Peter J Schwartz

Peter J Schwartz

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Peter J Schwartz

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An International Multi-Center Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.

Circulation 2020 Jan 16. Epub 2020 Jan 16.

Departments of Cardiovascular Medicine (Division of Heart Rhythm Services), Pediatric and Adolescent Medicine (Division of Pediatric Cardiology), and Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.043114DOI Listing
January 2020

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi006-A from a patient affected by an autosomal recessive form of long QT syndrome type 1.

Stem Cell Res 2019 Nov 20;42:101658. Epub 2019 Nov 20.

Coronary Care Unit and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101658DOI Listing
November 2019

When prescribing drugs, do medical doctors and healthcare professionals realize that their patient has the long QT syndrome?

Eur Heart J 2019 Oct;40(37):3118-3120

Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, 22 Via Pier Lombardo, Milan, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehz355DOI Listing
October 2019

Generation of two human induced pluripotent stem cell (hiPSC) lines from a long QT syndrome South African founder population.

Stem Cell Res 2019 08 24;39:101510. Epub 2019 Jul 24.

Coronary Care Unit and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101510DOI Listing
August 2019

Towards Precision Medicine With Human iPSCs for Cardiac Channelopathies.

Circ Res 2019 Aug 29;125(6):653-658. Epub 2019 Aug 29.

Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, and Laboratory of Cardiovascular Genetics, Milan, Italy (P.J.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315209DOI Listing
August 2019

Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1.

Int J Cardiol 2019 07 31;286:66-72. Epub 2019 Jan 31.

Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2019.01.098DOI Listing
July 2019

From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2.

Eur Heart J 2019 Jun;40(23):1832-1836

Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Via Pier Lombardo 22, Milan, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehz023DOI Listing
June 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation.

Stem Cell Res 2019 05 27;37:101431. Epub 2019 Mar 27.

Coronary Care Unit, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, Università degli Studi di Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061193006
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http://dx.doi.org/10.1016/j.scr.2019.101431DOI Listing
May 2019

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome.

Circ Arrhythm Electrophysiol 2019 05;12(5):e007280

Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine (J.M.B., R.K.R., M.J.A.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCEP.118.007280DOI Listing
May 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation.

Stem Cell Res 2019 05 13;37:101437. Epub 2019 Apr 13.

Coronary Care Unit, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18735061193006
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http://dx.doi.org/10.1016/j.scr.2019.101437DOI Listing
May 2019

Long QT Syndrome Modelling with Cardiomyocytes Derived from Human-induced Pluripotent Stem Cells.

Arrhythm Electrophysiol Rev 2019 05;8(2):105-110

Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics Milan, Italy.

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https://www.aerjournal.com/articles/long-qt-syndrome-modelli
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http://dx.doi.org/10.15420/aer.2019.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528025PMC
May 2019

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi007-A from a Long QT Syndrome type 1 patient carrier of two common variants in the NOS1AP gene.

Stem Cell Res 2019 04 6;36:101416. Epub 2019 Mar 6.

Coronary Care Unit and Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, Università degli studi di Pavia, Pavia, Italy.; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101416DOI Listing
April 2019

Cardiac Sympathetic Denervation in Channelopathies.

Front Cardiovasc Med 2019 26;6:27. Epub 2019 Mar 26.

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano, IRCCS, Milan, Italy.

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http://dx.doi.org/10.3389/fcvm.2019.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443634PMC
March 2019

International Triadin Knockout Syndrome Registry.

Circ Genom Precis Med 2019 02;12(2):e002419

Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology and Experimental Therapeutics, Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, and Division of Heart Rhythm Services, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (D.J.C., D.J.T., J.R.G., J.M.B., R.K.R., M.J.A.).

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http://dx.doi.org/10.1161/CIRCGEN.118.002419DOI Listing
February 2019

Precision Versus Traditional Medicine-Clinical Questions Trigger Progress in Basic Science.

