Peter M Siegel

Peter M Siegel

UNVERIFIED PROFILE

Are you Peter M Siegel?   Register this Author

Register author
Peter M Siegel

Peter M Siegel

Publications by authors named "Peter M Siegel"

Are you Peter M Siegel?   Register this Author

69Publications

1544Reads

12Profile Views

Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.

Cell 2019 Aug;178(5):1205-1221.e17

Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.07.017DOI Listing
August 2019

CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis.

Am J Pathol 2019 Jul 12;189(7):1451-1461. Epub 2019 Jun 12.

Goodman Cancer Research Centre, Department of Medicine, McGill University, Montréal, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2019.04.006DOI Listing
July 2019

Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis.

Cell Rep 2019 Jun;27(13):3902-3915.e6

Goodman Cancer Research Centre, McGill University, Montreal, Québec, QC H3A 1A3, Canada; Department of Medicine, McGill University, Montreal, Québec, QC H3G 1Y6, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.05.091DOI Listing
June 2019

Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis.

Transl Oncol 2019 Mar 21;12(3):462-474. Epub 2018 Dec 21.

Faculty of Dentistry, McGill University, 3640 rue University, Montreal, Quebec, Canada, H3A 0C7; Shriner's Hospital for Children - Canada, 1003 Decarie Boulevard, Montreal, Quebec H4A 0A9. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19365233183051
Publisher Site
http://dx.doi.org/10.1016/j.tranon.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305809PMC
March 2019

A Three-Dimensional Dense Collagen Hydrogel to Model Cancer Cell/Osteoblast Interactions.

J Funct Biomater 2018 Dec 12;9(4). Epub 2018 Dec 12.

Department of Mining and Materials Engineering, McGill University, Montréal, QC H3A 0C5, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jfb9040072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306762PMC
December 2018

Metabolic Profiles Associated With Metformin Efficacy in Cancer.

Front Endocrinol (Lausanne) 2018 21;9:372. Epub 2018 Aug 21.

Department of Biochemistry, Microbiology and Immunology, and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fendo.2018.00372
Publisher Site
http://dx.doi.org/10.3389/fendo.2018.00372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110930PMC
August 2018

Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations.

Oncogene 2018 06 15;37(24):3183-3199. Epub 2018 Mar 15.

Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0171-xDOI Listing
June 2018

Emerging roles for LPP in metastatic cancer progression.

J Cell Commun Signal 2018 Mar 13;12(1):143-156. Epub 2017 Oct 13.

Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Room 508, Montréal, Québec, H3A 1A3, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12079-017-0415-5
Publisher Site
http://dx.doi.org/10.1007/s12079-017-0415-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842179PMC
March 2018

Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer.

Pharmacol Ther 2017 Nov 22;179:127-141. Epub 2017 May 22.

Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada; Department of Medicine, McGill University, Montréal, Québec, Canada; Department of Biochemistry, McGill University, Montréal, Québec, Canada; Department of Anatomy and Cell Biology, McGill University, Montréal, Québec, Canada; Department of Oncology, McGill University, Montréal, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2017.05.010DOI Listing
November 2017

PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs.

Cell Metab 2017 Nov 5;26(5):778-787.e5. Epub 2017 Oct 5.

Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2017.09.006DOI Listing
November 2017

Expanding the armamentarium for neutrophil-mediated angiogenesis.

Hepatology 2017 06 28;65(6):1796-1798. Epub 2017 Apr 28.

Goodman Cancer Research Centre and the Department of Medicine, Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.29143DOI Listing
June 2017

LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis.

Nat Commun 2017 04 24;8:15059. Epub 2017 Apr 24.

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada H3A 1A3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms15059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413977PMC
April 2017

The influence of the pre-metastatic niche on breast cancer metastasis.

Cancer Lett 2016 09 11;380(1):281-8. Epub 2015 Nov 11.

Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Oncology, McGill University, Montreal, Quebec, Canada; Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada; Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2015.11.009DOI Listing
September 2016

The Tyrosine Kinome Dictates Breast Cancer Heterogeneity and Therapeutic Responsiveness.

J Cell Biochem 2016 09 14;117(9):1971-90. Epub 2016 Apr 14.

Lady Davis Institute for Medical Research, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.25561DOI Listing
September 2016

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis.

