Peter K Vogt

Peter K Vogt

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Cooperates with to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9.

Cancers (Basel) 2019 Oct 24;11(11). Epub 2019 Oct 24.

Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.3390/cancers11111634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896067PMC
October 2019

From Viruses to Genes to Cells.

Authors:
Peter K Vogt

Annu Rev Virol 2019 09;6(1):31-47

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037, USA; email:

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http://dx.doi.org/10.1146/annurev-virology-092818-015828DOI Listing
September 2019

The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda.

Authors:
Peter K Vogt

Viruses 2019 01 18;11(1). Epub 2019 Jan 18.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.3390/v11010080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360021PMC
January 2019

Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases - potentially novel therapeutic targets.

Expert Opin Ther Targets 2018 10 24;22(10):869-877. Epub 2018 Sep 24.

a Department of Molecular Medicine , The Scripps Research Institute , La Jolla , CA , USA.

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http://dx.doi.org/10.1080/14728222.2018.1522302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197473PMC
October 2018

Synthetic molecules for disruption of the MYC protein-protein interface.

Bioorg Med Chem 2018 08 11;26(14):4234-4239. Epub 2018 Jul 11.

Department of Chemistry, BCC-582, 10550 N Torrey Pines Road, The Scripps Research Institute, La Jolla, CA 92037, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214403PMC
August 2018

Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.

Oncotarget 2017 Aug 3;8(34):55863-55876. Epub 2017 Aug 3.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, San Diego, CA, USA.

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http://www.oncotarget.com/fulltext/19866
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http://dx.doi.org/10.18632/oncotarget.19866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593529PMC
August 2017

MYCNOS functions as an antisense RNA regulating MYCN.

RNA Biol 2015 ;12(8):893-9

a Molecular and Experimental Medicine ; The Scripps Research Institute ; La Jolla , CA USA.

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http://dx.doi.org/10.1080/15476286.2015.1063773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615167PMC
May 2016

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

Cell 2016 Apr;165(3):643-55

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006944PMC
April 2016

MINCR is not a MYC-induced lncRNA.

Proc Natl Acad Sci U S A 2016 Feb 25;113(5):E496-7. Epub 2016 Jan 25.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1519903113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747730PMC
February 2016

A butterfly effect in cancer.

Mol Cell Oncol 2016 Jan 14;3(1):e1029063. Epub 2015 Apr 14.

The Scripps Research Institute, Chemical Physiology ; La Jolla, CA USA.

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http://dx.doi.org/10.1080/23723556.2015.1029063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845179PMC
January 2016

Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR.

Nat Protoc 2015 Aug 16;10(8):1198-211. Epub 2015 Jul 16.

1] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. [2] School of Biotechnology and Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1038/nprot.2015.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790731PMC
August 2015

A brave new MYC-amplified world.

Aging (Albany NY) 2015 Jul;7(7):459-60

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543031PMC
http://dx.doi.org/10.18632/aging.100777DOI Listing
July 2015

MYC regulates the non-coding transcriptome.

Oncotarget 2014 Dec;5(24):12543-54

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350361PMC
http://dx.doi.org/10.18632/oncotarget.3033DOI Listing
December 2014

Oncogenic activity of the regulatory subunit p85β of phosphatidylinositol 3-kinase (PI3K).

Proc Natl Acad Sci U S A 2014 Nov 10;111(47):16826-9. Epub 2014 Nov 10.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037

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http://www.pnas.org/lookup/doi/10.1073/pnas.1420281111
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http://dx.doi.org/10.1073/pnas.1420281111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250105PMC
November 2014

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.

Oncotarget 2014 Oct;5(19):8869-78

Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253403PMC
http://dx.doi.org/10.18632/oncotarget.2588DOI Listing
October 2014

RICHARD BING: 12 OCTOBER 1909 - 8 NOVEMBER 2010.

Authors:
Peter K Vogt

Proc Am Philos Soc 2014 Sep;158(3):287-91

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September 2014

Inhibitor of MYC identified in a Kröhnke pyridine library.

Proc Natl Acad Sci U S A 2014 Aug 11;111(34):12556-61. Epub 2014 Aug 11.

Chemistry, The Scripps Research Institute, La Jolla, CA 92037; and

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http://dx.doi.org/10.1073/pnas.1319488111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151726PMC
August 2014

An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells.

Mol Ther Nucleic Acids 2013 Jul 9;2:e104. Epub 2013 Jul 9.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1038/mtna.2013.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731886PMC
July 2013

Retroviral oncogenes: a historical primer.