Circ Res 2019 02;124(4):459-461

Laboratory of Cardiovascular Genetics (P.J.S., L.S.), Milan, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314629DOI Listing
February 2019

Cardiac sympathetic denervation via a transtracheal approach: It's a long way to Tipperary.

Heart Rhythm 2019 Jan 25;16(1):125-127. Epub 2018 Sep 25.

Department of Surgery, Unit of General Surgery 2, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1016/j.hrthm.2018.09.020DOI Listing
January 2019

Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review.

Heart Rhythm 2018 12 3;15(12):1791-1799. Epub 2018 Jul 3.

BC Children's Hospital, Division of Cardiology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.06.046DOI Listing
December 2018

Bongani Mayosi, 1967-2018.

Eur Heart J 2018 12;39(46):4051-4061

Department of Cardiology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.

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http://dx.doi.org/10.1093/eurheartj/ehy715DOI Listing
December 2018

Can genetics predict risk for sudden cardiac death? The relentless search for the Holy Grail.

Eur Heart J 2018 11;39(44):3970-3972

Istituto Auxologico Italiano, IRCCS, Molecular Biology Laboratory, Unit of Bioinformatic and Statistical Genomic, Cusano Milanino, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehy508DOI Listing
November 2018

Modifier genes for sudden cardiac death.

Eur Heart J 2018 11;39(44):3925-3931

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Searle 8-510, East Superior Street, Chicago, IL, USA.

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http://dx.doi.org/10.1093/eurheartj/ehy502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247660PMC
November 2018

Letter concerning the editorial by Giustetto et al. Int J Cardiol 2018;254:170-171.

Int J Cardiol 2018 10;268:155

Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183148
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http://dx.doi.org/10.1016/j.ijcard.2018.03.035DOI Listing
October 2018

For neonatal ECG screening there is no reason to relinquish old Bazett's correction.

Eur Heart J 2018 08;39(31):2888-2895

Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Via Pier Lombardo 22, 20135 Milan, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehy284DOI Listing
August 2018

Electronic gadgets and their health-related claims.

Int J Cardiol 2018 05;258:163-164

Department of Cardiology and Pneumology - Heart Center, University of Göttingen Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2018.02.032DOI Listing
May 2018

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi002-A from a patient affected by the Jervell and Lange-Nielsen syndrome and carrier of two compound heterozygous mutations on the KCNQ1 gene.

Stem Cell Res 2018 05 7;29:157-161. Epub 2018 Apr 7.

Coronary Care Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; Laboratory of Experimental Cardiology for Cell and Molecular Therapy, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.04.002DOI Listing
May 2018

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi003-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1.

Stem Cell Res 2018 05 6;29:170-173. Epub 2018 Apr 6.

Coronary Care Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.; Laboratory of Experimental Cardiology for Cell and Molecular Therapy, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.; Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy.; Department of Medicine, University of Cape Town, Cape Town, South Africa.. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.04.003DOI Listing
May 2018

Cardiac arrest and Brugada syndrome: Is drug-induced type 1 ECG pattern always a marker of low risk?

Int J Cardiol 2018 03 16;254:142-145. Epub 2017 Nov 16.

Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.10.118DOI Listing
March 2018

Sudden Infant Death Syndrome and Genetics: Don't Throw Out the Infant With the Dirty Water.

J Am Coll Cardiol 2018 03;71(11):1228-1230

IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy.

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http://dx.doi.org/10.1016/j.jacc.2018.01.039DOI Listing
March 2018

Is Careful Assessment of Rare Variants in the Gene Piercing the Guidelines' Strong Armor?

Circ Genom Precis Med 2018 02;11(2):e002072

From the IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy.

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http://dx.doi.org/10.1161/CIRCGEN.118.002072DOI Listing
February 2018

The genetics underlying idiopathic ventricular fibrillation: A special role for catecholaminergic polymorphic ventricular tachycardia?

Int J Cardiol 2018 Jan 5;250:139-145. Epub 2017 Oct 5.

