Peter Libby

Peter Libby

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Editorial commentary: Arson in the artery: Who set the atheroma aflame?

Authors:
Peter Libby

Trends Cardiovasc Med 2019 Nov 28;29(8):473-475. Epub 2019 Mar 28.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2019.03.006DOI Listing
November 2019

Targeting RNA to lower triglycerides: long strides from short molecules.

Eur Heart J 2019 Sep;40(33):2797-2800

Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA.

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https://academic.oup.com/eurheartj/advance-article/doi/10.10
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http://dx.doi.org/10.1093/eurheartj/ehz321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735893PMC
September 2019

Fluorodeoxyglucose Uptake in Atheroma: Not So Simple.

J Am Coll Cardiol 2019 Sep;74(9):1233-1236

Department of Radiology/Nuclear Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2019.07.009DOI Listing
September 2019

Na-H exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis.

Nat Commun 2019 Sep 4;10(1):3978. Epub 2019 Sep 4.

Department of Cardiology, Institute of Clinical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1038/s41467-019-11983-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726618PMC
September 2019

Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis.

Eur Heart J 2019 Sep 1. Epub 2019 Sep 1.

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz542DOI Listing
September 2019

From Focal Lipid Storage to Systemic Inflammation: JACC Review Topic of the Week.

J Am Coll Cardiol 2019 Sep;74(12):1594-1607

Department of Medicine, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jacc.2019.07.061DOI Listing
September 2019

Anticytokine Immune Therapy and Atherothrombotic Cardiovascular Risk.

Arterioscler Thromb Vasc Biol 2019 Aug 11;39(8):1510-1519. Epub 2019 Jul 11.

From the Université de Paris, Inserm U970, Paris Cardiovascular Research Center, Paris, France (H.A.-O., A.T.).

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http://dx.doi.org/10.1161/ATVBAHA.119.311998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681658PMC
August 2019

Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.

Nat Rev Cardiol 2019 Aug 12. Epub 2019 Aug 12.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41569-019-0247-5DOI Listing
August 2019

Atherosclerosis.

Nat Rev Dis Primers 2019 Aug 16;5(1):56. Epub 2019 Aug 16.

Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41572-019-0106-zDOI Listing
August 2019

Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis.

iScience 2019 Aug 9;19:607-622. Epub 2019 Aug 9.

Department of Medicine, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB-7, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715892PMC
August 2019

Inhibiting NLRP3 Inflammasome Activity in Acute Myocardial Infarction: A Review of Pharmacologic Agents and Clinical Outcomes.

J Cardiovasc Pharmacol 2019 Jul 22. Epub 2019 Jul 22.

Brigham and Women's Hospital Boston MA.

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http://dx.doi.org/10.1097/FJC.0000000000000701DOI Listing
July 2019

Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction.

Biochim Biophys Acta Mol Basis Dis 2019 Jun 11;1865(6):1170-1181. Epub 2019 Jan 11.

Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou University, Zhengzhou 450000, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193001
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http://dx.doi.org/10.1016/j.bbadis.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502670PMC
June 2019

Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice.

Biochim Biophys Acta Mol Basis Dis 2019 Jun 9;1865(6):1690-1700. Epub 2019 Apr 9.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.04.006DOI Listing
June 2019

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.

Cardiovasc Diabetol 2019 Jun 4;18(1):71. Epub 2019 Jun 4.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12933-019-0864-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549355PMC
June 2019

Low-Density Lipoprotein Cholesterol After an Acute Coronary Syndrome: How Low to Go?

Curr Cardiol Rep 2019 Jun 27;21(8):77. Epub 2019 Jun 27.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11886-019-1160-6DOI Listing
June 2019

Leaders in Cardiovascular Research: Peter Libby.

Cardiovasc Res 2019 May;115(6):e61-e62

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, USA.

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http://dx.doi.org/10.1093/cvr/cvz069DOI Listing
May 2019

c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.

