Peter Kavsak

Peter Kavsak

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Peter Kavsak

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Macrocomplexes and high-sensitivity cardiac troponin assays in samples stored for over 15 years.

Clin Chim Acta 2020 06 15;505:6-8. Epub 2020 Feb 15.

Hamilton Health Sciences, Hamilton, ON, Canada; Division of Emergency Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.cca.2020.02.013DOI Listing
June 2020

A Three-Site Immunoassay for High-Sensitivity Cardiac Troponin I with Low Immunoreactivity for Macrocomplexes.

Clin Chem 2020 May 12. Epub 2020 May 12.

McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1093/clinchem/hvaa098DOI Listing
May 2020

Approaching 2020 acuity for high-sensitivity cardiac troponin assays in Clinical Biochemistry.

Authors:
Peter A Kavsak

Clin Biochem 2020 Apr 25;78:1-3. Epub 2020 Jan 25.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2020.01.007DOI Listing
April 2020

Clinical chemistry tests for patients with COVID-19 - important caveats for interpretation.

Clin Chem Lab Med 2020 Apr 16. Epub 2020 Apr 16.

Division of Emergency Medicine, Department of Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1515/cclm-2020-0436DOI Listing
April 2020

Emerging key laboratory tests for patients with COVID-19.

Clin Biochem 2020 Apr 30. Epub 2020 Apr 30.

Department of Pathology & Molecular Medicine, McMaster University, Canada; Division of Emergency Medicine, Department of Medicine, McMaster University, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2020.04.009DOI Listing
April 2020

Clinical outcomes for chest pain patients discharged home from emergency departments using high-sensitivity versus conventional cardiac troponin assays.

Am Heart J 2020 03 11;221:84-94. Epub 2019 Dec 11.

ICES, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Schulich Heart Center, Sunnybrook Health Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2019.12.007DOI Listing
March 2020

A Randomized Phase II Trial of Prostate Boost Irradiation With Stereotactic Body Radiotherapy (SBRT) or Conventional Fractionation (CF) External Beam Radiotherapy (EBRT) in Locally Advanced Prostate Cancer: The PBS Trial (NCT03380806).

Clin Genitourin Cancer 2020 Jan 8. Epub 2020 Jan 8.

Radiation Oncology, Department of Oncology, Juravinski Cancer Center, McMaster University, Hamilton, ON, Canada; Department of Oncology, McMaster University, Hamilton, ON, Canada; Departments of Oncology, Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.12.020DOI Listing
January 2020

High-sensitivity cardiac troponin testing during and after ACS: Complexed or not?

Clin Biochem 2019 Nov 27;73:32-34. Epub 2019 Jul 27.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.07.012DOI Listing
November 2019

High-sensitivity troponin testing months after an acute coronary syndrome: noise or notable results.

Heart 2019 Nov 12;105(22):1688-1690. Epub 2019 Aug 12.

Health Research, Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1136/heartjnl-2019-315434DOI Listing
November 2019

Long-term quality control testing on a high-sensitivity cardiac troponin I assay.

Clin Chim Acta 2019 Nov 13;498:27-29. Epub 2019 Aug 13.

Hamilton Health Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cca.2019.08.006DOI Listing
November 2019

Measurement of High-Sensitivity Cardiac Troponin in Pulmonary Embolism: Useful Test or a Clinical Distraction.

Semin Thromb Hemost 2019 Nov 17;45(8):784-792. Epub 2019 Oct 17.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1055/s-0039-1698762DOI Listing
November 2019

Rapid atrophy of cardiac left ventricular mass in patients with non-small cell carcinoma of the lung.

J Cachexia Sarcopenia Muscle 2019 Oct 10;10(5):1070-1082. Epub 2019 Jul 10.

Department of Oncology, Division of Palliative Care Medicine, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1002/jcsm.12451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818459PMC
October 2019

The importance of the methodology and sample matrix when interpreting chromogranin A results.

Clin Chem Lab Med 2019 Oct;57(11):e291-e293

London Health Sciences Centre and Western University, London, ON, Canada.

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http://dx.doi.org/10.1515/cclm-2019-0358DOI Listing
October 2019

A heterophile antibody affecting a contemporary but not a high-sensitivity cardiac troponin assay.

Clin Biochem 2019 Sep 4;71:72-73. Epub 2019 Jul 4.