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.10.016DOI Listing
January 2018

Rationale and design of a prospective study to assess the effect of left cardiac sympathetic denervation in chronic heart failure.

Int J Cardiol 2017 Dec 8;248:227-231. Epub 2017 Aug 8.

Division of Cardiology, Department of Medicine, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa; IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.08.012DOI Listing
December 2017

Founder populations with channelopathies and church records reveal all sorts of interesting secrets: Some are scientifically relevant.

Heart Rhythm 2017 12 14;14(12):1882-1883. Epub 2017 Sep 14.

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy; San Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

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http://dx.doi.org/10.1016/j.hrthm.2017.09.016DOI Listing
December 2017

Channelopathies as Causes of Sudden Cardiac Death.

Card Electrophysiol Clin 2017 12;9(4):537-549

Heart Center, Academic Medical Center, University of Amsterdam, PO-Box 22700, 1100DE, Amsterdam, The Netherlands; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1016/j.ccep.2017.07.005DOI Listing
December 2017

Counterfeit drugs: A plot worthy of John le Carrè.

Int J Cardiol 2017 09 19;243:279-280. Epub 2017 Jun 19.

IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy.

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http://dx.doi.org/10.1016/j.ijcard.2017.06.016DOI Listing
September 2017

The KCNH2-IVS9-28A/G mutation causes aberrant isoform expression and hERG trafficking defect in cardiomyocytes derived from patients affected by Long QT Syndrome type 2.

Int J Cardiol 2017 Aug 12;240:367-371. Epub 2017 Apr 12.

Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy; Department of Medicine, University of Cape Town, Cape Town, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.04.038DOI Listing
August 2017

Evolution in Managing Long QT Syndrome: From Registries to Centers of Excellence.

J Am Coll Cardiol 2017 07;70(4):463-465

IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy.

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http://dx.doi.org/10.1016/j.jacc.2017.06.004DOI Listing
July 2017

Cardiac sympathetic denervation 100years later: Jonnesco would have never believed it.

Int J Cardiol 2017 Jun 8;237:25-28. Epub 2017 Mar 8.

Unit of General Surgery 2, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

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http://dx.doi.org/10.1016/j.ijcard.2017.03.020DOI Listing
June 2017

Patient-Specific Induced Pluripotent Stem Cell-Based Disease Model for Pathogenesis Studies and Clinical Pharmacotherapy.

Circ Arrhythm Electrophysiol 2017 06;10(6)

From the Stanford Cardiovascular Institute, Departments of Medicine and Radiology, Institute of Stem Cell Biology & Regenerative Medicine (Y.L., K.S., J.C.W.), Stanford University, School of Medicine, CA; and Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milano, Italy (P.J.S.).

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http://dx.doi.org/10.1161/CIRCEP.117.005398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517015PMC
June 2017

Red Bull®: Red flag or red herring?

Int J Cardiol 2017 Mar;231:179-180

Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.1016/j.ijcard.2016.12.181DOI Listing
March 2017

Reference values of heart rate variability.

Heart Rhythm 2017 02 13;14(2):302-303. Epub 2016 Dec 13.

Graduate School of Education, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.hrthm.2016.12.015DOI Listing
February 2017

Regional Lack of Consistency in the Management of Atrial Fibrillation (from the RECORD-AF Trial).

Am J Cardiol 2017 Jan 30;119(1):47-51. Epub 2016 Sep 30.

Center for Cardiac Arrhythmias of Genetic Origin-IRCCS Instituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2016.09.009DOI Listing
January 2017

Evolving concepts for the Long QT Syndrome.

Authors:
Peter J Schwartz

Eur Heart J 2017 01;38(4):225-226

IRCCS Istituto Auxologico Italiano Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy and Centro Diagnostico e di Ricerca San Carlo Via Pier Lombardo, 22 20135 Milano, Italy Tel. +390255000408 Fax +390255000411.