Cancer Res 2016 09 1;76(18):5201-8. Epub 2016 Sep 1.

Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada. Department of Medicine, McGill University, Montréal, Québec, Canada. Department of Biochemistry, McGill University, Montréal, Québec, Canada. Department of Oncology, McGill University, Montréal, Québec, Canada. Department of Anatomy and Cell Biology, McGill University, Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-16-0266DOI Listing
September 2016

5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.

J Cell Biol 2016 09 5;214(6):719-34. Epub 2016 Sep 5.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A1, Canada Department of Biochemistry, McGill University, Montréal, Québec H3A 1A1, Canada Department of Medicine, McGill University, Montréal, Québec H3A 1A1, Canada Department of Oncology, McGill University, Montréal, Québec H3A 1A1, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201501003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021089PMC
September 2016

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L.

Elife 2016 07 29;5. Epub 2016 Jul 29.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.16844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991936PMC
July 2016

Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion.

Mol Cell Biol 2016 05 2;36(10):1509-25. Epub 2016 May 2.

Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada Department of Biochemistry, McGill University, Montréal, Québec, Canada Department of Medicine, McGill University, Montréal, Québec, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00600-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859683PMC
May 2016

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer.

Cell Metab 2015 Oct 10;22(4):577-89. Epub 2015 Sep 10.

Goodman Cancer Research Centre, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada; Department of Medicine, McGill University, Montréal, QC H3A 1A3, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2015.08.007DOI Listing
October 2015

Peroxiredoxin 4: a novel secreted mediator of cancer induced osteoclastogenesis.

Cancer Lett 2015 Jun 14;361(2):262-70. Epub 2015 Mar 14.

Department of Anatomy and Cell Biology, McGill University, Montréal, Quebec, Canada; Shriners Hospital for Children-Canada, Montréal, Quebec H3G IA6, Canada; Faculty of Dentistry, McGill University, Montréal, Quebec, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2015.03.012DOI Listing
June 2015

The IGF-Trap: Novel Inhibitor of Carcinoma Growth and Metastasis.

Mol Cancer Ther 2015 Apr 11;14(4):982-93. Epub 2015 Feb 11.

Department of Surgery, McGill University Health Centre, McGill University, Montreal, Québec, Canada. Department of Medicine, McGill University Health Centre, McGill University, Montreal, Québec, Canada. Department of Oncology, McGill University Health Centre, McGill University, Montreal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-14-0751DOI Listing
April 2015

Serial analysis of 38 proteins during the progression of human breast tumor in mice using an antibody colocalization microarray.

Mol Cell Proteomics 2015 Apr 13;14(4):1024-37. Epub 2015 Feb 13.

From the ‡Biomedical Engineering Department, §McGill University and Genome Quebec Innovation Centre, **Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 0G1, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M114.046516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390249PMC
April 2015

Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.

Cancer Res 2015 Mar 21;75(6):1102-12. Epub 2015 Jan 21.

Lady Davis Institute for Medical Research, Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-1996DOI Listing
March 2015

Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with locally advanced or metastatic breast cancer.

J Clin Oncol 2014 Nov 29;32(32):3619-25. Epub 2014 Sep 29.

Johanna Bendell and Suzanne Jones, Sarah Cannon Research Institute, Nashville, TN; Mansoor Saleh, Georgia Cancer Specialists, Atlanta, GA; April A.N. Rose and Peter M. Siegel, Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada; Lowell Hart, Florida Cancer Specialists, Fort Myers; Surendra Sirpal, Hematology Oncology Associates, Lake Worth, FL; Jennifer Green, Elizabeth Crowley, Ronit Simantov, Tibor Keler, and Thomas Davis, Celldex Therapeutics; and Linda Vahdat, Weill Cornell Medical College, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2013.52.5683DOI Listing
November 2014

Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer.

PLoS One 2013 31;8(12):e85995. Epub 2013 Dec 31.

Lady Davis Institute for Medical Research, McGill University, Montreal, Canada ; Department of Oncology, McGill University, Montreal, Canada.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085995PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877392PMC
August 2014

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Cancer Res 2013 Jul 21;73(14):4521-32. Epub 2013 May 21.

