Peter J Stogios

Peter J Stogios

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Peter J Stogios

Publications by authors named "Peter J Stogios"

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Structure of the full-length Serratia marcescens acetyltransferase AAC(3)-Ia in complex with coenzyme A.

Protein Sci 2020 03 30;29(3):803-808. Epub 2020 Jan 30.

Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/pro.3811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020991PMC
March 2020

Molecular mechanisms of vancomycin resistance.

Protein Sci 2020 03 23;29(3):654-669. Epub 2020 Jan 23.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pro.3819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020976PMC
March 2020

A penicillin-binding protein that can promote advanced-generation cephalosporin resistance and genome adaptation in the opportunistic pathogen Pseudomonas aeruginosa.

Int J Antimicrob Agents 2020 Mar 10;55(3):105896. Epub 2020 Jan 10.

London Research and Development Centre, Agriculture and Agri-Food Canada, London, Ontario, Canada; Department of Biology, University of Western Ontario, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2020.105896DOI Listing
March 2020

Rational engineering of 2-deoxyribose-5-phosphate aldolases for the biosynthesis of ()-1,3-butanediol.

J Biol Chem 2020 Jan 5;295(2):597-609. Epub 2019 Dec 5.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada

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http://dx.doi.org/10.1074/jbc.RA119.011363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956516PMC
January 2020

An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp.

Nature 2019 11 6;575(7784):674-678. Epub 2019 Nov 6.

Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1735-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883173PMC
November 2019

Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74.

J Biol Chem 2019 09 19;294(36):13233-13247. Epub 2019 Jul 19.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada

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http://dx.doi.org/10.1074/jbc.RA119.009861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737227PMC
September 2019

Structural enzymology reveals the molecular basis of substrate regiospecificity and processivity of an exemplar bacterial glycoside hydrolase family 74 -xyloglucanase.

Biochem J 2018 12 19;475(24):3963-3978. Epub 2018 Dec 19.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada

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http://dx.doi.org/10.1042/BCJ20180763DOI Listing
December 2018

Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.

ACS Infect Dis 2018 06 19;4(6):980-987. Epub 2018 Apr 19.

M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine , McMaster University , 1280 Main Street West , Hamilton , Ontario L8N 4K1 , Canada.

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http://dx.doi.org/10.1021/acsinfecdis.8b00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167752PMC
June 2018

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

ACS Chem Biol 2018 05 19;13(5):1322-1332. Epub 2018 Apr 19.

Center for Structural Genomics of Infectious Diseases (CSGID).

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http://dx.doi.org/10.1021/acschembio.8b00116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197822PMC
May 2018

The effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways.

J Biol Chem 2018 03 4;293(9):3307-3320. Epub 2018 Jan 4.

From the Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5, Canada,

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http://dx.doi.org/10.1074/jbc.M117.812727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836138PMC
March 2018

A novel acetyl xylan esterase enabling complete deacetylation of substituted xylans.

Biotechnol Biofuels 2018 22;11:74. Epub 2018 Mar 22.

1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5 Canada.

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https://biotechnologyforbiofuels.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s13068-018-1074-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863359PMC
March 2018

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.

Nat Commun 2018 01 9;9(1):112. Epub 2018 Jan 9.

Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, L8S 4L8, ON, Canada.

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http://dx.doi.org/10.1038/s41467-017-02680-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760710PMC
January 2018

Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes.

ACS Infect Dis 2017 09 16;3(9):653-665. Epub 2017 Aug 16.

Department of Chemical Engineering and Applied Chemistry, University of Toronto , 200 College Street, Room 333, Toronto, Ontario M5S 3E5, Canada.

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http://dx.doi.org/10.1021/acsinfecdis.7b00068DOI Listing
September 2017

Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.

ACS Infect Dis 2017 02 10;3(2):132-143. Epub 2016 Nov 10.

Department of Chemical Engineering and Applied Chemistry, University of Toronto , 200 College Street, Toronto, Ontario M5G 1L6, Canada.

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http://dx.doi.org/10.1021/acsinfecdis.6b00058DOI Listing
February 2017

Rifampin phosphotransferase is an unusual antibiotic resistance kinase.

Nat Commun 2016 Apr 22;7:11343. Epub 2016 Apr 22.

M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.

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http://dx.doi.org/10.1038/ncomms11343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844700PMC
April 2016

L-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti.

J Bacteriol 2016 Feb 1;198(7):1171-81. Epub 2016 Feb 1.

Department of Biology, McMaster University, Hamilton, Ontario, Canada

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http://dx.doi.org/10.1128/JB.00961-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800863PMC
February 2016

The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism.

Nucleic Acids Res 2016 Jan 22;44(2):595-607. Epub 2015 Sep 22.

Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada

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http://nar.oxfordjournals.org/content/early/2015/09/22/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv955
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http://dx.doi.org/10.1093/nar/gkv955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737184PMC
January 2016

Structure-function analysis identifies highly sensitive strigolactone receptors in Striga.

