Peter Lobel

Peter Lobel

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Peter Lobel

Peter Lobel

Publications by authors named "Peter Lobel"

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Comparative Analysis of Quantitative Mass Spectrometric Methods for Subcellular Proteomics.

J Proteome Res 2020 Apr 5;19(4):1718-1730. Epub 2020 Mar 5.

Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, United States.

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http://dx.doi.org/10.1021/acs.jproteome.9b00862DOI Listing
April 2020

Lysosomal protein thermal stability does not correlate with cellular half-life: global observations and a case study of tripeptidyl-peptidase 1.

Biochem J 2020 Feb;477(3):727-745

Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, U.S.A.

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http://dx.doi.org/10.1042/BCJ20190874DOI Listing
February 2020

Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis.

PLoS One 2018 6;13(2):e0192286. Epub 2018 Feb 6.

Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192286PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800698PMC
April 2018

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism.

Mol Ther 2017 07 26;25(7):1531-1543. Epub 2017 Apr 26.

Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498811PMC
July 2017

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease.

Mol Ther Methods Clin Dev 2017 Mar 13;4:204-212. Epub 2017 Feb 13.

Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23290501173000
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http://dx.doi.org/10.1016/j.omtm.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363315PMC
March 2017

Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome.

Mol Cell Proteomics 2017 02 6;16(2):194-212. Epub 2016 Dec 6.

¶Center for Advanced Biotechnology and Medicine, Rutgers Biomedical and Health Sciences, 679 Hoes Lane West, Piscataway, New Jersey 08854;

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http://dx.doi.org/10.1074/mcp.M116.064527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294208PMC
February 2017

Analysis of large-scale whole exome sequencing data to determine the prevalence of genetically-distinct forms of neuronal ceroid lipofuscinosis.

Gene 2016 Nov 20;593(2):284-91. Epub 2016 Aug 20.

Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA; Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2016.08.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505770PMC
November 2016

Potential pitfalls and solutions for use of fluorescent fusion proteins to study the lysosome.

PLoS One 2014 21;9(2):e88893. Epub 2014 Feb 21.

. Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, United States of America ; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088893PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931630PMC
January 2015

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain.

Mol Ther 2014 Mar 26;22(3):547-553. Epub 2013 Dec 26.

Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2013.267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944336PMC
March 2014

Proteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain.

Proteomics 2012 Dec 22;12(23-24):3499-509. Epub 2012 Nov 22.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1002/pmic.201200205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651901PMC
December 2012

Large-volume intrathecal enzyme delivery increases survival of a mouse model of late infantile neuronal ceroid lipofuscinosis.

Mol Ther 2011 Oct 5;19(10):1842-8. Epub 2011 Jul 5.

Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1038/mt.2011.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188738PMC
October 2011

Classification of subcellular location by comparative proteomic analysis of native and density-shifted lysosomes.

Mol Cell Proteomics 2011 Apr 20;10(4):M110.006403. Epub 2011 Jan 20.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1074/mcp.M110.006403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069348PMC
April 2011

Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.

Biochem J 2010 May 27;428(3):355-62. Epub 2010 May 27.

Center for Advanced Biotechnology and Medicine and Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1042/BJ20100128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892784PMC
May 2010

Functions of the alpha, beta, and gamma subunits of UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase.

J Biol Chem 2010 Jan 2;285(5):3360-70. Epub 2009 Dec 2.

Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M109.068650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823453PMC
January 2010

Mass spectrometry-based protein profiling to determine the cause of lysosomal storage diseases of unknown etiology.

Mol Cell Proteomics 2009 Jul 20;8(7):1708-18. Epub 2009 Apr 20.

Center for Advanced Biotechnology and Medicine, Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/mcp.M900122-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709195PMC
July 2009

Proteomics of the lysosome.

Biochim Biophys Acta 2009 Apr 15;1793(4):625-35. Epub 2008 Oct 15.

Zentrum Biochemie und Molekulare Zellbiologie, Abteilung Biochemie II, Georg-August Universität Göttingen, 37073 Göttingen, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2008.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684028PMC
April 2009

Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice.

Neurosci Lett 2009 Mar 4;453(1):27-30. Epub 2009 Feb 4.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States.

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http://dx.doi.org/10.1016/j.neulet.2009.01.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680787PMC
March 2009

Crystal structure and autoactivation pathway of the precursor form of human tripeptidyl-peptidase 1, the enzyme deficient in late infantile ceroid lipofuscinosis.

J Biol Chem 2009 Feb 26;284(6):3985-97. Epub 2008 Nov 26.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Jersey, USA.

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http://dx.doi.org/10.1074/jbc.M806943200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635056PMC
February 2009

Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.