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http://dx.doi.org/10.1093/eurheartj/ehw665DOI Listing
January 2017

Difficult management of Jervell and Lange-Nielsen syndrome: An endless search.

Authors:
Peter J Schwartz

Heart Rhythm 2016 11 9;13(11):2193-2194. Epub 2016 Aug 9.

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2016.08.019DOI Listing
November 2016

Management of survivors of cardiac arrest - the importance of genetic investigation.

Nat Rev Cardiol 2016 09 7;13(9):560-6. Epub 2016 Jul 7.

IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Centro Diagnostico e di Ricerca San Carlo, Via Pier Lombardo, Milan, 22-20135, Italy.

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http://dx.doi.org/10.1038/nrcardio.2016.104DOI Listing
September 2016

Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.

Circulation 2016 Sep 26;134(12):872-82. Epub 2016 Aug 26.

From AMC Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W., C.R.B.) and Department of Clinical Genetics (N.H., M.A.), Academic Medical Center, Amsterdam, The Netherlands; Cardiology Division of the Department of Medicine (A.J.M., C.L., W.Z., I.G., J.L.R., M.L.A., S.M., B.P.), the Department of Biostatistics (D.R.P.), and the Department of Pathology (M.Q.), University of Rochester School of Medicine and Dentistry, Rochester, NY; Heart and Vascular Research Center, MetroHealth Campus of Case Western Reserve University, Cleveland, OH (E.S.K.); Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (W.S.); Department of Cardiology Bikur Cholim Hospital, Jerusalem, Israel (J.B.); Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.A.T.); IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (C.P. L.C., P.J.S.); Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark (J.K.K.); Departments of Medicine, Pediatrics, and Molecular Pharmacology & Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (D.J.T., M.J.A.); Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine (W.S.) and Department of Preventive Cardiology (Y.M.), National Cerebral and Cardiovascular Center, Suita, Japan; Department of Molecular Medicine, University of Pavia, Italy (L.C.); Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Kingdom of Saudi Arabia (A.A.M.W.); and Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., P.J.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030177PMC
September 2016

Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1?

Circ Cardiovasc Genet 2016 Aug;9(4):330-9

From the Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan (L.C., C.S., P.J.S.); Department of Molecular Medicine (L.C.) and Department of Public Health (M.C.M., C.M.), Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia; Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., G.P.); Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland (A.M.L., K.K.); Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (E.M., P.L., T.M.); Department of Medicine and Surgery University of Milano-Bicocca, Milan, Italy (G.P.); Department of Internal Medicine, University of Stellenbosch, South Africa (M.H., A.G., P.A.B.); Institute of Human Genetics, Technische Universität München (T.M.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (T.M.); and Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland (H.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001419DOI Listing
August 2016

Electrocardiographic Screening for Prolonged QT Interval to Reduce Sudden Cardiac Death in Psychiatric Patients: A Cost-Effectiveness Analysis.

PLoS One 2015 12;10(6):e0127213. Epub 2015 Jun 12.

Department of Anesthesiology, Intensive Care, and Clinical Pharmacology, University Hospitals and University of Geneva, rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland; Medical Directorate, University Hospitals and University of Geneva, rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland; Centre for Health Economics, University of York, Heslington,York, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127213PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466505PMC
April 2016

Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes.

J Am Coll Cardiol 2016 04;67(13):1639-1650

Department of Biomedical Informatics, University of Arizona College of Medicine, Phoenix, Arizona; AZCERT, Inc., Oro Valley, Arizona.

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http://dx.doi.org/10.1016/j.jacc.2015.12.063DOI Listing
April 2016

Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.

Sci Rep 2016 Feb 26;6:22235. Epub 2016 Feb 26.

Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Old Groote Schuur Hospital, Groote Schuur Drive, Observatory, 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1038/srep22235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808831PMC
February 2016

When the risk is sudden death, does quality of life matter?

Authors:
Peter J Schwartz

Heart Rhythm 2016 Jan 25;13(1):70-1. Epub 2015 Sep 25.

IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2015.09.020DOI Listing
January 2016

Remodelling of cardiac sympathetic re-innervation with thoracic spinal cord stimulation improves left ventricular function in a porcine model of heart failure.

Europace 2015 Dec 12;17(12):1875-83. Epub 2015 Mar 12.

Cardiology Division, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China Research Center of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China Shenzhen Institutes of Research and Innovation, University of Hong Kong, Hong Kong, China

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http://dx.doi.org/10.1093/europace/euu409DOI Listing
December 2015

Reply to the Editor--Detection of long QT syndrome in the community.

Heart Rhythm 2015 Jul 17;12(7):e67-8. Epub 2015 Apr 17.

Boston Children's Hospital, Harvard Medical School Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.hrthm.2015.04.022DOI Listing
July 2015

Clinical Management of Catecholaminergic Polymorphic Ventricular Tachycardia: The Role of Left Cardiac Sympathetic Denervation.

Circulation 2015 Jun 27;131(25):2185-93. Epub 2015 May 27.

From Department of Cardiology and Cardiovascular Clinical Research Center (G.M.D.F., V.D.) and Division of Vascular Surgery (A.O.), Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Molecular Medicine, University of Pavia, Italy (G.M.D.T., V.D., C.S., L.C.); Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milano, Italy (C.S., L.C., P.J.S.); Departments of Medicine, Pediatrics, and Molecular Pharmacology & Experimental Therapeutics, Divisions of Cardiovascular Diseases and Pediatric Cardiology, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (J.M.B., C.R.M., M.J.A.); Cardiac Arrhythmia Service, Department of Cardiology, Children's Hospital, Boston, MA (D.J.A.); Division of Cardiology, Children's National Heart Institute, George Washington University, Washington, DC (C.I.B.); Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (L.C.); Department of Cardiology, The Royal Children's Hospital, Murdoch Children's Research Institute and Melbourne University, Melbourne, Australia (A.M.D.); Heart Institute, Leviev Heart Center, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel (M.E.); Department of Clinical Cardiology and Molecular Genetics, National Center for Preventive Medicine, Ministry of Healthcare, Russian Federation, Moscow, Russia (M.K.); Bruce Rappaport Faculty of Medicine; Technion, Haifa, Israel (A.K.); Division of Cardiology, University of British Columbia, Vancouver, Canada (A.D.K.); AP-HP, Hôpital Bichat, Service de Cardiologie et Centre de Référence des Maladies Cardiaques Héréditaires, Paris, France (A.L.); Université Paris Diderot, Sorbonne Paris Cité, Paris, France (A.L.); Heart Centre AMC, Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands (L.O.N., A.A.M.W.); Department of Pediatric Cardiology and Intensive Care Medicine, University Hospital, Georg-August-University,

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.015731DOI Listing
June 2015

MY APPROACH to the long QT syndrome (LQTS).

Authors:
Peter J Schwartz

Trends Cardiovasc Med 2015 May 7;25(4):376-7. Epub 2015 Feb 7.

Head, Center for Cardiac Arrhythmias of Genetic Origin; Director, Cardiovascular Genetics Laboratory, IRCCS Istituto Auxologico Italiano, Milan, Italy; Professor of Cardiology, Department of Molecular Medicine, University of Pavia, Pavia, Italy; Extraordinary Professor in Internal Medicine, Stellenbosch University, Stellenbosch, South Africa; Chair of Sudden Death, Department of Family and Community Medicine, King Saud University, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1016/j.tcm.2014.09.017DOI Listing
May 2015

Autonomic modulation for the management of patients with chronic heart failure.

Circ Heart Fail 2015 May;8(3):619-28

From the Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy (P.J.S.); Department of Cardiology, Fondazione "Salvatore Maugeri", IRCCS Istituto Scientifico di Montescano, Montescano, Pavia, Italy (M.T.L.R.); Department of Cardiology and Cardiovascular Clinical Research Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy (G.M.D.F.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (G.M.D.F.); and Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO (D.L.M.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001964DOI Listing
May 2015

Neonatal ECG screening: opinions and facts.