McMaster University, Hamilton, ON, Canada; Hamilton Health Sciences, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2019.07.004DOI Listing
September 2019

A Multicenter Assessment of the Sensitivity and Specificity for a Single High-Sensitivity Cardiac Troponin Test at Emergency Department Presentation for Hospital Admission.

J Appl Lab Med 2019 09 31;4(2):170-179. Epub 2019 Jul 31.

Division of Emergency Medicine, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1373/jalm.2019.029512DOI Listing
September 2019

Effect of Storage Temperature for B-Type Natriuretic Peptide Concentrations for Primary Healthcare Populations.

Clin Chem 2019 06 27;65(6):811-812. Epub 2019 Mar 27.

Department of Health Research Methods Evidence and Impact, McMaster University Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1373/clinchem.2018.300749DOI Listing
June 2019

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction.

N Engl J Med 2019 06;380(26):2529-2540

From the University Heart Center Hamburg (J.T.N., R.T., F.O., N.A.S., T.Z., D.W., S.B.), German Center for Cardiovascular Research (DZHK) Partner Site Hamburg-Kiel-Lübeck (J.T.N., N.A.S., T.Z., D.W., S.B.), and the Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (T.R.), Hamburg, the Department of Cardiology, Heidelberg University Hospital (M.M.-H., H.A.K., E.G.), and DZHK Partner Site Heidelberg-Mannheim (M.M.-H., H.A.K., E.G.), Heidelberg, Cardiology I (T.G., T.M.) and Preventive Cardiology and Preventive Medicine (P.W.), Center for Cardiology, and the Center for Thrombosis and Hemostasis (P.W.), University Medical Center of Johannes Gutenberg University Mainz, and the Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz (K.J.L.), Mainz, DZHK Partner Site Rhine-Main and the Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim (C.L., C.H., T.K.), the Department of Cardiology, Justus Liebig University of Giessen and Marburg, Giessen (C.L., C.H.), the Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin Institute of Health, and DZHK Partner Site Berlin, Berlin (U.L.), and the Institute of Epidemiology, Helmholtz Zentrum, German Research Center for Environmental Health (B.T., A.P.), and DZHK Partner Site Munich Heart Alliance (A.P.), Munich - all in Germany; the Cardiovascular Research Institute Basel and the Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland (R.T., J.B., T.N., P.B., C.M.); the British Heart Foundation Centre for Cardiovascular Science (A.R.C., A.S.V.S., A.A., N.L.M.) and the Usher Institute of Population Health Sciences and Informatics (A.S.V.S., N.L.M.), University of Edinburgh, Edinburgh, the University of Manchester and Manchester University Foundation Trust, Manchester (N.M., R. Body), U.K. Clinical Research Collaboration for Public Health, Queens University of Belfast, Belfast (F.K.), and the Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee (H.T.-P.) - all in the United Kingdom; the Department of Internal and Emergency Medicine, Lund University, Skåne University Hospital, Lund (A.M., U.E.), the Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm (T. Jernberg), the Department of Public Health and Clinical Medicine, and Heart Center, Cardiology, Umeå University, Umeå (S. Söderberg), and the Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala (B.L.) - all in Sweden; the Department of Medicine, University of Otago Christchurch, and Emergency Department, Christchurch Hospital, Christchurch, New Zealand (J.W.P., R.W.T., M.T.); the Departments of Emergency Medicine (J.G., L.A.C.) and Cardiology (W.P.), Royal Brisbane and Women's Hospital, Herston, QLD, and the Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove (J.G., W.P., L.A.C.) - all in Australia; the National Institute for Health and Welfare, Helsinki, Finland (V.S., K.K.); the Department of Epidemiology and Prevention, Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli (L.I.), the Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine, University of Insubria, Varese (L.I., M.M.F., R. Borchini), and the Department of Cardiovascular, Dysmetabolic, and Aging-Associated Diseases, National Institutes of Health, Rome (S.G.) - all in Italy; the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T. Jørgensen), the Research Center for Prevention and Health, Capital Region of Denmark, Glostrup (T. Jørgensen), and the Medical Faculty, Aalborg University, Aalborg (T. Jørgensen) - all in Denmark; the Catalan Department of Health, Barcelona (S. Sans); and the Division of Emergency Medicine (A.W.) and the Department of Pathology and Molecular Medicine (P.A.K.), McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1056/NEJMoa1803377DOI Listing
June 2019

The Evidence for Laboratory Test-Based Computer Clinical Decision Support Tools on Medication Errors and Adverse Drug Events.

