Peter H Sugden

Peter H Sugden

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Peter H Sugden

Peter H Sugden

Publications by authors named "Peter H Sugden"

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The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.

J Mol Cell Cardiol 2019 Feb 13;129:118-129. Epub 2019 Feb 13.

School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6AS, UK; National Heart and Lung Institute (Cardiovascular Sciences), Faculty of Medicine, Flowers Building, Imperial College, SW7 2AZ, UK and Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2019.02.006DOI Listing
February 2019

Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.

Cardiovasc Res 2015 Oct 10;108(1):87-98. Epub 2015 Aug 10.

School of Biological Sciences, University of Reading, Whiteknights Campus, Reading, Berkshire RG6 6AS, UK

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http://dx.doi.org/10.1093/cvr/cvv210DOI Listing
October 2015

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

Biochem J 2013 Aug;454(1):13-30

School of Biological Sciences, University of Reading, Whiteknights Campus, Harborne Building, Reading RG6 6AS, U.K.

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http://dx.doi.org/10.1042/BJ20130219DOI Listing
August 2013

The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.

Cytokine 2013 Feb 7;61(2):340-4. Epub 2012 Dec 7.

Department of Life Sciences, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.cyto.2012.11.004DOI Listing
February 2013

Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins.

Expert Rev Endocrinol Metab 2012 Mar;7(2):191-208

a Centre for Diabetes, Blizard Institute, Barts and the London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London, E1 2AT, UK.

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http://dx.doi.org/10.1586/eem.12.9DOI Listing
March 2012

MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.

Mol Cell Biol 2011 Sep 5;31(17):3603-15. Epub 2011 Jul 5.

Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

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http://mcb.asm.org/content/31/17/3603.full.pdf
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http://mcb.asm.org/content/early/2011/07/05/MCB.01389-10.ful
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http://mcb.asm.org/cgi/doi/10.1128/MCB.01389-10
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http://dx.doi.org/10.1128/MCB.01389-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165550PMC
September 2011

Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.

Eur J Heart Fail 2011 Aug 27;13(8):811-9. Epub 2011 Jun 27.

Myocardial Genetics, British Heart Foundation-Centre for Research Excellence, National Heart & Lung Institute, Imperial College London, Flowers Building, 4th floor, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1093/eurjhf/hfr071DOI Listing
August 2011

Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.

Cell Signal 2011 Feb 30;23(2):468-77. Epub 2010 Oct 30.

Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6UB, UK.

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http://dx.doi.org/10.1016/j.cellsig.2010.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038257PMC
February 2011

Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.

Int J Biochem Cell Biol 2010 Feb 25;42(2):263-72. Epub 2009 Oct 25.

National Heart and Lung Institute Division (Cardiovascular Sciences), Faculty of Medicine, Imperial College London, Guy Scadding Building, Dovehouse Street, London, UK.

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http://dx.doi.org/10.1016/j.biocel.2009.10.021DOI Listing
February 2010

Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2.

Adv Enzyme Regul 2009 31;49(1):30-42. Epub 2008 Dec 31.

NHLI Division (Cardiovascular Sciences), Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW72AZ, UK.

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http://dx.doi.org/10.1016/j.advenzreg.2008.12.007DOI Listing
September 2009

Effects of left ventricular volume overload on mitochondrial and death-receptor-mediated apoptotic pathways in the transition to heart failure.

Am J Cardiol 2009 May;103(9):1261-8

Department of Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.amjcard.2009.01.013DOI Listing
May 2009

Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?

J Mol Cell Cardiol 2009 Feb 21;46(2):118-29. Epub 2008 Nov 21.

NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2008.11.005DOI Listing
February 2009

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.

Cell Signal 2008 Aug 1;20(8):1564-77. Epub 2008 May 1.

National Heart and Lung Institute (NHLI) Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.cellsig.2008.04.013DOI Listing
August 2008

Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines.

Biochim Biophys Acta 2008 Jun 25;1783(6):1229-36. Epub 2008 Mar 25.

National Heart and Lung Institute (NHLI) Division, Faculty of Medicine, Imperial College London, Flowers Building (4th Floor), Armstrong Road, London SW7 2AZ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016748890800115
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http://dx.doi.org/10.1016/j.bbamcr.2008.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396231PMC
June 2008

ErbB receptors, their ligands, and the consequences of their activation and inhibition in the myocardium.

J Mol Cell Cardiol 2008 May 4;44(5):831-54. Epub 2008 Mar 4.

NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.yjmcc.2008.02.278DOI Listing
May 2008

Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition.

Cell Signal 2008 Jan 12;20(1):206-18. Epub 2007 Oct 12.

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.cellsig.2007.10.004DOI Listing
January 2008

Chemotherapeutic agents and gene expression in cardiac myocytes.

Adv Enzyme Regul 2007 6;47:140-53. Epub 2007 Mar 6.