Authors:
Peter K Vogt

Nat Rev Cancer 2012 09 17;12(9):639-48. Epub 2012 Aug 17.

The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428493PMC
http://dx.doi.org/10.1038/nrc3320DOI Listing
September 2012

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

Cell Cycle 2012 Jun 15;11(12):2391-401. Epub 2012 Jun 15.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/cc.20683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383597PMC
June 2012

Progress in breast cancer research.

Proc Natl Acad Sci U S A 2012 Feb 13;109(8):2715-7. Epub 2012 Feb 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.1201091109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286956PMC
February 2012

100 years of Rous sarcoma virus.

J Exp Med 2011 Nov;208(12):2351-5

Division of Infection and Immunity, University College London, WC1E 6BT, England, UK.

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http://dx.doi.org/10.1084/jem.20112160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256973PMC
November 2011

PI3K and STAT3: a new alliance.

Cancer Discov 2011 Nov;1(6):481-6

The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279943PMC
November 2011

Essential role of Stat3 in PI3K-induced oncogenic transformation.

Proc Natl Acad Sci U S A 2011 Aug 25;108(32):13247-52. Epub 2011 Jul 25.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1110486108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156164PMC
August 2011

Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.

J Am Chem Soc 2011 Jul 15;133(26):10184-94. Epub 2011 Jun 15.

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja201878v
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http://dx.doi.org/10.1021/ja201878vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134394PMC
July 2011

Phosphorylation of AKT: a mutational analysis.

Oncotarget 2011 Jun;2(6):467-76

The Scripps Research Institute, Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139455PMC
http://dx.doi.org/10.18632/oncotarget.293DOI Listing
June 2011

Protein expression profiles of C3H 10T1/2 murine fibroblasts and of isogenic cells transformed by the H1047R mutant of phosphoinositide 3-kinase (PI3K).

Cell Cycle 2011 Mar 15;10(6):971-6. Epub 2011 Mar 15.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100876PMC
http://dx.doi.org/10.4161/cc.10.6.15077DOI Listing
March 2011

PI3K p110β: more tightly controlled or constitutively active?

Authors:
Peter K Vogt

Mol Cell 2011 Mar;41(5):499-501

The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.02.017DOI Listing
March 2011

PI3K: from the bench to the clinic and back.

Curr Top Microbiol Immunol 2010 ;347:1-19

University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1007/82_2010_65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954281PMC
January 2011

Phosphatidylinositol 3-kinase: the oncoprotein.

Curr Top Microbiol Immunol 2010 ;347:79-104

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://link.springer.com/content/pdf/10.1007%2F82_2010_80.pd
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http://link.springer.com/10.1007/82_2010_80
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http://dx.doi.org/10.1007/82_2010_80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955792PMC
January 2011

Cell entry by non-enveloped viruses.

Curr Top Microbiol Immunol 2010 ;343:v-vii

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January 2011

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.

Proc Natl Acad Sci U S A 2010 Aug 16;107(35):15547-52. Epub 2010 Aug 16.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1009652107
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http://dx.doi.org/10.1073/pnas.1009652107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932613PMC
August 2010

Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.

Int J Cancer 2010 Jul;127(1):239-44

The Scripps Research Institute, Molecular and Experimental Medicine, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/ijc.25012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862841PMC
July 2010

Long antisense non-coding RNAs and their role in transcription and oncogenesis.

Cell Cycle 2010 Jul;9(13):2544-7

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/cc.9.13.12145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040850PMC
July 2010

Therapeutic Targeting of Myc.

Genes Cancer 2010 Jun;1(6):650-659

Section of Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601910377494
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http://dx.doi.org/10.1177/1947601910377494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995947PMC
June 2010

Smooth muscle α-actin is a direct target of PLZF: effects on the cytoskeleton and on susceptibility to oncogenic transformation.

Oncotarget 2010 May;1(1):9-21

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.oncotarget.com/fulltext/104
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903758PMC
http://dx.doi.org/10.18632/oncotarget.104DOI Listing
May 2010

Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.

Cell Cycle 2010 Feb;9(3):596-600

Department of Molecular and Experimental Medicine, The Scripps Research Institute; La Jolla, CA. USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.9.3.10599
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835815PMC
http://dx.doi.org/10.4161/cc.9.3.10599DOI Listing
February 2010

Oncogenes and the revolution in cancer research: homage to hidesaburo hanafusa (1929-2009).