Authors:
Peter A Kavsak

J Appl Lab Med 2019 05 11;3(6):922-924. Epub 2019 Mar 11.

McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1373/jalm.2018.028951DOI Listing
May 2019

High-Sensitivity Generation 5 Cardiac Troponin T Sex- and Age-Specific 99th Percentiles in the CALIPER Cohort of Healthy Children and Adolescents.

Clin Chem 2019 04 8;65(4):589-591. Epub 2019 Feb 8.

CALIPER Program Department of Pediatric Laboratory Medicine The Hospital for Sick Children and

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2018.299
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http://dx.doi.org/10.1373/clinchem.2018.299156DOI Listing
April 2019

Between-day versus within-day imprecision using the Abbott high-sensitivity cardiac troponin I assay at concentrations around 5 ng/l.

Clin Chim Acta 2019 Feb 28;489:58-60. Epub 2018 Nov 28.

Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.1016/j.cca.2018.11.031DOI Listing
February 2019

Pre-analytical variables affecting discordant results on repeat sample testing for cardiac troponin I.

Clin Biochem 2019 Jan 28;63:158-160. Epub 2018 Oct 28.

McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2018.10.014DOI Listing
January 2019

Perioperative heart-type fatty acid binding protein concentration cutoffs for the identification of severe acute kidney injury in patients undergoing cardiac surgery.

Clin Chem Lab Med 2018 12;57(2):e8-e10

Program of Applied Translational Research, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1515/cclm-2018-0547DOI Listing
December 2018

Multicenter comparison of imprecision at low concentrations of two regulatory approved high-sensitivity cardiac troponin I assays.

Clin Chim Acta 2018 Nov 10;486:219-220. Epub 2018 Aug 10.

Hamilton Health Sciences, Hamilton, Ontario, Canada; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2018.08.010DOI Listing
November 2018

The importance of tumour marker dual reporting during method transition: PSA high-dose hook effect detected.

Clin Biochem 2018 Nov 1;61:45-46. Epub 2018 Sep 1.

Hamilton Health Sciences, Hamilton, ON, Canada; McMaster University, Hamilton, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00099120183075
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http://dx.doi.org/10.1016/j.clinbiochem.2018.08.011DOI Listing
November 2018

External Quality Assessment Testing Near the Limit of Detection for High-Sensitivity Cardiac Troponin Assays.

Authors:
Peter A Kavsak

Clin Chem 2018 09 29;64(9):1402-1404. Epub 2018 Jun 29.

McMaster University, Hamilton ON, Canada.

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http://dx.doi.org/10.1373/clinchem.2018.288613DOI Listing
September 2018

Differences in total PSA results within and between manufacturers.

Clin Biochem 2018 Sep 20;60:91-92. Epub 2018 Jul 20.

Hamilton Health Sciences, Hamilton, ON, Canada; McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2018.07.009DOI Listing
September 2018

Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department.

CMAJ 2018 08;190(33):E974-E984

Departments of Pathology and Molecular Medicine (Kavsak, Hill, McQueen), Health Research Methods, Evidence and Impact (Ma, Griffith); and Medicine (Clayton); Division of Emergency Medicine (Shortt, Sherbino, Worster); Division of Cardiology (Mehta, Devereaux); Population Health Research Institute (Devereaux), McMaster University, Hamilton, Ont.; Department of General and Interventional Cardiology (Neumann, Ojeda, Westermann, Sörensen, Blankenberg), University Heart Center Hamburg Eppendorf, Hamburg, Germany; Royal Brisbane and Women's Hospital (Cullen, Greenslade, Parsonage), Brisbane, Australia; Christchurch Hospital (Than, Pickering, Troughton, Aldous), Christchurch, New Zealand; Department of Medicine and Christchurch Heart Institute, University of Otago (Richards, Pickering, Troughton, Pemberton), Christchurch, New Zealand; Cardiovascular Research Institute (Richards), National University of Singapore.

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http://dx.doi.org/10.1503/cmaj.180144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102106PMC
August 2018

Macrocomplexes and discordant high-sensitivity cardiac troponin concentrations.

Ann Clin Biochem 2018 Jul 8;55(4):500-504. Epub 2017 Nov 8.

4 Coronary Care Unit, Hamilton General Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.

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http://journals.sagepub.com/doi/10.1177/0004563217734883
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http://dx.doi.org/10.1177/0004563217734883DOI Listing
July 2018

Profile of Roche's Elecsys Troponin T Gen 5 STAT blood test (a high-sensitivity cardiac troponin assay) for diagnosing myocardial infarction in the emergency department.

