Peter K Rogan

Peter K Rogan

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Peter K Rogan

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Pan-cancer repository of validated natural and cryptic mRNA splicing mutations.

F1000Res 2018 7;7:1908. Epub 2018 Dec 7.

CytoGnomix Inc., London, Ontario, N5X 3X5, Canada.

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http://dx.doi.org/10.12688/f1000research.17204.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544075.3PMC
November 2019

Multigene signatures of responses to chemotherapy derived by biochemically-inspired machine learning.

Authors:
Peter K Rogan

Mol Genet Metab 2019 Sep - Oct;128(1-2):45-52. Epub 2019 Aug 19.

Departments of Biochemistry, Oncology, and Computer Science, University of Western Ontario, London, ON N6A 2C1, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2019.08.005DOI Listing
August 2019

RADIATION DOSE ESTIMATION BY COMPLETELY AUTOMATED INTERPRETATION OF THE DICENTRIC CHROMOSOME ASSAY.

Radiat Prot Dosimetry 2019 Jan 9. Epub 2019 Jan 9.

CytoGnomix, Inc., POB 27052, 60 N. Centre Rd, London, ON, Canada.

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http://dx.doi.org/10.1093/rpd/ncy282DOI Listing
January 2019

Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning.

Signal Transduct Target Ther 2019 11;4. Epub 2019 Jan 11.

1Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 2C1 Canada.

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http://www.nature.com/articles/s41392-018-0034-5
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http://dx.doi.org/10.1038/s41392-018-0034-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329797PMC
January 2019

Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations.

F1000Res 2018 14;7:1933. Epub 2018 Dec 14.

Computer Science, University of Western Ontario, London, Ontario, N6A 5B7, Canada.

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http://dx.doi.org/10.12688/f1000research.17363.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464064.2PMC
December 2018

Atypical Clinical Findings in Prader-Willi Syndrome Patients: Analysis of Survey Data.

Prader Willi Perspect 1996 Apr-Jun;4(3):3-6

Department of Pediatrics, College of Medicine, Pennsylvania State University Hershey, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128164PMC
September 2018

Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning.

F1000Res 2018 27;7:233. Epub 2018 Feb 27.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 2C1, Canada.

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http://dx.doi.org/10.12688/f1000research.14048.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981198.2PMC
February 2018

The Clinical Significance of Occult Gastrointestinal Primary Tumours in Metastatic Cancer: A Population Retrospective Cohort Study.

Cancer Res Treat 2018 Jan 21;50(1):183-194. Epub 2017 Mar 21.

Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

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http://dx.doi.org/10.4143/crt.2016.532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784645PMC
January 2018

Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia.

Breast Cancer Res Treat 2017 Oct 29;165(3):687-697. Epub 2017 Jun 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, NCI/NIH, Bethesda, Rockville, MD, USA.

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http://dx.doi.org/10.1007/s10549-017-4356-8DOI Listing
October 2017

Accurate cytogenetic biodosimetry through automated dicentric chromosome curation and metaphase cell selection.

F1000Res 2017 9;6:1396. Epub 2017 Aug 9.

Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.

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https://f1000research.com/articles/6-1396/v1
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http://dx.doi.org/10.12688/f1000research.12226.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583746PMC
August 2017

Discovery and validation of information theory-based transcription factor and cofactor binding site motifs.

Nucleic Acids Res 2017 03;45(5):e27

Department of Computer Science, Western University, London, Ontario, N6A 5B7, Canada.

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https://academic.oup.com/nar/article/45/5/e27/2605664
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http://dx.doi.org/10.1093/nar/gkw1036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389469PMC
March 2017

Radiation Dose Estimation by Automated Cytogenetic Biodosimetry.

Radiat Prot Dosimetry 2016 Dec 13;172(1-3):207-217. Epub 2016 Jul 13.

Cytognomix Inc., 60 North Centre Rd., Box 27052, London, Ontario N5X 3X5, Canada.

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http://dx.doi.org/10.1093/rpd/ncw161DOI Listing
December 2016

Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.

Hum Mutat 2016 07 18;37(7):640-52. Epub 2016 Mar 18.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.22972DOI Listing
July 2016

Automated discrimination of dicentric and monocentric chromosomes by machine learning-based image processing.

Microsc Res Tech 2016 May 1;79(5):393-402. Epub 2016 Mar 1.

Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1002/jemt.22642DOI Listing
May 2016

A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer.

BMC Med Genomics 2016 Apr 11;9:19. Epub 2016 Apr 11.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 2C1, Canada.

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http://dx.doi.org/10.1186/s12920-016-0178-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828881PMC
April 2016

Genomic signatures for paclitaxel and gemcitabine resistance in breast cancer derived by machine learning.

Mol Oncol 2016 Jan 22;10(1):85-100. Epub 2015 Aug 22.

Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Cytognomix Inc., London, ON, Canada; Department of Computer Science, University of Western Ontario, London, ON, Canada; Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528934PMC
January 2016

Identification and survival outcomes of a cohort of patients with cancer of unknown primary in Ontario, Canada.

Acta Oncol 2015 Nov 31;54(10):1781-7. Epub 2015 Mar 31.

a Department of Epidemiology and Biostatistics , Western University , London , Ontario , Canada.

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http://www.tandfonline.com/doi/full/10.3109/0284186X.2015.10
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http://dx.doi.org/10.3109/0284186X.2015.1020965DOI Listing
November 2015

FANCM c.5791C>T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor.

Authors:
Paolo Peterlongo Irene Catucci Mara Colombo Laura Caleca Eliseos Mucaki Massimo Bogliolo Maria Marin Francesca Damiola Loris Bernard Valeria Pensotti Sara Volorio Valentina Dall'Olio Alfons Meindl Claus Bartram Christian Sutter Harald Surowy Valérie Sornin Marie-Gabrielle Dondon Séverine Eon-Marchais Dominique Stoppa-Lyonnet Nadine Andrieu Olga M Sinilnikova Gillian Mitchell Paul A James Ella Thompson Marina Marchetti Cristina Verzeroli Carmen Tartari Gabriele Lorenzo Capone Anna Laura Putignano Maurizio Genuardi Veronica Medici Isabella Marchi Massimo Federico Silvia Tognazzo Laura Matricardi Simona Agata Riccardo Dolcetti Lara Della Puppa Giulia Cini Viviana Gismondi Valeria Viassolo Chiara Perfumo Maria Antonietta Mencarelli Margherita Baldassarri Bernard Peissel Gaia Roversi Valentina Silvestri Piera Rizzolo Francesca Spina Caterina Vivanet Maria Grazia Tibiletti Maria Adelaide Caligo Gaetana Gambino Stefania Tommasi Brunella Pilato Carlo Tondini Chiara Corna Bernardo Bonanni Monica Barile Ana Osorio Javier Benitez Luisa Balestrino Laura Ottini Siranoush Manoukian Marco A Pierotti Alessandra Renieri Liliana Varesco Fergus J Couch Xianshu Wang Peter Devilee Florentine S Hilbers Christi J van Asperen Alessandra Viel Marco Montagna Laura Cortesi Orland Diez Judith Balmaña Jan Hauke Rita K Schmutzler Laura Papi Miguel Angel Pujana Conxi Lázaro Anna Falanga Kenneth Offit Joseph Vijai Ian Campbell Barbara Burwinkel Anders Kvist Hans Ehrencrona Sylvie Mazoyer Sara Pizzamiglio Paolo Verderio Jordi Surralles Peter K Rogan Paolo Radice

Hum Mol Genet 2015 Sep 30;24(18):5345-55. Epub 2015 Jun 30.

IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine.

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http://dx.doi.org/10.1093/hmg/ddv251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550823PMC
September 2015

Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes.

Mol Cytogenet 2015 13;8:65. Epub 2015 Aug 13.

Department of Pathology and Laboratory Medicine, University of Western Ontario, London, N6A 5C1 ON Canada ; Cytognomix, Inc., London, N6G 4X8 ON Canada.

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http://www.molecularcytogenetics.org/content/8/1/65
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http://dx.doi.org/10.1186/s13039-015-0159-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535684PMC
August 2015

Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis.

F1000Res 2014 18;3:282. Epub 2014 Nov 18.

Departments of Biochemistry and Computer Science, Western University, London, ON, N6A 2C1, Canada.

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http://dx.doi.org/10.12688/f1000research.5654.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329672PMC
February 2015

Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes.

Mol Cytogenet 2014 19;7(1):70. Epub 2014 Nov 19.

Department of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 5C1 Canada ; Cytognomix, Inc, London, ON N6G 4X8 Canada.

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http://dx.doi.org/10.1186/s13039-014-0070-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269072PMC
December 2014

Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer.

Sci Rep 2014 Nov 14;4:7063. Epub 2014 Nov 14.

1] Department of Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada [2] Department of Computer Science, University of Western Ontario, London, Ontario, N6A 5B7, Canada.

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http://www.nature.com/articles/srep07063
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http://dx.doi.org/10.1038/srep07063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231324PMC
November 2014

Validation of predicted mRNA splicing mutations using high-throughput transcriptome data.

F1000Res 2014 13;3. Epub 2014 Jan 13.

Department of Computer Science, University of Western Ontario, London, Ontario, N6A 5B7, Canada ; Department of Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada ; Cytognomix, Inc., London, Ontario, N6G 4X8, Canada.

