Publications by authors named "Peter M Nilsson"

100Publications

Early and Supernormal Vascular Aging: Clinical Characteristics and Association With Incident Cardiovascular Events.

Hypertension 2020 Sep 8:HYPERTENSIONAHA12014971. Epub 2020 Sep 8.

From the INSERM, U970, Paris Cardiovascular Research Center-PARCC, France (R.M.B., J.-P.E., P.B., S.L.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14971DOI Listing
September 2020

Magnitude of rise in proneurotensin is related to amount of triglyceride appearance in blood after standardized oral intake of both saturated and unsaturated fat.

Lipids Health Dis 2020 Aug 21;19(1):191. Epub 2020 Aug 21.

Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmoe, CRC, Jan Waldenstroems gata 35, bldg 91, level 12, 214 28, Malmoe, SE, Sweden.

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http://dx.doi.org/10.1186/s12944-020-01361-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7441720PMC
August 2020

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation.

Cell Metab 2020 Aug 1. Epub 2020 Aug 1.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.07.012DOI Listing
August 2020

Patterns of urinary albumin and IgM associate with markers of vascular ageing in young to middle-aged individuals in the Malmö offspring study.

BMC Cardiovasc Disord 2020 Aug 5;20(1):358. Epub 2020 Aug 5.

Department of Nephrology, Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1186/s12872-020-01638-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409481PMC
August 2020

The association of the metabolic syndrome with target organ damage: focus on the heart, brain, and central arteries.

Expert Rev Cardiovasc Ther 2020 Aug 12:1-14. Epub 2020 Aug 12.

Department of Clinical Science, Lund University, Skåne University Hospital , Malmö, Sweden.

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http://dx.doi.org/10.1080/14779072.2020.1807327DOI Listing
August 2020

Probabilistic Quantification Of Bias to Combine the Strengths Of Population-Based Register Data and Clinical Cohorts - Studying Mortality in Osteoarthritis.

Am J Epidemiol 2020 Jul 8. Epub 2020 Jul 8.

Clinical Epidemiology Unit, Orthopedics, Clinical Sciences, Lund, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1093/aje/kwaa134DOI Listing
July 2020

Neighborhood socioeconomic status and aortic stenosis: A Swedish study based on nationwide registries and an echocardiographic screening cohort.

Int J Cardiol 2020 Nov 29;318:153-159. Epub 2020 Jun 29.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1016/j.ijcard.2020.06.034DOI Listing
November 2020

Self-reported bowel symptoms are associated with differences in overall gut microbiota composition and enrichment of Blautia in a population-based cohort.

J Gastroenterol Hepatol 2020 May 19. Epub 2020 May 19.

Department of Internal Medicine, Skane University Hospital, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1111/jgh.15104DOI Listing
May 2020

Exploring and comparing definitions of healthy vascular ageing in the population: characteristics and prospective cardiovascular risk.

J Hum Hypertens 2020 May 15. Epub 2020 May 15.

Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1038/s41371-020-0353-1DOI Listing
May 2020

Do patients or their physicians more accurately assess long-term risk associated with hypertension? A population-based study.

Scand J Prim Health Care 2020 Jun 2;38(2):166-175. Epub 2020 May 2.

Department of Medical and Health Sciences, Division of Drug Research, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1080/02813432.2020.1753345DOI Listing
June 2020

Early life exposures and risk of adult respiratory disease during 50 years of follow-up.

Eur J Epidemiol 2020 Apr 8. Epub 2020 Apr 8.

Department of Clinical Sciences, Internal Medicine, Skane University Hospital, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1007/s10654-020-00626-3DOI Listing
April 2020

Hypertension and Reproduction.

Curr Hypertens Rep 2020 03 13;22(4):29. Epub 2020 Mar 13.

Center for Cardiovascular Prevention, First Faculty of Medicine and Thomayer Hospital, Charles University in Prague, Prague, Czech Republic.

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http://dx.doi.org/10.1007/s11906-020-01036-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069900PMC
March 2020

Early Vascular Aging in Hypertension.

Authors:
Peter M Nilsson

Front Cardiovasc Med 2020 4;7. Epub 2020 Feb 4.

Skane University Hospital, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.3389/fcvm.2020.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011189PMC
February 2020

High water intake and low urine osmolality are associated with favorable metabolic profile at a population level: low vasopressin secretion as a possible explanation.

Eur J Nutr 2020 Feb 18. Epub 2020 Feb 18.

Department of Clinical Sciences, Clinical Research Center, Jan Waldenströms gata 35, Lund University, 214 28, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00394-020-02202-7DOI Listing
February 2020

Metabolically Healthy Obesity (MHO)-New Research Directions for Personalised Medicine in Cardiovascular Prevention.

