Peter McNamara

Peter McNamara

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Peter McNamara

Peter McNamara

Publications by authors named "Peter McNamara"

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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.

Bioorg Med Chem Lett 2014 Dec 13;24(23):5478-83. Epub 2014 Oct 13.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.10.010DOI Listing
December 2014

Discovery of structurally novel, potent and orally efficacious GPR119 agonists.

Bioorg Med Chem Lett 2014 May 27;24(10):2383-7. Epub 2014 Mar 27.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.03.023DOI Listing
May 2014

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.

J Med Chem 2014 Apr 4;57(8):3263-82. Epub 2014 Apr 4.

Departments of †Medicinal Chemistry, ‡Drug Discovery Biology, §Pharmacology, ∥Pharmacokinetics, and ⊥Structural Biology, Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

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http://dx.doi.org/10.1021/jm401731qDOI Listing
April 2014

Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.

Antimicrob Agents Chemother 2009 May 17;53(5):1898-906. Epub 2009 Feb 17.

University of Wisconsin-Madison, Department of Medical Microbiology and Immunology, 1550 Linden Dr., Madison, WI 53706, USA.

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http://dx.doi.org/10.1128/AAC.01293-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681528PMC
May 2009

A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence.

PLoS Genet 2007 Jan 30;3(1):e8. Epub 2006 Nov 30.

Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0030008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761047PMC
January 2007

Bacterial interactions and the microevolution of cytochrome bd: implications for pathogenesis.

J Bacteriol 2006 Dec;188(23):7997-8

Department Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, WI 53706, USA.

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http://dx.doi.org/10.1128/JB.01364-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698182PMC
December 2006

Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections.

Nat Rev Microbiol 2006 Apr;4(4):295-305

University of Wisconsin Medical School, 436 SMI, 1300 University Avenue, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1038/nrmicro1384DOI Listing
April 2006

Bioinformatic analysis of circadian gene oscillation in mouse aorta.

Circulation 2005 Oct 17;112(17):2716-24. Epub 2005 Oct 17.

The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.568626DOI Listing
October 2005

A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.

Infect Immun 2005 Jun;73(6):3806-9

Department of Medical Microbiology & Immunology, 1300 University Avenue, University of Wisconsin, Biochemistry Building, Room 250, Madison, WI 53706, USA.

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http://dx.doi.org/10.1128/IAI.73.6.3806-3809.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1111829PMC
June 2005

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.

PLoS Biol 2004 Nov 2;2(11):e377. Epub 2004 Nov 2.

Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1371/journal.pbio.0020377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524471PMC
November 2004

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock.

Neuron 2004 Aug;43(4):527-37

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1016/j.neuron.2004.07.018DOI Listing
August 2004

Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

J Biol Chem 2004 Feb 26;279(8):7091-7. Epub 2003 Nov 26.

Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M311973200
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http://dx.doi.org/10.1074/jbc.M311973200DOI Listing
February 2004

Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma.

J Clin Invest 2003 Sep;112(6):945-55

Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, USA.

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http://dx.doi.org/10.1172/JCI18012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193665PMC
September 2003

Isoprostane activation of the nuclear hormone receptor PPAR.

Adv Exp Med Biol 2002 ;507:351-5

Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/978-1-4615-0193-0_54DOI Listing
May 2003

COX-2-dependent cardiac failure in Gh/tTG transgenic mice.

Circ Res 2003 May 17;92(10):1153-61. Epub 2003 Apr 17.

Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pa 19104-6084, USA.

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http://dx.doi.org/10.1161/01.RES.0000071749.22027.45DOI Listing
May 2003

Staphylococcus aureus menD and hemB mutants are as infective as the parent strains, but the menadione biosynthetic mutant persists within the kidney.

J Infect Dis 2003 May 30;187(10):1654-61. Epub 2003 Apr 30.

Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA.

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https://academic.oup.com/jid/article-lookup/doi/10.1086/3746
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http://dx.doi.org/10.1086/374642DOI Listing
May 2003

A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.

Mol Cell Biol 2002 Nov;22(22):7993-8004

Center for Research on Reproduction and Women's Health. Department of Psychiatry. Center for Experimental Therapeutics, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC134734PMC
http://dx.doi.org/10.1128/mcb.22.22.7993-8004.2002DOI Listing
November 2002

Regulation of histone acetylation and transcription by nuclear protein pp32, a subunit of the INHAT complex.

J Biol Chem 2002 Apr 5;277(16):14005-10. Epub 2002 Feb 5.

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M112455200DOI Listing
April 2002