Publications by authors named "Peter H G M Willems"

100Publications

Long-Term and Acute Benefits of Reduced Sitting on Vascular Flow and Function.

Med Sci Sports Exerc 2020 Aug 21. Epub 2020 Aug 21.

1Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands 2Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands 3Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands 4Department of Geriatric Medicine, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands 5Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.

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http://dx.doi.org/10.1249/MSS.0000000000002462DOI Listing
August 2020

NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4 mice and Leigh syndrome patients: A stabilizing role for NDUFAF2.

Biochim Biophys Acta Bioenerg 2020 08 23;1861(8):148213. Epub 2020 Apr 23.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud Center for Mitochondrial Medicine, Radboudumc, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2020.148213DOI Listing
August 2020

Sixteen-Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State.

J Am Heart Assoc 2019 11 18;8(21):e013764. Epub 2019 Oct 18.

Department of Internal Medicine Radboud Institute for Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands.

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http://dx.doi.org/10.1161/JAHA.119.013764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898840PMC
November 2019

Octa-arginine boosts the penetration of elastin-like polypeptide nanoparticles in 3D cancer models.

Eur J Pharm Biopharm 2019 Apr 15;137:175-184. Epub 2019 Feb 15.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2019.02.010DOI Listing
April 2019

Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD

Cell Death Dis 2018 11 14;9(11):1135. Epub 2018 Nov 14.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud Center for Mitochondrial Medicine, Radboudumc, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41419-018-1179-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235972PMC
November 2018

Mitochondrial Morphofunction in Mammalian Cells.

Antioxid Redox Signal 2019 06 29;30(18):2066-2109. Epub 2018 Nov 29.

Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1089/ars.2018.7534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529879PMC
June 2019

Corrigendum to "Mitigation of NADH:ubiquinone oxidoreductase deficiency by chronic Trolox treatment" [Biochimica et Biophysica Acta 1777/7-8 (2008) 853-859].

Biochim Biophys Acta Bioenerg 2018 12 6;1859(12):1328. Epub 2018 Jun 6.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands; Microscopical Imaging Centre, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.bbabio.2018.06.003DOI Listing
December 2018

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells.

Redox Biol 2018 05 30;15:394-404. Epub 2017 Dec 30.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767902PMC
May 2018

Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells.

Stem Cell Res Ther 2017 06 24;8(1):150. Epub 2017 Jun 24.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children's Hospital, Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/s13287-017-0601-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482938PMC
June 2017

Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect.

ACS Omega 2017 Mar 16;2(3):937-945. Epub 2017 Mar 16.

Department of Molecular Materials, Institute for Molecules and Materials, Radboud University , Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

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http://dx.doi.org/10.1021/acsomega.6b00436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377267PMC
March 2017

Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR.

J Cell Sci 2016 12 28;129(23):4411-4423. Epub 2016 Oct 28.

Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500HB, Nijmegen, The Netherlands

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http://dx.doi.org/10.1242/jcs.194480DOI Listing
December 2016

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy.

Nat Protoc 2016 09 18;11(9):1693-710. Epub 2016 Aug 18.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1038/nprot.2016.094DOI Listing
September 2016

Integrated High-Content Quantification of Intracellular ROS Levels and Mitochondrial Morphofunction.

Adv Anat Embryol Cell Biol 2016 ;219:149-77

Cell Systems and Imaging Research Group (CSI), Department of Molecular Biotechnology, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/978-3-319-28549-8_6DOI Listing
August 2016

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells.

Redox Biol 2015 Dec 23;6:607-616. Epub 2015 Oct 23.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.redox.2015.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635408PMC
December 2015

Mitoenergetic Dysfunction Triggers a Rapid Compensatory Increase in Steady-State Glucose Flux.

Biophys J 2015 Oct;109(7):1372-86

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Systems Biology and Bioenergetics, Radboud University and Radboud University Medical Center, Nijmegen, The Netherlands; Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601044PMC
October 2015

Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity.

Sci Rep 2015 Sep 29;5:14533. Epub 2015 Sep 29.

Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1038/srep14533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586513PMC
September 2015

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

Cell Metab 2015 Sep;22(3):399-407

Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.08.002DOI Listing
September 2015

Redox Homeostasis and Mitochondrial Dynamics.

Cell Metab 2015 Aug 9;22(2):207-18. Epub 2015 Jul 9.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500HB Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131150027
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http://dx.doi.org/10.1016/j.cmet.2015.06.006DOI Listing
August 2015

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism.