Expert Rev Mol Diagn 2018 06 18;18(6):481-489. Epub 2018 May 18.

c Division of Emergency Medicine , McMaster University , Hamilton , Ontario , Canada.

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http://dx.doi.org/10.1080/14737159.2018.1476141DOI Listing
June 2018

Should detectable cardiac troponin concentrations in a healthy population be the only criterion for classifying high-sensitivity cardiac troponin assays?

Authors:
Peter A Kavsak

Clin Biochem 2018 Jun 24;56:1-3. Epub 2018 May 24.

McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2018.05.015DOI Listing
June 2018

Analytical validation of cardiac troponin I assays in horses.

J Vet Diagn Invest 2018 Mar 10;30(2):226-232. Epub 2017 Dec 10.

Departments of Population Medicine (Rossi, Pearl, Physick-Sheard) and Biomedical Sciences (Pyle), Laboratory Services Division, University of Guelph, Guelph, Ontario, Canada.

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http://dx.doi.org/10.1177/1040638717747070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505877PMC
March 2018

Comprehensive Age and Sex 99th Percentiles for a High-Sensitivity Cardiac Troponin I Assay.

Clin Chem 2018 02 18;64(2):398-399. Epub 2017 Oct 18.

Department of Pathology and Molecular Medicine McMaster University Hamilton, ON, Canada.

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http://dx.doi.org/10.1373/clinchem.2017.276972DOI Listing
February 2018

Contemporary Emergency Department Management of Patients with Chest Pain: A Concise Review and Guide for the High-Sensitivity Troponin Era.

Can J Cardiol 2018 02 2;34(2):98-108. Epub 2017 Dec 2.

Department of Emergency Medicine, University of Calgary, Calgary, Alberta, Canada; Alberta Health Services, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.11.012DOI Listing
February 2018

Development of biomarker combinations for postoperative acute kidney injury via Bayesian model selection in a multicenter cohort study.

Biomark Res 2018 12;6. Epub 2018 Jan 12.

2Program of Applied Translational Research, Yale University School of Medicine and VA Medical Center, 60 Temple Street, Suite 6C, New Haven, CT 06510 USA.

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http://dx.doi.org/10.1186/s40364-018-0117-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767010PMC
January 2018

Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery.

J Am Soc Nephrol 2017 Dec 14;28(12):3699-3707. Epub 2017 Aug 14.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1681/ASN.2017010055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698070PMC
December 2017

Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: An exploratory analysis of a randomized dietary trial.

Clin Biochem 2017 Dec 25;50(18):1104-1109. Epub 2017 Sep 25.

Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2017.09.021DOI Listing
December 2017

Variability and Error in Cardiac Troponin Testing: An ACLPS Critical Review.

Am J Clin Pathol 2017 Oct;148(4):281-295

Department of Laboratory Medicine, University of Washington, Seattle.

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http://dx.doi.org/10.1093/ajcp/aqx066DOI Listing
October 2017

Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations.

Ann Thorac Surg 2017 Aug 21;104(2):613-620. Epub 2017 Feb 21.

Program of Applied Translational Research, Department of Medicine, Yale School of Medicine, New Haven, Connecticut; Department of Internal Medicine, Veterans Affairs Medical Center, West Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2016.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588689PMC
August 2017

Bleeding impacting mortality after noncardiac surgery: a protocol to establish diagnostic criteria, estimate prognostic importance, and develop and validate a prediction guide in an international prospective cohort study.

CMAJ Open 2017 Aug;5(3):E594-E603

Affiliations: Lilibeth Caberto Kidney Clinical Research Unit (Roshanov, Garg), London Health Sciences Centre, London, Ont.; Department of Medicine (Eikelboom, Tandon, Borges, Kearon, Panju, Sheth, Mizera, Ribas, Devereaux), Department of Surgery (Lamy, Whitlock, de Beer, Winemaker, Pinthus, Simunovic), Department of Health Research Methods, Evidence, and Impact (Lamy, Guyatt, Le Manach, Thabane, Simunovic, Devereaux), Department of Pathology and Molecular Medicine (Crowther, Kavsak), Department of Anesthesia (Spence, VanHelder, Le Manach), Thrombosis and Atherosclerosis Research Institute (Kearon) and School of Nursing (McGillion), Faculty of Health Sciences, McMaster University, Hamilton, Ont.; Population Health Research Institute (Eikelboom, Borges, Lamy, Whitlock, Spence, McGillion, Le Manach, Devereaux), Hamilton, Ont.; Department of Anaesthesia and Perioperative Medicine (Biccard), Groote Schuur Hospital, Observatory, South Africa, and University of Cape Town, South Africa; Department of Intensive Care and Perioperative Medicine (Szczeklik), Jagiellonian University Medical College, Krakow, Poland; Institute for Clinical Evaluative Sciences at Western (Garg), London, Ont.; Faculty of Health and Life Sciences (McGillion), Coventry University, Coventry, United Kingdom; Department of Outcomes Research (Sessler), Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio.; Biostatistics Unit (Thabane), St. Joseph's Healthcare, Hamilton, Ont.

