Peter H Backx

Peter H Backx

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Peter H Backx

Publications by authors named "Peter H Backx"

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Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload.

J Mol Cell Cardiol 2019 Jul 30;132:60-70. Epub 2019 Apr 30.

Department of Biology, York University, Toronto, ON M3J 1P3, Canada; Division of Cardiology, University Health Network, Toronto, ON M5S 3E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.028DOI Listing
July 2019

Biowire Model of Interstitial and Focal Cardiac Fibrosis.

ACS Cent Sci 2019 Jul 4;5(7):1146-1158. Epub 2019 Jun 4.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

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http://dx.doi.org/10.1021/acscentsci.9b00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661857PMC
July 2019

Inhibition of soluble TNFα prevents adverse atrial remodeling and atrial arrhythmia susceptibility induced in mice by endurance exercise.

J Mol Cell Cardiol 2019 Apr 21;129:165-173. Epub 2019 Feb 21.

Department of Biology, York University, Toronto, ON, M3J 1P3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.01.012DOI Listing
April 2019

Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform.

Matrix Biol 2019 Apr 11. Epub 2019 Apr 11.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario M5S 3E5; Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Toronto General Research Institute, Toronto, Ontario M5G 2C4; Canada. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.04.001DOI Listing
April 2019

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.

Cell 2019 Feb 24;176(4):913-927.e18. Epub 2019 Jan 24.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada; Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456036PMC
February 2019

Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy.

J Physiol 2019 Jan 23. Epub 2019 Jan 23.

School of Kinesiology and Health Science and the Muscle Health Research Centre, York University, Toronto, ON, Canada.

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http://dx.doi.org/10.1113/JP277306DOI Listing
January 2019

Excessive exercise in endurance athletes: Is atrial fibrillation a possible consequence?

Appl Physiol Nutr Metab 2018 Sep 29;43(9):973-976. Epub 2018 May 29.

c Division of Cardiology, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

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http://dx.doi.org/10.1139/apnm-2017-0764DOI Listing
September 2018

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.

Cell Stem Cell 2017 08;21(2):179-194.e4

McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7 Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.003DOI Listing
August 2017

Ultrasound biomicroscopy validation of a murine model of cardiac hypertrophic preconditioning: comparison with a hemodynamic assessment.

Am J Physiol Heart Circ Physiol 2017 Jul 28;313(1):H138-H148. Epub 2017 Apr 28.

Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China;

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http://dx.doi.org/10.1152/ajpheart.00004.2017DOI Listing
July 2017

Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.

Nat Commun 2017 05 26;8:15518. Epub 2017 May 26.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1038/ncomms15518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458545PMC
May 2017

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.

Nat Biotechnol 2017 Jan 12;35(1):56-68. Epub 2016 Dec 12.

McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://www.nature.com/doifinder/10.1038/nbt.3745
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http://dx.doi.org/10.1038/nbt.3745DOI Listing
January 2017

Amlodipine Therapy for Iron-Overload Cardiomyopathy: The Enduring Value of Translational Research.

Can J Cardiol 2016 08 26;32(8):938-40. Epub 2015 Nov 26.

Division of Cardiology, Peter Munk Heart Centre, University Health Network, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.11.017DOI Listing
August 2016

Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

PLoS One 2015 21;10(7):e0133274. Epub 2015 Jul 21.

The Departments of Physiology and Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, University Health Network, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133274PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510596PMC
May 2016

Reductions in the Cardiac Transient Outward K+ Current Ito Caused by Chronic β-Adrenergic Receptor Stimulation Are Partly Rescued by Inhibition of Nuclear Factor κB.

J Biol Chem 2016 Feb 7;291(8):4156-65. Epub 2016 Jan 7.

From the Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada, the Division of Cardiology, University Health Network, University of Toronto, Toronto, Ontario M5G 1L7, Canada,

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http://dx.doi.org/10.1074/jbc.M115.694984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759190PMC
February 2016

Physiological roles of the transient outward current Ito in normal and diseased hearts.

Front Biosci (Schol Ed) 2016 Jan 1;8:143-59. Epub 2016 Jan 1.

Department of Experimental Cardiology, Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, New York, 13501 USA,

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January 2016

Irx3 is required for postnatal maturation of the mouse ventricular conduction system.

