Peter J Ratcliffe

Peter J Ratcliffe

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Peter J Ratcliffe

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Mechanisms of hypoxia signalling: new implications for nephrology.

Nat Rev Nephrol 2019 Oct 5;15(10):641-659. Epub 2019 Sep 5.

Ludwig Instute for Cancer Research and Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41581-019-0182-zDOI Listing
October 2019

Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively.

J Cell Sci 2018 11 19;131(22). Epub 2018 Nov 19.

Ludwig Institute for Cancer Research Ltd., Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom

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http://dx.doi.org/10.1242/jcs.219782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250434PMC
November 2018

New horizons in hypoxia signaling pathways.

Exp Cell Res 2017 07 15;356(2):116-121. Epub 2017 Mar 15.

Target Discovery Institute, University of Oxford, OX3 7FZ, UK; Francis Crick Institute, Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2017.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653532PMC
July 2017

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

PLoS Genet 2017 Jul 17;13(7):e1006872. Epub 2017 Jul 17.

Department of Nephrology and Hypertension, Universitätsklinikum Erlangen und Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1006872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536434PMC
July 2017

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development.

Mol Aspects Med 2016 Feb-Mar;47-48:54-75. Epub 2016 Jan 11.

Centre for Cellular and Molecular Physiology, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2016.01.001DOI Listing
October 2016

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.

EMBO Rep 2016 10 8;17(10):1410-1421. Epub 2016 Aug 8.

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK

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http://dx.doi.org/10.15252/embr.201642198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048371PMC
October 2016

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.

Nat Commun 2016 10 24;7:13183. Epub 2016 Oct 24.

Department of Nephrology and Hypertension, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Ulmenweg 18, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1038/ncomms13183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079059PMC
October 2016

Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award.

JAMA 2016 Sep;316(12):1252-3

McKusick-Nathans Institute of Genetic Medicine and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jama.2016.12386DOI Listing
September 2016

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Nat Commun 2016 08 26;7:12673. Epub 2016 Aug 26.

Chemistry Research Laboratory, Department of Chemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1038/ncomms12673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007464PMC
August 2016

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.

Eur Urol 2016 Apr 19;69(4):646-657. Epub 2015 Aug 19.

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.eururo.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012644PMC
April 2016

Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice.

Hypoxia (Auckl) 2016 12;4:69-80. Epub 2016 Apr 12.

Division of Pathology, Department of Pediatric Laboratory Medicine, The Research Institute, The Hospital for Sick Children; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.2147/HP.S103957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085281PMC
April 2016

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.

J Exp Med 2015 Dec 7;212(13):2223-34. Epub 2015 Dec 7.

MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, Scotland, UK Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, Scotland, UK

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http://dx.doi.org/10.1084/jem.20150452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689165PMC
December 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

HIF hydroxylase pathways in cardiovascular physiology and medicine.

Circ Res 2015 Jun;117(1):65-79

From the Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501273PMC
June 2015

Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives.

Hypoxia (Auckl) 2014 5;2:197-213. Epub 2014 Dec 5.

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://www.dovepress.com/signaling-hypoxia-by-hypoxia-induci
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http://dx.doi.org/10.2147/HP.S47598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045067PMC
December 2014

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

Proc Natl Acad Sci U S A 2014 Mar 18;111(11):4019-24. Epub 2014 Feb 18.

Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford OX1 3TA, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1311750111
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http://dx.doi.org/10.1073/pnas.1311750111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964080PMC
March 2014

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.

Cancer Metab 2014 Feb 4;2(1). Epub 2014 Feb 4.

The Hypoxia Biology Laboratory, The Henry Wellcome Building for Molecular Physiology, The University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://www.cancerandmetabolism.com/content/2/1/3
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http://dx.doi.org/10.1186/2049-3002-2-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938304PMC
February 2014

Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.

Blood 2013 Sep 26;122(10):1741-5. Epub 2013 Jul 26.

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1182/blood-2013-02-484923DOI Listing
September 2013

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.

J Physiol 2013 Apr 11;591(8):2027-42. Epub 2013 Feb 11.

Henry Wellcome Building for Molecular Physiology, Old Road Campus, University of Oxford, Oxford OX3 7BN, UK.

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http://doi.wiley.com/10.1113/jphysiol.2013.251470
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http://dx.doi.org/10.1113/jphysiol.2013.251470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634517PMC
April 2013

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

J Physiol 2012 Aug 21;590(16):4079-91. Epub 2012 May 21.

Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1113/jphysiol.2012.232884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476649PMC
August 2012

Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice.

J Biol Chem 2012 Feb 12;287(6):4188-97. Epub 2011 Dec 12.