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http://dx.doi.org/10.9778/cmajo.20160106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963363PMC
August 2017

High-Sensitivity Cardiac Troponin Risk Cutoffs for Acute Cardiac Outcomes at Emergency Department Presentation.

Can J Cardiol 2017 07 3;33(7):898-903. Epub 2017 May 3.

Division of Cardiology, and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2017.04.011DOI Listing
July 2017

Total Analytic Error for Low Cardiac Troponin Concentrations (≤10 ng/L) by Use of a High-Sensitivity Cardiac Troponin Assay.

Clin Chem 2017 05 21;63(5):1043-1045. Epub 2017 Mar 21.

Department of Laboratory Medicine University of California San Francisco, CA.

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http://dx.doi.org/10.1373/clinchem.2017.271361DOI Listing
May 2017

Response by Than et al to Letter Regarding Article, "Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction".

Circulation 2017 04;135(16):e923-e924

From Emergency Department, Christchurch Hospital, New Zealand (M.P.T., J.W.P.); Department of Medicine, University of Otago, Christchurch, New Zealand (J.W.P.); Department of Emergency Medicine, Royal Brisbane and Women's Hospital, The University of Queensland and School of Public Health, Queensland University of Technology, Brisbane, Australia (L.C.); and McMaster University, Hamilton, Ontario, Canada (P.A.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027479DOI Listing
April 2017

Simulation Models of Misclassification Error for Single Thresholds of High-Sensitivity Cardiac Troponin I Due to Assay Bias and Imprecision.

Clin Chem 2017 Feb 14;63(2):585-592. Epub 2016 Dec 14.

Department of Pathology and Laboratory Medicine, Saskatoon Health Region, Saskatoon, SK, Canada.

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http://dx.doi.org/10.1373/clinchem.2016.265058DOI Listing
February 2017

Editorial commentary: High-sensitivity cardiac troponin: Like every new tool there is a learning curve.

Authors:
Peter A Kavsak

Trends Cardiovasc Med 2017 01 24;27(1):48-50. Epub 2016 Jun 24.

McMaster University & Juravinski Hospital and Cancer Centre, 711 Concession Street, Hamilton, Ontario, Canada L8V 1C3. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2016.06.008DOI Listing
January 2017

Can 100 papers over 50years tell the story of a scientific journal?

Authors:
Peter A Kavsak

Clin Biochem 2017 Jan 6;50(1-2):1-5. Epub 2016 Dec 6.

McMaster University, Hamilton, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00099120163064
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http://dx.doi.org/10.1016/j.clinbiochem.2016.12.001DOI Listing
January 2017

Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury.

Clin Chem 2017 01 6;63(1):37-44. Epub 2016 Oct 6.

Emergency Physician at Hennepin County Medical Center and Professor of Emergency Medicine at the University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1373/clinchem.2016.257428DOI Listing
January 2017

Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction.

Circulation 2016 Nov 17;134(20):1532-1541. Epub 2016 Oct 17.

From Emergency Department (J.W.P., M.P.T.), and Cardiology Department (S.A.), Christchurch Hospital, Christchurch, New Zealand; Department of Medicine, University of Otago, Christchurch, New Zealand (J.W.P.); Department of Emergency Medicine, Royal Brisbane and Women's Hospital, The University of Queensland and School of Public Health, Queensland University of Technology, Brisbane, Australia (J.H.G., L.C., D.F.); Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, Australia (W.P.); Canterbury Health Laboratories, Christchurch, New Zealand (P.G.); and McMaster University, Hamilton, Ontario, Canada (A.W., P.A.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022677DOI Listing
November 2016

Statistical issues with the determination of the troponin 99th percentile - Not just a problem for troponin?