NHLI Division (Cardiac Medicine Section), Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.advenzreg.2006.12.004DOI Listing
November 2007

Cardiac myocyte gene expression profiling during H2O2-induced apoptosis.

Physiol Genomics 2007 Apr 5;29(2):118-27. Epub 2006 Dec 5.

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://www.physiology.org/doi/10.1152/physiolgenomics.00168.
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http://dx.doi.org/10.1152/physiolgenomics.00168.2006DOI Listing
April 2007

Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes.

Antioxid Redox Signal 2006 Nov-Dec;8(11-12):2111-24

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://www.liebertpub.com/doi/10.1089/ars.2006.8.2111
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http://dx.doi.org/10.1089/ars.2006.8.2111DOI Listing
January 2007

Ras: the stress and the strain.

J Mol Cell Cardiol 2006 Oct 28;41(4):595-600. Epub 2006 Aug 28.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280600712
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http://dx.doi.org/10.1016/j.yjmcc.2006.06.075DOI Listing
October 2006

Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.

J Mol Cell Cardiol 2006 Aug 6;41(2):236-47. Epub 2006 Jun 6.

National Heart and Lung Institute (NHLI) Division, Faculty of Medicine, Imperial College London, Flowers Building (Floor 4), UK.

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http://dx.doi.org/10.1016/j.yjmcc.2006.04.011DOI Listing
August 2006

Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes.

J Biol Chem 2006 Mar 18;281(13):8321-31. Epub 2005 Dec 18.

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M508398200DOI Listing
March 2006

Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes.

Cell Signal 2006 Feb 3;18(2):225-35. Epub 2005 Jun 3.

NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building (4th Floor), Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.cellsig.2005.04.005DOI Listing
February 2006

Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis.

Adv Enzyme Regul 2005 8;45:94-111. Epub 2005 Aug 8.

NHLI Division (Cardiac Medicine Section), Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.advenzreg.2005.02.007DOI Listing
February 2006

Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins.

J Mol Cell Cardiol 2006 Jan 1;40(1):157-72. Epub 2005 Dec 1.

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building (Floor 4), Armstrong Road, London SW7 2AZ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280500317
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http://dx.doi.org/10.1016/j.yjmcc.2005.10.004DOI Listing
January 2006

Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.

Curr Vasc Pharmacol 2005 Oct;3(4):343-51

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

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October 2005

Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases.

Adv Enzyme Regul 2004 ;44:233-48

Imperial College of Science, Technology and Medicine, NHLI Division (Cardiac Medicine Section), Faculty of Medicine, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S006525710300035
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http://dx.doi.org/10.1016/j.advenzreg.2003.11.002DOI Listing
March 2005

Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants.

Oncogene 2005 Jan;24(1):90-100

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1038/sj.onc.1208168DOI Listing
January 2005

Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes.

Biochem Cell Biol 2004 Dec;82(6):603-9

NHLI Division (Cardiac Medicine Section), Faculty of Medicine, Imperial College London, Flowers Building, 4th Floor, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1139/o04-110DOI Listing
December 2004

Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes.

J Mol Cell Cardiol 2004 Aug;37(2):603-6

NHLI Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002228280400140
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http://dx.doi.org/10.1016/j.yjmcc.2004.04.022DOI Listing
August 2004

Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression.

Biochim Biophys Acta 2004 Feb;1644(1):17-25

NHLI Division (Cardiac Medicine Section), Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, South Kensington, London SW7 2AZ, UK.

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February 2004

Ras, Akt, and mechanotransduction in the cardiac myocyte.

Authors:
Peter H Sugden

Circ Res 2003 Dec;93(12):1179-92

National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, Flowers Building (4th Floor), Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1161/01.RES.0000106132.04301.F5DOI Listing
December 2003

An overview of endothelin signaling in the cardiac myocyte.

Authors:
Peter H Sugden

J Mol Cell Cardiol 2003 Aug;35(8):871-86

Cardiac Medicine, Faculty of Medicine NHLI Division, Imperial College of Science, Technology and Medicine, Flowers Building 4th Floor, Armstrong Road, London SW7 2AZ, UK.

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August 2003

Signaling pathways activated by vasoactive peptides in the cardiac myocyte and their role in myocardial pathologies.

Authors:
Peter H Sugden

J Card Fail 2002 Dec;8(6 Suppl):S359-69

National Heart and Lung Institute Division (Cardiac Medicine Section), Faculty of Medicine, Imperial College of Science, Technology, and Medicine, London, UK.

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http://dx.doi.org/10.1054/jcaf.2002.129282DOI Listing
December 2002

Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

Biochem J 2002 Nov;368(Pt 1):101-10

Cardiac Medicine Section, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1042/BJ20021083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222976PMC
November 2002

Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A.

J Mol Cell Cardiol 2002 Jul;34(7):749-63

Division of Biomedical Sciences (Cell and Molecular Biology Section), Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, SW7 2AZ, UK.

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July 2002