Peter P Liu

Peter P Liu

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Ethnic differences in acute heart failure outcomes in Ontario.

Int J Cardiol 2019 Sep 22;291:177-182. Epub 2019 May 22.

Department of Anaesthesia, Burn, and Critical Care, Saint-Louis Lariboisière University Hospital, Paris, France; Université de Paris, France.

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http://dx.doi.org/10.1016/j.ijcard.2019.05.043DOI Listing
September 2019

Targeting metabolic dysregulation for fibrosis therapy.

Nat Rev Drug Discov 2019 Sep 23. Epub 2019 Sep 23.

Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41573-019-0040-5DOI Listing
September 2019

Dilated cardiomyopathy.

Nat Rev Dis Primers 2019 05 9;5(1):32. Epub 2019 May 9.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1038/s41572-019-0084-1DOI Listing
May 2019

Biomarkers in the Diagnosis, Management, and Prognostication of Perioperative Right Ventricular Failure in Cardiac Surgery-Are We There Yet?

J Clin Med 2019 Apr 25;8(4). Epub 2019 Apr 25.

Cardiac Anesthesiology, University of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.

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http://dx.doi.org/10.3390/jcm8040559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517903PMC
April 2019

Innate Immune Signaling and Its Role in Metabolic and Cardiovascular Diseases.

Physiol Rev 2019 01;99(1):893-948

Department of Cardiology, Renmin Hospital of Wuhan University , Wuhan , China ; Medical Research Center, Zhongnan Hospital of Wuhan University , Wuhan , China ; Animal Experiment Center, Wuhan University , Wuhan , China ; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario , Canada.

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http://dx.doi.org/10.1152/physrev.00065.2017DOI Listing
January 2019

Utility of Novel Cardiorenal Biomarkers in the Prediction and Early Detection of Congestive Kidney Injury Following Cardiac Surgery.

J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.

Division of Cardiac Anesthesiology, Department of Anesthesiology and Pain Medicine, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada.

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http://dx.doi.org/10.3390/jcm7120540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306702PMC
December 2018

Disability-free survival after coronary artery bypass grafting in women and men with heart failure.

Open Heart 2018 5;5(2):e000911. Epub 2018 Nov 5.

Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1136/openhrt-2018-000911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242014PMC
November 2018

Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update.

CMAJ 2018 10;190(40):E1192-E1206

Libin Cardiovascular Institute, Cumming School of Medicine (Anderson), University of Calgary, Calgary, Alta.; Department of Health, Kinesiology, and Applied Physiology (Bacon), Concordia University, Montreal, Que. & Montreal Behavioural Medicine Centre, CIUSSS-NIM, Montreal, Que.; St. Michael's Hospital (Cheng), University of Toronto, Toronto, Ont.; McGill University (Daskalopoulou), Montreal, Que.; Department of Medicine (Ezekowitz), University of Alberta, Edmonton, Alta.; Institut de cardiologie de Montreal (Gregoire), Montreal, Que.; Universite de Montreal (Gubitz), Montreal, Que.; Sunnybrook Research Institute (Hua-Stewart), Toronto, Ont.; Department of Family and Community Medicine (Jain), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Keshavjee), University of Toronto, Toronto, Ont.; Department of Nutritional Sciences (L'Abbe), University of Toronto, Toronto, Ont.; Department of Medicine and Libin Cardiovascular Institute (Lau), Cumming School of Medicine, University of Calgary, Calgary, Alta.; Li Ka Shing Knowledge Institute (Leiter), St. Michael's Hospital, University of Toronto, Toronto, Ont.; Heart and Stroke Foundation (Lindsay), Ottawa, Ont.; Ottawa Heart Institute (Liu), University of Ottawa, Ottawa, Ont.; Insitut de Cardiologie de Montreal (O'Meara), Universite de Montreal, Montreal, Que.; Division of Cardiology, Mazankowski Alberta Heart Institute; University of Alberta, Faculty of Medicine and Dentistry (Pearson), Edmonton, Alta.; Departments of Medicine, Community Health and Cardiac Sciences (Rabi), University of Calgary, Calgary, Alta.; Centre for Addiction and Mental Health, Departments of Family and Community Medicine, Psychiatry and Public Health Sciences (Selby), University of Toronto, Toronto, Ont.; School of Nursing and Health Research Methods, Evidence and Impact, Faculty of Health Sciences (Sherifali), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Stone), University of Calgary, Calgary, Alta.; Division of Nephrology (Tobe), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; ICES, Sunnybrook Research Institute (Tu), University of Toronto, Toronto, Ont.; St. Joseph's Health Care Centre (Walker), Toronto, Ont.; McMaster University (Wharton), Hamilton Ont.; York University (Wharton), Toronto, Ont.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.180194
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http://dx.doi.org/10.1503/cmaj.180194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175624PMC
October 2018

Prevalence and Long-Term Survival After Coronary Artery Bypass Grafting in Women and Men With Heart Failure and Preserved Versus Reduced Ejection Fraction.

