Publications by authors named "Peter J Castaldi"

74Publications

Characterization of a COPD-Associated Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing.

Authors:
Aabida Saferali Zhonghui Xu Gloria M Sheynkman Craig P Hersh Michael H Cho Edwin K Silverman Alain Laederach Christopher Vollmers Peter J Castaldi

medRxiv 2020 Nov 3. Epub 2020 Nov 3.

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November 2020

Statistical considerations for the analysis of massively parallel reporter assays data.

Authors:
Dandi Qiao Corwin M Zigler Michael H Cho Edwin K Silverman Xiaobo Zhou Peter J Castaldi Nan H Laird

Genet Epidemiol 2020 Oct 18;44(7):785-794. Epub 2020 Jul 18.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

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October 2020

Deep neural network analyses of spirometry for structural phenotyping of chronic obstructive pulmonary disease.

Authors:
Sandeep Bodduluri Arie Nakhmani Joseph M Reinhardt Carla G Wilson Merry-Lynn McDonald Ramaraju Rudraraju Byron C Jaeger Nirav R Bhakta Peter J Castaldi Frank C Sciurba Chengcui Zhang Purushotham V Bangalore Surya P Bhatt

JCI Insight 2020 07 9;5(13). Epub 2020 Jul 9.

UAB Lung Imaging Core.

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July 2020

Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells.

Authors:
Yuan Hao Samuel Bates Hongmei Mou Jeong H Yun Betty Pham Jiangyuan Liu Weiliang Qiu Feng Guo Jarrett D Morrow Craig P Hersh Christopher J Benway Lu Gong Yihan Zhang Ivan O Rosas Michael H Cho Jin-Ah Park Peter J Castaldi Fei Du Xiaobo Zhou

Am J Respir Crit Care Med 2020 11;202(9):1225-1236

Channing Division of Network Medicine and.

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November 2020

Heme metabolism genes Downregulated in COPD Cachexia.

Authors:
Ava C Wilson Preeti L Kumar Sool Lee Margaret M Parker Itika Arora Jarrett D Morrow Emiel F M Wouters Richard Casaburi Stephen I Rennard David A Lomas Alvar Agusti Ruth Tal-Singer Mark T Dransfield J Michael Wells Surya P Bhatt George Washko Victor J Thannickal Hemant K Tiwari Craig P Hersh Peter J Castaldi Edwin K Silverman Merry-Lynn N McDonald

Respir Res 2020 May 1;21(1):100. Epub 2020 May 1.

Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.

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May 2020

Machine Learning and Prediction of All-Cause Mortality in COPD.

Authors:
Matthew Moll Dandi Qiao Elizabeth A Regan Gary M Hunninghake Barry J Make Ruth Tal-Singer Michael J McGeachie Peter J Castaldi Raul San Jose Estepar George R Washko James M Wells David LaFon Matthew Strand Russell P Bowler MeiLan K Han Jorgen Vestbo Bartolome Celli Peter Calverley James Crapo Edwin K Silverman Brian D Hobbs Michael H Cho

Chest 2020 Sep 27;158(3):952-964. Epub 2020 Apr 27.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address:

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September 2020

Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study.

Authors:
Peter J Castaldi Adel Boueiz Jeong Yun Raul San Jose Estepar James C Ross George Washko Michael H Cho Craig P Hersh Gregory L Kinney Kendra A Young Elizabeth A Regan David A Lynch Gerald J Criner Jennifer G Dy Stephen I Rennard Richard Casaburi Barry J Make James Crapo Edwin K Silverman John E Hokanson

Chest 2020 May 28;157(5):1147-1157. Epub 2019 Dec 28.

Department of Epidemiology, University of Colorado, Denver, Aurora, CO.

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May 2020

Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking.

Authors:
Margaret M Parker Robert P Chase Andrew Lamb Alejandro Reyes Aabida Saferali Jeong H Yun Blanca E Himes Edwin K Silverman Craig P Hersh Peter J Castaldi

BMC Med Genomics 2019 11 18;12(1):166. Epub 2019 Nov 18.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA, USA.

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November 2019

Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality.

Authors:
Kendra A Young Elizabeth A Regan MeiLan K Han Sharon M Lutz Margaret Ragland Peter J Castaldi George R Washko Michael H Cho Mathew Strand Douglas Curran-Everett Terri H Beaty Russell P Bowler Emily S Wan David A Lynch Barry J Make Edwin K Silverman James D Crapo John E Hokanson Gregory L Kinney

Chronic Obstr Pulm Dis 2019 Nov;6(5):400-413

Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora.

