Peter L Jansen

Peter L M Jansen

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Peter L Jansen

Peter L M Jansen

Publications by authors named "Peter L M Jansen"

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1PubMed Central Citations

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients.

Hepatology 2019 Jul 5;70(1):308-318. Epub 2019 Jun 5.

Department of Surgery, Maastricht University Medical Center and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30629
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http://dx.doi.org/10.1002/hep.30629DOI Listing
July 2019

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy.

J Inherit Metab Dis 2019 Mar 21;42(2):303-312. Epub 2019 Feb 21.

Department of Pediatric Neurology, Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/jimd.12042
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http://dx.doi.org/10.1002/jimd.12042DOI Listing
March 2019

Hydrodynamics of bile flow: Lessons from computational modeling.

Authors:
Peter L M Jansen

Hepatology 2018 04 20;67(4):1624-1627. Epub 2018 Feb 20.

Maastricht Centre for Systems Biology (MaCSBio), University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/hep.29618DOI Listing
April 2018

New therapies target the toxic consequences of cholestatic liver disease.

Authors:
Peter L M Jansen

Expert Rev Gastroenterol Hepatol 2018 Mar 10;12(3):277-285. Epub 2018 Jan 10.

a Maastricht Center for Systems Biology (MaCSBio) , Maastricht University , Maastricht , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/17474124.2018.1
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http://dx.doi.org/10.1080/17474124.2018.1424538DOI Listing
March 2018

Chronic elevation of plasma fibroblast growth factor 19 in long-term farnesoid X receptor agonist therapy, a happy marriage or cause for oncological concern?

Hepatology 2018 02 26;67(2):782-784. Epub 2017 Dec 26.

Department of Surgery, Maastricht University NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/hep.29511DOI Listing
February 2018

The ascending pathophysiology of cholestatic liver disease.

Hepatology 2017 02;65(2):722-738

Research Network of Liver Systems Medicine, Freiburg, Germany.

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http://dx.doi.org/10.1002/hep.28965DOI Listing
February 2017

The portal-drained viscera release fibroblast growth factor 19 in humans.

Physiol Rep 2016 12;4(24)

Department of Surgery, Maastricht University Medical Center and NUTRIM School of Nutrition and Translational Research in Metabolism Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.14814/phy2.13037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210390PMC
December 2016

Cholic acid therapy in Zellweger spectrum disorders.

J Inherit Metab Dis 2016 11 28;39(6):859-868. Epub 2016 Jul 28.

Department of Pediatric Neurology, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10545-016-9962-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065608PMC
November 2016

The role of bile salts in liver regeneration.

Hepatol Int 2016 Sep 5;10(5):733-40. Epub 2016 Apr 5.

Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, PO BOX 616, 6200 MD, Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s12072-016-9723-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003899PMC
September 2016

Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis.

Eur J Gastroenterol Hepatol 2016 Aug;28(8):955-62

aDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht bDepartment of Gastroenterology and Hepatology cDepartment of Surgery, Erasmus Medical Center, Rotterdam dDepartment of Medical Oncology eDepartment of Gastroenterology and Hepatology fDepartment of Pathology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0000000000000641DOI Listing
August 2016

Pandora's box opens for cholestatic liver disease.

Hepatology 2016 Mar 12;63(3):694-6. Epub 2016 Jan 12.

Department of Surgery NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/hep.28364DOI Listing
March 2016

Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands.

Eur J Gastroenterol Hepatol 2016 Mar;28(3):352-9

aDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht Departments of bGastroenterology and Hepatology cSurgery, Erasmus Medical Center, Rotterdam dDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden Departments of eMedical Oncology fGastroenterology and Hepatology gPathology, Academic Medical Center Amsterdam hDepartment of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0000000000000527DOI Listing
March 2016

Nonalcoholic fatty liver disease and cardiovascular risk in children with obesity.

Obesity (Silver Spring) 2015 Jun 9;23(6):1239-43. Epub 2015 May 9.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/oby.21076DOI Listing
June 2015

Pituitary TSH controls bile salt synthesis.

J Hepatol 2015 May 9;62(5):1005-7. Epub 2015 Feb 9.

Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, PO BOX 616, 6200 MD Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2015.02.003DOI Listing
May 2015

Characterization and treatment of persistent hepatocellular secretory failure.

Liver Int 2015 Apr 4;35(4):1478-88. Epub 2014 Jul 4.

Department of Gastroenterology & Hepatology and Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/liv.12603DOI Listing
April 2015

FXR, intestinal FiXeR of hepatocellular carcinoma?