J Am Heart Assoc 2018 06 16;7(12). Epub 2018 Jun 16.

Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1161/JAHA.118.008902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220539PMC
June 2018

Erratum to: Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.

J Mol Med (Berl) 2017 11;95(11):1251-1253

Department of Cardiology, Renmin Hospital of Wuhan University, JieFang Road 238, Wuhan, 430060, People's Republic of China.

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http://dx.doi.org/10.1007/s00109-017-1588-3DOI Listing
November 2017

N-Terminal Pro B-Type Natriuretic Peptide and High-Sensitivity Cardiac Troponin T Levels Are Related to the Extent of Hibernating Myocardium in Patients With Ischemic Heart Failure.

Can J Cardiol 2017 11 27;33(11):1478-1488. Epub 2017 Jun 27.

Molecular Function and Imaging Program, The National Cardiac PET Centre, and the Advanced Heart Disease Program, Division of Cardiology, Department of Medicine, and the Cardiac Research Methods Centre, University of Ottawa Heart Institute and University of Ottawa, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2017.06.012DOI Listing
November 2017

Applications of 3D printing in cardiovascular diseases.

Nat Rev Cardiol 2016 12 27;13(12):701-718. Epub 2016 Oct 27.

Department of Radiology, Faculty of Medicine, University of Ottawa, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.

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http://dx.doi.org/10.1038/nrcardio.2016.170DOI Listing
December 2016

Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases.

Circulation 2016 Jul;134(4):286-9

From Department of Physiology, Ted Rogers Centre for Heart Research, University of Toronto, Canada (A.G., P.P.L.); NIH BD2K Center of Excellence in Biomedical Computing, Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA (E.L.); and University of Ottawa Heart Institute, Departments of Medicine & Cellular Molecular Medicine, University of Ottawa, Canada (P.P.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022940DOI Listing
July 2016

Long Noncoding RNAs in the Heart: The Regulatory Roadmap of Cardiovascular Development and Disease.

Circ Cardiovasc Genet 2016 Apr;9(2):101-3

From the University of Ottawa Heart Institute; Departments of Medicine, Cellular & Molecular Medicine, and Biochemistry, Microbiology and Immunology, Ottawa, Ontario, Canada.

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https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.116.001
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http://dx.doi.org/10.1161/CIRCGENETICS.116.001413DOI Listing
April 2016

Wild-Type Transthyretin Amyloid Cardiomyopathy: A Missed Cause of Heart Failure With Preserved Ejection Fraction With Evolving Treatment Implications.

Circulation 2016 Jan 11;133(3):245-7. Epub 2015 Dec 11.

From University of Ottawa Heart Institute, ON, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020351DOI Listing
January 2016

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling.

Nat Commun 2014 ;5:3303

1] Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China [2] Cardiovascular Research Institute of Wuhan University, Wuhan 430060, China.

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http://dx.doi.org/10.1038/ncomms4303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929801PMC
November 2015

Pharmacologic Options for the Management of Systolic Heart Failure: Examining Underlying Mechanisms.

Can J Cardiol 2015 Oct 19;31(10):1282-92. Epub 2015 Feb 19.

Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.cjca.2015.02.013DOI Listing
October 2015

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes.

Proc Natl Acad Sci U S A 2015 Jun 26;112(23):7165-70. Epub 2015 May 26.

Department of Physiology, University of Toronto, Toronto, ON, Canada M5G 1L7; Toronto General Hospital, University Health Network, Toronto, ON, Canada M5G 1L7; Ted Rogers Centre for Heart Research, Toronto, ON, Canada M5G 1L7

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http://dx.doi.org/10.1073/pnas.1508815112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466728PMC
June 2015

Role of innate and adaptive immune mechanisms in cardiac injury and repair.

Nat Rev Immunol 2015 Feb;15(2):117-29

Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nri3800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669103PMC
February 2015

Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE): 2014 update.