Arch Toxicol 2015 Aug 6;89(8):1209-26. Epub 2015 Jun 6.

Department of Biochemistry (286), Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center (RUMC), P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00204-015-1520-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508370PMC
August 2015

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2.

Biochim Biophys Acta 2015 Jul 28;1853(7):1606-14. Epub 2015 Mar 28.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2015.03.010DOI Listing
July 2015

PKC-mediated inhibitory feedback of the cholecystokinin 1 receptor controls the shape of oscillatory Ca²⁺ signals.

FEBS J 2015 Jun 13;282(11):2187-201. Epub 2015 Apr 13.

Department of Modelling of Biological Processes, COS Heidelberg/BioQuant, Heidelberg University, Germany.

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http://dx.doi.org/10.1111/febs.13267DOI Listing
June 2015

Skeletal muscle mitochondria of NDUFS4-/- mice display normal maximal pyruvate oxidation and ATP production.

Biochim Biophys Acta 2015 Jun-Jul;1847(6-7):526-33. Epub 2015 Feb 14.

Department of Biochemistry, RIMLS, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Systems Biology and Bioenergetics, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2015.02.006DOI Listing
August 2015

Toward high-content screening of mitochondrial morphology and membrane potential in living cells.

Int J Biochem Cell Biol 2015 Jun 8;63:66-70. Epub 2015 Feb 8.

Khondrion BV, Nijmegen, The Netherlands; Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.01.020DOI Listing
June 2015

Live-cell assessment of mitochondrial reactive oxygen species using dihydroethidine.

Methods Mol Biol 2015 ;1264:161-9

Department of Biochemistry, Raboud Institute for Molecular Life Sciences, Radboud University Medical Centre, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-2257-4_15DOI Listing
October 2015

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.

Sci Rep 2015 Jan 26;5:8035. Epub 2015 Jan 26.

1] Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands [2] Centre for Systems Biology and Bioenergetics, Radboud University Medical Center, Nijmegen, The Netherlands [3] Khondrion BV, Philips van Leydenlaan 15, 6525EX Nijmegen, The Netherlands.

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http://www.nature.com/articles/srep08035
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http://dx.doi.org/10.1038/srep08035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306129PMC
January 2015

Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α.

Biochim Biophys Acta 2015 Mar 20;1852(3):529-40. Epub 2014 Dec 20.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.12.012DOI Listing
March 2015

Photo-induction and automated quantification of reversible mitochondrial permeability transition pore opening in primary mouse myotubes.

PLoS One 2014 25;9(11):e114090. Epub 2014 Nov 25.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Systems Biology and Bioenergetics, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114090PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244163PMC
January 2016

Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V.

Biochim Biophys Acta 2014 Aug 24;1837(8):1247-56. Epub 2014 Apr 24.

Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbabio.2014.04.008DOI Listing
August 2014

Regulation and quantification of cellular mitochondrial morphology and content.

Curr Pharm Des 2014 ;20(35):5634-52

286 Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.2174/1381612820666140305230546DOI Listing
June 2015

Cellular and animal models for mitochondrial complex I deficiency: a focus on the NDUFS4 subunit.

IUBMB Life 2013 Mar 3;65(3):202-8. Epub 2013 Feb 3.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/iub.1127DOI Listing
March 2013

Primary fibroblasts of NDUFS4(-/-) mice display increased ROS levels and aberrant mitochondrial morphology.

Mitochondrion 2013 Sep 9;13(5):436-43. Epub 2012 Dec 9.

Department of Biochemistry, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.mito.2012.12.001DOI Listing
September 2013

OXPHOS mutations and neurodegeneration.

EMBO J 2013 Jan 13;32(1):9-29. Epub 2012 Nov 13.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2012.300
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http://dx.doi.org/10.1038/emboj.2012.300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545297PMC
January 2013

Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis.

J Biol Chem 2012 Dec 4;287(50):41851-60. Epub 2012 Oct 4.

Department of Biochemistry, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M112.391151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516733PMC
December 2012

Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells.

Antioxid Redox Signal 2012 Dec 13;17(12):1657-69. Epub 2012 Jun 13.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1089/ars.2011.4294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474189PMC
December 2012

Monogenic mitochondrial disorders.

N Engl J Med 2012 Mar;366(12):1132-41

Department of Biochemistry, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://www.nejm.org/doi/abs/10.1056/NEJMra1012478
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http://dx.doi.org/10.1056/NEJMra1012478DOI Listing
March 2012

Isolated mitochondrial complex I deficiency: explorative data analysis of patient cell parameters.

