Peter Marynen

Peter Marynen

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Peter Marynen

Peter Marynen

Publications by authors named "Peter Marynen"

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Evidence for increased SOX3 dosage as a risk factor for X-linked hypopituitarism and neural tube defects.

Am J Med Genet A 2014 Aug 15;164A(8):1947-52. Epub 2014 Apr 15.

Human Genome Laboratory, Department of Human Genetics, KU Leuven, Leuven, Belgium; Human Genome Laboratory, VIB Center for the Biology of Disease, Leuven, Belgium.

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http://doi.wiley.com/10.1002/ajmg.a.36580
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http://dx.doi.org/10.1002/ajmg.a.36580DOI Listing
August 2014

Allele-specific copy number analysis of tumors.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):16910-5. Epub 2010 Sep 13.

Department of Genetics, Institute for Cancer Research, Clinic for Cancer and Surgery, Oslo University Hospital, Montebello, N-0310 Oslo, Norway.

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http://link.springer.com/content/pdf/10.1186%2Fgb-2013-14-3-
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http://www.pnas.org/cgi/doi/10.1073/pnas.1009843107
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http://dx.doi.org/10.1073/pnas.1009843107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947907PMC
September 2010

Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs.

Mod Pathol 2010 Mar 15;23(3):458-69. Epub 2010 Jan 15.

Section of Morphology and Molecular Pathology, Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/modpathol.2009.182DOI Listing
March 2010

Computational methods for the detection of cis-regulatory modules.

Brief Bioinform 2009 Sep 4;10(5):509-24. Epub 2009 Jun 4.

Department of Human Genetics, VIB and University of Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/bib/bbp025DOI Listing
September 2009

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

J Immunol 2009 Jun;182(12):7718-28

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Toxicology, Neuherberg, Germany.

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http://dx.doi.org/10.4049/jimmunol.0803313DOI Listing
June 2009

Evidence for co-evolution between human microRNAs and Alu-repeats.

PLoS One 2009 11;4(2):e4456. Epub 2009 Feb 11.

Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004456PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637760PMC
April 2009

The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.

PLoS Biol 2009 Feb;7(2):e40

Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium.

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http://dx.doi.org/10.1371/journal.pbio.1000040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652389PMC
February 2009

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.

Nat Immunol 2008 Mar 27;9(3):263-71. Epub 2008 Jan 27.

Department of Molecular Biology, Ghent University, B-9052 Ghent, Belgium.

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http://dx.doi.org/10.1038/ni1561DOI Listing
March 2008

Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia.

Cancer Genet Cytogenet 2007 Jul;176(1):67-71

Department of Hematology, University of Perugia, IBiT Foundation (Fondazione IRCCS Biotecnologie nel Trapianto), via Brunamonti 51, 06122 Perugia, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.03.004DOI Listing
July 2007

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.

Nat Genet 2007 May 15;39(5):593-5. Epub 2007 Apr 15.

Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.

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http://dx.doi.org/10.1038/ng2025DOI Listing
May 2007

A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions.

J Biol Chem 2007 Apr 7;282(14):10180-9. Epub 2007 Feb 7.

Human Genome Laboratory, Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology VIB, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M611038200DOI Listing
April 2007

X-linked mental retardation and epigenetics.

J Cell Mol Med 2006 Oct-Dec;10(4):808-25

Human Genome Laboratory, VIB, Department Molecular and Developmental Genetics, University of Leuven, Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933076PMC
http://dx.doi.org/10.1111/j.1582-4934.2006.tb00526.xDOI Listing
January 2007

The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors.

Haematologica 2007 Jan;92(1):27-34

Department of Molecular and Developmental Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3324/haematol.10692DOI Listing
January 2007

Splenic marginal zone lymphoma-like features in API2-MALT1 transgenic mice that are exposed to antigenic stimulation.

Haematologica 2006 Dec;91(12):1693-6

Department of Morphology and Molecular Pathology, University of Leuven, Leuven, Belgium.

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December 2006

The dark side of EGFP: defective polyubiquitination.

PLoS One 2006 Dec 20;1:e54. Epub 2006 Dec 20.

Applied Human Genomics, Center for Human Genetics, Molecular Genetics-Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762387PMC
December 2006

Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13).

Haematologica 2006 Jul 1;91(7):949-51. Epub 2006 Jun 1.

Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium.

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July 2006

Gene prioritization through genomic data fusion.

Nat Biotechnol 2006 May;24(5):537-44

Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Herestraat 49, bus 602, 3000 Leuven, Belgium.

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https://endeavour.esat.kuleuven.be/files/pdfs/Paris_Curie09_
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http://cbio.ensmp.fr/~jvert/svn/bibli/local/Aerts2006Gene.pd
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ftp://ftp.esat.kuleuven.be/pub/SISTA/ida/reports/11-114.pdf
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http://dx.doi.org/10.1038/nbt1203DOI Listing
May 2006

Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent.