CMAJ 2014 Nov 20;186(17):1299-305. Epub 2014 Oct 20.

Division of Nephrology (Tobe), Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont.; Libin Cardiovascular Institute of Alberta (Stone), University of Calgary, Cardiac Wellness Institute of Calgary, Calgary, Alta.; University Health Network, Toronto General Hospital (Walker), Toronto, Ont.; Libin Cardiovascular Institute of Alberta (Anderson), University of Calgary Calgary Alta.; Women's College Hospital (Bhattacharrya), University of Toronto, Toronto, Ont.; Division of Endocrinology and Metabolism (Cheng), St. Michael's Hospital, University of Toronto, Toronto, Ont.; Institut de cardiologie de Montréal (Gregoire), Université de Montréal, Montréal, Que.; Division of Neurology (Gubitz), Dalhousie University, Halifax, NS.; Department of Nutritional Sciences (L'Abbé), University of Toronto, Toronto, Ont.; Division of Endocrinology and Metabolism (Lau), Julia McFarlane Diabetes Research Centre, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alta.; Keenan Research Centre (Leiter), Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Toronto Rehabilitation Institute (Oh), University Health Network, University of Toronto, Toronto, Ont.; Departments of Clinical Epidemiology and Pharmacology, and Division of General Internal Medicine (Padwal), University of Alberta, Edmonton, Alta.; Département de pharmacie, Centre Hospitalier Universitaire de Québec et Faculté de Pharmacie, Université Laval, Québec, Que.; Centre for Addiction and Mental Health, the Departments of Family and Community Medicine, and Psychiatry, and Dalla Lana School of Public Health (Selby), University of Toronto, Toronto, Ont.; The Children's Hospital of Eastern Ontario Research Institute (Tremblay), Ottawa, Ont.; the Department of Family Medicine (Ward), University of Calgary, Alta.; Sunnybrook Research Institute (Hua) Toronto, Ont.; University of Ottawa Heart Institute (Liu), Ottawa, Ont.

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http://dx.doi.org/10.1503/cmaj.140387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234715PMC
November 2014

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

J Am Heart Assoc 2014 Oct 20;3(5):e001018. Epub 2014 Oct 20.

Department of Physiology, University of Toronto, Ontario, Canada (D.Y.W., C.A., J.Y.L., P.S., N.B., S.S., P.H.B., B.C., X.Y.W., P.P.L., A.O.G.) Faculty of Medicine and Institute of Medical Science, University of Toronto, Ontario, Canada (S.E.R., F.D., K.N., P.H.B., X.Y.W., P.P.L., A.O.G.).

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http://dx.doi.org/10.1161/JAHA.114.001018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323785PMC
October 2014

Clinical, biochemical, and genetic predictors of coronary artery bypass graft failure.

J Thorac Cardiovasc Surg 2014 Aug 9;148(2):515-520.e2. Epub 2013 Dec 9.

Division of Cardiac Surgery, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2013.10.011DOI Listing
August 2014

Synergistic nanoparticulate drug combination overcomes multidrug resistance, increases efficacy, and reduces cardiotoxicity in a nonimmunocompromised breast tumor model.

Mol Pharm 2014 Aug 3;11(8):2659-74. Epub 2014 Jun 3.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1021/mp500093cDOI Listing
August 2014

The adapter protein c-Cbl-associated protein (CAP) protects from acute CVB3-mediated myocarditis through stabilization of type I interferon production and reduced cytotoxicity.

Basic Res Cardiol 2014 May 24;109(3):411. Epub 2014 Apr 24.

Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada,

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http://dx.doi.org/10.1007/s00395-014-0411-3DOI Listing
May 2014

Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy.

Hypertension 2014 Apr 6;63(4):713-22. Epub 2014 Jan 6.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Jiefang Road 238, Wuhan 430060, PR China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349187PMC
April 2014

Healthy food procurement policies and their impact.

Int J Environ Res Public Health 2014 Mar 3;11(3):2608-27. Epub 2014 Mar 3.

Toronto General Hospital, University of Toronto, 200 Elizabeth St., Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.3390/ijerph110302608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986994PMC
March 2014

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.

Nat Commun 2014 Mar 11;5:3430. Epub 2014 Mar 11.

1] University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7 [2] Heart and Stroke/Richard Lewar Centre of Excellent for Cardiovascular Research, University of Toronto and Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2C4 [3] Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 [4] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1038/ncomms4430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959209PMC
March 2014

Dynamic changes in myocardial matrix and relevance to disease: translational perspectives.