Cell Rep 2019 May;27(8):2304-2312.e6

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S1A1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S1A1, Canada; Toronto General Research Institute, University Health Network, Toronto, ON M5G1L7, Canada; Peter Munk Cardiac Centre, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.090DOI Listing
May 2019

Residual vascular risk in diabetes - Will the SPPARM alpha concept hold the key?

Diabetes Metab Syndr 2019 Jul - Aug;13(4):2723-2725. Epub 2019 May 30.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.dsx.2019.05.034DOI Listing
May 2019

Novel Antiatherosclerotic Therapies.

Arterioscler Thromb Vasc Biol 2019 Apr;39(4):538-545

From the Division of Cardiovascular Medicine (P.L., B.M.E.), Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/ATVBAHA.118.310958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436984PMC
April 2019

Inflammation: a common contributor to cancer, aging, and cardiovascular diseases-expanding the concept of cardio-oncology.

Cardiovasc Res 2019 Apr;115(5):824-829

Division of Clinical Pharmacology, Department of Medicine IV, Center of Integrated Protein Science Munich (CIPS-M), Klinikum der Universität München, Munich, Germany.

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http://dx.doi.org/10.1093/cvr/cvz058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452304PMC
April 2019

Arterial Inflammation: The Heat Before the Storm.

J Am Coll Cardiol 2019 Apr;73(12):1383-1385

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: https://twitter.com/DLBHATTMD.

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http://dx.doi.org/10.1016/j.jacc.2019.02.002DOI Listing
April 2019

Modulating Adaptive Immunity in Vascular Disease: CD4 to the Fore.

J Am Coll Cardiol 2019 Apr;73(14):1824-1826

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Vascular Research Division, Department of Pathology and the Center of Excellence in Vascular Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2019.01.050DOI Listing
April 2019

Johann Sebastian Bach.

Authors:
Peter Libby

Circ Res 2019 Apr;124(9):1303-1308

From the Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315025DOI Listing
April 2019

Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure.

Circulation 2019 Mar;139(10):1289-1299

From the Divisions of Cardiovascular (B.M.E., P.L., P.M.R.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038010DOI Listing
March 2019

Dysregulation of IL-33/ST2 signaling and myocardial periarteriolar fibrosis.

J Mol Cell Cardiol 2019 Mar 11;128:179-186. Epub 2019 Feb 11.

Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, 7 Divinity Ave, Cambridge, MA 02138, United States of America; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02115, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402609PMC
March 2019

Once more unto the breach: endothelial permeability and atherogenesis.

Authors:
Peter Libby

Eur Heart J 2019 Mar;40(11):938-940

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz081DOI Listing
March 2019

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.

N Engl J Med 2019 02 10;380(8):752-762. Epub 2018 Nov 10.

From the Center for Cardiovascular Disease Prevention, Division of Preventive Medicine (P.M.R., B.M.E., A.P., J.G.M., E.Z., V.M., N.P.P., R.J.G.), and the Divisions of Cardiovascular Medicine (P.M.R., B.M.E., P.L., S.Z.G.) and Rheumatology (D.H.S.), Brigham and Women's Hospital, Boston; the National Heart, Lung, and Blood Institute, Bethesda, MD (A.H., Y.R., E.I.); McMaster University, Hamilton (M.G.), the Canadian Collaborative Research Network, Brampton (M.T.), St. Michael's Hospital, Toronto (S.V.), the University of Ottawa Heart Institute, Ottawa (M.L.M.), and KMH Cardiology, Diagnostic and Research Centres, Mississauga (J.J.), ON, and Laval University, Quebec City, QB (O.B.) - all in Canada; Touro University, Vallejo, CA (M.C.); Cardiology Associates Carolina, Morganton, NC (R.S.); Wooster Community Hospital, Wooster (C.O.), and Dayton Veteran Affairs Medical Center, Dayton (M.S.) - both in Ohio; Verde Valley Medical Center, Cottonwood, AZ (S.B.); and Atlanta Heart Specialists, Atlanta (N.S.).