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http://f1000research.com/articles/3-8/v2
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http://dx.doi.org/10.12688/f1000research.3-8.v2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983938PMC
April 2014

Best practices for evaluating mutation prediction methods.

Hum Mutat 2013 Nov 10;34(11):1581-2. Epub 2013 Sep 10.

Departments of Biochemistry, Schulich School of Medicine and Dentistry, Western University, Ontario, Canada; Department of Computer Science, Faculty of Science, Western University, Ontario, Canada.

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http://dx.doi.org/10.1002/humu.22401DOI Listing
November 2013

Intensity integrated Laplacian-based thickness measurement for detecting human metaphase chromosome centromere location.

IEEE Trans Biomed Eng 2013 Jul 20;60(7):2005-13. Epub 2013 Feb 20.

Department of Electrical and Computer Engineering, Western University, London, ON N6A 5B9, Canada.

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http://dx.doi.org/10.1109/TBME.2013.2248008DOI Listing
July 2013

Prediction of mutant mRNA splice isoforms by information theory-based exon definition.

Hum Mutat 2013 Apr 21;34(4):557-65. Epub 2013 Feb 21.

Department of Biochemistry, Western University, London, Ontario, Canada.

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http://doi.wiley.com/10.1002/humu.22277
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http://dx.doi.org/10.1002/humu.22277DOI Listing
April 2013

Expanding probe repertoire and improving reproducibility in human genomic hybridization.

Nucleic Acids Res 2013 Apr 1;41(7):e81. Epub 2013 Feb 1.

Department of Biochemistry, University of Western Ontario, London, Ontario N6A 3K7, Canada.

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http://dx.doi.org/10.1093/nar/gkt048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627568PMC
April 2013

Interpretation, stratification and evidence for sequence variants affecting mRNA splicing in complete human genome sequences.

Genomics Proteomics Bioinformatics 2013 Apr 14;11(2):77-85. Epub 2013 Mar 14.

Department of Computer Science, Middlesex College, The University of Western Ontario, London, ON N6A 5B7, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S16720229130002
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http://dx.doi.org/10.1016/j.gpb.2013.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357664PMC
April 2013

Structural and genic characterization of stable genomic regions in breast cancer: relevance to chemotherapy.

Mol Oncol 2012 Jun 15;6(3):347-59. Epub 2012 Jan 15.

Department of Pathology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1016/j.molonc.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528331PMC
June 2012

Context-based FISH localization of genomic rearrangements within chromosome 15q11.2q13 duplicons.

Mol Cytogenet 2011 Aug 8;4(1):15. Epub 2011 Aug 8.

Department of Biochemistry, University of Western Ontario, Laboratories of Genome Bioinformatics and Genomic Disorders, 1151 Richmond Street, London, ON, Canada.

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http://dx.doi.org/10.1186/1755-8166-4-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171312PMC
August 2011

Comprehensive prediction of mRNA splicing effects of BRCA1 and BRCA2 variants.

Hum Mutat 2011 Jul 5;32(7):735-42. Epub 2011 May 5.

Department of Biochemistry, SchulichSchool of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1002/humu.21513DOI Listing
July 2011

Usher syndrome splicing variants evaluated in nasal epithelial cells.

Authors:
Peter K Rogan

Hum Mutat 2010 Jun;31(6)

University of Western Ontario.

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http://dx.doi.org/10.1002/humu.21291DOI Listing
June 2010

Deeper understanding of unclassified intronic variants and ESEs.

Authors:
Peter K Rogan

Hum Mutat 2010 Apr;31(4)

University of Western Ontario.

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http://dx.doi.org/10.1002/humu.21247DOI Listing
April 2010

Dendrimer FISH detection of single-copy intervals in acute promyelocytic leukemia.

Mol Cell Probes 2006 Apr 7;20(2):114-20. Epub 2006 Feb 7.

Department of Chemistry, University of Kansas, Lawrence, 66045, USA.

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http://dx.doi.org/10.1016/j.mcp.2005.11.005DOI Listing
April 2006

Determination of genomic copy number with quantitative microsphere hybridization.

Hum Mutat 2006 Apr;27(4):376-86

Laboratory of Genomic Disorders, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri 64108, USA.

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http://dx.doi.org/10.1002/humu.20312DOI Listing
April 2006

BIPAD: a web server for modeling bipartite sequence elements.

BMC Bioinformatics 2006 Feb 17;7:76. Epub 2006 Feb 17.

Laboratory of Human Molecular Genetics, Children's Mercy Hospital & Clinics, Kansas City, MO 64108, USA.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-7-76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1388241PMC
February 2006

Splice-site contribution in alternative splicing of PLP1 and DM20: molecular studies in oligodendrocytes.

Hum Mutat 2006 Jan;27(1):69-77

Nemours Biomedical Research, Alfred I. duPont Hospital for Children, Nemours Children's Clinic, Wilmington, Delaware, USA.