Circ Res 2014 Feb;114(5):916-27

From the University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.-H.L., P.P.L.); University of Toronto, Heart & Stroke/Lewar Centre of Excellence, Toronto, Ontario, Canada (P.P.L.); University of California, San Diego, School of Medicine (F.J.V., R.A.G.); and Bristol-Myers Squibb Company, Pennington, NJ (R.A.G.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.302819DOI Listing
February 2014

Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin.

Hypertension 2014 Jan 21;63(1):119-27. Epub 2013 Oct 21.

Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University, Jiefang Rd 238, Wuhan 430060, PR China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.02083DOI Listing
January 2014

Association of heart rate at hospital discharge with mortality and hospitalizations in patients with heart failure.

Circ Heart Fail 2014 Jan 2;7(1):12-20. Epub 2013 Dec 2.

Institute for Clinical Evaluative Sciences, Toronto, Canada.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000429DOI Listing
January 2014

Vaccination with Flt3L-induced CD8α+ dendritic cells prevents CD4+ T helper cell-mediated experimental autoimmune myocarditis.

Vaccine 2013 Oct 12;31(42):4802-11. Epub 2013 Aug 12.

Division of Cardioimmunology, Cardiovascular Research, Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Switzerland; Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2013.07.084DOI Listing
October 2013

Innate immune interleukin-1 receptor-associated kinase 4 exacerbates viral myocarditis by reducing CCR5(+) CD11b(+) monocyte migration and impairing interferon production.

Circulation 2013 Oct 12;128(14):1542-54. Epub 2013 Sep 12.

Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada (A.V., M.N., Y.L., K.N., M.C., L.Z., P.P.L.); University of Ottawa Heart Institute, University of Ottawa, Ottawa, Ontario, Canada (L.Z., G.A.W., P.P.L.); Department of Cardiology and Pneumology, Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany (C.S., H.S.); and Division of Cardioimmunology, Cardiovascular Research, Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Zurich, and Department of Medicine, GZO-Zurich Regional Health Centre, Wetzikon, Switzerland (U.E.).

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http://circ.ahajournals.org/content/early/2013/09/12/CIRCULA
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http://circ.ahajournals.org/cgi/doi/10.1161/CIRCULATIONAHA.1
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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002275DOI Listing
October 2013

Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure.

Proteomics 2013 Aug 1;13(15):2324-34. Epub 2013 Jul 1.

Department of Physiology, University of Toronto, Toronto, ON, Canada; Heart and Stroke/Richard Lewar Centre of Cardiovascular Excellence, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pmic.201200455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735469PMC
August 2013

Canada's contribution to global research in cardiovascular diseases.

Can J Cardiol 2013 Jun 6;29(6):742-6. Epub 2012 Dec 6.

Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2012.09.013DOI Listing
June 2013

The cardiovascular exosome: current perspectives and potential.

Proteomics 2013 May 20;13(10-11):1654-9. Epub 2013 Apr 20.

Department of Physiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/pmic.201200441DOI Listing
May 2013

Estimating the payoffs from cardiovascular disease research in Canada: an economic analysis.

CMAJ Open 2013 May 25;1(2):E83-90. Epub 2013 Jul 25.

University Health Network, Toronto, Ont. ; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ont. ; Toronto Health Economics and Technology Assessment Collaborative, Toronto, Ont ; Department of Medicine, University of Toronto, Toronto, Ont.

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http://dx.doi.org/10.9778/cmajo.20130003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986018PMC
May 2013

Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.

J Am Heart Assoc 2013 Apr 22;2(2):e000191. Epub 2013 Apr 22.

Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/JAHA.113.000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647266PMC
April 2013

Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy.

Basic Res Cardiol 2013 Mar 11;108(2):326. Epub 2013 Jan 11.

Department of Cardiology, Renmin Hospital, Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.

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http://dx.doi.org/10.1007/s00395-012-0326-9DOI Listing
March 2013

Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.

J Mol Med (Berl) 2012 Aug 25;90(8):895-910. Epub 2012 Feb 25.

Department of Cardiology, Renmin Hospital of Wuhan University, JieFang Road 238, Wuhan 430060, People's Republic of China.

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http://link.springer.com/10.1007/s00109-012-0883-2
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http://dx.doi.org/10.1007/s00109-012-0883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734934PMC
August 2012

Impact of frequent nocturnal hemodialysis on myocardial mechanics and cardiomyocyte gene expression.