Curr Hypertens Rep 2020 02 17;22(2):18. Epub 2020 Feb 17.

Department of Clinical Sciences, Department of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th floor, S-20502, Malmö, Sweden.

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http://dx.doi.org/10.1007/s11906-020-1027-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026231PMC
February 2020

A diabetes-associated genetic variant is associated with diastolic dysfunction and cardiovascular disease.

ESC Heart Fail 2020 Feb 20;7(1):348-356. Epub 2019 Dec 20.

Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1002/ehf2.12573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083427PMC
February 2020

A Health-Conscious Food Pattern Is Associated with Prediabetes and Gut Microbiota in the Malmö Offspring Study.

J Nutr 2020 04;150(4):861-872

Department of Clinical Sciences, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1093/jn/nxz293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138670PMC
April 2020

Low Levels of CD4CD28 T Cells at Baseline Are Associated With First-Time Coronary Events in a Prospective Population-Based Case-Control Cohort.

Arterioscler Thromb Vasc Biol 2020 02 5;40(2):426-436. Epub 2019 Dec 5.

From the Department of Clinical Sciences Malmö, Lund University, Sweden (L.T., E.B., L.A., W.B., C.T., A.P., A.E., P.M.N., A.S., J.N., I.G., H.B.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313032DOI Listing
February 2020

Do we really need more new biomarkers for cardiovascular risk prediction?

Authors:
Peter M Nilsson

Eur J Prev Cardiol 2020 Apr 3;27(6):567-569. Epub 2019 Dec 3.

Department of Clinical Sciences, Lund University, Sweden.

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http://dx.doi.org/10.1177/2047487319893050DOI Listing
April 2020

The metabolic syndrome - What is it and how should it be managed?

Eur J Prev Cardiol 2019 Dec;26(2_suppl):33-46

Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1177/2047487319886404DOI Listing
December 2019

Family patterns of arterial stiffness across three generations in the Malmö Offspring Study.

J Hypertens 2020 03;38(3):474-480

Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden.

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http://dx.doi.org/10.1097/HJH.0000000000002293DOI Listing
March 2020

Metabolically healthy obesity (MHO) in the Malmö diet cancer study - Epidemiology and prospective risks.

Obes Res Clin Pract 2019 Nov - Dec;13(6):548-554. Epub 2019 Nov 8.

Department of Clinical Sciences, Lund University, Jan Waldenströms gata 15, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Jan Waldenströms gata 15, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.orcp.2019.10.002DOI Listing
July 2020

Birth size and cancer prognosis: a systematic review and meta-analysis.

J Dev Orig Health Dis 2019 Oct 24:1-8. Epub 2019 Oct 24.

Department of Clinical Sciences, Lund University, Skåne University Hospital, S-20502Malmö, Sweden.

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https://www.cambridge.org/core/product/identifier/S204017441
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http://dx.doi.org/10.1017/S2040174419000631DOI Listing
October 2019

Does early life programming influence arterial stiffness and central hemodynamics in adulthood?

J Hypertens 2020 03;38(3):481-488

Internal Medicine Research Group, Department of Clinical Sciences, Skane University Hospital, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1097/HJH.0000000000002292DOI Listing
March 2020

Association of Estimated Pulse Wave Velocity With Survival: A Secondary Analysis of SPRINT.

JAMA Netw Open 2019 10 2;2(10):e1912831. Epub 2019 Oct 2.

Hypertension and Cardiometabolic Unit, First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.12831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802234PMC
October 2019

Modelling the Effect of Compliance with Nordic Nutrition Recommendations on Cardiovascular Disease and Cancer Mortality in the Nordic Countries.

Nutrients 2019 Jun 25;11(6). Epub 2019 Jun 25.

Health Economics Unit, Department of Clinical Science (Malmö), Lund University, SE-22381 Lund, Sweden.

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http://dx.doi.org/10.3390/nu11061434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627195PMC
June 2019

A Vascular Aging Index as Independent Predictor of Cardiovascular Events and Total Mortality in an Elderly Urban Population.

Angiology 2019 Nov 24;70(10):929-937. Epub 2019 Jun 24.

2 Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1177/0003319719857270DOI Listing
November 2019

Concept of Extremes in Vascular Aging.

Hypertension 2019 08 17;74(2):218-228. Epub 2019 Jun 17.

Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden (P.M.N.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12655DOI Listing
August 2019

Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study.

Diabetes Care 2019 08 14;42(8):1582-1588. Epub 2019 Jun 14.

Department of Clinical Sciences, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.2337/dc18-2556DOI Listing
August 2019

Primary screening for increased fracture risk by the FRAX® questionnaire-uptake rates in relation to invitation method.

Arch Osteoporos 2019 05 8;14(1):51. Epub 2019 May 8.