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http://doi.wiley.com/10.1002/humu.20276
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http://dx.doi.org/10.1002/humu.20276DOI Listing
January 2006

Distortion of quantitative genomic and expression hybridization by Cot-1 DNA: mitigation of this effect.

Nucleic Acids Res 2005 Dec 14;33(22):e191. Epub 2005 Dec 14.

Laboratories of Genomic Disorders, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, KS, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gni190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316118PMC
December 2005

Normal and abnormal mechanisms of gene splicing and relevance to inherited skin diseases.

J Dermatol Sci 2005 Nov 27;40(2):73-84. Epub 2005 Jul 27.

Genetic Skin Disease Group, St. John's Institute of Dermatology, The Guy's, King's College and St. Thomas' Hospitals' Medical School, St. Thomas Hospital, Lambeth Palace Road, London SE1 7EH, England, UK.

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http://dx.doi.org/10.1016/j.jdermsci.2005.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351063PMC
November 2005

A variant form of Oguchi disease mapped to 13q34 associated with partial deletion of GRK1 gene.

Mol Vis 2005 Nov 14;11:977-85. Epub 2005 Nov 14.

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1860, USA.

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November 2005

Tandem machine learning for the identification of genes regulated by transcription factors.

BMC Bioinformatics 2005 Aug 22;6:204. Epub 2005 Aug 22.

School of Computing and Engineering, University Of Missouri-Kansas City, Kansas City, Missouri, USA.

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http://dx.doi.org/10.1186/1471-2105-6-204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208855PMC
August 2005

Fish versus aCGH.

MLO Med Lab Obs 2005 May;37(5):8; author reply 8, 12

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May 2005

Automated splicing mutation analysis by information theory.

Hum Mutat 2005 Apr;25(4):334-42

Laboratory of Human Molecular Genetics, Children's Mercy Hospital and Clinics, University of Missouri-Kansas City, Kansas City, Missouri, USA.

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http://doi.wiley.com/10.1002/humu.20151
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http://dx.doi.org/10.1002/humu.20151DOI Listing
April 2005

Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation.

J Biol Chem 2004 Nov 16;279(45):46779-86. Epub 2004 Aug 16.

Section of Developmental Pharmacology and Experimental Therapeutics, Division of Pediatric Clinical Pharmacology and Medical Toxicology and Laboratory of Human Molecular Genetics, Children's Mercy Hospital and Clinics, Kansas City, Missouri 64108, USA.

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http://dx.doi.org/10.1074/jbc.M408395200DOI Listing
November 2004

Bipartite pattern discovery by entropy minimization-based multiple local alignment.

Nucleic Acids Res 2004 23;32(17):4979-91. Epub 2004 Sep 23.

Laboratory of Human Molecular Genetics, Children's Mercy Hospital & Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1093/nar/gkh825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521645PMC
September 2004

High resolution definition of chromosome abnormalities with probes designed from genome sequences.

Discov Med 2004 Apr;4(21):99-101

Laboratories of Human Molecular Genetics and Genomic Disorders, Children's Mercy Hospitals and Clinics, University of Missouri, Kansas City, Missouri 64108, USA.

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April 2004

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.

J Pharmacol Exp Ther 2003 Dec 9;307(3):906-22. Epub 2003 Oct 9.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.103.05486
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http://dx.doi.org/10.1124/jpet.103.054866DOI Listing
December 2003

Sequence-based, in situ detection of chromosomal abnormalities at high resolution.

Am J Med Genet A 2003 Sep;121A(3):245-57

Children's Mercy Hospital and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.

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http://doi.wiley.com/10.1002/ajmg.a.20123
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http://dx.doi.org/10.1002/ajmg.a.20123DOI Listing
September 2003

Genome-wide prediction, display and refinement of binding sites with information theory-based models.

BMC Bioinformatics 2003 Sep 8;4:38. Epub 2003 Sep 8.

Laboratory of Human Molecular Genetics, Children's Mercy Hospital and Clinics, School of Medicine, and School of Interdisciplinary Computer Science and Engineering University of Missouri-Kansas City, Kansas City, MO 64108 USA.

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http://dx.doi.org/10.1186/1471-2105-4-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC200970PMC
September 2003

Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.

Pharmacogenetics 2003 Apr;13(4):207-18

Laboratory of Human Molecular Genetics, Children's Mercy Hospital and Clinics, Kansas City, Missouri 64108, USA.

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http://dx.doi.org/10.1097/00008571-200304000-00005DOI Listing
April 2003

Splice variants but not mutations of DNA polymerase beta are common in bladder cancer.

Cancer Res 2002 Jun;62(11):3251-6

Molecular and Genetic Epidemiology Group, The Laboratory of Molecular Carcinogenesis, The National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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June 2002