Circ Cardiovasc Imaging 2012 Jul 30;5(4):474-80. Epub 2012 May 30.

Divisions of Nephrology and Cardiology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCIMAGING.111.971606DOI Listing
July 2012

Managing cardiovascular risk in patients with chronic inflammatory diseases.

Clin Rheumatol 2012 Apr 14;31(4):585-94. Epub 2012 Jan 14.

Rheumatology, CHUM, Hôpital Notre-Dame, Montréal, QC H2L 4M1, Canada.

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http://dx.doi.org/10.1007/s10067-011-1921-0DOI Listing
April 2012

Myocarditis.

Lancet 2012 Feb 18;379(9817):738-47. Epub 2011 Dec 18.

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736116064
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http://dx.doi.org/10.1016/S0140-6736(11)60648-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814111PMC
February 2012

Targeting myocardial substrate metabolism in heart failure: potential for new therapies.

Eur J Heart Fail 2012 Feb;14(2):120-9

Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1093/eurjhf/hfr173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260022PMC
February 2012

Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction.

Basic Res Cardiol 2012 Jan 28;107(1):239. Epub 2011 Dec 28.

Department of Cardiology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, People's Republic of China.

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http://dx.doi.org/10.1007/s00395-011-0239-zDOI Listing
January 2012

Cardiotoxicity due to cancer therapy.

Tex Heart Inst J 2011 ;38(3):253-6

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113124PMC
October 2011

Harmonization of guidelines for the prevention and treatment of cardiovascular disease: the C-CHANGE Initiative.

CMAJ 2011 Oct 12;183(15):E1135-50. Epub 2011 Sep 12.

Sunnybrook Health Sciences Centre, University of Toronto, and the Department of Family and Community Medicine, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario.

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http://dx.doi.org/10.1503/cmaj.101508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193113PMC
October 2011

Valvular aortic stenosis as a major sequelae in patients with pre-existing subaortic stenosis changing spectrum of outcomes.

J Am Coll Cardiol 2011 Aug;58(9):962-5

Division of Cardiology, Toronto Congenital Cardiac Centre for Adults, University of Toronto, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S073510971102046
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http://dx.doi.org/10.1016/j.jacc.2011.04.029DOI Listing
August 2011

Diastolic heart failure: progress, treatment challenges, and prevention.

Can J Cardiol 2011 May-Jun;27(3):302-10

The Heart & Stroke/Richard Lewar Centre for Excellence, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2011.02.008DOI Listing
July 2011

Cathepsin-L contributes to cardiac repair and remodelling post-infarction.

Cardiovasc Res 2011 Feb 8;89(2):374-83. Epub 2010 Dec 8.

Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/cvr/cvq328DOI Listing
February 2011

Patterns of cardiac and extracardiac anomalies in adults with tetralogy of fallot.

Am Heart J 2011 Jan;161(1):131-7

Toronto Congenital Cardiac Centre for Adults, Peter Munk Cardiac Centre, University Health Network, Division of Cardiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ahj.2010.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142274PMC
January 2011

Cellular FLICE-inhibitory protein protects against cardiac remodeling induced by angiotensin II in mice.

Hypertension 2010 Dec 25;56(6):1109-17. Epub 2010 Oct 25.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, People's Republic of China.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.157412DOI Listing
December 2010

Early detection of myocardial dysfunction and heart failure.

Nat Rev Cardiol 2010 Jun 11;7(6):334-44. Epub 2010 May 11.

Toronto General Hospital, University Health Network, NCSB 11-1266, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.1038/nrcardio.2010.51DOI Listing
June 2010

Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway.

Circulation 2010 Jun 7;121(24):2624-34. Epub 2010 Jun 7.

Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.8
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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.893248DOI Listing
June 2010

Association of blood pressure at hospital discharge with mortality in patients diagnosed with heart failure.

Circ Heart Fail 2009 Nov 24;2(6):616-23. Epub 2009 Sep 24.

Institute for Clinical Evaluative Sciences, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.869743DOI Listing
November 2009

Anticoagulation in patients with heart failure.

Cardiovasc Hematol Agents Med Chem 2009 Jul;7(3):193-7

Institute for Clinical Evaluative Sciences, Toronto, Ontario, M4N 3M5 Canada.

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July 2009

Statin therapy and clinical outcomes in heart failure: a propensity-matched analysis.