Authors:
Peter K Vogt

Genes Cancer 2010 Jan;1(1):6-11

The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, CA, USA.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601909356102
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http://dx.doi.org/10.1177/1947601909356102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092171PMC
January 2010

Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt.

Int J Cancer 2009 Dec;125(12):2863-70

The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://doi.wiley.com/10.1002/ijc.24748
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http://dx.doi.org/10.1002/ijc.24748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767458PMC
December 2009

Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.

Bioorg Med Chem Lett 2009 Nov 17;19(21):6038-41. Epub 2009 Sep 17.

Department of Molecular and Experimental Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767179PMC
November 2009

Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein.

Int J Cancer 2009 Oct;125(7):1558-65

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/ijc.24449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721905PMC
October 2009

Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function.

Mol Pharmacol 2009 Sep 4;76(3):491-502. Epub 2009 Jun 4.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1124/mol.109.054858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730382PMC
September 2009

Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation.

Mol Cancer Res 2009 Jul 7;7(7):1132-8. Epub 2009 Jul 7.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767251PMC
July 2009

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

J Am Chem Soc 2009 Apr;131(15):5564-72

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja810025g
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http://dx.doi.org/10.1021/ja810025gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765553PMC
April 2009

Akt demoted in glioblastoma.

Sci Signal 2009 Apr 21;2(67):pe26. Epub 2009 Apr 21.

The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scisignal.267pe26DOI Listing
April 2009

Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation.

J Am Chem Soc 2009 Mar;131(9):3342-8

Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, usa.

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http://pubs.acs.org/doi/abs/10.1021/ja809083d
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http://dx.doi.org/10.1021/ja809083dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787879PMC
March 2009

PI 3-kinase and cancer: changing accents.

Curr Opin Genet Dev 2009 Feb;19(1):12-7

Department of Molecular and Experimental Medicine, Division of Oncovirology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.gde.2008.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746202PMC
February 2009

A humble chicken virus that changed biology and medicine.

Authors:
Peter K Vogt

Lancet Oncol 2009 Jan;10(1):96

Scripps Research Institute, La Jolla, California, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S147020450870338
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http://dx.doi.org/10.1016/S1470-2045(08)70338-3DOI Listing
January 2009

Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike.

Authors:
Peter K Vogt

Cancer Cell 2008 Aug;14(2):107-8

Division of Oncovirology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080800231
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http://dx.doi.org/10.1016/j.ccr.2008.07.008DOI Listing
August 2008

Biochemical and biological characterization of tumor-associated mutations of p110alpha.

Methods Enzymol 2008 ;438:291-305

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)38020-8DOI Listing
June 2008

Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization.

Oncol Rep 2008 Mar;19(3):825-30

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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March 2008

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2652-7. Epub 2008 Feb 11.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037.

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http://dx.doi.org/10.1073/pnas.0712169105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268191PMC
February 2008

Cancer-specific mutations in phosphatidylinositol 3-kinase.

Trends Biochem Sci 2007 Jul 11;32(7):342-9. Epub 2007 Jun 11.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.tibs.2007.05.005DOI Listing
July 2007

Rare cancer-specific mutations in PIK3CA show gain of function.

Proc Natl Acad Sci U S A 2007 Mar 21;104(13):5569-74. Epub 2007 Mar 21.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0701005104
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http://dx.doi.org/10.1073/pnas.0701005104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838453PMC
March 2007

A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability.

J Cell Physiol 2006 Nov;209(2):261-5

Department of Microbiology, Immunology and Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506-9300, USA.

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http://dx.doi.org/10.1002/jcp.20749DOI Listing
November 2006

Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo.

Proc Natl Acad Sci U S A 2006 Aug 8;103(33):12371-6. Epub 2006 Aug 8.

Department of Chemistry and The Skaggs Institute for Chemical Biology and Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://daais.sinica.edu.tw/download/publication_list/en/90.p
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http://www.pnas.org/cgi/doi/10.1073/pnas.0605418103
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http://dx.doi.org/10.1073/pnas.0605418103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567886PMC
August 2006

PI 3-kinases: hidden potentials revealed.

Cell Cycle 2006 May 1;5(9):946-9. Epub 2006 May 1.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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May 2006

Kinase inhibitors: vice becomes virtue.

Cancer Cell 2006 May;9(5):327-8

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.05.002DOI Listing
May 2006

A credit-card library approach for disrupting protein-protein interactions.

Bioorg Med Chem 2006 Apr 27;14(8):2660-73. Epub 2005 Dec 27.

Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.11.052DOI Listing
April 2006

Phosphoinositide 3-kinase: from viral oncoprotein to drug target.