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http://www.nejm.org/doi/10.1056/NEJMoa1809798
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http://dx.doi.org/10.1056/NEJMoa1809798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587584PMC
February 2019

Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction.

J Mol Cell Cardiol 2019 Feb 19;127:44-56. Epub 2018 Nov 19.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2018.11.010DOI Listing
February 2019

CHIPping Away at the Pathogenesis of Heart Failure.

JAMA Cardiol 2019 Jan;4(1):5-6

Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamacardio.2018.4039DOI Listing
January 2019

Reassessing the Mechanisms of Acute Coronary Syndromes.

Circ Res 2019 Jan;124(1):150-160

Massachusetts General Hospital (I.-K.J.), Harvard Medical School, Boston.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31109
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http://dx.doi.org/10.1161/CIRCRESAHA.118.311098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447371PMC
January 2019

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena.

Eur Heart J 2018 Dec;39(47):4150-4158

Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, Schlieren, Zurich, Switzerland.

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http://dx.doi.org/10.1093/eurheartj/ehx568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293269PMC
December 2018

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study.

Am Heart J 2018 12 29;206:80-93. Epub 2018 Sep 29.

Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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https://linkinghub.elsevier.com/retrieve/pii/S00028703183028
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http://dx.doi.org/10.1016/j.ahj.2018.09.011DOI Listing
December 2018

Medical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome: JACC State-of-the-Art Review.

J Am Coll Cardiol 2018 12;72(23 Pt A):2886-2903

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.

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http://dx.doi.org/10.1016/j.jacc.2018.09.052DOI Listing
December 2018

Cardiovascular Benefits of GLP-1 Receptor Agonism: Is Inflammation a Key?

JACC Basic Transl Sci 2018 Dec 31;3(6):858-860. Epub 2018 Dec 31.

Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacbts.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314960PMC
December 2018

Coronary Plaque Microstructure and Composition Modify Optical Polarization: A New Endogenous Contrast Mechanism for Optical Frequency Domain Imaging.

JACC Cardiovasc Imaging 2018 Nov 13;11(11):1666-1676. Epub 2017 Dec 13.

Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmg.2017.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994172PMC
November 2018

Fish Oil and Perioperative Bleeding.

Circ Cardiovasc Qual Outcomes 2018 11;11(11):e004584

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.).

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376981PMC
November 2018

Jak-ing Up the Plaque's Lipid Core…and Even More.

Circ Res 2018 11;123(11):1180-1182

Brigham and Women's Hospital, and Dana Farber Cancer Institute (B.L.E.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309975PMC
November 2018

Relationship of Interleukin-1β Blockade With Incident Gout and Serum Uric Acid Levels: Exploratory Analysis of a Randomized Controlled Trial.

Ann Intern Med 2018 10 18;169(8):535-542. Epub 2018 Sep 18.

Brigham and Women's Hospital, Boston, Massachusetts (D.H.S., R.J.G., J.G.M., P.L., B.M.E., P.M.R.).

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http://dx.doi.org/10.7326/M18-1167DOI Listing
October 2018

Internal Bleeding: Is Intraplaque Hemorrhage a Decoration or a Driver?

JACC Basic Transl Sci 2018 Aug 28;3(4):481-484. Epub 2018 Aug 28.

Unité mixte de Recherche 1148 Inserm-Paris7 University, Xavier Bichat Hospital, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S2452302X183009
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http://dx.doi.org/10.1016/j.jacbts.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115641PMC
August 2018

CHIP (Clonal Hematopoiesis of Indeterminate Potential).

Circulation 2018 08;138(7):666-668

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (B.L.E.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.034392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277144PMC
August 2018

Acute pancreatitis with long-term celecoxib vs. ibuprofen or naproxen: data from the PRECISION trial.

