Peter J Crouch

Peter J Crouch

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Peter J Crouch

Peter J Crouch

Publications by authors named "Peter J Crouch"

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Cu (atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease.

Br J Pharmacol 2020 Feb 14;177(3):656-667. Epub 2020 Jan 14.

Melbourne Dementia Research Centre, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/bph.14881DOI Listing
February 2020

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups.

Inorg Chem 2019 Apr 14;58(7):4540-4552. Epub 2019 Mar 14.

The Centre for Molecular Imaging and Translational Research Laboratory , The Peter MacCallum Cancer Centre , Melbourne , Victoria 3000 , Australia.

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http://dx.doi.org/10.1021/acs.inorgchem.9b00117DOI Listing
April 2019

Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques.

Inorg Chem 2019 Mar 20;58(5):3382-3395. Epub 2019 Feb 20.

Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences , Monash University , Parkville , Victoria , Australia , 3052.

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http://dx.doi.org/10.1021/acs.inorgchem.8b03466DOI Listing
March 2019

A versatile quantitative microdroplet elemental imaging method optimised for integration in biochemical workflows for low-volume samples.

Anal Bioanal Chem 2019 Jan 15;411(3):603-616. Epub 2018 Sep 15.

Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1007/s00216-018-1362-6DOI Listing
January 2019

The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1 mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1.

Exp Neurol 2018 09 12;307:118-128. Epub 2018 Jun 12.

Department of Pharmacology and Therapeutics, the University of Melbourne, Victoria 3010, Australia; Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.expneurol.2018.06.006DOI Listing
September 2018

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

Int J Biochem Cell Biol 2016 10 30;79:128-138. Epub 2016 Aug 30.

Department of Pathology, University of Melbourne, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.08.029DOI Listing
October 2016

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.

Hum Mol Genet 2016 09 27;25(18):4080-4093. Epub 2016 Jul 27.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3052, Australia

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http://dx.doi.org/10.1093/hmg/ddw247DOI Listing
September 2016

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

Hum Mol Genet 2016 07 14;25(14):2923-2933. Epub 2016 May 14.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Pde, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1093/hmg/ddw144DOI Listing
July 2016

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Cell Mol Life Sci 2016 Feb 23;73(3):667-83. Epub 2015 Aug 23.

Department of Medicine, RMH, The University of Melbourne, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/s00018-015-2022-zDOI Listing
February 2016

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes.

Inorg Chem 2015 Oct 16;54(19):9594-610. Epub 2015 Sep 16.

Ludwig Institute for Cancer Research , Melbourne-Austin Branch, 145 Studley Road, Heidelberg, Victoria 3084, Australia.

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http://dx.doi.org/10.1021/acs.inorgchem.5b01691DOI Listing
October 2015

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

Neurobiol Dis 2015 Sep 10;81:20-4. Epub 2015 Mar 10.

Department of Pathology, The University of Melbourne, Victoria 3010, Australia; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.02.023DOI Listing
September 2015

Editorial: Metals and neurodegeneration: restoring the balance.

Front Aging Neurosci 2015 2;7:127. Epub 2015 Jul 2.

Department of Pathology, University of Melbourne Parkville VIC, Australia.

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http://dx.doi.org/10.3389/fnagi.2015.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488751PMC
July 2015

Metal-deficient SOD1 in amyotrophic lateral sclerosis.

J Mol Med (Berl) 2015 May 11;93(5):481-7. Epub 2015 Mar 11.

Department of Pathology, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

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http://dx.doi.org/10.1007/s00109-015-1273-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408375PMC
May 2015

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis.

Authors:
Peter J Crouch

Neurology 2015 May 22;84(20):2038. Epub 2015 Apr 22.

From the Department of Pathology and Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000001600DOI Listing
May 2015

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation.

PLoS One 2013 29;8(11):e81170. Epub 2013 Nov 29.

Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia ; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081170PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843686PMC
December 2014

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

PLoS One 2014 28;9(2):e90070. Epub 2014 Feb 28.

Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia ; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090070PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938583PMC
October 2014

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Front Aging Neurosci 2014 11;6:15. Epub 2014 Feb 11.

Department of Pathology, The University of Melbourne VIC, Australia ; Florey Institute of Neuroscience and Mental Health, The University of Melbourne VIC, Australia.

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http://dx.doi.org/10.3389/fnagi.2014.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920072PMC
February 2014

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease.

Free Radic Biol Med 2013 Jul 4;60:147-56. Epub 2013 Feb 4.

Department of Pathology, University of Melbourne, and Mental Health Research Institute, Melbourne Brain Centre, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.01.027DOI Listing
July 2013

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells.

Biochim Biophys Acta 2013 Jul 6;1827(7):817-25. Epub 2013 Apr 6.

Department of Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbabio.2013.03.012DOI Listing
July 2013

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.

Biol Open 2013 Jun 20;2(6):635-46. Epub 2013 May 20.