Department of Obstetrics and Gynaecology, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-221 85, Lund, Sweden.

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http://dx.doi.org/10.1007/s11657-019-0603-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924260PMC
May 2019

Skin autofluorescence as a measure of advanced glycation end product levels is associated with carotid atherosclerotic plaque burden in an elderly population.

Diab Vasc Dis Res 2019 09 8;16(5):466-473. Epub 2019 May 8.

1 Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1177/1479164119845319DOI Listing
September 2019

Non-invasive fibrosis scoring systems can predict future metabolic complications and overall mortality in non-alcoholic fatty liver disease (NAFLD).

Scand J Gastroenterol 2019 Mar 23;54(3):328-334. Epub 2019 Mar 23.

a Department of Gastroenterology and Hepatology , Skåne University Hospital , Malmö , Sweden.

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http://dx.doi.org/10.1080/00365521.2019.1583366DOI Listing
March 2019

Prevention of Cardiovascular Disease and Cancer Mortality by Achieving Healthy Dietary Goals for the Swedish Population: A Macro-Simulation Modelling Study.

Int J Environ Res Public Health 2019 03 12;16(5). Epub 2019 Mar 12.

British Heart Foundation Centre on Population Approaches for Non-Communicable Disease Prevention and NIHR Biomedical Research Centre at Oxford, Nuffield Department of Population Health, University of Oxford, Oxford OX37LF, UK.

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http://dx.doi.org/10.3390/ijerph16050890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427376PMC
March 2019

Increased mortality in non-alcoholic fatty liver disease with chronic kidney disease is explained by metabolic comorbidities.

Clin Res Hepatol Gastroenterol 2019 10 1;43(5):542-550. Epub 2019 Mar 1.

Department of Gastroenterology and Hepatology, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S22107401193004
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http://dx.doi.org/10.1016/j.clinre.2019.02.004DOI Listing
October 2019

Effects of a randomized, culturally adapted, lifestyle intervention on mental health among Middle-Eastern immigrants.

Eur J Public Health 2019 10;29(5):888-894

Department of Clinical Sciences, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1093/eurpub/ckz020DOI Listing
October 2019

Difference in the risk profiles of carotid-femoral pulse wave velocity: results from two community-based studies in China and Sweden.

J Hum Hypertens 2020 03 15;34(3):207-213. Epub 2019 Jan 15.

Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1038/s41371-018-0160-0DOI Listing
March 2020

Midregional proadrenomedullin predicts reduced blood pressure and glucose elevation over time despite enhanced progression of obesity markers.

J Hypertens 2019 03;37(3):590-595

Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1097/HJH.0000000000001893DOI Listing
March 2019

Treatment of Hypertensive Left Ventricular Hypertrophy.

Curr Pharm Des 2018 ;24(37):4391-4396

Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden.

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http://dx.doi.org/10.2174/1381612825666181203092918DOI Listing
November 2019

Pre-diabetes and diabetes are independently associated with adverse cognitive test results: a cross-sectional, population-based study.

BMC Endocr Disord 2018 Dec 4;18(1):91. Epub 2018 Dec 4.

Department of Acute Internal Medicine and Geriatrics, Linköping University, S-581 85, Linköping, Sweden.

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http://dx.doi.org/10.1186/s12902-018-0318-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278035PMC
December 2018

Blood glucose and hypertension development: the hen and egg controversy.

Authors:
Peter M Nilsson

J Hypertens 2019 01;37(1):11-12

Department of Clinical Sciences, Lund University, Skane University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1097/HJH.0000000000001946DOI Listing
January 2019

Physical activity may compensate for prolonged TV time regarding pulse rate-a cross-sectional study.

Ups J Med Sci 2018 Dec 23;123(4):247-254. Epub 2018 Nov 23.

a Department of Medical Sciences , Uppsala University, Uppsala University Hospital , Uppsala Sweden.

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http://dx.doi.org/10.1080/03009734.2018.1540505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327624PMC
December 2018

Optimal Blood Pressure Target in Diabetic and Nondiabetic Hypertensive Patients.

Circ Res 2018 08;123(5):528-530

Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden (P.M.N.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31276
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http://dx.doi.org/10.1161/CIRCRESAHA.118.312763DOI Listing
August 2018

Characteristics of endometriosis: A case-cohort study showing elevated IgG titers against the TSH receptor (TRAb) and mental comorbidity.

Eur J Obstet Gynecol Reprod Biol 2018 Dec 6;231:8-14. Epub 2018 Oct 6.

Lund University, Skane University Hospital, Department of Internal Medicine, Malmö, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03012115183100
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http://dx.doi.org/10.1016/j.ejogrb.2018.09.034DOI Listing
December 2018

Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L).