Curr Pharm Des 2011 Dec;17(36):4023-33

Department of Analytical Chemistry, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2174/138161211798764870DOI Listing
December 2011

Defective mitochondrial translation differently affects the live cell dynamics of complex I subunits.

Biochim Biophys Acta 2011 Dec 24;1807(12):1624-33. Epub 2011 Sep 24.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000527281100223
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http://dx.doi.org/10.1016/j.bbabio.2011.09.013DOI Listing
December 2011

Pharmacological targeting of mitochondrial complex I deficiency: the cellular level and beyond.

Mitochondrion 2012 Jan 2;12(1):57-65. Epub 2011 Jul 2.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.mito.2011.06.011DOI Listing
January 2012

Modeling mitochondrial dysfunctions in the brain: from mice to men.

J Inherit Metab Dis 2012 Mar 14;35(2):193-210. Epub 2011 Jul 14.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s10545-011-9375-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278625PMC
March 2012

Quantitative glucose and ATP sensing in mammalian cells.

Pharm Res 2011 Nov 21;28(11):2745-57. Epub 2011 Jun 21.

Department of Biochemistry (286) Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s11095-011-0492-8
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http://dx.doi.org/10.1007/s11095-011-0492-8DOI Listing
November 2011

Solute diffusion is hindered in the mitochondrial matrix.

Proc Natl Acad Sci U S A 2011 May 9;108(21):8657-62. Epub 2011 May 9.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1017581108
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http://dx.doi.org/10.1073/pnas.1017581108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102363PMC
May 2011

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance.

J Cell Sci 2011 Apr 8;124(Pt 7):1115-25. Epub 2011 Mar 8.

Laboratory for Neurobiology and Gene Therapy, Molecular Medicine, Katholieke Universiteit Leuven, 3000 Leuven, Flanders, Belgium.

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http://dx.doi.org/10.1242/jcs.078303DOI Listing
April 2011

Complex I disorders: causes, mechanisms, and development of treatment strategies at the cellular level.

Dev Disabil Res Rev 2010 ;16(2):175-82

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/ddrr.107DOI Listing
January 2011

Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency.

J Inherit Metab Dis 2011 Apr 27;34(2):293-307. Epub 2010 Jan 27.

Department of Paediatrics, Nijmegen Centre for Mitochondrial Disorders, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://link.springer.com/content/pdf/10.1007/s10545-009-9005
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http://link.springer.com/10.1007/s10545-009-9005-x
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http://dx.doi.org/10.1007/s10545-009-9005-xDOI Listing
April 2011

Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells.

Biochim Biophys Acta 2010 Jun-Jul;1797(6-7):1034-44. Epub 2010 Jan 25.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbabio.2010.01.022DOI Listing
January 2011

Clinical spectrum of the pseudotumor cerebri complex in children.

Childs Nerv Syst 2010 Mar 10;26(3):313-21. Epub 2009 Nov 10.

Department of General Pediatrics, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

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http://www.springerlink.com/index/m78l676m56jg6155.pdf
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http://link.springer.com/content/pdf/10.1007/s00381-009-1018
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http://link.springer.com/10.1007/s00381-009-1018-0
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http://dx.doi.org/10.1007/s00381-009-1018-0DOI Listing
March 2010

C. elegans ATAD-3 is essential for mitochondrial activity and development.

PLoS One 2009 Oct 30;4(10):e7644. Epub 2009 Oct 30.

Department of General Pediatrics, University Children's Hospital, Heinrich-Heine-University, Düsseldorf, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007644PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765634PMC
October 2009

FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia?

J Membr Biol 2009 Oct 29;231(2-3):117-24. Epub 2009 Oct 29.

Department of Biochemistry, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s00232-009-9210-4
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http://dx.doi.org/10.1007/s00232-009-9210-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776943PMC
October 2009

Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation.

Antioxid Redox Signal 2010 Jun;12(12):1431-70

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1089/ars.2009.2743DOI Listing
June 2010

Mitochondrial dynamics in human NADH:ubiquinone oxidoreductase deficiency.

Int J Biochem Cell Biol 2009 Oct 28;41(10):1773-82. Epub 2009 Jan 28.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S135727250900014
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http://dx.doi.org/10.1016/j.biocel.2009.01.012DOI Listing
October 2009

Chapter 16 The use of fluorescence correlation spectroscopy to probe mitochondrial mobility and intramatrix protein diffusion.