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November 2019

COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Authors:
Katherine E Lowe Elizabeth A Regan Antonio Anzueto Erin Austin John H M Austin Terri H Beaty Panayiotis V Benos Christopher J Benway Surya P Bhatt Eugene R Bleecker Sandeep Bodduluri Jessica Bon Aladin M Boriek Adel Re Boueiz Russell P Bowler Matthew Budoff Richard Casaburi Peter J Castaldi Jean-Paul Charbonnier Michael H Cho Alejandro Comellas Douglas Conrad Corinne Costa Davis Gerard J Criner Douglas Curran-Everett Jeffrey L Curtis Dawn L DeMeo Alejandro A Diaz Mark T Dransfield Jennifer G Dy Ashraf Fawzy Margaret Fleming Eric L Flenaugh Marilyn G Foreman Spyridon Fortis Hirut Gebrekristos Sarah Grant Philippe A Grenier Tian Gu Abhya Gupta MeiLan K Han Nicola A Hanania Nadia N Hansel Lystra P Hayden Craig P Hersh Brian D Hobbs Eric A Hoffman James C Hogg John E Hokanson Karin F Hoth Albert Hsiao Stephen Humphries Kathleen Jacobs Francine L Jacobson Ella A Kazerooni Victor Kim Woo Jin Kim Gregory L Kinney Harald Koegler Sharon M Lutz David A Lynch Neil R MacIntye Barry J Make Nathaniel Marchetti Fernando J Martinez Diego J Maselli Anne M Mathews Meredith C McCormack Merry-Lynn N McDonald Charlene E McEvoy Matthew Moll Sarah S Molye Susan Murray Hrudaya Nath John D Newell Mariaelena Occhipinti Matteo Paoletti Trisha Parekh Massimo Pistolesi Katherine A Pratte Nirupama Putcha Margaret Ragland Joseph M Reinhardt Stephen I Rennard Richard A Rosiello James C Ross Harry B Rossiter Ingo Ruczinski Raul San Jose Estepar Frank C Sciurba Jessica C Sieren Harjinder Singh Xavier Soler Robert M Steiner Matthew J Strand William W Stringer Ruth Tal-Singer Byron Thomashow Gonzalo Vegas Sánchez-Ferrero John W Walsh Emily S Wan George R Washko J Michael Wells Chris H Wendt Gloria Westney Ava Wilson Robert A Wise Andrew Yen Kendra Young Jeong Yun Edwin K Silverman James D Crapo

Chronic Obstr Pulm Dis 2019 Nov;6(5):384-399

National Jewish Health, Denver, Colorado.

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November 2019

Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease.

Authors:
Jeong H Yun Robert Chase Margaret M Parker Aabida Saferali Peter J Castaldi Edwin K Silverman Craig P Hersh

Am J Respir Cell Mol Biol 2019 09;61(3):398-401

Brigham and Women's HospitalBoston, Massachusettsand.

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September 2019

Identification of an emphysema-associated genetic variant near with regulatory effects in lung fibroblasts.

Authors:
Margaret M Parker Yuan Hao Feng Guo Betty Pham Robert Chase John Platig Michael H Cho Craig P Hersh Victor J Thannickal James Crapo George Washko Scott H Randell Edwin K Silverman Raúl San José Estépar Xiaobo Zhou Peter J Castaldi

Elife 2019 07 25;8. Epub 2019 Jul 25.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, United States.

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July 2019

Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene.

Authors:
Aabida Saferali Jeong H Yun Margaret M Parker Phuwanat Sakornsakolpat Robert P Chase Andrew Lamb Brian D Hobbs Marike H Boezen Xiangpeng Dai Kim de Jong Terri H Beaty Wenyi Wei Xiaobo Zhou Edwin K Silverman Michael H Cho Peter J Castaldi Craig P Hersh

PLoS Genet 2019 07 3;15(7):e1008229. Epub 2019 Jul 3.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

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July 2019

Unsupervised discovery of phenotype-specific multi-omics networks.

Authors:
W Jenny Shi Yonghua Zhuang Pamela H Russell Brian D Hobbs Margaret M Parker Peter J Castaldi Pratyaydipta Rudra Brian Vestal Craig P Hersh Laura M Saba Katerina Kechris

Bioinformatics 2019 11;35(21):4336-4343

Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

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November 2019

Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.

Authors:
Margaret F Ragland Christopher J Benway Sharon M Lutz Russell P Bowler Julian Hecker John E Hokanson James D Crapo Peter J Castaldi Dawn L DeMeo Craig P Hersh Brian D Hobbs Christoph Lange Terri H Beaty Michael H Cho Edwin K Silverman

Am J Respir Crit Care Med 2019 09;200(6):677-690

Channing Division of Network Medicine and.

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September 2019

Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.

Authors:
Elizabeth A Regan Craig P Hersh Peter J Castaldi Dawn L DeMeo Edwin K Silverman James D Crapo Russell P Bowler

Am J Respir Cell Mol Biol 2019 08;61(2):143-149

1Department of Medicine, National Jewish Health, Denver, Colorado; and.

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August 2019

Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease.

