Publications by authors named "Peter J Campbell"

100Publications

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.

Cell Stem Cell 2020 Aug 15;27(2):326-335.e4. Epub 2020 Jul 15.

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494054PMC
August 2020

Evaluation of Potential Systemic Adverse Events Related to Fluorescein Angiography in Pediatric Patients.

Ophthalmol Retina 2020 06 16;4(6):595-601. Epub 2019 Dec 16.

Department of Ophthalmology, Weill Cornell Medical College, New York, New York; Department of Ophthalmology & Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.oret.2019.12.012DOI Listing
June 2020

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

Nature 2020 02 5;578(7793):102-111. Epub 2020 Feb 5.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-1965-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054214PMC
February 2020

Genome Sequencing during a Patient's Journey through Cancer.

N Engl J Med 2019 11;381(22):2145-2156

From the Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, and Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research, the Department of Haematology, University of Cambridge, and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge - all in the United Kingdom.

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http://dx.doi.org/10.1056/NEJMra1910138DOI Listing
November 2019

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

Cancer Cell 2019 03;35(3):441-456.e8

Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428691PMC
March 2019

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.

Nat Genet 2019 04 4;51(4):705-715. Epub 2019 Mar 4.

Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41588-019-0360-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441390PMC
April 2019

Improving services requires resources not targets.

Authors:
Peter J Campbell

BMJ 2019 02 22;364:l830. Epub 2019 Feb 22.

Heidelberg 69120, Germany.

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http://dx.doi.org/10.1136/bmj.l830DOI Listing
February 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716614
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http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030948PMC
October 2018

Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.

J Clin Oncol 2018 12 28;36(34):3361-3369. Epub 2018 Aug 28.

Anna L. Godfrey, Jacob Grinfeld, and Anthony R. Green, Cambridge University Hospitals National Health Service (NHS) Foundation Trust; Peter J. Campbell and Jyoti Nangalia, Wellcome Trust Sanger Institute, Hinxton; Cathy MacLean, Julia Cook, Julie Temple, and Anthony R. Green, University of Cambridge; Anthony R. Green, Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge; Georgina Buck, University of Oxford, Oxford; Bridget S. Wilkins and Claire N. Harrison, Guy's and St Thomas' NHS Foundation Trust, London; Keith Wheatley, University of Birmingham, Birmingham; Mary Frances McMullin, Queen's University Belfast, Belfast, United Kingdom; Cecily Forsyth, Gosford Hospital, Gosford, and Australasian Leukaemia and Lymphoma Group, Australia; and Jean-Jacques Kiladjian, Hôpital Saint-Louis, Paris, France.

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http://dx.doi.org/10.1200/JCO.2018.78.8414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269131PMC
December 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Mutational signatures of DNA mismatch repair deficiency in and human cancers.

Genome Res 2018 05 10;28(5):666-675. Epub 2018 Apr 10.

Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.226845.117
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http://dx.doi.org/10.1101/gr.226845.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932607PMC
May 2018

Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

Br J Haematol 2019 02 30;184(4):676-679. Epub 2018 Mar 30.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1111/bjh.15155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766952PMC
February 2019

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.

Mol Cell 2018 01;69(2):292-305.e6

DSB Repair Metabolism Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783719PMC
January 2018

Universal Patterns of Selection in Cancer and Somatic Tissues.

Cell 2017 Nov 19;171(5):1029-1041.e21. Epub 2017 Oct 19.

Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720395PMC
November 2017

Cliques and Schisms of Cancer Genes.

Authors:
Peter J Campbell

Cancer Cell 2017 08;32(2):129-130

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.07.009DOI Listing
August 2017

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.

Genes Chromosomes Cancer 2017 05 18;56(5):363-372. Epub 2017 Jan 18.

Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, UK.

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http://dx.doi.org/10.1002/gcc.22439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396319PMC
May 2017

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

Curr Protoc Bioinformatics 2016 12 8;56:15.9.1-15.9.17. Epub 2016 Dec 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/cpbi.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097604PMC
December 2016

cgpCaVEManWrapper: Simple Execution of CaVEMan in Order to Detect Somatic Single Nucleotide Variants in NGS Data.

Curr Protoc Bioinformatics 2016 12 8;56:15.10.1-15.10.18. Epub 2016 Dec 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/cpbi.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097605PMC
December 2016

Genomic Classification in Acute Myeloid Leukemia.

N Engl J Med 2016 09;375(9):900-1

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http://dx.doi.org/10.1056/NEJMc1608739DOI Listing
September 2016

Colony impact of pesticide-induced sublethal effects on honeybee workers: A simulation study using BEEHAVE.

Environ Toxicol Chem 2017 03 15;36(3):831-840. Epub 2016 Sep 15.

Jealott's Hill International Research Centre, Syngenta, Bracknell, United Kingdom.

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http://dx.doi.org/10.1002/etc.3581DOI Listing
March 2017

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

Using BEEHAVE to explore pesticide protection goals for European honeybee (Apis melifera L.) worker losses at different forage qualities.

Environ Toxicol Chem 2017 01 26;36(1):254-264. Epub 2016 Jul 26.

Environmental Safety, Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, United Kingdom.

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http://dx.doi.org/10.1002/etc.3504DOI Listing
January 2017

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Impact of socioeconomic status on disease phenotype, genomic landscape and outcomes in myelodysplastic syndromes.

Br J Haematol 2016 07 20;174(2):227-34. Epub 2016 Apr 20.

Dundee Cancer Centre, Ninewells Hospital & Medical School, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/bjh.14042DOI Listing
July 2016

Genomic Characterization of Primary Invasive Lobular Breast Cancer.

J Clin Oncol 2016 06 29;34(16):1872-81. Epub 2016 Feb 29.

Christine Desmedt, Gabriele Zoppoli, Denis Larsimont, Debora Fumagalli, David Brown, Françoise Rothé, Delphine Vincent, Naima Kheddoumi, Ghizlane Rouas, Samira Majjaj, Sylvain Brohée, Roberto Salgado, Martine Piccart-Gebhart, and Christos Sotiriou, Institut Jules Bordet; Christine Galant, Cliniques Universitaires Saint Luc, Brussels; Peter Van Loo, University of Leuven; Thomas Van Brussel and Diether Lambrechts, VIB Vesalius Research Center, Leuven, Belgium; Gabriele Zoppoli, University of Genoa and Istituto di Ricerca a Carattere Clinico-Scientifico San Martino-National Cancer Institute, Genoa; Giancarlo Pruneri, Patrick Maisonneuve, and Giuseppe Viale, European Institute of Oncology; Marco Fornili and Elia Biganzoli, University of Milan, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy; Gunes Gundem and Peter J. Campbell, Wellcome Trust Sanger Institute, Cambridgeshire; Peter Van Loo, The Francis Crick Institute, London, United Kingdom; Ron Bose, Washington University School of Medicine, St Louis, MO; Otto Metzger, Dana-Farber Cancer Institute, Boston, MA; and François Bertucci, Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1200/JCO.2015.64.0334DOI Listing
June 2016

Constrained positive selection on cancer mutations in normal skin.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):E1128-9. Epub 2016 Feb 16.

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom; Department of Haematology, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://www.pnas.org/content/113/9/E1128.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1600910113
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http://dx.doi.org/10.1073/pnas.1600910113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780655PMC
March 2016

Chromothripsis and Kataegis Induced by Telomere Crisis.

Cell 2015 Dec;163(7):1641-54

Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687025PMC
December 2015