Publications by authors named "Peter L Jones"

54Publications

The Good, The Bad, and The Unexpected: Roles of DUX4 in Health and Disease.

Dev Cell 2019 09;50(5):525-526

Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA. Electronic address:

View Article and Find Full Text PDF
September 2019

Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy.

Exp Neurol 2019 10 12;320:113011. Epub 2019 Jul 12.

Department of Physiology, University of Maryland, Baltimore, 655 W, Baltimore St., Baltimore, MD 21201, United States of America. Electronic address:

View Article and Find Full Text PDF
October 2019

The Genetics and Epigenetics of Facioscapulohumeral Muscular Dystrophy.

Annu Rev Genomics Hum Genet 2019 08 24;20:265-291. Epub 2019 Apr 24.

Department of Pharmacology, School of Medicine, University of Nevada, Reno, Nevada 89557, USA; email:

View Article and Find Full Text PDF
August 2019

Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy.

Mol Ther 2018 07 26;26(7):1797-1807. Epub 2018 Apr 26.

Department of Pharmacology, University of Nevada, Reno, School of Medicine, Reno, NV 89557, USA; Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

View Article and Find Full Text PDF
July 2018

A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.

PLoS One 2018 7;13(2):e0192657. Epub 2018 Feb 7.

Department of Pharmacology, Center for Molecular Medicine, University of Nevada, Reno School of Medicine, Reno, Nevada, United States of America.

View Article and Find Full Text PDF
April 2018

Large family cohorts of lymphoblastoid cells provide a new cellular model for investigating facioscapulohumeral muscular dystrophy.

Neuromuscul Disord 2017 Mar 23;27(3):221-238. Epub 2016 Dec 23.

The Department of Cell and Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address:

View Article and Find Full Text PDF
March 2017

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome.

Nat Genet 2017 Feb 9;49(2):238-248. Epub 2017 Jan 9.

Molecular Neurogenetics Unit and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
February 2017

Transgenic Drosophila for Investigating DUX4 and FRG1, Two Genes Associated with Facioscapulohumeral Muscular Dystrophy (FSHD).

PLoS One 2016 4;11(3):e0150938. Epub 2016 Mar 4.

The Department of Cell and Developmental Biology, University of Massachusetts Medical School Worcester, Massachusetts, United States of America.

View Article and Find Full Text PDF
July 2016

Scalpel or Straitjacket: CRISPR/Cas9 Approaches for Muscular Dystrophies.

Trends Pharmacol Sci 2016 Apr 22;37(4):249-251. Epub 2016 Feb 22.

The Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address:

View Article and Find Full Text PDF
April 2016

CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy.

Mol Ther 2016 Mar 3;24(3):527-35. Epub 2015 Nov 3.

The Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

View Article and Find Full Text PDF
March 2016

Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs.

Pulm Circ 2015 Jun;5(2):382-97

Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA ; Departments of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article and Find Full Text PDF
June 2015

Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.

Clin Epigenetics 2015 29;7:37. Epub 2015 Mar 29.

Department of Neurology and Department of Cell and Developmental Biology, The Wellstone Program, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 USA ; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Sen. Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, 31 Center Drive, Bethesda, MD USA.

View Article and Find Full Text PDF
April 2015

Emerging preclinical animal models for FSHD.

Trends Mol Med 2015 May 20;21(5):295-306. Epub 2015 Mar 20.

Division of Genetics and Genomics, Manton Center for Orphan Disease Research, Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; The Wellstone Program, Departments of Neurology and Cell and Developmental Biology, University of Massachusetts Medical School (UMMS), Worcester, MA 01655, USA.

View Article and Find Full Text PDF
May 2015

The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob Agents Chemother 2015 Mar 22;59(3):1534-41. Epub 2014 Dec 22.

Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, USA

View Article and Find Full Text PDF
March 2015

Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing.

Clin Epigenetics 2014 29;6(1):23. Epub 2014 Oct 29.

The Wellstone Program & The Department of Cell and Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 USA ; The Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 USA ; The Eunice Kennedy Shriver National Institute of Child Health and Human Development Sen. Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 USA.

View Article and Find Full Text PDF
November 2014

Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease.

Antioxid Redox Signal 2015 Jun 4;22(16):1463-82. Epub 2014 Dec 4.

The Wellstone Program and the Departments of Cell and Developmental Biology and Neurology, University of Massachusetts Medical School , Worcester, Massachusetts.

View Article and Find Full Text PDF
June 2015