Am J Gastroenterol 2018 07;113(7):1053-1054

University of Melbourne Department of Medicine, Austin Health, Melbourne, Victoria, and Western Sydney University, Campbelltown, NSW, Australia. Baylor College of Medicine, Veterans Affairs Medical Center, Houston, TX, USA. Cleveland Clinic, Cleveland, OH, USA. Downstate College of Medicine, State University of New York, New York, NY, USA. Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Royal Brompton and Harefield Hospital Trust and Imperial College, London, United Kingdom. Pfizer, New York, NY, USA. Pfizer Ltd, Tadworth, UK.

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http://dx.doi.org/10.1038/s41395-018-0051-6DOI Listing
July 2018

Clonal Hematopoiesis Confers Predisposition to Both Cardiovascular Disease and Cancer: A Newly Recognized Link Between Two Major Killers.

Ann Intern Med 2018 07 29;169(2):116-117. Epub 2018 May 29.

Brigham and Women's Hospital, Boston, Massachusetts (P.L.).

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http://annals.org/article.aspx?doi=10.7326/M18-0737
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http://dx.doi.org/10.7326/M18-0737DOI Listing
July 2018

Biologically-Based Therapies for Aortic Diseases: Why the Long Lag in Translation?

Authors:
Peter Libby

J Am Coll Cardiol 2018 07;72(1):58-61

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.05.005DOI Listing
July 2018

Plaque erosion: a new in vivo diagnosis and a potential major shift in the management of patients with acute coronary syndromes.

Eur Heart J 2018 Jun;39(22):2070-2076

Cardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRB 800, Boston, MA 02114, USA.

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http://dx.doi.org/10.1093/eurheartj/ehx786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991215PMC
June 2018

Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials.

Nat Rev Cardiol 2018 06;15(6):351-370

Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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http://dx.doi.org/10.1038/s41569-018-0002-3DOI Listing
June 2018

Atherosclerosis and inflammation: overview and updates.

Clin Sci (Lond) 2018 06 21;132(12):1243-1252. Epub 2018 Jun 21.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, U.S.A.

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http://dx.doi.org/10.1042/CS20180306DOI Listing
June 2018

Partnerships Promote Translation in Biomedicine.

Authors:
Peter Libby

JACC Basic Transl Sci 2018 Jun 25;3(3):431-433. Epub 2018 Jun 25.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacbts.2018.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058993PMC
June 2018

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes.

J Am Coll Cardiol 2018 05 12;71(21):2392-2401. Epub 2018 Mar 12.

Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, Massachusetts; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2018.03.002DOI Listing
May 2018

Casting NETs to predict cardiovascular outcomes.

Eur J Prev Cardiol 2018 05 21;25(7):759-761. Epub 2018 Mar 21.

Cardiovascular Medicine, Brigham and Women's Hospital, USA.

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http://dx.doi.org/10.1177/2047487318766413DOI Listing
May 2018

All roads lead to IL-6: A central hub of cardiometabolic signaling.

Int J Cardiol 2018 05;259:213-215

Lipid Clinic, Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.ijcard.2018.02.062DOI Listing
May 2018

Adaptive immunity in acute coronary syndromes: chicken or egg?

Eur Heart J 2018 Apr;39(13):1098-1099

Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1093/eurheartj/ehx743DOI Listing
April 2018

Elevations in neutrophils with obstructive sleep apnea: The Multi-Ethnic Study of Atherosclerosis (MESA).

Int J Cardiol 2018 04;257:318-323

Department of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.10.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842816PMC
April 2018

Effect of Aspirin Coadministration on the Safety of Celecoxib, Naproxen, or Ibuprofen.

J Am Coll Cardiol 2018 04;71(16):1741-1751

Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2018.02.036DOI Listing
April 2018

Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to Clinical Translation.

Curr Atheroscler Rep 2018 03 10;20(4):20. Epub 2018 Mar 10.

Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, 982265 Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://dx.doi.org/10.1007/s11883-018-0718-xDOI Listing
March 2018

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial.

Lancet 2018 01 13;391(10118):319-328. Epub 2017 Nov 13.

Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S0140-6736(17)32814-3DOI Listing
January 2018

Taming Immune and Inflammatory Responses to Treat Atherosclerosis.

J Am Coll Cardiol 2018 01;71(2):173-176

Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S07351097174158
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http://dx.doi.org/10.1016/j.jacc.2017.10.081DOI Listing
January 2018

Swell, or Not Too Swell: Cytokines Regulate Arterial Aneurysm Formation.

Immunity 2017 11;47(5):814-816

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.immuni.2017.11.011DOI Listing
November 2017

Mechanisms of erosion of atherosclerotic plaques.

Curr Opin Lipidol 2017 Oct;28(5):434-441

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://Insights.ovid.com/crossref?an=00041433-201710000-0000
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http://dx.doi.org/10.1097/MOL.0000000000000440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676466PMC
October 2017

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial.

Lancet 2017 Oct 27;390(10105):1833-1842. Epub 2017 Aug 27.

Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/S0140-6736(17)32247-XDOI Listing
October 2017

Unfriendly Fire From Neutrophils Promiscuously Potentiates Cardiovascular Inflammation.

Circ Res 2017 10;121(9):1029-1031

From the Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679447PMC
October 2017

Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and Beyond.

Authors:
Peter Libby

J Am Coll Cardiol 2017 Oct;70(18):2278-2289

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687846PMC
October 2017

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

N Engl J Med 2017 09 27;377(12):1119-1131. Epub 2017 Aug 27.

From the Center for Cardiovascular Disease Prevention (P.M.R., B.M.E., J.G.M., R.J.G.) and the Cardiovascular Division (P.M.R., B.M.E., P.L.), Brigham and Women's Hospital, Harvard Medical School, Boston; Novartis, East Hanover, NJ, and Basel, Switzerland (T.T., W.H.C.); Baylor College of Medicine, Houston (C.B.); Federal University of São Paulo (F.F.) and the Heart Institute (InCor), University of São Paulo Medical School (J.N.), São Paulo, and Faculdade Evangelica de Medicina do Parana, Curitiba (P.R.F.R.) - all in Brazil; Deutsches Herzzentrum München, Technische Universität München, German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich (W.K.), and the Department of Cardiology and Berlin-Brandenburg Center for Regenerative Therapies, Charité Campus Virchow Klinikum, Universitätsmedizin Berlin, Berlin (S.D.A.) - both in Germany; Academic Medical Center of the University of Amsterdam, Amsterdam (J.J.P.K.), Alkmaar Medical Center, Alkmaar (J.H.C.), and VieCuri Medical Center for Northern Limburg, Venlo (R.P.T.T.) - all in the Netherlands; Manipal Hospital, St. John's Research Institute, Bangalore, India (P.P.); Pavol Jozef Safarik University, Kosice, Slovakia (D.P.); McGill University, Montreal (J.G.); First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic (R.C.); Cordoba Hospital, Cordoba, Argentina (A.L.); University of Szeged, Szeged, Hungary (T.F.); City Hospital No. 64, Medical Institute RUDN University, Moscow (Z.K.); Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania (L.V.-S.); University of East Anglia, Norwich Medical School, Norwich, United Kingdom (M.F.); Tohoku University Hospital, Sendai (H.S.), and National Cerebral and Cardiovascular Center, Osaka (H.O.) - both in Japan; and Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden (M.D.).

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http://dx.doi.org/10.1056/NEJMoa1707914DOI Listing
September 2017

Tilting at the tilted protease balance in arterial aneurysmal disease.

Cardiovasc Res 2017 09;113(11):1279-1281

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 741G Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/cvr/cvx140DOI Listing
September 2017

Acute Coronary Syndromes: The Way Forward From Mechanisms to Precision Treatment.

Circulation 2017 Sep;136(12):1155-1166

From Department of Cardiovascular and Thoracic Sciences, Catholic University, Rome, Italy (F.C.); and Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679086PMC
September 2017

Lipoprotein(a) and coronary atheroma progression rates during long-term high-intensity statin therapy: Insights from SATURN.