Authors:
Margaret M Parker Sharon M Lutz Brian D Hobbs Robert Busch MerryLynn N McDonald Peter J Castaldi Terri H Beaty John E Hokanson Edwin K Silverman Michael H Cho

Genet Epidemiol 2019 04 11;43(3):318-329. Epub 2019 Feb 11.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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April 2019

New Spirometry Indices for Detecting Mild Airflow Obstruction.

Authors:
Surya P Bhatt Nirav R Bhakta Carla G Wilson Christopher B Cooper Igor Barjaktarevic Sandeep Bodduluri Young-Il Kim Michael Eberlein Prescott G Woodruff Frank C Sciurba Peter J Castaldi MeiLan K Han Mark T Dransfield Arie Nakhmani

Sci Rep 2018 11 30;8(1):17484. Epub 2018 Nov 30.

Department of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

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November 2018

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

Authors:
J Michael Wells Margaret M Parker Robert A Oster Russ P Bowler Mark T Dransfield Surya P Bhatt Michael H Cho Victor Kim Jeffrey L Curtis Fernando J Martinez Robert Paine Wanda O'Neal Wassim W Labaki Robert J Kaner Igor Barjaktarevic MeiLan K Han Edwin K Silverman James D Crapo R Graham Barr Prescott Woodruff Peter J Castaldi Amit Gaggar

JCI Insight 2018 11 15;3(22). Epub 2018 Nov 15.

The SPIROMICS and COPDGene groups are detailed in the Supplemental Acknowledgments.

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November 2018

Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution.

Authors:
Adel Boueiz Betty Pham Robert Chase Andrew Lamb Sool Lee Zun Zar Chi Naing Michael H Cho Margaret M Parker Phuwanat Sakornsakolpat Craig P Hersh James D Crapo Andrew B Stergachis Ruth Tal-Singer Dawn L DeMeo Edwin K Silverman Xiaobo Zhou Peter J Castaldi

Am J Respir Cell Mol Biol 2019 04;60(4):388-398

1 Channing Division of Network Medicine.

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April 2019

Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke.

Authors:
Kimberly Glass Derek Thibault Feng Guo Jennifer A Mitchel Betty Pham Weiliang Qiu Yan Li Zhiqiang Jiang Peter J Castaldi Edwin K Silverman Benjamin Raby Jin-Ah Park Guo-Cheng Yuan Xiaobo Zhou

Sci Rep 2018 08 24;8(1):12750. Epub 2018 Aug 24.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

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August 2018

Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays.

Authors:
Peter J Castaldi Feng Guo Dandi Qiao Fei Du Zun Zar Chi Naing Yan Li Betty Pham Tarjei S Mikkelsen Michael H Cho Edwin K Silverman Xiaobo Zhou

Am J Respir Crit Care Med 2019 01;199(1):52-61

1 Channing Division of Network Medicine and.

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January 2019

Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study.

Authors:
Gregory L Kinney Stephanie A Santorico Kendra A Young Michael H Cho Peter J Castaldi Raul San José Estépar James C Ross Jennifer G Dy Barry J Make Elizabeth A Regan David A Lynch Douglas C Everett Sharon M Lutz Edwin K Silverman George R Washko James D Crapo John E Hokanson

Am J Epidemiol 2018 10;187(10):2109-2116

Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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October 2018

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease.

Authors:
Jeong H Yun Andrew Lamb Robert Chase Dave Singh Margaret M Parker Aabida Saferali Jørgen Vestbo Ruth Tal-Singer Peter J Castaldi Edwin K Silverman Craig P Hersh

J Allergy Clin Immunol 2018 06 28;141(6):2037-2047.e10. Epub 2018 Apr 28.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address:

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June 2018

Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease.

Authors:
James C Ross Peter J Castaldi Michael H Cho Craig P Hersh Farbod N Rahaghi Gonzalo V Sánchez-Ferrero Margaret M Parker Augusto A Litonjua David Sparrow Jennifer G Dy Edwin K Silverman George R Washko Raúl San José Estépar

Am J Respir Crit Care Med 2018 10;198(8):1033-1042

1 Department of Radiology.

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October 2018

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Authors:
Phuwanat Sakornsakolpat Jarrett D Morrow Peter J Castaldi Craig P Hersh Yohan Bossé Edwin K Silverman Ani Manichaikul Michael H Cho

Respir Res 2018 03 22;19(1):46. Epub 2018 Mar 22.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Room 451, Boston, MA, 02115, USA.

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March 2018

Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression.

Authors:
Eitan Halper-Stromberg Jeong H Yun Margaret M Parker Ruth Tal Singer Amit Gaggar Edwin K Silverman Sonia Leach Russell P Bowler Peter J Castaldi

Am J Respir Cell Mol Biol 2018 04;58(4):500-509

3 Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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April 2018

The value of blood cytokines and chemokines in assessing COPD.