Hepatology 2015 Jan 25;61(1):21-3. Epub 2014 Nov 25.

Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/hep.27397DOI Listing
January 2015

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects.

Clin Endocrinol (Oxf) 2014 Dec 12;81(6):862-70. Epub 2014 Jun 12.

Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/cen.12496DOI Listing
December 2014

[Bariatric surgery: part of a systematic approach to obesity].

Authors:
Peter L M Jansen

Ned Tijdschr Geneeskd 2013 ;156(0):A4754

Academisch Medisch Centrum, afd. Maag-, Darm- en Leverziekten, Amsterdam.

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July 2014

How sweet it is to activate FXR.

Hepatology 2014 May 24;59(5):1665-7. Epub 2014 Mar 24.

Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands; Department of Surgery, NUTRIM School of Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1002/hep.26778DOI Listing
May 2014

Bile acid receptors as targets for drug development.

Nat Rev Gastroenterol Hepatol 2014 Jan 27;11(1):55-67. Epub 2013 Aug 27.

Department of Gastroenterology and Hepatology, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrgastro.2013.151DOI Listing
January 2014

Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth.

J Hepatol 2013 Nov 16;59(5):1121-3. Epub 2013 Jul 16.

Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, PO BOX 616, 6200 MD Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2013.07.013DOI Listing
November 2013

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress.

Biochimie 2013 Apr 2;95(4):692-9. Epub 2012 Nov 2.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, 1105 BK Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.biochi.2012.10.019DOI Listing
April 2013

Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children.

Obesity (Silver Spring) 2013 Mar;21(3):583-90

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/oby.20173
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http://dx.doi.org/10.1002/oby.20173DOI Listing
March 2013

Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma.

J Hepatol 2012 Jun 5;56(6):1371-83. Epub 2012 Feb 5.

Department of Research & Development, Amsterdam Molecular Therapeutics, Meibergdreef 61, 1105 BA Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278120008
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http://dx.doi.org/10.1016/j.jhep.2011.11.026DOI Listing
June 2012

[Consequences of non-alcoholic fatty liver disease still unclear].

Authors:
Peter L M Jansen

Ned Tijdschr Geneeskd 2012 ;156(9):A4568

Academisch Medisch Centrum, afd. Maag-, Darm-, Leverziekten, Amsterdam, the Netherlands.

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April 2012

Transient elevation of serum bile salts after partial hepatectomy is due to metabolic overload and not to cholestasis.

Authors:
Peter L M Jansen

J Hepatol 2012 Mar 30;56(3):743-4; author reply 744-5. Epub 2011 Aug 30.

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http://dx.doi.org/10.1016/j.jhep.2011.08.004DOI Listing
March 2012

Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs.

Hepatology 2012 Mar 13;55(3):821-32. Epub 2012 Jan 13.

Department of Research & Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.24682DOI Listing
March 2012

Fibroblast growth factor 19, an anticholestatic drug produced by human liver.

Gastroenterology 2012 Mar 24;142(3):e29-30. Epub 2012 Jan 24.

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http://dx.doi.org/10.1053/j.gastro.2012.01.027DOI Listing
March 2012

The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract.

Hepatology 2012 Feb 19;55(2):575-83. Epub 2011 Dec 19.

Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/hep.24702
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http://dx.doi.org/10.1002/hep.24702DOI Listing
February 2012

US cannot be used to predict the presence or severity of hepatic steatosis in severely obese adolescents.

Radiology 2012 Jan 21;262(1):327-34. Epub 2011 Nov 21.

Department of Radiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, the Netherlands.

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http://pubs.rsna.org/doi/10.1148/radiol.11111094
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http://dx.doi.org/10.1148/radiol.11111094DOI Listing
January 2012

Controlled-release interferon alpha 2b, a new member of the interferon family for the treatment of chronic hepatitis C.

Expert Opin Investig Drugs 2012 Jan 30;21(1):111-8. Epub 2011 Nov 30.

Academic Medical Center, Department of Gastroenterology and Hepatology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1517/13543784.2012.640671DOI Listing
January 2012

Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery.

Dig Dis 2011 17;29(1):48-51. Epub 2011 Jun 17.

Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000324128DOI Listing
October 2011

Lifestyle intervention for non-alcoholic fatty liver disease: prospective cohort study of its efficacy and factors related to improvement.

Arch Dis Child 2011 Jul 25;96(7):669-74. Epub 2011 Apr 25.

Department of Paediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/adc.2010.199760DOI Listing
July 2011

The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies.