Heart Rhythm 2015 Mar 10;12(3):610-611. Epub 2014 Dec 10.

Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.hrthm.2014.11.032DOI Listing
March 2015

Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1.

J Am Coll Cardiol 2015 Feb;65(4):367-374

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.1016/j.jacc.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312415PMC
February 2015

Vox clamantis in deserto. We spoke but nobody was listening: echocardiography can help risk stratification of the long-QT syndrome.

Eur Heart J 2015 Jan 21;36(3):148-50. Epub 2014 Oct 21.

Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milano, Italy

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http://dx.doi.org/10.1093/eurheartj/ehu406DOI Listing
January 2015

Rationale and objectives for ECG screening in infancy.

Heart Rhythm 2014 Dec 18;11(12):2316-21. Epub 2014 Sep 18.

Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.hrthm.2014.09.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254269PMC
December 2014

Health-related quality of life in patients with atrial fibrillation treated with rhythm control versus rate control: insights from a prospective international registry (Registry on Cardiac Rhythm Disorders Assessing the Control of Atrial Fibrillation: RECORD-AF).

Circ Cardiovasc Qual Outcomes 2014 Nov 11;7(6):896-904. Epub 2014 Nov 11.

From the University Health Network (A.C.T.H.) and St. Michael's Hospital (P.D.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Cardiovascular Medicine, Universitätsklinikum Münster, Münster, Germany (G.B.); St. George's University of London, London, United Kingdom (A.J.C.); Maastricht University Medical Centre, Maastricht, The Netherlands (H.J.C.); Harvard School of Public Health, Boston, MA (G.M.F.); The Lankenau Institute for Medical Research, Wynnewood, PA (P.R.K.); Hôpital Européen Georges Pompidou and Université René Descartes, Paris, France (J.-Y.L.H.); Sanofi, Paris, France (L.N.-B.); St. Vincent Medical Group, Indianapolis, IN (E.N.P.); Center for Cardiac Arrhythmias of Genetic Origin-IRCCS Istituto Auxologico Italiano, Milan, Italy (P.J.S.); Department of Health, Science and Technology, Aalborg University, Aalborg, Denmark (C.T.-P.); and Christiana Care Health System, Newark, Delaware (W.S.W.).

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http://dx.doi.org/10.1161/HCQ.0000000000000011DOI Listing
November 2014

AKAP9 is a genetic modifier of congenital long-QT syndrome type 1.

Circ Cardiovasc Genet 2014 Oct 2;7(5):599-606. Epub 2014 Aug 2.