Virology 2006 Jan;344(1):131-8

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road BCC 239, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.virol.2005.09.027DOI Listing
January 2006

Cancer-specific mutations in PIK3CA are oncogenic in vivo.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1475-9. Epub 2006 Jan 23.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0510857103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360603PMC
January 2006

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1289-94. Epub 2006 Jan 23.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 239, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0510772103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360601PMC
January 2006

Oncogenic PI3K deregulates transcription and translation.

Nat Rev Cancer 2005 Dec;5(12):921-9

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nrc1753DOI Listing
December 2005

Jun: stealth, stability, and transformation.

Mol Cell 2005 Aug;19(4):432-3

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.08.004DOI Listing
August 2005

Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

Cell Cycle 2005 Jul 3;4(7):908-13. Epub 2005 Jul 3.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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July 2005

Mutated PI 3-kinases: cancer targets on a silver platter.

Cell Cycle 2005 Apr 7;4(4):578-81. Epub 2005 Apr 7.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.4161/cc.4.4.1586DOI Listing
April 2005

Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.

Mol Cell Biol 2005 Mar;25(6):2095-106

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Rd., BCC239, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1128/MCB.25.6.2095-2106.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1061623PMC
March 2005

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

Proc Natl Acad Sci U S A 2005 Jan 12;102(3):802-7. Epub 2005 Jan 12.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0408864102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545580PMC
January 2005

Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside).

Proc Natl Acad Sci U S A 2004 Nov 8;101(46):16204-9. Epub 2004 Nov 8.

Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122-4302, USA.

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http://dx.doi.org/10.1073/pnas.0407297101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC528971PMC
November 2004

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins.

Proc Natl Acad Sci U S A 2004 Sep 1;101(37):13613-7. Epub 2004 Sep 1.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC518802PMC
September 2004

v-Jun targets showing an expression pattern that correlates with the transformed cellular phenotype.

Oncogene 2004 Jul;23(33):5703-6

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/sj.onc.1207737DOI Listing
July 2004

Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides.

J Am Chem Soc 2004 Apr;126(15):4774-5

Department of Chemistry and the Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/ja0495359DOI Listing
April 2004

An essential role for protein synthesis in oncogenic cellular transformation.

Oncogene 2004 Apr;23(18):3145-50

Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA.

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http://dx.doi.org/10.1038/sj.onc.1207550DOI Listing
April 2004

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway.

Proc Natl Acad Sci U S A 2003 Oct 6;100(21):12384-9. Epub 2003 Oct 6.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.2135336100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC218767PMC
October 2003

MafA has strong cell transforming ability but is a weak transactivator.

Oncogene 2003 Sep;22(39):7882-90

Department of Molecular and Experimental Medicine, BCC239, The Scripps Research Institute, La Jolla, CA, 92037, USA.

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http://www.nature.com/articles/1206526
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September 2003

Artificial oncoproteins: modified versions of the yeast bZip protein GCN4 induce cellular transformation.

Oncogene 2003 Sep;22(39):7931-41

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.nature.com/articles/1206527
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September 2003

The C-terminal region of cellular Qin oligomerizes: correlation with oncogenic transformation and transcriptional repression.

Oncogene 2003 Apr;22(13):1908-15

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.nature.com/articles/1206307
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April 2003

Partial oncogenic transformation of chicken embryo fibroblasts by Jun dimerization protein 2, a negative regulator of TRE- and CRE-dependent transcription.

Oncogene 2003 Apr;22(14):2151-9

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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April 2003

Binding of the corepressor TLE1 to Qin enhances Qin-mediated transformation of chicken embryo fibroblasts.

Oncogene 2003 Mar;22(12):1749-57

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/sj.onc.1206308DOI Listing
March 2003

Oncogenic transformation by beta-catenin: deletion analysis and characterization of selected target genes.

Oncogene 2002 Oct;21(46):6983-91

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, CA 92037, USA.

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http://dx.doi.org/10.1038/sj.onc.1205796DOI Listing
October 2002

Fortuitous convergences: the beginnings of JUN.

Authors:
Peter K Vogt

Nat Rev Cancer 2002 Jun;2(6):465-9

Division of Oncovirology, The Scripps Research Institute, 10550 N. Torrey Pines Road BCC239, La Jolla, California 92037, USA.

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http://www.nature.com/articles/nrc818
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June 2002

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.

Proc Natl Acad Sci U S A 2002 Mar 12;99(6):3830-5. Epub 2002 Mar 12.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.062036999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122609PMC
March 2002