Hepatology 2010 Oct;52(4):1489-96

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.23810DOI Listing
October 2010

Detection of hepatitis B virus covalently closed circular DNA in paraffin-embedded and cryo-preserved liver biopsies of chronic hepatitis B patients.

Eur J Gastroenterol Hepatol 2010 Aug;22(8):952-60

Department of Gastroenterology and Hepatology, AMC Liver Center, Center for Infectious Disease and Immunology (CINIMA), University of Amsterdam and Royal Tropical Institute, KIT biomedical Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0b013e3283376a63DOI Listing
August 2010

A new life for bile acids.

Authors:
Peter L M Jansen

J Hepatol 2010 Jun 15;52(6):937-8. Epub 2010 Mar 15.

Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2010.02.003DOI Listing
June 2010

Progressive familial intrahepatic cholestasis type 1.

Semin Liver Dis 2010 May 26;30(2):117-24. Epub 2010 Apr 26.

Tytgat Institute of Liver and Gastrointestinal Research and Department of Gastroenterology and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1055/s-0030-1253221DOI Listing
May 2010

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance.

Am J Physiol Gastrointest Liver Physiol 2010 Mar 21;298(3):G440-5. Epub 2010 Jan 21.

Academic Medical Center, Department of Gastroenterology, Amsterdam.

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http://dx.doi.org/10.1152/ajpgi.00322.2009DOI Listing
March 2010

[Reactivation of hepatitis B virus in patients with hematological neoplasms].

Ned Tijdschr Geneeskd 2009 May;153(19):926-31

Academisch Medisch Centrum/Universiteit van Amsterdam.

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May 2009

[The treatment of hepatocellular carcinoma. New developments].

Ned Tijdschr Geneeskd 2009 Apr;153(14):668-72

Academisch Medisch Centrum/Universiteit van Amsterdam.

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April 2009

Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.

Hepatology 2009 Jan;49(1):151-9

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.22661DOI Listing
January 2009

Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease.

J Biol Chem 2008 Dec 6;283(51):35630-7. Epub 2008 Oct 6.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M804374200DOI Listing
December 2008

PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells.

Mol Pharm 2008 May-Jun;5(3):399-406. Epub 2008 Jan 25.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1021/mp700118pDOI Listing
August 2008

Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform.

Free Radic Biol Med 2008 Apr 23;44(7):1323-33. Epub 2007 Dec 23.

Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S089158490700814
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http://dx.doi.org/10.1016/j.freeradbiomed.2007.12.011DOI Listing
April 2008

Liver adenomatosis: re-evaluation of aetiology and management.

Liver Int 2008 Apr;28(4):499-508

Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1478-3231.2008.01669.xDOI Listing
April 2008

Endogenous bile acids as carcinogens.

Authors:
Peter L M Jansen

J Hepatol 2007 Sep 14;47(3):434-5. Epub 2007 Jun 14.

Liver Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2007.06.001DOI Listing
September 2007

Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile.

Liver Int 2007 Sep;27(7):944-53

Department of Gastroenterology and Hepatology, AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/j.1478-3231.2007.01507.xDOI Listing
September 2007

Low-level HCV viraemia after initial response during antiviral therapy: transcription-mediated amplification predicts treatment failure.

Antivir Ther 2007 ;12(3):423-7

Section of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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August 2007

Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels.

Inflamm Bowel Dis 2007 Jun;13(6):710-20

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/ibd.20088DOI Listing
June 2007

Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport.

Hepatology 2007 Feb;45(2):340-8

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://doi.wiley.com/10.1002/hep.21528
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http://dx.doi.org/10.1002/hep.21528DOI Listing
February 2007

Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease.

Scand J Gastroenterol 2006 Oct;41(10):1174-82

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1080/00365520600575746DOI Listing
October 2006

Antiviral effect of peginterferon alfa-2b and alfa-2a compared.

J Hepatol 2006 Aug 13;45(2):172-3. Epub 2006 Jun 13.

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http://dx.doi.org/10.1016/j.jhep.2006.06.003DOI Listing
August 2006

Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.

J Hepatol 2006 May 12;44(5):918-29. Epub 2005 Sep 12.

Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, P.O. 30.001, 9700 RB, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2005.07.034DOI Listing
May 2006

Clinical outcome of Crohn's disease according to the Vienna classification: disease location is a useful predictor of disease course.

Eur J Gastroenterol Hepatol 2006 Mar;18(3):255-61

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1097/00042737-200603000-00005DOI Listing
March 2006

Budesonide in previously untreated autoimmune hepatitis.