Methods Enzymol 2009 ;456:287-302

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790804416
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http://dx.doi.org/10.1016/S0076-6879(08)04416-9DOI Listing
June 2009

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease.

Brain 2009 Apr 31;132(Pt 4):833-42. Epub 2009 Mar 31.

Department of Membrane Biochemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/brain/awp058DOI Listing
April 2009

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+ -stimulated ATP production in human complex I deficiency.

J Mol Med (Berl) 2009 May 3;87(5):515-22. Epub 2009 Mar 3.

Department of Biochemistry (286), Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://link.springer.com/10.1007/s00109-009-0452-5
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http://dx.doi.org/10.1007/s00109-009-0452-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836243PMC
May 2009

Calcium and ATP handling in human NADH:ubiquinone oxidoreductase deficiency.

Biochim Biophys Acta 2009 Dec 10;1792(12):1130-7. Epub 2009 Jan 10.

Department of Membrane Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2009.01.001DOI Listing
December 2009

Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor.

Clin Nutr 2009 Feb 25;28(1):59-64. Epub 2008 Oct 25.

Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.clnu.2008.09.001DOI Listing
February 2009

Computer-assisted live cell analysis of mitochondrial membrane potential, morphology and calcium handling.

Methods 2008 Dec 16;46(4):304-11. Epub 2008 Oct 16.

Department of Biochemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ymeth.2008.09.018DOI Listing
December 2008

Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells.

J Biol Chem 2008 Dec 30;283(50):34753-61. Epub 2008 Sep 30.

Department of Biochemistry, Nijmegen Centre for Mitochondrial Disorders, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M807323200
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http://dx.doi.org/10.1074/jbc.M807323200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259887PMC
December 2008

Mitochondrial processes are impaired in hereditary inclusion body myopathy.

Hum Mol Genet 2008 Dec 23;17(23):3663-74. Epub 2008 Aug 23.

Goldyne Savad Institute for Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1093/hmg/ddn261DOI Listing
December 2008

Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):853-9. Epub 2008 Apr 8.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.bbabio.2008.03.028DOI Listing
August 2008

Inherited complex I deficiency is associated with faster protein diffusion in the matrix of moving mitochondria.

Am J Physiol Cell Physiol 2008 May 19;294(5):C1124-32. Epub 2008 Mar 19.

Department of Biochemistry, Nijmegen, Nijmegen Centre for Molecular Life Sciences, The Netherlands.

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http://dx.doi.org/10.1152/ajpcell.00079.2008DOI Listing
May 2008

The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase.

Pflugers Arch 2009 Jan 7;457(3):623-34. Epub 2008 Mar 7.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://link.springer.com/content/pdf/10.1007/s00424-008-0467
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January 2009

Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency.

Cell Calcium 2008 Jul 4;44(1):123-33. Epub 2008 Mar 4.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ceca.2008.01.002DOI Listing
July 2008

Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking.

J Virol 2008 Apr 23;82(7):3782-90. Epub 2008 Jan 23.

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/JVI.02076-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268507PMC
April 2008

Life cell quantification of mitochondrial membrane potential at the single organelle level.

Cytometry A 2008 Feb;73(2):129-38

Department of Membrane Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/cyto.a.20503DOI Listing
February 2008

Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia.

Biochim Biophys Acta 2008 Feb 17;1778(2):398-404. Epub 2007 Oct 17.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000527360700402
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http://dx.doi.org/10.1016/j.bbamem.2007.10.009DOI Listing
February 2008

Reduction of phospholipase D activity during coxsackievirus infection.

J Gen Virol 2007 Nov;88(Pt 11):3027-3030

Department of Medical Microbiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1099/vir.0.83169-0DOI Listing
November 2007

Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency.

Biochim Biophys Acta 2007 Sep 25;1772(9):1041-51. Epub 2007 May 25.

Department of Membrane Biochemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2007.05.004DOI Listing
September 2007

Partial complex I inhibition decreases mitochondrial motility and increases matrix protein diffusion as revealed by fluorescence correlation spectroscopy.

Biochim Biophys Acta 2007 Jul 6;1767(7):940-7. Epub 2007 Apr 6.

Department of Membrane Biochemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbabio.2007.03.013DOI Listing
July 2007

Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?

Am J Physiol Cell Physiol 2007 Jul 11;293(1):C22-9. Epub 2007 Apr 11.

Department of Membrane Biochemistry, Radboud University Nijmegen Medical Centre, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajpcell.00194.2006DOI Listing
July 2007

Superoxide production is inversely related to complex I activity in inherited complex I deficiency.