Authors:
Eric Bradford Sean Jacobson Jason Varasteh Alejandro P Comellas Prescott Woodruff Wanda O'Neal Dawn L DeMeo Xingnan Li Victor Kim Michael Cho Peter J Castaldi Craig Hersh Edwin K Silverman James D Crapo Katerina Kechris Russell P Bowler

Respir Res 2017 10 24;18(1):180. Epub 2017 Oct 24.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, 1400 Jackson St., K715, Denver, CO, 80206, USA.

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October 2017

RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking.

Authors:
Margaret M Parker Robert P Chase Andrew Lamb Alejandro Reyes Aabida Saferali Jeong H Yun Blanca E Himes Edwin K Silverman Craig P Hersh Peter J Castaldi

BMC Med Genomics 2017 10 6;10(1):58. Epub 2017 Oct 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Ave, Boston, MA, USA.

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October 2017

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.

Authors:
Adel Boueiz Yale Chang Michael H Cho George R Washko Raul San José Estépar Russell P Bowler James D Crapo Dawn L DeMeo Jennifer G Dy Edwin K Silverman Peter J Castaldi

Chest 2018 01 21;153(1):65-76. Epub 2017 Sep 21.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of General Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

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January 2018

Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics.

Authors:
Sara Zarei Ali Mirtar Jarrett D Morrow Peter J Castaldi Paula Belloni Craig P Hersh

Chronic Obstr Pulm Dis 2017 Feb 8;4(2):97-108. Epub 2017 Feb 8.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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February 2017

Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts.

Authors:
Peter J Castaldi Marta Benet Hans Petersen Nicholas Rafaels James Finigan Matteo Paoletti H Marike Boezen Judith M Vonk Russell Bowler Massimo Pistolesi Milo A Puhan Josep Anto Els Wauters Diether Lambrechts Wim Janssens Francesca Bigazzi Gianna Camiciottoli Michael H Cho Craig P Hersh Kathleen Barnes Stephen Rennard Meher Preethi Boorgula Jennifer Dy Nadia N Hansel James D Crapo Yohannes Tesfaigzi Alvar Agusti Edwin K Silverman Judith Garcia-Aymerich

Thorax 2017 11 21;72(11):998-1006. Epub 2017 Jun 21.

ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.

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November 2017

Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease.

Authors:
Ma'en Obeidat Yunlong Nie Virginia Chen Casey P Shannon Anand Kumar Andiappan Bernett Lee Olaf Rotzschke Peter J Castaldi Craig P Hersh Nick Fishbane Raymond T Ng Bruce McManus Bruce E Miller Stephen Rennard Peter D Paré Don D Sin

Respir Res 2017 04 24;18(1):72. Epub 2017 Apr 24.

The University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

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April 2017

Screening for interaction effects in gene expression data.

Authors:
Peter J Castaldi Michael H Cho Liming Liang Edwin K Silverman Craig P Hersh Kenneth Rice Hugues Aschard

PLoS One 2017 16;12(3):e0173847. Epub 2017 Mar 16.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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September 2017

Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.

Authors:
Robert Busch Brian D Hobbs Jin Zhou Peter J Castaldi Michael J McGeachie Megan E Hardin Iwona Hawrylkiewicz Pawel Sliwinski Jae-Joon Yim Woo Jin Kim Deog K Kim Alvar Agusti Barry J Make James D Crapo Peter M Calverley Claudio F Donner David A Lomas Emiel F Wouters Jørgen Vestbo Ruth Tal-Singer Per Bakke Amund Gulsvik Augusto A Litonjua David Sparrow Peter D Paré Robert D Levy Stephen I Rennard Terri H Beaty John Hokanson Edwin K Silverman Michael H Cho

Am J Respir Cell Mol Biol 2017 07;57(1):35-46

1 Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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July 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Authors:
Brian D Hobbs Kim de Jong Maxime Lamontagne Yohan Bossé Nick Shrine María Soler Artigas Louise V Wain Ian P Hall Victoria E Jackson Annah B Wyss Stephanie J London Kari E North Nora Franceschini David P Strachan Terri H Beaty John E Hokanson James D Crapo Peter J Castaldi Robert P Chase Traci M Bartz Susan R Heckbert Bruce M Psaty Sina A Gharib Pieter Zanen Jan W Lammers Matthijs Oudkerk H J Groen Nicholas Locantore Ruth Tal-Singer Stephen I Rennard Jørgen Vestbo Wim Timens Peter D Paré Jeanne C Latourelle Josée Dupuis George T O'Connor Jemma B Wilk Woo Jin Kim Mi Kyeong Lee Yeon-Mok Oh Judith M Vonk Harry J de Koning Shuguang Leng Steven A Belinsky Yohannes Tesfaigzi Ani Manichaikul Xin-Qun Wang Stephen S Rich R Graham Barr David Sparrow Augusto A Litonjua Per Bakke Amund Gulsvik Lies Lahousse Guy G Brusselle Bruno H Stricker André G Uitterlinden Elizabeth J Ampleford Eugene R Bleecker Prescott G Woodruff Deborah A Meyers Dandi Qiao David A Lomas Jae-Joon Yim Deog Kyeom Kim Iwona Hawrylkiewicz Pawel Sliwinski Megan Hardin Tasha E Fingerlin David A Schwartz Dirkje S Postma William MacNee Martin D Tobin Edwin K Silverman H Marike Boezen Michael H Cho

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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March 2017

A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes.