Liver Int 2005 Oct;25(5):927-34

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.1111/j.1478-3231.2005.01122.xDOI Listing
October 2005

Association between Toll-like receptor 4 and inflammatory bowel disease.

Inflamm Bowel Dis 2005 Jun;11(6):567-75

Department of Gastroenterology and Hepatology, University of Groningen Medical Center, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/01.mib.0000161305.81198.0fDOI Listing
June 2005

Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation.

J Hepatol 2004 Dec;41(6):1017-25

Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016882780400415
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http://dx.doi.org/10.1016/j.jhep.2004.08.023DOI Listing
December 2004

Non-alcoholic steatohepatitis.

Authors:
Peter L M Jansen

Eur J Gastroenterol Hepatol 2004 Nov;16(11):1079-85

Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/00042737-200411000-00001DOI Listing
November 2004

Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity.

Am J Physiol Gastrointest Liver Physiol 2004 Oct 24;287(4):G865-74. Epub 2004 Jun 24.

Division of Gastroenterology, British Columbia's Children's Hospital, Vancouver, British Columbia, V6H 3V4.

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http://dx.doi.org/10.1152/ajpgi.00187.2004DOI Listing
October 2004

Immunoglobulin coating of faecal bacteria in inflammatory bowel disease.

Eur J Gastroenterol Hepatol 2004 Jul;16(7):669-74

Department of Internal Medicine--Gastroenterology Section, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1097/01.meg.0000108346.41221.19DOI Listing
July 2004

Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.

Hepatology 2004 Jun;39(6):1563-73

Center for Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration, Groningen, The Netherlands.

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http://doi.wiley.com/10.1002/hep.20246
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http://dx.doi.org/10.1002/hep.20246DOI Listing
June 2004

Targeting nitric oxide in the gastrointestinal tract.

Curr Opin Investig Drugs 2004 May;5(5):529-36

Department of Gastroenterology and Hepatology, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

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May 2004

A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump.

J Hepatol 2004 Jan;40(1):24-30

Department of Gastroenterology and Hepatology, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1016/s0168-8278(03)00483-5DOI Listing
January 2004

Paediatric cholestasis: is villin the villain?

Lancet 2003 Oct;362(9390):1090-1

Department of Pediatrics, University Hospital Groningen, 9713 GZ, Groningen, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(03)14498-4DOI Listing
October 2003

Genetic cholestasis, causes and consequences for hepatobiliary transport.

Liver Int 2003 Oct;23(5):315-22

Department of Gastroenterology,University Hospital Groningen, The Netherlands.

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October 2003

High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease.

J Pathol 2003 Aug;200(5):553-60

Center for the Study of Liver, Digestive and Metabolic Diseases, Groningen University Institute for Drug Exploration (GUIDE), University Hospital Groningen, Groningen, The Netherlands.

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http://www.rug.nl/research/portal/files/14522222/c4.pdf
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http://doi.wiley.com/10.1002/path.1379
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http://dx.doi.org/10.1002/path.1379DOI Listing
August 2003

Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions.

Mol Pharmacol 2003 Jul;64(1):154-9

Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1124/mol.64.1.154DOI Listing
July 2003

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.

Biochem J 2003 Feb;369(Pt 3):539-47

Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, University Hospital Groningen, The Netherlands.

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http://dx.doi.org/10.1042/BJ20020981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223107PMC
February 2003

Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse.

Gastroenterology 2003 Jan;124(1):160-71

Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, CMC IV, Room Y2.163, Groningen University Institute for Drug Exploration, Academic Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands.

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http://dx.doi.org/10.1053/gast.2003.50007DOI Listing
January 2003

Drug transport proteins in the liver.

Adv Drug Deliv Rev 2003 Jan;55(1):107-24

Department of Gastroenterology and Hepatology, State University Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

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January 2003

Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis.

J Hepatol 2002 Jun;36(6):742-50

Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/s0168-8278(02)00063-6DOI Listing
June 2002

Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins.

Br J Pharmacol 2002 Apr;135(7):1685-94

Groningen University Institute for Drug Exploration, Division of Gastroenterology and Hepatology, University Hospital Groningen, Hanzeplein 1, NL-9713 GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/sj.bjp.0704620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573286PMC
April 2002

Liver disease in the elderly.

Authors:
Peter L M Jansen

Best Pract Res Clin Gastroenterol 2002 Feb;16(1):149-58

Department of Hepatology and Gastroenterology, University Hospital Groningen, The Netherlands.

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http://dx.doi.org/10.1053/bega.2002.0271DOI Listing
February 2002