Sci Rep 2016 Jan 20;6:19197. Epub 2016 Jan 20.

The Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON M5S 3E2, Canada.

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http://dx.doi.org/10.1038/srep19197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726432PMC
January 2016

The electrophysiological development of cardiomyocytes.

Adv Drug Deliv Rev 2016 Jan;96:253-73

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http://dx.doi.org/10.1016/j.addr.2015.12.023DOI Listing
January 2016

Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy.

J Mol Cell Cardiol 2015 Sep 19;86:102-9. Epub 2015 Jul 19.

Department of Biology, York University, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.06.020DOI Listing
September 2015

Patch-clamp technique in ESC-derived cardiomyocytes.

Methods Mol Biol 2014 ;1181:203-14

Departments of Physiology and Medicine, University of Toronto, Medical Science Building, Rm 3247, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8.

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http://dx.doi.org/10.1007/978-1-4939-1047-2_18DOI Listing
March 2015

Atrial fibrillation and the athletic heart.

Curr Opin Cardiol 2015 Jan;30(1):17-23

aArrhythmia Service and the Cellular Electrophysiology Laboratory, University of Ottawa Heart Institute, Ottawa bDivision of Cardiology, Departments of Physiology and Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/HCO.0000000000000130DOI Listing
January 2015

Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.

Nat Commun 2015 Jan 19;6:6018. Epub 2015 Jan 19.

1] Department of Physiology, University of Toronto, 1 King's College Cir., Toronto, Ontario, Canada M5S1A8 [2] Department of Medicine, University of Toronto, 1 King's College Cir., Toronto, Ontario, Canada M5S1A8 [3] Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, 200 Elizabeth St, Toronto, Ontario, Canada M5G2C4 [4] Heart &Stroke Richard Lewar Centre of Excellence, University of Toronto, 1 King's College Cir., Toronto, Ontario, Canada M5S1A8.

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http://dx.doi.org/10.1038/ncomms7018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661059PMC
January 2015

Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.

Circ Cardiovasc Genet 2014 Dec 11;7(6):782-9. Epub 2014 Sep 11.

From the Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa (M.J.P., A.A., S.G., F.A.-Z., P.D., N.O., S.U., D.B.); Population Health Research Institute, McMaster University, Hamilton, ON (J.S.H.); Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC (S.S., A.D.K.); Division of Cardiology, Department of Medicine, Dalhousie University, Halifax, NS (M.G.); Division of Cardiology, Department of Medicine, Laval University, Québec, QC (J.C.); Division of Cardiology, Department of Medicine, Queens University, Kingston (C.S.); Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada (K.A.); Department of Genetics, University of Groningen, University Medical Center, Groningen, the Netherlands (M.P.v.d.B., J.P.v.T.); Division of Cardiology, Toronto General Hospital, University of Toronto, Toronto, ON, Canada (V.C., P.H.B., M.H.G.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000623DOI Listing
December 2014

Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects.

J Am Heart Assoc 2014 Oct 20;3(5):e001018. Epub 2014 Oct 20.

Department of Physiology, University of Toronto, Ontario, Canada (D.Y.W., C.A., J.Y.L., P.S., N.B., S.S., P.H.B., B.C., X.Y.W., P.P.L., A.O.G.) Faculty of Medicine and Institute of Medical Science, University of Toronto, Ontario, Canada (S.E.R., F.D., K.N., P.H.B., X.Y.W., P.P.L., A.O.G.).

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http://dx.doi.org/10.1161/JAHA.114.001018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323785PMC
October 2014

Coagulation factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease.

J Hypertens 2014 Jul;32(7):1523-33; discussion 1533

aHeart and Stroke/Richard Lewar Centre of Excellence bDepartment of Medicine, University Health Network and Mount Sinai Hospital cDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/HJH.0000000000000192DOI Listing
July 2014

Heart failure in congenital heart disease: the role of genes and hemodynamics.

Pflugers Arch 2014 Jun 1;466(6):1025-35. Epub 2014 Feb 1.

Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s00424-014-1447-9DOI Listing
June 2014

Enhanced cell volume regulation: a key mechanism in local and remote ischemic preconditioning.

Am J Physiol Cell Physiol 2014 Jun 23;306(12):C1191-9. Epub 2014 Apr 23.