Department of Pathology, The University of Melbourne , Parkville, Victoria 3010 , Australia ; Present address: AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio 70211, Finland.

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http://bio.biologists.org/cgi/doi/10.1242/bio.20134804
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http://dx.doi.org/10.1242/bio.20134804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683166PMC
June 2013

Therapeutic redistribution of metal ions to treat Alzheimer's disease.

Acc Chem Res 2012 Sep 29;45(9):1604-11. Epub 2012 Jun 29.

Department of Pathology, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1021/ar300074tDOI Listing
September 2012

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates.

Neurochem Int 2012 Mar 27;60(4):415-24. Epub 2012 Jan 27.

Department of Pathology, Centre for Neuroscience, The University of Melbourne, Mental Health Research Institute, Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.neuint.2012.01.019DOI Listing
March 2012

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

Metallomics 2011 Dec 19;3(12):1280-90. Epub 2011 Sep 19.

Department of Pathology, The University of Melbourne, Victoria, Australia.

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http://xlink.rsc.org/?DOI=c1mt00092f
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http://dx.doi.org/10.1039/c1mt00092fDOI Listing
December 2011

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5.

Free Radic Biol Med 2011 Dec 16;51(11):2060-72. Epub 2011 Sep 16.

Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.09.006DOI Listing
December 2011

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

Inorg Chem 2011 Oct 1;50(19):9594-605. Epub 2011 Sep 1.

Department of Pathology, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1021/ic201334qDOI Listing
October 2011

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

Biometals 2011 Feb 8;24(1):117-33. Epub 2010 Oct 8.

Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.

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http://dx.doi.org/10.1007/s10534-010-9380-7DOI Listing
February 2011

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper.

Dalton Trans 2011 Feb 21;40(6):1338-47. Epub 2010 Dec 21.

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1039/c0dt01176bDOI Listing
February 2011

Zinc induces depletion and aggregation of endogenous TDP-43.

Free Radic Biol Med 2010 May 4;48(9):1152-61. Epub 2010 Feb 4.

Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.01.035DOI Listing
May 2010

Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease.

Mol Biosyst 2009 Feb 12;5(2):134-42. Epub 2008 Dec 12.

Department of Pathology, The University of Melbourne, 3010, Victoria, Australia.

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http://dx.doi.org/10.1039/b816577gDOI Listing
February 2009

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

J Cell Mol Med 2009 Feb;13(2):249-61

Department of Pathology, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00642.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823352PMC
February 2009

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.

Proc Natl Acad Sci U S A 2009 Jan 2;106(2):381-6. Epub 2009 Jan 2.

Department of Pathology, Centre for Neuroscience, School of Chemistry, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victorial, 3010, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0809057106
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http://dx.doi.org/10.1073/pnas.0809057106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626711PMC
January 2009

Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity.

Int J Biochem Cell Biol 2008 17;40(5):1030-42. Epub 2007 Nov 17.

Centre for Neuroscience and Department of Pathology, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.biocel.2007.11.003DOI Listing
June 2008

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease.

Int J Biochem Cell Biol 2008 1;40(2):181-98. Epub 2007 Aug 1.

Department of Pathology, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.biocel.2007.07.013DOI Listing
March 2008

The role of metals in modulating metalloprotease activity in the AD brain.

Eur Biophys J 2008 Mar 13;37(3):315-21. Epub 2008 Feb 13.

Department of Pathology and the Centre for Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia.

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http://link.springer.com/content/pdf/10.1007/s00249-007-0244
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http://link.springer.com/10.1007/s00249-007-0244-1
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http://dx.doi.org/10.1007/s00249-007-0244-1DOI Listing
March 2008

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages.

J Pharmacol Exp Ther 2008 Jan 16;324(1):360-7. Epub 2007 Oct 16.

Centre for Neuroscience and Department of Pathology, University of Melbourne, Victoria, Australia 3010.

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http://dx.doi.org/10.1124/jpet.107.130377DOI Listing
January 2008

Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation.

Free Radic Biol Med 2008 Jan 15;44(1):44-55. Epub 2007 Sep 15.

Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.09.001DOI Listing
January 2008

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

Recent Pat CNS Drug Discov 2007 Nov;2(3):180-7

Department of Pathology and the Centre for Neuroscience, The University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/157488907782411774DOI Listing
November 2007

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.

FEBS J 2007 Aug 6;274(15):3775-83. Epub 2007 Jul 6.

Department of Pathology and Centre for Neuroscience, The University of Melbourne, Australia.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05918.xDOI Listing
August 2007

Therapeutic treatments for Alzheimer's disease based on metal bioavailability.

Drug News Perspect 2006 Oct;19(8):469-74

Department of Pathology, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1358/dnp.2006.19.8.1021492DOI Listing
October 2006

Linker histone H1 binds to disease associated amyloid-like fibrils.

J Mol Biol 2006 Aug 3;361(3):493-505. Epub 2006 Jul 3.

Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.jmb.2006.06.038DOI Listing
August 2006