Clin Biochem 2016 Oct 13;49(15):1105-1106. Epub 2016 Sep 13.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.09.013DOI Listing
October 2016

Reality check for cardiac troponin testing - Sometimes the result is wrong.

Clin Biochem 2016 Oct 17;49(15):1107-1108. Epub 2016 Sep 17.

Australian National University, Canberra, ACT, Australia.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.09.007DOI Listing
October 2016

Adopting 'ng/L' as the units for high-sensitivity cardiac troponin assays and commitment by the entire health-care team could be the key for adopting recommendations.

Ann Clin Biochem 2016 Jul 7;53(Pt 4):516-7. Epub 2016 Jan 7.

McMaster University, Hamilton, Ontario, Canada Hamilton Health Sciences, Hamilton, Ontario, Canada

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http://dx.doi.org/10.1177/0004563215613533DOI Listing
July 2016

Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study.

J Thorac Cardiovasc Surg 2016 Jul 24;152(1):245-251.e4. Epub 2016 Feb 24.

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada; Department of Surgery, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2016.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921336PMC
July 2016

Carryover: More than just a major hangover for the clinical laboratory.

Clin Biochem 2016 Jul 21;49(10-11):735-6. Epub 2016 May 21.

McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.05.020DOI Listing
July 2016

Acceptable Analytical Variation May Exceed High-Sensitivity Cardiac Troponin I Cutoffs in Early Rule-Out and Rule-In Acute Myocardial Infarction Algorithms.

Clin Chem 2016 06 26;62(6):887-9. Epub 2016 Apr 26.

McMaster University and Hamilton Heath Sciences Hamilton, ON, Canada.

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http://dx.doi.org/10.1373/clinchem.2016.255448DOI Listing
June 2016

The International Committee of Medical Journal Editors proposal for sharing clinical trial data and the possible implications for the peer review process.

Authors:
Peter A Kavsak

Ann Transl Med 2016 Mar;4(6):115

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.21037/atm.2016.02.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828733PMC
March 2016

Error detection in routine clinical chemistry laboratory test results.

Clin Biochem 2016 Feb 19;49(3):199-200. Epub 2016 Jan 19.

McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.01.013DOI Listing
February 2016

A STAR-Document for those interested in evaluating diagnostic research studies.

Authors:
Peter A Kavsak

Ann Transl Med 2016 Feb;4(3):45

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.12.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739994PMC
February 2016

Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer.

Heliyon 2016 Jan 22;2(1):e00059. Epub 2016 Jan 22.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1016/j.heliyon.2015.e00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945896PMC
January 2016

Negative interference of N-acetyl cysteine (NAC) on selected chemistries on the Abbott architect platform.

Clin Chim Acta 2015 Dec 3;451(Pt B):219-21. Epub 2015 Oct 3.

Department of Pathology and Molecular Medicine McMaster University, Hamilton, ON, Canada; Juravinski Hospital and Cancer Centre, Hamilton Health Sciences, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2015.09.032DOI Listing
December 2015

Clinical Biochemistry 2015 year in review: Material not for the faint of heart.

Clin Biochem 2015 Dec 18;48(18):1211-2. Epub 2015 Nov 18.

University of North Carolina, Chapel Hill, NC, United States.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.11.013DOI Listing
December 2015

Troponin in Stable Ischemic Heart Disease and Diabetes.

Authors:
Peter A Kavsak

N Engl J Med 2015 11;373(20):1976-7

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http://dx.doi.org/10.1056/NEJMc1511645DOI Listing
November 2015

Hospital Admission and Myocardial Injury Prevalence after the Clinical Introduction of a High-Sensitivity Cardiac Troponin I Assay.

Clin Chem 2015 Sep 16;61(9):1209-10. Epub 2015 Jul 16.

Hamilton Health Sciences Division of Emergency Medicine Department of Medicine McMaster University Hamilton, ON, Canada.

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http://dx.doi.org/10.1373/clinchem.2015.243345DOI Listing
September 2015

Sex-specific cutoffs for cardiac troponin using high-sensitivity assays--Is there clinical equipoise?

Clin Biochem 2015 Aug 8;48(12):749-50. Epub 2015 Jul 8.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.07.005DOI Listing
August 2015

What is in that sample ? A pertinent question when assessing quality for patient laboratory results and beyond.

Authors:
Peter A Kavsak

Clin Biochem 2015 May 16;48(7-8):465-6. Epub 2015 Apr 16.

Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2015.04.010DOI Listing
May 2015