Atherosclerosis 2017 Aug 15;263:137-144. Epub 2017 Jun 15.

Cleveland Clinic Coordinating Center for Clinical Research (C5R), Cleveland Clinic, Cleveland, OH, United States; Department of Medicine, University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.026DOI Listing
August 2017

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

N Engl J Med 2017 07 21;377(2):111-121. Epub 2017 Jun 21.

From the Department of Medicine, Division of Hematology, Brigham and Women's Hospital (S.J., A.J.S., M.M.) and Harvard Medical School (B.L.E.), the Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital (E.S.) and Harvard Medical School (G.K.S., P.L.), the Department of Pathology (S.J.) and the Center for Genomic Medicine (P.N., S.K.), Massachusetts General Hospital, the Department of Medicine, Division of Cardiology, and Cardiovascular Research Center (P.N., S.K.), and the Department of Medicine (A.G.B.), Massachusetts General Hospital and Harvard Medical School, and the Departments of Medical Oncology (C.J.G.) and Biostatistics and Computational Biology (D.N.), Dana-Farber Cancer Institute, Boston, and the Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge (P.N., A.G.B., N.G., S.G., S.K.) - all in Massachusetts; the Department of Cardiology, University Hospital, Parma, Italy (D.A.); the Department of Medicine, Division of Cardiology, Mt. Sinai School of Medicine, New York (U.B., R.M., V.F.); Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid (V.F.); Medical Research Council-British Heart Foundation Cardiovascular Epidemiology Unit and National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, and the British Heart Foundation, Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge (J.D.), and the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton (J.D.) - both in the United Kingdom; the Center for Non-Communicable Diseases, Karachi, Pakistan (P.F., D.S.); the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia (D.S.); and the Department of Clinical Sciences Malmö, Lund University, Lund, Sweden (O.M.).

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http://dx.doi.org/10.1056/NEJMoa1701719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717509PMC
July 2017

Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion.

Circ Res 2017 Jun 20;121(1):31-42. Epub 2017 Apr 20.

From the Department of Cardiovascular Medicine (G.F., T.M., G.S., M.S., A.C., M.B.-M., Y.C., T.Q., Y.T., E.S., G.K.S., E.A., K.J.C., P.L.), and Center for Interdisciplinary Cardiovascular Sciences (E.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston (G.S.M., F.K.S., M.N.); and Department of Engineering and Technology, College of Engineering and Computing, Nova Southeastern University, Fort Lauderdale, FL (M.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488735PMC
June 2017

Interferon-γ Released by Activated CD8 T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.

Am J Pathol 2017 Jun 19;187(6):1413-1425. Epub 2017 Apr 19.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455058PMC
June 2017

Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging.

Circ Cardiovasc Imaging 2017 May;10(5)

From the Cardiovascular Research Center, Cardiology Division (A.F.S., T.H., A.M., F.A.J.) and Center for Systems Biology (J.R.M.), Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Physiology and Biophysics, Boston University School of Medicine, MA (J.A.H.); Department of Biomedical Engineering, Boston University, MA (J.A.H.); Institute of Biological and Medical Imaging, Chair of Biological Imaging, Technical University of Munich, Germany (V.N.); and Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.L.).

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http://dx.doi.org/10.1161/CIRCIMAGING.116.005813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509162PMC
May 2017

A Rock and a Hard Place: Chiseling Away at the Multiple Mechanisms of Aortic Stenosis.

Circulation 2017 05;135(20):1951-1955

From Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479353PMC
May 2017

The Aging Cardiovascular System: Understanding It at the Cellular and Clinical Levels.

J Am Coll Cardiol 2017 Apr;69(15):1952-1967

Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland; University Heart Center, Cardiology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.01.064DOI Listing
April 2017

Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Mice.

J Immunol 2017 03 16;198(5):1846-1854. Epub 2017 Jan 16.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.4049/jimmunol.1501145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321845PMC
March 2017