Biochem J 2008 Oct;415(2):225-32

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1042/BJ20080411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353488PMC
October 2008

Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins.

Proc Natl Acad Sci U S A 2008 Oct 21;105(43):16590-5. Epub 2008 Oct 21.

Center for Advanced Biotechnology and Medicine and Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1073/pnas.0807472105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575464PMC
October 2008

The mannose 6-phosphate glycoprotein proteome.

J Proteome Res 2008 Jul 29;7(7):3010-21. Epub 2008 May 29.

Center for Advanced Biotechnology and Medicine and Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1021/pr800135vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739600PMC
July 2008

Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages.

Neurobiol Aging 2008 May 11;29(5):707-15. Epub 2007 Jan 11.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424018PMC
May 2008

Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis.

Mol Ther 2008 Apr 12;16(4):649-56. Epub 2008 Feb 12.

Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1038/mt.2008.9DOI Listing
April 2008

Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptors.

Mol Cell Proteomics 2008 Jan 11;7(1):58-70. Epub 2007 Sep 11.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1074/mcp.M700217-MCP200DOI Listing
January 2008

Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?

Biochem J 2007 Nov;408(1):1-5

Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1042/BJ20071167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2049080PMC
November 2007

Lysosomal proteomics and disease.

Proteomics Clin Appl 2007 Sep 17;1(9):1134-46. Epub 2007 Aug 17.

Center for Advanced Biotechnology and Medicine, and Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, USA.

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http://dx.doi.org/10.1002/prca.200700250DOI Listing
September 2007

Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease.

J Biol Chem 2007 Aug 14;282(32):23525-31. Epub 2007 Jun 14.

Center for Advanced Biotechnology and Medicine, Department of Biochemistry, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M703848200
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http://dx.doi.org/10.1074/jbc.M703848200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645284PMC
August 2007

Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils.

Mol Biol Cell 2007 Apr 21;18(4):1490-6. Epub 2007 Feb 21.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e06-10-0975
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http://dx.doi.org/10.1091/mbc.e06-10-0975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838985PMC
April 2007

The human urine mannose 6-phosphate glycoproteome.

Biochim Biophys Acta 2007 Mar 20;1774(3):368-72. Epub 2006 Dec 20.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/j.bbapap.2006.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859868PMC
March 2007

NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols.

J Biol Chem 2006 Dec 2;281(48):36710-23. Epub 2006 Oct 2.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M608743200
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http://dx.doi.org/10.1074/jbc.M608743200DOI Listing
December 2006

A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis.

Mol Genet Metab 2006 Nov 18;89(3):254-60. Epub 2006 Apr 18.

Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, MO, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109671920600071
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http://dx.doi.org/10.1016/j.ymgme.2006.02.016DOI Listing
November 2006

Demonstration of lysosomal localization for the mammalian ependymin-related protein using classical approaches combined with a novel density shift method.

J Biol Chem 2006 Nov 5;281(46):35436-45. Epub 2006 Sep 5.

Center for Advanced Biotechnology and Medicine, Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M606208200DOI Listing
November 2006

Mechanism of cholesterol transfer from the Niemann-Pick type C2 protein to model membranes supports a role in lysosomal cholesterol transport.

J Biol Chem 2006 Oct 10;281(42):31594-604. Epub 2006 Apr 10.

Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA.

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http://dx.doi.org/10.1074/jbc.M602765200DOI Listing
October 2006

Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins.

Mol Cell Proteomics 2006 Oct 17;5(10):1942-56. Epub 2006 May 17.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, 08854, USA.

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http://dx.doi.org/10.1074/mcp.M600030-MCP200DOI Listing
October 2006

A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis.

Mol Genet Metab 2006 Apr 4;87(4):341-8. Epub 2006 Jan 4.

Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, USA.

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http://dx.doi.org/10.1016/j.ymgme.2005.11.005DOI Listing
April 2006

Identification of sites of mannose 6-phosphorylation on lysosomal proteins.

Mol Cell Proteomics 2006 Apr 5;5(4):686-701. Epub 2006 Jan 5.

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/mcp.M500343-MCP200DOI Listing
April 2006

Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates.

J Biol Chem 2006 Mar 8;281(10):6559-72. Epub 2005 Dec 8.

Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1074/jbc.M507336200DOI Listing
March 2006

The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteins.

Proteomics 2005 Apr;5(6):1520-32

Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1002/pmic.200401054DOI Listing
April 2005

Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease.

Proc Natl Acad Sci U S A 2003 Mar 18;100(5):2512-7. Epub 2003 Feb 18.

Center for Advanced Biotechnology and Medicine, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0437840100
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http://dx.doi.org/10.1073/pnas.0437840100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151372PMC
March 2003