Authors:
James C Ross Peter J Castaldi Michael H Cho Junxiang Chen Yale Chang Jennifer G Dy Edwin K Silverman George R Washko Raul San Jose Estepar

IEEE Trans Med Imaging 2017 01;36(1):343-354

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January 2017

Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.

Authors:
Merry-Lynn Noelle McDonald Sungho Won Manuel Mattheisen Peter J Castaldi Michael H Cho Erica Rutten Megan Hardin Wai-Ki Yip Stephen I Rennard David A Lomas Emiel F M Wouters Alvar Agusti Richard Casaburi Christoph P Lange George O'Connor Craig P Hersh Edwin K Silverman

J Cachexia Sarcopenia Muscle 2017 Jun 2;8(3):428-436. Epub 2017 Jan 2.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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June 2017

Whole genome prediction and heritability of childhood asthma phenotypes.

Authors:
Michael J McGeachie George L Clemmer Damien C Croteau-Chonka Peter J Castaldi Michael H Cho Joanne E Sordillo Jessica A Lasky-Su Benjamin A Raby Kelan G Tantisira Scott T Weiss

Immun Inflamm Dis 2016 12 28;4(4):487-496. Epub 2016 Nov 28.

Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts.

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December 2016

Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

Authors:
Megan Hardin Michael H Cho Sunita Sharma Kimberly Glass Peter J Castaldi Merry-Lynn McDonald Hugues Aschard Jody Senter-Sylvia Kelan Tantisira Scott T Weiss Craig P Hersh Jarrett D Morrow David Lomas Alvar Agusti Per Bakke Amund Gulsvik George T O'Connor Josée Dupuis John Hokanson James D Crapo Terri H Beaty Nan Laird Edwin K Silverman Dawn L DeMeo

Am J Respir Cell Mol Biol 2017 03;56(3):332-341

1 Channing Division of Network Medicine and.

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March 2017

Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease.

Authors:
Eitan Halper-Stromberg Michael H Cho Carla Wilson Dipti Nevrekar James D Crapo George Washko Raúl San José Estépar David A Lynch Edwin K Silverman Sonia Leach Peter J Castaldi

Ann Am Thorac Soc 2017 Jan;14(1):33-40

3 Channing Division of Network Medicine.

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January 2017

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Authors:
Adel Boueiz Sharon M Lutz Michael H Cho Craig P Hersh Russell P Bowler George R Washko Eitan Halper-Stromberg Per Bakke Amund Gulsvik Nan M Laird Terri H Beaty Harvey O Coxson James D Crapo Edwin K Silverman Peter J Castaldi Dawn L DeMeo

Am J Respir Crit Care Med 2017 03;195(6):757-771

1 Channing Division of Network Medicine.

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March 2017

Bipartite Community Structure of eQTLs.

Authors:
John Platig Peter J Castaldi Dawn DeMeo John Quackenbush

PLoS Comput Biol 2016 09 12;12(9):e1005033. Epub 2016 Sep 12.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

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September 2016

A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria.

Authors:
Asli Gorek Dilektasli Janos Porszasz Richard Casaburi William W Stringer Surya P Bhatt Youngju Pak Harry B Rossiter George Washko Peter J Castaldi Raul San Jose Estepar James E Hansen

Chest 2016 Nov 22;150(5):1080-1090. Epub 2016 Jul 22.

Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.

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November 2016

Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma.

Authors:
Michael J McGeachie Katherine P Yates Xiaobo Zhou Feng Guo Alice L Sternberg Mark L Van Natta Robert A Wise Stanley J Szefler Sunita Sharma Alvin T Kho Michael H Cho Damien C Croteau-Chonka Peter J Castaldi Gaurav Jain Amartya Sanyal Ye Zhan Bryan R Lajoie Job Dekker John Stamatoyannopoulos Ronina A Covar Robert S Zeiger N Franklin Adkinson Paul V Williams H William Kelly Hartmut Grasemann Judith M Vonk Gerard H Koppelman Dirkje S Postma Benjamin A Raby Isaac Houston Quan Lu Anne L Fuhlbrigge Kelan G Tantisira Edwin K Silverman James Tonascia Robert C Strunk Scott T Weiss

Am J Respir Crit Care Med 2016 12;194(12):1465-1474

1 Channing Division of Network Medicine and.

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December 2016

Recognizing the Many Faces of Chronic Obstructive Pulmonary Disease.