Diabetes Res Clin Pract 2018 Dec 28;146:18-33. Epub 2018 Sep 28.

Institut d'Investigacions Biomèdiques August Pi I Sunyer and Centro de Investigación Biomedica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain; Department of Cardiovascular and Metabolic Diseases, Istituto Ricerca Cura Carattere Scientifico Multimedica, Sesto, San Giovanni, MI, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183146
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http://dx.doi.org/10.1016/j.diabres.2018.09.017DOI Listing
December 2018

Risk of metabolic disorders in childless men: a population-based cohort study.

BMJ Open 2018 08 17;8(8):e020293. Epub 2018 Aug 17.

Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Kobenhavn, Denmark.

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http://dx.doi.org/10.1136/bmjopen-2017-020293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104745PMC
August 2018

Physical Activity in a Randomized Culturally Adapted Lifestyle Intervention.

Am J Prev Med 2018 08;55(2):187-196

Department of Clinical Sciences, Lund University, Malmö, Sweden; Center for Primary Health Care Research, Region Skåne and Lund University, Malmö, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.amepre.2018.04.016DOI Listing
August 2018

Does Intensive Glucose Control Cancel Out Benefits of Systolic Blood Pressure Target <120 mm Hg in Patients With Diabetes Mellitus Participating in ACCORD?

Hypertension 2018 08 2;72(2):291-293. Epub 2018 Jul 2.

Oslo University Hospital Ullevål, Norway; and Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden (P.M.N.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11455DOI Listing
August 2018

Food patterns in relation to weight change and incidence of type 2 diabetes, coronary events and stroke in the Malmö Diet and Cancer cohort.

Eur J Nutr 2019 Aug 31;58(5):1801-1814. Epub 2018 May 31.

Department of Clinical Sciences in Malmö, Diabetes and Cardiovascular Disease, Genetic Epidemiology, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00394-018-1727-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647222PMC
August 2019

Blood Lead Levels and Decreased Kidney Function in a Population-Based Cohort.

Am J Kidney Dis 2018 09 23;72(3):381-389. Epub 2018 Apr 23.

Occupational and Environmental Medicine, Sahlgrenska University Hospital and University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1053/j.ajkd.2018.02.358DOI Listing
September 2018

Which Target Blood Pressure in Year 2018? Evidence from Recent Clinical Trials.

High Blood Press Cardiovasc Prev 2018 Jun 16;25(2):151-158. Epub 2018 Apr 16.

Department of Cardiology, Ullevaal University Hospital, Oslo, Norway.

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http://dx.doi.org/10.1007/s40292-018-0258-zDOI Listing
June 2018

Proneurotensin Predicts Cardiovascular Disease in an Elderly Population.

J Clin Endocrinol Metab 2018 05;103(5):1940-1947

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1210/jc.2017-02424DOI Listing
May 2018

Frequency of early vascular aging and associated risk factors among an adult population in Latin America: the OPTIMO study.

J Hum Hypertens 2018 03 20;32(3):219-227. Epub 2018 Feb 20.

Center of Hypertension and Vascular Aging, Cardiology Institute and Cardiovascular Therapeutics, Hospital Universitario Austral, Pilar, Buenos Aires, Argentina.

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http://www.nature.com/articles/s41371-018-0038-1
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http://dx.doi.org/10.1038/s41371-018-0038-1DOI Listing
March 2018

B-type natriuretic peptide for prediction of incident clinically significant abdominal aortic aneurysm: A population-based prospective study.

Vasc Med 2018 02 17;23(1):46-51. Epub 2018 Jan 17.

1 Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

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http://dx.doi.org/10.1177/1358863X17745150DOI Listing
February 2018

One-hour glucose value as a long-term predictor of cardiovascular morbidity and mortality: the Malmö Preventive Project.

Eur J Endocrinol 2018 Mar 19;178(3):225-236. Epub 2017 Dec 19.

Department of Endocrinology, Cardiovascular and Metabolic Preventive Clinic, Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.1530/EJE-17-0824DOI Listing
March 2018

Enhanced Predictive Capability of a 1-Hour Oral Glucose Tolerance Test: A Prospective Population-Based Cohort Study.

Diabetes Care 2018 01 14;41(1):171-177. Epub 2017 Nov 14.

Cardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, Odense, Denmark.

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http://dx.doi.org/10.2337/dc17-1351DOI Listing
January 2018

Incident diabetes mellitus may explain the association between sleep duration and incident coronary heart disease.

Diabetologia 2018 02 4;61(2):331-341. Epub 2017 Nov 4.

Department of Clinical Sciences, Lund University, Skåne University Hospital, CRC, Jan Waldenströms gata 35, 20502, Malmö, Sweden.

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http://dx.doi.org/10.1007/s00125-017-4464-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448951PMC
February 2018