Lady Davis Institute for Medical Research, McGill Centre for Bioinformatics, McGill University, Goodman Cancer Research Centre, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/73/14/4521.full.pd
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-12-4178DOI Listing
July 2013

Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer.

Onco Targets Ther 2013 9;6:839-52. Epub 2013 Jul 9.

Goodman Cancer Research Centre, McGill University, Montréal, Québec, Canada ; Department of Medicine, McGill University, Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S44906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711880PMC
July 2013

CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis.

J Cell Commun Signal 2012 Jun 18;6(2):73-85. Epub 2012 Mar 18.

Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Room 513, Montreal, Quebec, Canada, H3A 1A3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12079-012-0161-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368020PMC
June 2012

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target.

J Clin Invest 2011 Dec 7;121(12):4655-69. Epub 2011 Nov 7.

Department of Medicine, McGill University Health Centre, Montréal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI46134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225988PMC
December 2011

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model.

Int J Cancer 2011 Jul 12;129(1):225-32. Epub 2010 Nov 12.

Department of Oncology, Lady Davis Institute, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.25665DOI Listing
July 2011

Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells.

Am J Pathol 2010 Jun 9;176(6):3023-31. Epub 2010 Apr 9.

Institut national de la recherche scientifique-Institut Armand-Frappier, Laval, Québec, Canada, H7V 1B7.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2353/ajpath.2010.090876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877862PMC
June 2010

Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer.

Clin Cancer Res 2010 Apr 9;16(7):2147-56. Epub 2010 Mar 9.

Department of Medicine, Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West Montréal, Québec, Canada, H3A 1A3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-09-1611DOI Listing
April 2010

Emerging therapeutic targets in breast cancer bone metastasis.

Future Oncol 2010 Jan;6(1):55-74

Department of Medicine, Goodman Cancer Centre, McGill University, QC H3A 1A3, Canada.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/fon.09.138
Publisher Site
http://dx.doi.org/10.2217/fon.09.138DOI Listing
January 2010

Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation.

Bone 2008 Aug 15;43(2):386-93. Epub 2008 Apr 15.

Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2008.03.026DOI Listing
August 2008

Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.

Mol Cell Biol 2008 May 10;28(10):3162-76. Epub 2008 Mar 10.

Departments of Biochemistry, Anatomy and Cell Biology, McGill University, Montréal, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.01734-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423163PMC
May 2008

Osteoactivin promotes breast cancer metastasis to bone.

Mol Cancer Res 2007 Oct;5(10):1001-14

Department of Medicine, McGill University, Montreal, Quebec, Canada.

View Article

Download full-text PDF

Source
http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-07
Publisher Site
http://dx.doi.org/10.1158/1541-7786.MCR-07-0119DOI Listing
October 2007

Breast cancer-derived factors facilitate osteolytic bone metastasis.

Bull Cancer 2006 Sep;93(9):931-43

Department of Medicine, McGill University, 740 Dr. Penfield Avenue, Room 2201, Montreal, Quebec, Canada, H3A 1A4.

View Article

Download full-text PDF

Source
September 2006

Genes that mediate breast cancer metastasis to lung.

Nature 2005 Jul;436(7050):518-24

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature03799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283098PMC
July 2005

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.

Nat Rev Cancer 2003 Nov;3(11):807-21

Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc1208DOI Listing
November 2003

Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.

Proc Natl Acad Sci U S A 2003 Oct 2;100(21):12337-42. Epub 2003 Oct 2.

Program in Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2031337100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC218759PMC
October 2003

Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.

J Biol Chem 2003 Sep 24;278(37):35444-50. Epub 2003 Jun 24.

Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M301413200DOI Listing
September 2003

Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers.

Cancer Res 2003 Aug;63(16):4920-6

Institute for Molecular Biology and Biotechnology, Department of Biology, McMaster University, Hamilton, Canada.

View Article

Download full-text PDF

Source
August 2003

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis.

Proc Natl Acad Sci U S A 2003 Jul 13;100(14):8430-5. Epub 2003 Jun 13.

Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0932636100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166246PMC
July 2003

A multigenic program mediating breast cancer metastasis to bone.

Cancer Cell 2003 Jun;3(6):537-49

Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

View Article

Download full-text PDF

Source
June 2003

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.

Cell 2002 Jul;110(1):19-32

Cell Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0092-8674(02)00801-2DOI Listing
July 2002