Authors:
Peter J Castaldi Anil Vachani

Am J Respir Crit Care Med 2016 06;193(11):1190-2

3 Department of Medicine Perelman School of Medicine Philadelphia, Pennsylvania and.

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June 2016

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Authors:
Zhiqiang Jiang Taotao Lao Weiliang Qiu Francesca Polverino Kushagra Gupta Feng Guo John D Mancini Zun Zar Chi Naing Michael H Cho Peter J Castaldi Yang Sun Jane Yu Maria E Laucho-Contreras Lester Kobzik Benjamin A Raby Augustine M K Choi Mark A Perrella Caroline A Owen Edwin K Silverman Xiaobo Zhou

Am J Respir Crit Care Med 2016 07;194(2):185-97

1 Channing Division of Network Medicine, Department of Medicine.

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July 2016

Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.

Authors:
Brian D Hobbs Margaret M Parker Han Chen Taotao Lao Megan Hardin Dandi Qiao Iwona Hawrylkiewicz Pawel Sliwinski Jae-Joon Yim Woo Jin Kim Deog Kyeom Kim Peter J Castaldi Craig P Hersh Jarrett Morrow Bartolome R Celli Victor M Pinto-Plata Gerald J Criner Nathaniel Marchetti Raphael Bueno Alvar Agustí Barry J Make James D Crapo Peter M Calverley Claudio F Donner David A Lomas Emiel F M Wouters Jorgen Vestbo Peter D Paré Robert D Levy Stephen I Rennard Xiaobo Zhou Nan M Laird Xihong Lin Terri H Beaty Edwin K Silverman Michael H Cho

Am J Respir Crit Care Med 2016 07;194(1):48-57

1 Channing Division of Network Medicine.

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July 2016

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Authors:
Sharon M Lutz Michael H Cho Kendra Young Craig P Hersh Peter J Castaldi Merry-Lynn McDonald Elizabeth Regan Manuel Mattheisen Dawn L DeMeo Margaret Parker Marilyn Foreman Barry J Make Robert L Jensen Richard Casaburi David A Lomas Surya P Bhatt Per Bakke Amund Gulsvik James D Crapo Terri H Beaty Nan M Laird Christoph Lange John E Hokanson Edwin K Silverman

BMC Genet 2015 Dec 3;16:138. Epub 2015 Dec 3.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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December 2015

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes.

Authors:
Michael H Cho Peter J Castaldi Craig P Hersh Brian D Hobbs R Graham Barr Ruth Tal-Singer Per Bakke Amund Gulsvik Raúl San José Estépar Edwin J R Van Beek Harvey O Coxson David A Lynch George R Washko Nan M Laird James D Crapo Terri H Beaty Edwin K Silverman

Am J Respir Crit Care Med 2015 Sep;192(5):559-69

1 Channing Division of Network Medicine and.

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September 2015

External validation of new risk prediction models is infrequent and reveals worse prognostic discrimination.

Authors:
George C M Siontis Ioanna Tzoulaki Peter J Castaldi John P A Ioannidis

J Clin Epidemiol 2015 Jan 23;68(1):25-34. Epub 2014 Oct 23.

Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, 1265 Welch Rd, MSOB X306, Stanford, CA 94305, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA. Electronic address:

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January 2015

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus.

Authors:
Craig P Hersh Barry J Make David A Lynch R Graham Barr Russell P Bowler Peter M A Calverley Peter J Castaldi Michael H Cho Harvey O Coxson Dawn L DeMeo Marilyn G Foreman MeiLan K Han Benjamin J Harshfield John E Hokanson Sharon Lutz Joe W Ramsdell Elizabeth A Regan Stephen I Rennard Joyce D Schroeder Frank C Sciurba Robert M Steiner Ruth Tal-Singer Edwin van Beek Edwin K Silverman James D Crapo

BMC Pulm Med 2014 Oct 24;14:164. Epub 2014 Oct 24.

Channing Division of Network Medicine, Boston, MA, USA.

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October 2014

Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.

Authors:
Peter J Castaldi Michael H Cho Xiaobo Zhou Weiliang Qiu Michael Mcgeachie Bartolome Celli Per Bakke Amund Gulsvik David A Lomas James D Crapo Terri H Beaty Stephen Rennard Benjamin Harshfield Christoph Lange Dave Singh Ruth Tal-Singer John H Riley John Quackenbush Benjamin A Raby Vincent J Carey Edwin K Silverman Craig P Hersh

Hum Mol Genet 2015 Feb 14;24(4):1200-10. Epub 2014 Oct 14.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, USA, Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.

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February 2015

Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease.

Authors:
Brian D Hobbs Marilyn G Foreman Russell Bowler Francine Jacobson Barry J Make Peter J Castaldi Raúl San José Estépar Edwin K Silverman Craig P Hersh

Ann Am Thorac Soc 2014 Nov;11(9):1387-94

1 Channing Division of Network Medicine and.

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November 2014

Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene.