J Card Fail 2009 Apr 23;15(3):241-8. Epub 2008 Dec 23.

Heart & Stroke/Richard Lewar Centre for Excellence, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cardfail.2008.10.026DOI Listing
April 2009

Nocturnal hemodialysis improves erythropoietin responsiveness and growth of hematopoietic stem cells.

J Am Soc Nephrol 2009 Mar 17;20(3):665-71. Epub 2008 Dec 17.

Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1681/ASN.2008050498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653688PMC
March 2009

Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.

Mol Ther 2009 Feb 11;17(2):262-8. Epub 2008 Nov 11.

Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2008.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835055PMC
February 2009

Diastolic heart failure: mechanisms and controversies.

Nat Clin Pract Cardiovasc Med 2008 Jul 10;5(7):375-86. Epub 2008 Jun 10.

Institute of Circulatory and Respiratory Health, CIHR, NCSB 11-1266, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.

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http://www.nature.com/articles/ncpcardio1245
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July 2008

Cardiorenal syndrome in heart failure: a cardiologist's perspective.

Authors:
Peter P Liu

Can J Cardiol 2008 Jul;24 Suppl B:25B-9B

The Heart and Stroke/Richard Lewar Centre of Excellence, and Toronto General Research Institute, University Health Network, Toronto, Ottawa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794438PMC
http://dx.doi.org/10.1016/s0828-282x(08)71027-4DOI Listing
July 2008

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.

Cardiovasc Res 2008 Jun 15;78(3):505-14. Epub 2008 Feb 15.

Division of Cardiology, Department of Medicine, Rm 7326, Medical Sciences Building, One King's College Circle, University of Toronto, Toronto, Canada M5S 1A8.

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http://dx.doi.org/10.1093/cvr/cvn041DOI Listing
June 2008

Curcumin prevents and reverses murine cardiac hypertrophy.

J Clin Invest 2008 Mar;118(3):879-93

Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI32865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248327PMC
March 2008

Chlamydophila pneumoniae inhibits differentiation of progenitor adipose cells and impairs insulin signaling.

J Infect Dis 2008 Feb;197(3):439-48

Toronto General Hospital Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1086/525045DOI Listing
February 2008

Relationships between plasma levels of matrix metalloproteinases and neurohormonal profile in patients with heart failure.

Eur J Heart Fail 2008 Feb 29;10(2):125-8. Epub 2008 Jan 29.

Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1016/j.ejheart.2007.12.002
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http://dx.doi.org/10.1016/j.ejheart.2007.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693229PMC
February 2008

Review: contrast-enhanced MRA is more sensitive and specific than CT angiography or ultrasonography for detection of lower-limb PAD.

ACP J Club 2007 Nov-Dec;147(3):77

University of Toronto, Toronto, Ontario, Canada.

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December 2007

Lost in translation: five grand challenges for proteomic biomarker discovery.

Expert Opin Med Diagn 2007 Nov;1(3):325-36

University of Toronto, Toronto General Hospital, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1517/17530059.1.3.325DOI Listing
November 2007

The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.

Nat Med 2007 Sep 12;13(9):1060-9. Epub 2007 Aug 12.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohrgasse 3, 1030 Vienna, Austria.

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http://dx.doi.org/10.1038/nm1621DOI Listing
September 2007

Sex hormones as novel risk biomarkers for atherosclerosis in peripheral vascular disease.

J Am Coll Cardiol 2007 Sep 24;50(11):1077-9. Epub 2007 Aug 24.

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http://dx.doi.org/10.1016/j.jacc.2007.05.031DOI Listing
September 2007

Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery.

J Thorac Cardiovasc Surg 2007 Jul;134(1):74-81, 81.e1-2

Richard Lewar Centre of Excellence, Toronto General Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jtcvs.2007.01.025DOI Listing
July 2007

Heat shock paradox and a new role of heat shock proteins and their receptors as anti-inflammation targets.

Inflamm Allergy Drug Targets 2007 Jun;6(2):91-100

School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada.

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June 2007

Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction.

Circulation 2007 Apr 26;115(14):1885-94. Epub 2007 Mar 26.

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, PR China.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.6
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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.656835DOI Listing
April 2007

Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state.

Circulation 2007 Mar 12;115(11):1398-407. Epub 2007 Mar 12.

The Heart and Stroke/Richard Lewar Centre of Excellence and Toronto General University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.643585DOI Listing
March 2007