Medical Research Council Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.259325
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http://dx.doi.org/10.1074/jbc.M111.259325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281676PMC
February 2012

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

J Biol Chem 2011 Sep 30;286(39):33784-94. Epub 2011 Jul 30.

Center for Cellular and Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.262808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190818PMC
September 2011

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

Chem Biol 2011 May;18(5):642-654

Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1016/j.chembiol.2011.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681097PMC
May 2011

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.

J Biol Chem 2011 Apr 18;286(15):13041-51. Epub 2011 Feb 18.

Nuffield Department of Clinical Medicine, Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.211110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075650PMC
April 2011

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

J Biol Chem 2011 Feb 21;286(6):4090-7. Epub 2010 Oct 21.

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.173096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039360PMC
February 2011

Sodium sulfite is a potential hypoxia inducer that mimics hypoxic stress in Caenorhabditis elegans.

J Biol Inorg Chem 2011 Feb 30;16(2):267-74. Epub 2010 Oct 30.

Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Taiping Road 27, Beijing, 100850, China.

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http://dx.doi.org/10.1007/s00775-010-0723-1DOI Listing
February 2011

Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions.

Chem Commun (Camb) 2011 Feb 13;47(5):1488-90. Epub 2010 Dec 13.

University of Oxford, Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1039/c0cc04457aDOI Listing
February 2011

The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens.

EMBO Rep 2011 Jan 26;12(1):63-70. Epub 2010 Nov 26.

Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1038/embor.2010.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024122PMC
January 2011

HLA has strongest association with IgA nephropathy in genome-wide analysis.

J Am Soc Nephrol 2010 Oct 1;21(10):1791-7. Epub 2010 Jul 1.

The John Walls Renal Unit, Leicester General Hospital and Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1681/ASN.2010010076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013538PMC
October 2010

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.

Anticancer Res 2009 Nov;29(11):4337-43

Department of Medical and Molecular Genetics, University of Birmingham, Institute of Biomedical Research, Edgbaston, Birmingham, B15 2TT, UK.

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November 2009

Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials.

JAMA 2009 Oct;302(13):1444-50

Department of Physiology, Anatomy, and Genetics, University of Oxford, Sherrington Bldg, Parks Road, Oxford OX1 3PT, England.

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http://dx.doi.org/10.1001/jama.2009.1404DOI Listing
October 2009

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Ann N Y Acad Sci 2009 Oct;1177:9-18

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05042.xDOI Listing
October 2009

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

Biochem J 2009 May 13;420(2):327-33. Epub 2009 May 13.

Nuffield Department of Clinical Medicine, University of Oxford, Headington, UK.

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http://dx.doi.org/10.1042/BJ20081905DOI Listing
May 2009

Angiogenesis: escape from hypoxia.

Nat Med 2009 May;15(5):491-3

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http://dx.doi.org/10.1038/nm0509-491DOI Listing
May 2009

Cancer. Puzzling patterns of predisposition.

Science 2009 Apr;324(5924):192-4

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1126/science.1173362DOI Listing
April 2009

Regulation of growth differentiation factor 15 expression by intracellular iron.

Blood 2009 Feb 1;113(7):1555-63. Epub 2008 Dec 1.

Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1182/blood-2008-07-170431DOI Listing
February 2009

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold.

Mol Biosyst 2009 Jan 29;5(1):52-8. Epub 2008 Oct 29.

The Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, UKOX1 3TA.

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http://dx.doi.org/10.1039/b815271cDOI Listing
January 2009

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.

Biochem J 2008 Dec;416(3):387-94

Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1042/BJ20081238DOI Listing
December 2008

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status.

J Physiol 2008 Dec 27;586(24):5999-6005. Epub 2008 Oct 27.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1113/jphysiol.2008.160960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655431PMC
December 2008

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.

Chem Commun (Camb) 2008 Dec 5(47):6393-5. Epub 2008 Nov 5.

The Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, United Kingdom.

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http://dx.doi.org/10.1039/b814440kDOI Listing
December 2008

Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia.

BJU Int 2008 Jun;101 Suppl 4:8-15

Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovak Republic.

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http://dx.doi.org/10.1111/j.1464-410X.2008.07642.xDOI Listing
June 2008

The human side of hypoxia-inducible factor.

Br J Haematol 2008 May;141(3):325-34

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1111/j.1365-2141.2008.07029.x
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http://dx.doi.org/10.1111/j.1365-2141.2008.07029.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408651PMC
May 2008

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Mol Cell 2008 May;30(4):393-402

Howard Hughes Medical Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.04.009DOI Listing
May 2008

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Methods Enzymol 2007 ;435:25-42

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(07)35002-7DOI Listing
February 2008