Authors:
Jin Hwa Lee Michael H Cho Merry-Lynn N McDonald Craig P Hersh Peter J Castaldi James D Crapo Emily S Wan Jennifer G Dy Yale Chang Elizabeth A Regan Megan Hardin Dawn L DeMeo Edwin K Silverman

Respir Med 2014 Oct 11;108(10):1469-80. Epub 2014 Aug 11.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

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October 2014

DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.

Authors:
Jin Hwa Lee Merry-Lynn N McDonald Michael H Cho Emily S Wan Peter J Castaldi Gary M Hunninghake Nathaniel Marchetti David A Lynch James D Crapo David A Lomas Harvey O Coxson Per S Bakke Edwin K Silverman Craig P Hersh

Respir Res 2014 Aug 20;15:97. Epub 2014 Aug 20.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston 02115, MA, USA.

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August 2014

Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.

Authors:
Emily S Wan Peter J Castaldi Michael H Cho John E Hokanson Elizabeth A Regan Barry J Make Terri H Beaty MeiLan K Han Jeffrey L Curtis Douglas Curran-Everett David A Lynch Dawn L DeMeo James D Crapo Edwin K Silverman

Respir Res 2014 Aug 6;15:89. Epub 2014 Aug 6.

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August 2014

Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns.

Authors:
Peter J Castaldi Michael H Cho Raúl San José Estépar Merry-Lynn N McDonald Nan Laird Terri H Beaty George Washko James D Crapo Edwin K Silverman

Am J Respir Crit Care Med 2014 Aug;190(4):399-409

1 Channing Division of Network Medicine and.

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August 2014

Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD.

Authors:
Jen-hwa Chu Craig P Hersh Peter J Castaldi Michael H Cho Benjamin A Raby Nan Laird Russell Bowler Stephen Rennard Joseph Loscalzo John Quackenbush Edwin K Silverman

BMC Syst Biol 2014 Jun 25;8:78. Epub 2014 Jun 25.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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June 2014

Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.

Authors:
Merry-Lynn N McDonald Michael H Cho Inga-Cecilie Sørheim Sharon M Lutz Peter J Castaldi David A Lomas Harvey O Coxson Lisa D Edwards William MacNee Jørgen Vestbo Julie C Yates Alvar Agusti Peter M A Calverley Bartolome Celli Courtney Crim Stephen I Rennard Emiel F M Wouters Per Bakke Ruth Tal-Singer Bruce E Miller Amund Gulsvik Richard Casaburi J Michael Wells Elizabeth A Regan Barry J Make John E Hokanson Christoph Lange James D Crapo Terri H Beaty Edwin K Silverman Craig P Hersh

Am J Respir Cell Mol Biol 2014 Nov;51(5):678-87

1 Channing Division of Network Medicine, and.

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November 2014

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.

Authors:
Michael H Cho Merry-Lynn N McDonald Xiaobo Zhou Manuel Mattheisen Peter J Castaldi Craig P Hersh Dawn L Demeo Jody S Sylvia John Ziniti Nan M Laird Christoph Lange Augusto A Litonjua David Sparrow Richard Casaburi R Graham Barr Elizabeth A Regan Barry J Make John E Hokanson Sharon Lutz Tanda Murray Dudenkov Homayoon Farzadegan Jacqueline B Hetmanski Ruth Tal-Singer David A Lomas Per Bakke Amund Gulsvik James D Crapo Edwin K Silverman Terri H Beaty

Lancet Respir Med 2014 Mar 7;2(3):214-25. Epub 2014 Feb 7.

Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

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March 2014

Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema.

Authors:
Peter J Castaldi Jennifer Dy James Ross Yale Chang George R Washko Douglas Curran-Everett Andre Williams David A Lynch Barry J Make James D Crapo Russ P Bowler Elizabeth A Regan John E Hokanson Greg L Kinney Meilan K Han Xavier Soler Joseph W Ramsdell R Graham Barr Marilyn Foreman Edwin van Beek Richard Casaburi Gerald J Criner Sharon M Lutz Steven I Rennard Stephanie Santorico Frank C Sciurba Dawn L DeMeo Craig P Hersh Edwin K Silverman Michael H Cho

Thorax 2014 May 21;69(5):415-22. Epub 2014 Feb 21.

Channing Division of Network Medicine, Brigham and Women's Hospital, , Boston, Massachusetts, USA.

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May 2014

Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells.

Authors:
Hesham Basma Yoko Gunji Shunichiro Iwasawa Amy Nelson Maha Farid Jun Ikari Xiangde Liu Xingqi Wang Joel Michalski Lynette Smith Javeed Iqbal Radwa El Behery William West Sowmya Yelamanchili Deborah Rennard Olaf Holz Kai-Christian Mueller Helgo Magnussen Klaus Rabe Peter J Castaldi Stephen I Rennard

Am J Physiol Lung Cell Mol Physiol 2014 Mar 31;306(6):L552-65. Epub 2014 Jan 31.

