Peter H St George-Hyslop

Peter H St George-Hyslop

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Peter H St George-Hyslop

Peter H St George-Hyslop

Publications by authors named "Peter H St George-Hyslop"

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41Publications

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Structural and Chemical Biology of Presenilin Complexes.

Cold Spring Harb Perspect Med 2017 Dec 1;7(12). Epub 2017 Dec 1.

Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a024067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710098PMC
December 2017

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Alzheimers Dement 2017 Jul 7;13(7):727-738. Epub 2017 Feb 7.

Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496797PMC
July 2017

Deciphering microglial diversity in Alzheimer's disease.

Science 2017 06;356(6343):1123-1124

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1126/science.aan7893DOI Listing
June 2017

Structural biology of presenilin 1 complexes.

Mol Neurodegener 2014 Dec 18;9:59. Epub 2014 Dec 18.

Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1186/1750-1326-9-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326451PMC
December 2014

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model.

J Comp Neurol 2014 Jul;522(10):2319-35

Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, 10065, USA; Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1002/cne.23536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251468PMC
July 2014

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.

Structure 2014 Jan 7;22(1):125-35. Epub 2013 Nov 7.

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Tanz Centre for Research in Neurodegenerative Diseases, and Departments of Medicine, Laboratory Medicine and Pathobiology, and Medical Biophysics, University of Toronto, Toronto, ON M5S 3H2, Canada. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(13)00369-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261300369
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http://dx.doi.org/10.1016/j.str.2013.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887256PMC
January 2014

Variant Alzheimer disease with spastic paraparesis: a rare presenilin-1 mutation.

Can J Neurol Sci 2011 Jul;38(4):659-61

Department of Medicine (Neurology), University of British Columbia, Vancouver Northern Medical Program, University of Northern British Columbia, Prince George, BC.

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http://dx.doi.org/10.1017/s0317167100012233DOI Listing
July 2011

Family reunion--the ZIP/prion gene family.

Prog Neurobiol 2011 Mar 14;93(3):405-20. Epub 2010 Dec 14.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5S3H2, Canada.

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http://dx.doi.org/10.1016/j.pneurobio.2010.12.001DOI Listing
March 2011

SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis.

Brain 2010 Feb 28;133(Pt 2):591-8. Epub 2010 Jan 28.

Centro Europeo di Ricerca sul Cervello -Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, 64 Via del Fosso di Fiorano, Rome 00143, Italy.

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http://dx.doi.org/10.1093/brain/awp325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822627PMC
February 2010

Will anti-amyloid therapies work for Alzheimer's disease?

Lancet 2008 Jul;372(9634):180-2

Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1016/S0140-6736(08)61047-8DOI Listing
July 2008

The apolipoprotein E2 isoform is associated with accelerated onset of coronary artery disease in systemic lupus erythematosus.

Med Sci Monit 2008 May;14(5):CR233-237

Laboratorio di Neurogenetica, CERC-IRCCS Santa Lucia, Rome, Italy and Dipartimento di Neuroscienze, Università di Roma "Tor Vergata", Rome, Italy.

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May 2008

Characterization of the kindred of Alois Alzheimer's patient with plaque-only dementia.

Alzheimer Dis Assoc Disord 2006 Oct-Dec;20(4):291-4

Universitätsklinik für Psychiatrie, Universitätsstr. 84, D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1097/01.wad.0000213855.81989.c8DOI Listing
February 2007

Clinical and genetic study of a Brazilian family with spastic paraplegia (SPG6 locus).

Mov Disord 2006 Feb;21(2):279-81

Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.

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http://dx.doi.org/10.1002/mds.20775DOI Listing
February 2006

Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

Neurosci Lett 2006 Jan 12;391(3):142-6. Epub 2005 Sep 12.

Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ont., Canada M5S 3H2.

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http://dx.doi.org/10.1016/j.neulet.2005.08.048DOI Listing
January 2006

New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1.

Ann Neurol 2005 Sep;58(3):423-9

Laboratorio di Neurogenetica, Centro Europeo Di Ricerca Sul Cervello-Istituto di Ricovero e cura a Carattere Scientifico Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1002/ana.20590DOI Listing
September 2005

Molecular biology and genetics of Alzheimer's disease.

C R Biol 2005 Feb;328(2):119-30

Department of Medicine, Division of Neurology, The Toronto Hospital, University of Toronto, 6, Queen's Park Crescent West, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.crvi.2004.10.013DOI Listing
February 2005

Hereditary spastic paraplegia: clinical genetic study of 15 families.

Arch Neurol 2004 Jun;61(6):849-55

Laboratorio di Neurogenetica, Istituto di Ricovero e Cura a Carattere Scientifico, Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1001/archneur.61.6.849DOI Listing
June 2004

Functional variants of OCTN cation transporter genes are associated with Crohn disease.

Nat Genet 2004 May 11;36(5):471-5. Epub 2004 Apr 11.

Department of Medicine, University of Toronto, and Department of Immunology, Mount Sinai Hospital Samuel Lunenfeld Research Institute, Ontario, Canada.

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http://www.nature.com/articles/ng1339
Publisher Site
http://dx.doi.org/10.1038/ng1339DOI Listing
May 2004

Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms.

Neurosci Lett 2002 Nov;333(2):115-8

Laboratorio di Neurogenetica, IRCCS Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy.

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http://dx.doi.org/10.1016/s0304-3940(02)01022-4DOI Listing
November 2002

Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease.

Neurosci Lett 2002 May;325(1):13-6

Laboratorio di Neurogenetica, I.R.C.C.S. Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy.

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http://dx.doi.org/10.1016/s0304-3940(02)00221-5DOI Listing
May 2002

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Nat Rev Neurosci 2002 Apr;3(4):281-90

Center for Molecular Neurobiology, Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nrn785DOI Listing
April 2002

Genetic markers in the diagnosis of Alzheimer's disease.

J Alzheimers Dis 2001 Jun;3(3):293-304

Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Bldg., University of Toronto, 6 Queen's Park Crescent West, Toronto, Ontario, Canada M5S 3H2. Tel.: +1 416 978 2503; Fax: +1 416 978 1878.

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http://dx.doi.org/10.3233/jad-2001-3304DOI Listing
June 2001