma hypothesis: a role of glymphatic system dysfunction.

Fluids Barriers CNS 2015 Jun 29;12:16. Epub 2015 Jun 29.

Department of Ophthalmology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Antwerp, Belgium.

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http://dx.doi.org/10.1186/s12987-015-0012-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485867PMC
June 2015

Importance and impact of preanalytical variables on Alzheimer disease biomarker concentrations in cerebrospinal fluid.

Clin Chem 2015 May 13;61(5):734-43. Epub 2015 Apr 13.

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium;

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http://dx.doi.org/10.1373/clinchem.2014.236679DOI Listing
May 2015

The relationship of weight change trajectory with medial temporal lobe atrophy in patients with mild Alzheimer's disease: results from a cohort study.

Alzheimers Res Ther 2015 6;7(1):18. Epub 2015 Apr 6.

Department of Neurology and Alzheimer Research Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, the Netherlands ; Department of Neurology and Memory Clinic, ZNA and Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, 2610 Wilrijk, Antwerp Belgium.

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http://dx.doi.org/10.1186/s13195-015-0098-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386098PMC
April 2015

Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.

Neurochem Res 2015 Jan 5;40(1):81-8. Epub 2014 Nov 5.

Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s11064-014-1468-yDOI Listing
January 2015

Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels.

Alzheimers Dement 2014 Oct 15;10(5 Suppl):S290-8. Epub 2014 Jan 15.

Reference Center for Biological Markers of Dementia (BIODEM), Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.10.004DOI Listing
October 2014

Validation assessment of risk tools to predict outcome after thrombolytic therapy for acute ischemic stroke.

Clin Neurol Neurosurg 2014 Oct 15;125:189-93. Epub 2014 Aug 15.

Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussel, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03038467140031
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http://dx.doi.org/10.1016/j.clineuro.2014.08.011DOI Listing
October 2014

Long-term safety of rivastigmine in parkinson disease dementia: an open-label, randomized study.

Clin Neuropharmacol 2014 Jan-Feb;37(1):9-16

*Department of Neurology, Behavioural Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; †Department of Neurology, Medical University Innsbruck, Innsbruck, Austria; ‡Middelheim Hospital, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; §Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ║Neurodegenerative Diseases Centre, Department of Medicine, University of Salerno, Italy; ¶Department of Neurology, Movement Disorders Unit, Hospital de Sant Pau (IIB-Sant Pau) and CIBERNED, Universitat Autònoma de Barcelona, Barcelona, Spain; #Québec Memory and Motor Skills Disorders Research Center, Clinique Sainte Anne, Québec, Canada; **Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany; ††Department of Neurology, Hospital de Clinicas, University of Buenos Aires, Argentina; ‡‡Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; §§Service De Neurologie CHU, Clermont-Ferrand, France; ║║Parkinson's Disease and Movement Disorder Center, University of Kansas Medical Center, Kansas City, KS; ¶¶Novartis Pharma AG, Basel, Switzerland; and ##Novartis Pharmaceuticals Corporation, East Hanover, NJ.

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http://dx.doi.org/10.1097/WNF.0000000000000010DOI Listing
September 2014

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.

Acta Neuropathol 2014 Sep 5;128(3):397-410. Epub 2014 Jun 5.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00401-014-1298-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131163PMC
September 2014

Novel and sensitive reversed-phase high-pressure liquid chromatography method with electrochemical detection for the simultaneous and fast determination of eight biogenic amines and metabolites in human brain tissue.

J Chromatogr A 2014 Aug 9;1353:28-39. Epub 2014 May 9.

Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, Wilrijk B-2610, Belgium; Biobank, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium; Department of Neurology/Memory Clinic, Middelheim General Hospital, ZNA, Lindendreef 1, Antwerp 2020, Belgium; University of Groningen, Department of Neurology and Alzheimer Research Center, University Medical Center Groningen (UMCG), Hanzeplein 1, Groningen 9713 GZ, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2014.05.004DOI Listing
August 2014

Glaucoma considered as an imbalance between production and clearance of neurotoxins.

Invest Ophthalmol Vis Sci 2014 Aug 26;55(8):5351-2. Epub 2014 Aug 26.

Department of Psychiatry, Ghent University Hospital, Ghent, Belgium; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Antwerp, Belgium; and the Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1167/iovs.14-15041DOI Listing
August 2014

Nutritional interventions in community-dwelling Alzheimer patients with (risk of) undernutrition: a systematic review.

Int Psychogeriatr 2014 May 20:1-9. Epub 2014 May 20.

Department of Neurology and Alzheimer Research Center,University Medical Center Groningen,University of Groningen,Groningen,the Netherlands.

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http://dx.doi.org/10.1017/S1041610214000817DOI Listing
May 2014

Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels.

J Alzheimers Dis 2013 ;36(4):759-67

Reference Center for Biological Markers of Dementia, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium.

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http://dx.doi.org/10.3233/JAD-130107DOI Listing
March 2014

The role of low intracranial pressure in the development of glaucoma in patients with Alzheimer's disease.

Prog Retin Eye Res 2014 Mar 4;39:107-8. Epub 2014 Jan 4.

Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Neurology and Memory Clinic, Middelheim General Hospital (ZNA), Lindendreef 1, 2020 Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.preteyeres.2013.12.002DOI Listing
March 2014

Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease.

J Alzheimers Dis 2013 ;35(1):67-73

Department of Neurology and Memory Clinic, Middelheim and Hoge Beuken General Hospitals (ZNA), Antwerpen, Belgium.

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http://dx.doi.org/10.3233/JAD-101305DOI Listing
December 2013

A behavioural study of neuroglobin-overexpressing mice under normoxic and hypoxic conditions.

Biochim Biophys Acta 2013 Sep 21;1834(9):1764-71. Epub 2013 Apr 21.

Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.bbapap.2013.04.015DOI Listing
September 2013

Senescent changes in cerebrospinal fluid circulatory physiology and their role in the pathogenesis of normal-tension glaucoma.

Am J Ophthalmol 2013 Jul 19;156(1):5-14.e2. Epub 2013 Apr 19.

Department of Psychiatry, PC Sint-Amandus, Beernem, Belgium.

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http://dx.doi.org/10.1016/j.ajo.2013.03.003DOI Listing
July 2013

Neuropeptides in Alzheimer's disease: from pathophysiological mechanisms to therapeutic opportunities.

Curr Alzheimer Res 2013 Jun;10(5):449-68

Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences Universiteitsplein 1, 2610 Wilrijk, Belgium.

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http://dx.doi.org/10.2174/1567205011310050001DOI Listing
June 2013

Aripiprazole in the treatment of Alzheimer's disease.

Expert Opin Pharmacother 2013 Mar 28;14(4):459-74. Epub 2013 Jan 28.

University of Groningen, University Medical Center Groningen, Alzheimer Research Center, Department of Neurology, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1517/14656566.2013.764989DOI Listing
March 2013

A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats.

Authors:
Julie van der Zee Ilse Gijselinck Lubina Dillen Tim Van Langenhove Jessie Theuns Sebastiaan Engelborghs Stéphanie Philtjens Mathieu Vandenbulcke Kristel Sleegers Anne Sieben Veerle Bäumer Githa Maes Ellen Corsmit Barbara Borroni Alessandro Padovani Silvana Archetti Robert Perneczky Janine Diehl-Schmid Alexandre de Mendonça Gabriel Miltenberger-Miltenyi Sónia Pereira José Pimentel Benedetta Nacmias Silvia Bagnoli Sandro Sorbi Caroline Graff Huei-Hsin Chiang Marie Westerlund Raquel Sanchez-Valle Albert Llado Ellen Gelpi Isabel Santana Maria Rosário Almeida Beatriz Santiago Giovanni Frisoni Orazio Zanetti Cristian Bonvicini Matthis Synofzik Walter Maetzler Jennifer Müller Vom Hagen Ludger Schöls Michael T Heneka Frank Jessen Radoslav Matej Eva Parobkova Gabor G Kovacs Thomas Ströbel Stayko Sarafov Ivailo Tournev Albena Jordanova Adrian Danek Thomas Arzberger Gian Maria Fabrizi Silvia Testi Eric Salmon Patrick Santens Jean-Jacques Martin Patrick Cras Rik Vandenberghe Peter Paul De Deyn Marc Cruts Christine Van Broeckhoven Julie van der Zee Ilse Gijselinck Lubina Dillen Tim Van Langenhove Jessie Theuns Stéphanie Philtjens Kristel Sleegers Veerle Bäumer Githa Maes Ellen Corsmit Marc Cruts Christine Van Broeckhoven Julie van der Zee Ilse Gijselinck Lubina Dillen Tim Van Langenhove Stéphanie Philtjens Jessie Theuns Kristel Sleegers Veerle Bäumer Githa Maes Marc Cruts Christine Van Broeckhoven Sebastiaan Engelborghs Peter P De Deyn Patrick Cras Sebastiaan Engelborghs Peter P De Deyn Mathieu Vandenbulcke Mathieu Vandenbulcke Barbara Borroni Alessandro Padovani Silvana Archetti Robert Perneczky Janine Diehl-Schmid Matthis Synofzik Walter Maetzler Jennifer Müller Vom Hagen Ludger Schöls Matthis Synofzik Walter Maetzler Jennifer Müller Vom Hagen Ludger Schöls Michael T Heneka Frank Jessen Alfredo Ramirez Delia Kurzwelly Carmen Sachtleben Wolfgang Mairer Alexandre de Mendonça Gabriel Miltenberger-Miltenyi Sónia Pereira Clara Firmo José Pimentel Raquel Sanchez-Valle Albert Llado Anna Antonell Jose Molinuevo Ellen Gelpi Caroline Graff Huei-Hsin Chiang Marie Westerlund Caroline Graff Anne Kinhult Ståhlbom Håkan Thonberg Inger Nennesmo Anne Börjesson-Hanson Benedetta Nacmias Silvia Bagnoli Sandro Sorbi Valentina Bessi Irene Piaceri Isabel Santana Beatriz Santiago Isabel Santana Maria Helena Ribeiro Maria Rosário Almeida Catarina Oliveira João Massano Carolina Garret Paula Pires Giovanni Frisoni Orazio Zanetti Cristian Bonvicini Stayko Sarafov Ivailo Tournev Albena Jordanova Ivailo Tournev Gabor G Kovacs Thomas Ströbel Michael T Heneka Frank Jessen Alfredo Ramirez Delia Kurzwelly Carmen Sachtleben Wolfgang Mairer Frank Jessen Radoslav Matej Eva Parobkova Adrian Danel Thomas Arzberger Gian Maria Fabrizi Silvia Testi Sergio Ferrari Tiziana Cavallaro Eric Salmon Patrick Santens Patrick Cras

Hum Mutat 2013 Feb 4;34(2):363-73. Epub 2013 Jan 4.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.22244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638346PMC
February 2013

Non-motor symptoms in a Flanders-Belgian population of 215 Parkinson's disease patients as assessed by the Non-Motor Symptoms Questionnaire.

Am J Neurodegener Dis 2012 23;1(2):160-7. Epub 2012 Jul 23.

Department of Neurology, Antwerp University Hospital Antwerpen, Belgium ; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics VIB, Antwerpen, Belgium ; Laboratory of Neurobiology, Institute Born-Bunge, University of Antwerp Antwerpen, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560460PMC
February 2013