Univ. of Nebraska Medical Center, 985910 Nebraska Medical Center, Omaha, Nebraska 68198-5910.

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March 2014

Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers.

Authors:
Peter J Castaldi Raúl San José Estépar Carlos S Mendoza Craig P Hersh Nan Laird James D Crapo David A Lynch Edwin K Silverman George R Washko

Am J Respir Crit Care Med 2013 Nov;188(9):1083-90

1 Channing Division of Network Medicine.

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November 2013

Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers.

Authors:
Jin J Zhou Michael H Cho Peter J Castaldi Craig P Hersh Edwin K Silverman Nan M Laird

Am J Respir Crit Care Med 2013 Oct;188(8):941-7

1 Biostatistics Department, Harvard School of Public Health, Boston, Massachusetts.

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October 2013

CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.

Authors:
Megan Hardin Jan Zielinski Emily S Wan Craig P Hersh Peter J Castaldi Eric Schwinder Iwona Hawrylkiewicz Pawel Sliwinski Michael H Cho Edwin K Silverman

Am J Respir Cell Mol Biol 2012 Aug 29;47(2):203-8. Epub 2012 Mar 29.

Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA.

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August 2012

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

Authors:
Michael H Cho Peter J Castaldi Emily S Wan Mateusz Siedlinski Craig P Hersh Dawn L Demeo Blanca E Himes Jody S Sylvia Barbara J Klanderman John P Ziniti Christoph Lange Augusto A Litonjua David Sparrow Elizabeth A Regan Barry J Make John E Hokanson Tanda Murray Jacqueline B Hetmanski Sreekumar G Pillai Xiangyang Kong Wayne H Anderson Ruth Tal-Singer David A Lomas Harvey O Coxson Lisa D Edwards William MacNee Jørgen Vestbo Julie C Yates Alvar Agusti Peter M A Calverley Bartolome Celli Courtney Crim Stephen Rennard Emiel Wouters Per Bakke Amund Gulsvik James D Crapo Terri H Beaty Edwin K Silverman

Hum Mol Genet 2012 Feb 11;21(4):947-57. Epub 2011 Nov 11.

Channing Laboratory, Brigham & Women’s Hospital, Boston, MA 02115, USA.

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February 2012

The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility.

Authors:
Peter J Castaldi Michael H Cho Augusto A Litonjua Per Bakke Amund Gulsvik David A Lomas Wayne Anderson Terri H Beaty John E Hokanson James D Crapo Nan Laird Edwin K Silverman

Am J Respir Cell Mol Biol 2011 Dec 9;45(6):1147-53. Epub 2011 Jun 9.

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA.

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December 2011

An empirical assessment of validation practices for molecular classifiers.

Authors:
Peter J Castaldi Issa J Dahabreh John P A Ioannidis

Brief Bioinform 2011 May 7;12(3):189-202. Epub 2011 Feb 7.

Institute for Clinical Research and Health Policy Studies at Tufts Medical Center, USA.

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May 2011

Systematic review: Anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer.

Authors:
Issa J Dahabreh Teruhiko Terasawa Peter J Castaldi Thomas A Trikalinos

Ann Intern Med 2011 Jan;154(1):37-49

Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA.

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January 2011

Laboratory mouse models for the human genome-wide associations.

Authors:
Georgios D Kitsios Navdeep Tangri Peter J Castaldi John P A Ioannidis

PLoS One 2010 Nov 1;5(11):e13782. Epub 2010 Nov 1.

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, United States of America.

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November 2010

Inhaler costs and medication nonadherence among seniors with chronic pulmonary disease.

Authors:
Peter J Castaldi William H Rogers Dana Gelb Safran Ira B Wilson

Chest 2010 Sep 23;138(3):614-20. Epub 2010 Apr 23.

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA.

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September 2010

The COPD genetic association compendium: a comprehensive online database of COPD genetic associations.

Authors:
Peter J Castaldi Michael H Cho Matthew Cohn Fawn Langerman Sienna Moran Nestor Tarragona Hala Moukhachen Radhika Venugopal Delvina Hasimja Esther Kao Byron Wallace Craig P Hersh Sachin Bagade Lars Bertram Edwin K Silverman Thomas A Trikalinos

Hum Mol Genet 2010 Feb 20;19(3):526-34. Epub 2009 Nov 20.

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.

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February 2010

Genetic associations with hypoxemia and pulmonary arterial pressure in COPD.

Authors:
Peter J Castaldi Craig P Hersh John J Reilly Edwin K Silverman

Chest 2009 Mar 18;135(3):737-744. Epub 2008 Nov 18.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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March 2009