Biochim Biophys Acta 2007 Mar 4;1772(3):373-81. Epub 2007 Jan 4.

Department of Membrane Biochemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2006.12.009DOI Listing
March 2007

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.

J Biol Chem 2007 Mar 5;282(10):7582-90. Epub 2007 Jan 5.

Nijmegen Centre for Mitochondrial Disorders, Department of Paediatrics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M609410200
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March 2007

The human non-gastric H,K-ATPase has a different cation specificity than the rat enzyme.

Biochim Biophys Acta 2007 Mar 26;1768(3):580-9. Epub 2006 Oct 26.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbamem.2006.10.010DOI Listing
March 2007

Simultaneous quantification of oxidative stress and cell spreading using 5-(and-6)-chloromethyl-2',7'-dichlorofluorescein.

Cytometry A 2006 Dec;69(12):1184-92

Department of Membrane Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/cyto.a.20348DOI Listing
December 2006

Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency.

Am J Physiol Cell Physiol 2006 Aug 22;291(2):C308-16. Epub 2006 Mar 22.

Nijmegen Centre for Mitochondrial Disorders, Dept. of Pediatrics, Radboud Univ. Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajpcell.00561.2005DOI Listing
August 2006

Conversion of the low affinity ouabain-binding site of non-gastric H,K-ATPase into a high affinity binding site by substitution of only five amino acids.

J Biol Chem 2006 May 10;281(19):13533-9. Epub 2006 Mar 10.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M600551200
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May 2006

Simultaneous quantitative measurement and automated analysis of mitochondrial morphology, mass, potential, and motility in living human skin fibroblasts.

Cytometry A 2006 Jan;69(1):1-12

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/cyto.a.20198DOI Listing
January 2006

Decreased agonist-stimulated mitochondrial ATP production caused by a pathological reduction in endoplasmic reticulum calcium content in human complex I deficiency.

Biochim Biophys Acta 2006 Jan 16;1762(1):115-23. Epub 2005 Sep 16.

Department of Biochemistry for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbadis.2005.09.001DOI Listing
January 2006

Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity.

Cancer Res 2005 Oct;65(19):8801-8

Department of Biochemistry 161, Nijmegen Center of Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0378DOI Listing
October 2005

Cell biological consequences of mitochondrial NADH: ubiquinone oxidoreductase deficiency.

Curr Neurovasc Res 2004 Jan;1(1):29-40

Department of Pediatrics, Nijmegen Center for Mitochondrial Disorders, University Medical Center Nijmegen, The Netherlands.

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http://dx.doi.org/10.2174/1567202043480224DOI Listing
January 2004

Amplitude modulation of nuclear Ca2+ signals in human skeletal myotubes: a possible role for nuclear Ca2+ buffering.

Cell Calcium 2005 Aug;38(2):141-52

Department of 160 Biochemistry NCMLS, Radboud University Nijmegen Medical Center, The Netherlands.

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http://dx.doi.org/10.1016/j.ceca.2005.06.003DOI Listing
August 2005

Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids.

J Biol Chem 2005 Sep 28;280(37):32349-55. Epub 2005 Jul 28.

Department of Biochemistry (160), Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M505168200
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September 2005

The non-gastric H,K-ATPase is oligomycin-sensitive and can function as an H+,NH4(+)-ATPase.

J Biol Chem 2005 Sep 26;280(39):33115-22. Epub 2005 Jul 26.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M504535200
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September 2005

Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency.

Am J Physiol Cell Physiol 2005 Oct 18;289(4):C881-90. Epub 2005 May 18.

Microscopical Imaging Cente, Nijmegen Center for Mitochondrial Disorders, The Netherlands.

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http://dx.doi.org/10.1152/ajpcell.00104.2005DOI Listing
October 2005

Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive?

Trends Microbiol 2005 Feb;13(2):41-4

Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen Center for Molecular Life Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.tim.2004.12.005DOI Listing
February 2005

Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth.

Am J Physiol Cell Physiol 2005 Jun 12;288(6):C1440-50. Epub 2005 Jan 12.

Microscopal Imaging Center, Department of Biochemistry, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1152/ajpcell.00607.2004DOI Listing
June 2005

Asn792 participates in the hydrogen bond network around the K+-binding pocket of gastric H,K-ATPase.

J Biol Chem 2005 Mar 11;280(12):11488-94. Epub 2005 Jan 11.

Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M412321200DOI Listing
March 2005