Proc Natl Acad Sci U S A 2006 May 11;103(21):8078-83. Epub 2006 May 11.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0601192103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472432PMC
May 2006

Selective expansion of marginal zone B cells in Emicro-API2-MALT1 mice is linked to enhanced IkappaB kinase gamma polyubiquitination.

Cancer Res 2006 May;66(10):5270-7

Center for Human Genetics, Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Catholic University of Leuven, Leuven, Belgium.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-4590DOI Listing
May 2006

Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?

Exp Cell Res 2006 Apr 28;312(7):1194-204. Epub 2006 Feb 28.

Human Genome Laboratory, Department of Human Genetics, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), VIB4, Campus Gasthuisberg O&N 06, Herestraat 49 Box 602, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.yexcr.2006.02.001DOI Listing
April 2006

Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate.

Clin Cancer Res 2006 Apr;12(8):2622-7

Departments of General Medical Oncology and Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-2275DOI Listing
April 2006

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas.

J Clin Invest 2006 Jan;116(1):174-81

Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI25641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1323253PMC
January 2006

X chromosome array-CGH for the identification of novel X-linked mental retardation genes.

Eur J Med Genet 2005 Jul-Sep;48(3):263-75

Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ejmg.2005.04.008DOI Listing
November 2005

Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia.

Haematologica 2005 Aug;90(8):1116-27

Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Leuven, Belgium.

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August 2005

Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).

Blood 2005 Jun 15;105(12):4849-52. Epub 2005 Feb 15.

Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2004-12-4897DOI Listing
June 2005

Resistance to tyrosine kinase inhibitors: calling on extra forces.

Drug Resist Updat 2005 Jun;8(3):119-29

Department of Human Genetics, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.drup.2005.04.005DOI Listing
June 2005

Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions.

J Cell Biochem 2005 Apr;94(6):1112-25

Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1002/jcb.20369DOI Listing
April 2005

The der(12)t(12;16) breakpoint in an acute leukaemia case targets a Sec7 domain containing protein.

Int J Oncol 2005 Apr;26(4):1111-20

Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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April 2005

FIP1L1-PDGFRalpha in hypereosinophilic syndrome and mastocytosis.

Hematol J 2004 ;5 Suppl 3:S133-7

Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/sj.thj.6200439DOI Listing
November 2004

Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia.

Cancer Res 2004 Sep;64(18):6385-9

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2148DOI Listing
September 2004

Genomic organization and evolution of the NF1 microdeletion region.

Genomics 2004 Aug;84(2):346-60

Center of Human Genetics, KULeuven, Herestraat 49, 3000 Louvain, Belgium.

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http://dx.doi.org/10.1016/j.ygeno.2004.03.006DOI Listing
August 2004

The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.

Blood 2004 Apr 20;103(7):2802-5. Epub 2003 Nov 20.

Division of Hematology and the Howard Hughes Medical Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2003-07-2479DOI Listing
April 2004

Submicroscopic deletions in 5q- associated malignancies.

Haematologica 2004 Mar;89(3):281-5

Hematology and Bone Marrow Trasplantation Unit, University of Perugia, Italy.

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March 2004

The FIP1L1-PDGFRalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia.

Curr Opin Hematol 2004 Jan;11(1):51-7

Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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January 2004

Controlled transgene dosage and PAC-mediated transgenesis in mice using a chromosomal vector.

Genomics 2003 Dec;82(6):596-605

Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, Herestraat 49, University of Leuven, Louvain B-3000, Belgium.

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http://dx.doi.org/10.1016/s0888-7543(03)00112-5DOI Listing
December 2003

ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.

Blood 2003 Oct 15;102(7):2638-41. Epub 2003 May 15.

Department of Pathology, Center of Medical Genetics and Pediatric Oncology, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1182/blood-2003-04-1050DOI Listing
October 2003

ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor.

Genes Chromosomes Cancer 2003 Oct;38(2):187-90

Center for Human Genetics, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.10267DOI Listing
October 2003

MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation.

Oncogene 2003 Oct;22(49):7728-36

Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/sj.onc.1207089DOI Listing
October 2003

Telomere-independent homologue pairing and checkpoint escape of accessory ring chromosomes in male mouse meiosis.

J Cell Biol 2003 Sep;162(5):795-807

Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium.

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http://dx.doi.org/10.1083/jcb.200305065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172825PMC
September 2003

Clinical study and haplotype analysis in two brothers with Partington syndrome.

Am J Med Genet 2002 Nov;112(4):361-8

Human Genome Laboratory, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium.

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http://dx.doi.org/10.1002/ajmg.10630DOI Listing
November 2002

Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.

Genes Chromosomes Cancer 2002 Aug;34(4):354-62

Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Campus Gasthuisberg O&N 06, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1002/gcc.10033DOI Listing
August 2002

Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13).

Blood 2002 Mar;99(5):1776-84

Human Genome Laboratory, Center for Human Genetics-Flanders Interuniversity Institute for Biotechnology (VIB), University of Leuven, Belgium.

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http://dx.doi.org/10.1182/blood.v99.5.1776DOI Listing
March 2002