From the Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Medical Research Council (MRC) Centre for Molecular and Cellular Biology, (C.P.d.V., L.v.d.M., J.C.M.-S., V.A.C.), and Department of Internal Medicine (A.G., P.A.B.), Stellenbosch University, Stellenbosch, South Africa; Department of Statistics, University of Western Cape, Bellville, South Africa (L.v.d.M.); IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (L.C., P.J.S.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (L.C.); Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (L.C.); and Departments of Medicine and Pharmacology, and Institute for Integrative Genomics, Vanderbilt University, Nashville, TN (A.L.G.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270884PMC
October 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:
Dan E Arking Sara L Pulit Lia Crotti Pim van der Harst Patricia B Munroe Tamara T Koopmann Nona Sotoodehnia Elizabeth J Rossin Michael Morley Xinchen Wang Andrew D Johnson Alicia Lundby Daníel F Gudbjartsson Peter A Noseworthy Mark Eijgelsheim Yuki Bradford Kirill V Tarasov Marcus Dörr Martina Müller-Nurasyid Annukka M Lahtinen Ilja M Nolte Albert Vernon Smith Joshua C Bis Aaron Isaacs Stephen J Newhouse Daniel S Evans Wendy S Post Daryl Waggott Leo-Pekka Lyytikäinen Andrew A Hicks Lewin Eisele David Ellinghaus Caroline Hayward Pau Navarro Sheila Ulivi Toshiko Tanaka David J Tester Stéphanie Chatel Stefan Gustafsson Meena Kumari Richard W Morris Åsa T Naluai Sandosh Padmanabhan Alexander Kluttig Bernhard Strohmer Andrie G Panayiotou Maria Torres Michael Knoflach Jaroslav A Hubacek Kamil Slowikowski Soumya Raychaudhuri Runjun D Kumar Tamara B Harris Lenore J Launer Alan R Shuldiner Alvaro Alonso Joel S Bader Georg Ehret Hailiang Huang W H Linda Kao James B Strait Peter W Macfarlane Morris Brown Mark J Caulfield Nilesh J Samani Florian Kronenberg Johann Willeit J Gustav Smith Karin H Greiser Henriette Meyer Zu Schwabedissen Karl Werdan Massimo Carella Leopoldo Zelante Susan R Heckbert Bruce M Psaty Jerome I Rotter Ivana Kolcic Ozren Polašek Alan F Wright Maura Griffin Mark J Daly David O Arnar Hilma Hólm Unnur Thorsteinsdottir Joshua C Denny Dan M Roden Rebecca L Zuvich Valur Emilsson Andrew S Plump Martin G Larson Christopher J O'Donnell Xiaoyan Yin Marco Bobbo Adamo P D'Adamo Annamaria Iorio Gianfranco Sinagra Angel Carracedo Steven R Cummings Michael A Nalls Antti Jula Kimmo K Kontula Annukka Marjamaa Lasse Oikarinen Markus Perola Kimmo Porthan Raimund Erbel Per Hoffmann Karl-Heinz Jöckel Hagen Kälsch Markus M Nöthen Marcel den Hoed Ruth J F Loos Dag S Thelle Christian Gieger Thomas Meitinger Siegfried Perz Annette Peters Hanna Prucha Moritz F Sinner Melanie Waldenberger Rudolf A de Boer Lude Franke Pieter A van der Vleuten Britt Maria Beckmann Eimo Martens Abdennasser Bardai Nynke Hofman Arthur A M Wilde Elijah R Behr Chrysoula Dalageorgou John R Giudicessi Argelia Medeiros-Domingo Julien Barc Florence Kyndt Vincent Probst Alice Ghidoni Roberto Insolia Robert M Hamilton Stephen W Scherer Jeffrey Brandimarto Kenneth Margulies Christine E Moravec Fabiola del Greco M Christian Fuchsberger Jeffrey R O'Connell Wai K Lee Graham C M Watt Harry Campbell Sarah H Wild Nour E El Mokhtari Norbert Frey Folkert W Asselbergs Irene Mateo Leach Gerjan Navis Maarten P van den Berg Dirk J van Veldhuisen Manolis Kellis Bouwe P Krijthe Oscar H Franco Albert Hofman Jan A Kors André G Uitterlinden Jacqueline C M Witteman Lyudmyla Kedenko Claudia Lamina Ben A Oostra Gonçalo R Abecasis Edward G Lakatta Antonella Mulas Marco Orrú David Schlessinger Manuela Uda Marcello R P Markus Uwe Völker Harold Snieder Timothy D Spector Johan Ärnlöv Lars Lind Johan Sundström Ann-Christine Syvänen Mika Kivimaki Mika Kähönen Nina Mononen Olli T Raitakari Jorma S Viikari Vera Adamkova Stefan Kiechl Maria Brion Andrew N Nicolaides Bernhard Paulweber Johannes Haerting Anna F Dominiczak Fredrik Nyberg Peter H Whincup Aroon D Hingorani Jean-Jacques Schott Connie R Bezzina Erik Ingelsson Luigi Ferrucci Paolo Gasparini James F Wilson Igor Rudan Andre Franke Thomas W Mühleisen Peter P Pramstaller Terho J Lehtimäki Andrew D Paterson Afshin Parsa Yongmei Liu Cornelia M van Duijn David S Siscovick Vilmundur Gudnason Yalda Jamshidi Veikko Salomaa Stephan B Felix Serena Sanna Marylyn D Ritchie Bruno H Stricker Kari Stefansson Laurie A Boyer Thomas P Cappola Jesper V Olsen Kasper Lage Peter J Schwartz Stefan Kääb Aravinda Chakravarti Michael J Ackerman Arne Pfeufer Paul I W de Bakker Christopher Newton-Cheh

