Peter H St George-Hyslop

Peter H St George-Hyslop

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Peter H St George-Hyslop

Peter H St George-Hyslop

Publications by authors named "Peter H St George-Hyslop"

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41Publications

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Inherited and Sporadic Amyotrophic Lateral Sclerosis and Fronto-Temporal Lobar Degenerations arising from Pathological Condensates of Phase Separating Proteins.

Hum Mol Genet 2019 Oct 10. Epub 2019 Oct 10.

Cambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK, CB2 0XY.

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http://dx.doi.org/10.1093/hmg/ddz162DOI Listing
October 2019

Structural and Chemical Biology of Presenilin Complexes.

Cold Spring Harb Perspect Med 2017 Dec 1;7(12). Epub 2017 Dec 1.

Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a024067DOI Listing
December 2017

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Alzheimers Dement 2017 Jul 7;13(7):727-738. Epub 2017 Feb 7.

Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2016.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496797PMC
July 2017

Deciphering microglial diversity in Alzheimer's disease.

Science 2017 06;356(6343):1123-1124

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1126/science.aan7893DOI Listing
June 2017

Structural biology of presenilin 1 complexes.

Mol Neurodegener 2014 Dec 18;9:59. Epub 2014 Dec 18.

Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1186/1750-1326-9-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326451PMC
December 2014

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model.

J Comp Neurol 2014 Jul;522(10):2319-35

Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, 10065, USA; Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1002/cne.23536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251468PMC
July 2014

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.

Structure 2014 Jan 7;22(1):125-35. Epub 2013 Nov 7.

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK; Tanz Centre for Research in Neurodegenerative Diseases, and Departments of Medicine, Laboratory Medicine and Pathobiology, and Medical Biophysics, University of Toronto, Toronto, ON M5S 3H2, Canada. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(13)00369-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261300369
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http://dx.doi.org/10.1016/j.str.2013.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887256PMC
January 2014

Variant Alzheimer disease with spastic paraparesis: a rare presenilin-1 mutation.

Can J Neurol Sci 2011 Jul;38(4):659-61

Department of Medicine (Neurology), University of British Columbia, Vancouver Northern Medical Program, University of Northern British Columbia, Prince George, BC.

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http://dx.doi.org/10.1017/s0317167100012233DOI Listing
July 2011

Family reunion--the ZIP/prion gene family.

Prog Neurobiol 2011 Mar 14;93(3):405-20. Epub 2010 Dec 14.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON M5S3H2, Canada.

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http://dx.doi.org/10.1016/j.pneurobio.2010.12.001DOI Listing
March 2011

SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis.

Brain 2010 Feb 28;133(Pt 2):591-8. Epub 2010 Jan 28.

Centro Europeo di Ricerca sul Cervello -Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, 64 Via del Fosso di Fiorano, Rome 00143, Italy.

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http://dx.doi.org/10.1093/brain/awp325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822627PMC
February 2010

Will anti-amyloid therapies work for Alzheimer's disease?

Lancet 2008 Jul;372(9634):180-2

Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1016/S0140-6736(08)61047-8DOI Listing
July 2008

The apolipoprotein E2 isoform is associated with accelerated onset of coronary artery disease in systemic lupus erythematosus.

Med Sci Monit 2008 May;14(5):CR233-237

Laboratorio di Neurogenetica, CERC-IRCCS Santa Lucia, Rome, Italy and Dipartimento di Neuroscienze, Università di Roma "Tor Vergata", Rome, Italy.

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May 2008

Characterization of the kindred of Alois Alzheimer's patient with plaque-only dementia.

Alzheimer Dis Assoc Disord 2006 Oct-Dec;20(4):291-4

Universitätsklinik für Psychiatrie, Universitätsstr. 84, D-93053 Regensburg, Germany.

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http://dx.doi.org/10.1097/01.wad.0000213855.81989.c8DOI Listing
February 2007

Clinical and genetic study of a Brazilian family with spastic paraplegia (SPG6 locus).

Mov Disord 2006 Feb;21(2):279-81

Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.

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http://dx.doi.org/10.1002/mds.20775DOI Listing
February 2006

Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

Neurosci Lett 2006 Jan 12;391(3):142-6. Epub 2005 Sep 12.

Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen's Park Crescent West, Toronto, Ont., Canada M5S 3H2.

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http://dx.doi.org/10.1016/j.neulet.2005.08.048DOI Listing
January 2006

New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1.

Ann Neurol 2005 Sep;58(3):423-9

Laboratorio di Neurogenetica, Centro Europeo Di Ricerca Sul Cervello-Istituto di Ricovero e cura a Carattere Scientifico Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1002/ana.20590DOI Listing
September 2005

Molecular biology and genetics of Alzheimer's disease.

C R Biol 2005 Feb;328(2):119-30

Department of Medicine, Division of Neurology, The Toronto Hospital, University of Toronto, 6, Queen's Park Crescent West, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.crvi.2004.10.013DOI Listing
February 2005

Hereditary spastic paraplegia: clinical genetic study of 15 families.

Arch Neurol 2004 Jun;61(6):849-55

Laboratorio di Neurogenetica, Istituto di Ricovero e Cura a Carattere Scientifico, Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1001/archneur.61.6.849DOI Listing
June 2004

Functional variants of OCTN cation transporter genes are associated with Crohn disease.

Nat Genet 2004 May 11;36(5):471-5. Epub 2004 Apr 11.

Department of Medicine, University of Toronto, and Department of Immunology, Mount Sinai Hospital Samuel Lunenfeld Research Institute, Ontario, Canada.

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http://www.nature.com/articles/ng1339
Publisher Site
http://dx.doi.org/10.1038/ng1339DOI Listing
May 2004

Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms.

Neurosci Lett 2002 Nov;333(2):115-8

Laboratorio di Neurogenetica, IRCCS Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy.

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http://dx.doi.org/10.1016/s0304-3940(02)01022-4DOI Listing
November 2002

Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease.

Neurosci Lett 2002 May;325(1):13-6

Laboratorio di Neurogenetica, I.R.C.C.S. Santa Lucia, Via Ardeatina 354, 00179, Rome, Italy.

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http://dx.doi.org/10.1016/s0304-3940(02)00221-5DOI Listing
May 2002

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

Nat Rev Neurosci 2002 Apr;3(4):281-90

Center for Molecular Neurobiology, Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nrn785DOI Listing
April 2002

Genetic markers in the diagnosis of Alzheimer's disease.

J Alzheimers Dis 2001 Jun;3(3):293-304

Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Bldg., University of Toronto, 6 Queen's Park Crescent West, Toronto, Ontario, Canada M5S 3H2. Tel.: +1 416 978 2503; Fax: +1 416 978 1878.

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http://dx.doi.org/10.3233/jad-2001-3304DOI Listing
June 2001