Science 2015 Oct;350(6257):203-7

Cell and Systems Biology, University of Toronto, 25 Willcocks Street, Toronto M5S 3B2, Canada.

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http://dx.doi.org/10.1126/science.aac9476DOI Listing
October 2015

Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.

Structure 2015 Aug 2;23(8):1459-1469. Epub 2015 Jul 2.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada; Midwest Center for Structural Genomics, Bioscience Division, Argonne National Laboratory, Lemont, IL 60439, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547693PMC
August 2015

Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).

J Mol Biol 2015 Jun 18;427(12):2229-43. Epub 2015 Apr 18.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L6; Center for Structural Genomics of Infectious Diseases (CSGID). Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433856PMC
June 2015

Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification.

Mol Microbiol 2015 Feb 16;95(4):678-91. Epub 2015 Jan 16.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.

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http://doi.wiley.com/10.1111/mmi.12895
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http://dx.doi.org/10.1111/mmi.12895DOI Listing
February 2015

Structural and functional characterization of a ketosteroid transcriptional regulator of Mycobacterium tuberculosis.

J Biol Chem 2015 Jan 18;290(2):872-82. Epub 2014 Nov 18.

From the Departments of Biochemistry and Molecular Biology and Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver V6T 1Z3, Canada,

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http://dx.doi.org/10.1074/jbc.M114.607481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294509PMC
January 2015

Structural and molecular basis for resistance to aminoglycoside antibiotics by the adenylyltransferase ANT(2″)-Ia.

mBio 2015 Jan 6;6(1). Epub 2015 Jan 6.

Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

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http://dx.doi.org/10.1128/mBio.02180-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313920PMC
January 2015

Potential for reduction of streptogramin A resistance revealed by structural analysis of acetyltransferase VatA.

Antimicrob Agents Chemother 2014 Dec 15;58(12):7083-92. Epub 2014 Sep 15.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada Center for Structural Genomics of Infectious Diseases (CSGID)

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http://aac.asm.org/lookup/doi/10.1128/AAC.03743-14
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http://dx.doi.org/10.1128/AAC.03743-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249515PMC
December 2014

Multiple influenza A (H3N2) mutations conferring resistance to neuraminidase inhibitors in a bone marrow transplant recipient.

Antimicrob Agents Chemother 2014 Dec 22;58(12):7188-97. Epub 2014 Sep 22.

Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada The Hospital for Sick Children, Toronto, Ontario, Canada

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http://dx.doi.org/10.1128/AAC.03667-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249562PMC
December 2014

Elucidation of the molecular basis for arabinoxylan-debranching activity of a thermostable family GH62 α-l-arabinofuranosidase from Streptomyces thermoviolaceus.

Appl Environ Microbiol 2014 Sep 20;80(17):5317-29. Epub 2014 Jun 20.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada Department of Biotechnology and Chemical Technology, Aalto University, Espoo, Finland

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http://aem.asm.org/lookup/doi/10.1128/AEM.00685-14
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http://dx.doi.org/10.1128/AEM.00685-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136092PMC
September 2014

Structural basis for the evolution of vancomycin resistance D,D-peptidases.

Proc Natl Acad Sci U S A 2014 Apr 7;111(16):5872-7. Epub 2014 Apr 7.

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France.

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http://dx.doi.org/10.1073/pnas.1402259111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000784PMC
April 2014

An inserted α/β subdomain shapes the catalytic pocket of Lactobacillus johnsonii cinnamoyl esterase.

PLoS One 2011 18;6(8):e23269. Epub 2011 Aug 18.

Department of Microbiology and Cell Science, Genetics Institute, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023269PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158066PMC
December 2011

A small molecule discrimination map of the antibiotic resistance kinome.

Chem Biol 2011 Dec;18(12):1591-601

M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8S 3Z5, Canada.

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http://dx.doi.org/10.1016/j.chembiol.2011.10.018DOI Listing
December 2011

Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.

J Biol Chem 2011 Jan 17;286(3):1966-75. Epub 2010 Nov 17.

Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada.

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http://dx.doi.org/10.1074/jbc.M110.194266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023493PMC
January 2011

Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.

J Mol Biol 2010 Jul 21;400(5):983-97. Epub 2010 May 21.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jmb.2010.05.028DOI Listing
July 2010

Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.

Protein Sci 2007 Feb 22;16(2):336-42. Epub 2006 Dec 22.

Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1110/ps.062660907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203294PMC
February 2007

Sequence and structural analysis of BTB domain proteins.

Genome Biol 2005 15;6(10):R82. Epub 2005 Sep 15.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/gb-2005-6-10-r82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257465PMC
December 2006

The BACK domain in BTB-kelch proteins.

Trends Biochem Sci 2004 Dec;29(12):634-7

Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.1016/j.tibs.2004.10.003DOI Listing
December 2004

Dramatic acceleration of protein folding by stabilization of a nonnative backbone conformation.

Proc Natl Acad Sci U S A 2004 May 17;101(21):7954-9. Epub 2004 May 17.

Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8.

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http://dx.doi.org/10.1073/pnas.0400550101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419538PMC
May 2004