Nat Genet 2014 Aug 22;46(8):826-36. Epub 2014 Jun 22.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124521PMC
August 2014

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome.

Circ Res 2014 Aug 24;115(4):460-9. Epub 2014 Jun 24.

From the Center for Clinical and Translational Science (N.J.B.) and Mayo Graduate School (N.J.B.), Department Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (D.Y., D.J.T., J.R.G., M.J.A.), Department of Medicine (J.R.G.), Division of Cardiovascular Diseases (M.J.A.), and Division of Pediatric Cardiology (M.J.A.), Mayo Clinic, Rochester, MN; Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO (E.K.J., W.W., J.M.N.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (L.C.); Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., F.D., M.T., P.J.S.); Institute of Human Genetics, Helmholtz Zentrum Munich, Neuherberg, Germany (L.C.); and Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands (Y.M., M.A., A.A.M.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.303657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907370PMC
August 2014

Rapid recovery of baroreceptor reflexes in acute myocardial infarction is a marker of effective tissue reperfusion.

J Cardiovasc Transl Res 2014 Aug 29;7(6):553-9. Epub 2014 Jul 29.

Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Viale Golgi, 19, 27100, Pavia, Italy,

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http://dx.doi.org/10.1007/s12265-014-9578-0DOI Listing
August 2014

Can we Modulate the Autonomic Nervous System to Improve the Life of Patients with Heart Failure? The Case of Vagal Stimulation.

Authors:
Peter J Schwartz

Arrhythm Electrophysiol Rev 2014 Aug 30;3(2):120-2. Epub 2014 Aug 30.

Professor and Head, Centre for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.15420/aer.2014.3.2.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711534PMC
August 2014

A comprehensive electrocardiographic, molecular, and echocardiographic study of Brugada syndrome: validation of the 2013 diagnostic criteria.

Heart Rhythm 2014 Jul 8;11(7):1176-83. Epub 2014 Apr 8.

Laboratory of Cardiovascular Genetics and Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2014.04.010DOI Listing
July 2014

Risk stratification for sudden cardiac death: current status and challenges for the future.

Eur Heart J 2014 Jul 5;35(25):1642-51. Epub 2014 May 5.

Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands Princess Al Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1093/eurheartj/ehu176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076664PMC
July 2014

Cardiac sympathetic denervation to prevent life-threatening arrhythmias.

Authors:
Peter J Schwartz

Nat Rev Cardiol 2014 Jun 11;11(6):346-53. Epub 2014 Mar 11.

Center for Cardiac Arrhythmias of Genetic Origin, IRCCS Istituto Auxologico Italiano, Casa di Cura San Carlo, Via Pier Lombardo 22, 20135 Milan, Italy.

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http://dx.doi.org/10.1038/nrcardio.2014.19DOI Listing
June 2014

Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.

J Am Heart Assoc 2014 Jun 23;3(3):e000996. Epub 2014 Jun 23.

Department of Physiology, University of Kentucky College of Medicine, Lexington, KY (G.Y., F.H., A.R.H., J.S.).

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http://dx.doi.org/10.1161/JAHA.114.000996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309107PMC
June 2014

Drug-induced long QT syndrome and exome sequencing: Chinese shadows link past and future.

J Am Coll Cardiol 2014 Apr 19;63(14):1438-40. Epub 2014 Feb 19.

IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2014.01.030DOI Listing
April 2014