Division of Physiology and Experimental Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatric Laboratory Medicine and Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; and

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http://dx.doi.org/10.1152/ajpcell.00259.2013DOI Listing
June 2014

Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells.

J Hypertens 2014 Feb;32(2):318-30

aDepartments of Physiology and Medicine bDivision of Cardiology, University Health Network, University of Toronto, Toronto, Canada cChina-Japan Union Hospital, Jilin University, Changchun, China dDivision of Respirology eThe Li Ka Shing Knowledge Institute, St. Michael's Hospital,University of Toronto, Toronto, Canada fCedars-Sinai Heart Institute, Los Angeles, California, USA *Wenbin Liang and Lihong Huang contributed equally to this study. **Deceased.

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http://dx.doi.org/10.1097/HJH.0000000000000013DOI Listing
February 2014

Mesenchymal stem cell transplantation mitigates electrophysiological remodeling in a rat model of myocardial infarction.

J Cardiovasc Electrophysiol 2013 Jul 3;24(7):813-21. Epub 2013 May 3.

The Hull Family Cardiac Fibrillation Management Laboratory, Division of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/jce.12162DOI Listing
July 2013

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure.

Nat Med 2013 May 31;19(5):567-75. Epub 2013 Mar 31.

Department of Medicine, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nm.3128DOI Listing
May 2013

Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q.

Heart Rhythm 2012 Oct 16;9(10):1681-1688.e1. Epub 2012 Jun 16.

Division of Cardiology, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.hrthm.2012.06.029DOI Listing
October 2012

α-Crystallin B prevents apoptosis after H2O2 exposure in mouse neonatal cardiomyocytes.

Am J Physiol Heart Circ Physiol 2012 Oct 17;303(8):H967-78. Epub 2012 Aug 17.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5G 1L6.

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http://dx.doi.org/10.1152/ajpheart.00040.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706333PMC
October 2012

Activated plasma coagulation β-Factor XII-induced vasoconstriction in rats.

Clin Sci (Lond) 2012 Jun;122(12):581-90

Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1042/CS20110517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294432PMC
June 2012

Iroquois homeodomain transcription factors in heart development and function.

Circ Res 2012 May;110(11):1513-24

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.112.265041DOI Listing
May 2012

A new enzyme-linked immunosorbent assay recognizing both rat and human activated coagulation Factor XII (FXIIa).

J Immunol Methods 2012 Feb 10;376(1-2):132-8. Epub 2012 Jan 10.

Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jim.2012.01.002DOI Listing
February 2012

Regulation of murine cardiac function by phosphodiesterases type 3 and 4.

Curr Opin Pharmacol 2011 Dec 31;11(6):714-9. Epub 2011 Oct 31.

Department of Physiology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.coph.2011.10.017DOI Listing
December 2011

Intracellular [Na(+)] modulates synergy between Na(+)/Ca (2+) exchanger and L-type Ca (2+) current in cardiac excitation-contraction coupling during action potentials.

Basic Res Cardiol 2011 Nov 21;106(6):967-77. Epub 2011 Jul 21.

Department of Physiology, University of Toronto, Heart and Stroke/Richard Lewar Centre of Excellence, Fitzgerald Building, 150 College Street, Room 68, Toronto, ON M5S 3E2, Canada.

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http://dx.doi.org/10.1007/s00395-011-0202-zDOI Listing
November 2011

PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility.

Nat Neurosci 2011 Oct 23;14(11):1447-54. Epub 2011 Oct 23.

National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.

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http://dx.doi.org/10.1038/nn.2937DOI Listing
October 2011

Remote preconditioning provides potent cardioprotection via PI3K/Akt activation and is associated with nuclear accumulation of β-catenin.

Clin Sci (Lond) 2011 May;120(10):451-62

Division of Cardiology, Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8.

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http://dx.doi.org/10.1042/CS20100466DOI Listing
May 2011

Serving up the ping-pong mechanisms for biventricular ventricular tachycardia.

Authors:
Peter H Backx

Heart Rhythm 2011 Apr 23;8(4):606-7. Epub 2011 Feb 23.

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http://dx.doi.org/10.1016/j.hrthm.2011.02.031DOI Listing
April 2011

Nuclear factor kappaB downregulates the transient outward potassium current I(to,f) through control of KChIP2 expression.

Circ Res 2011 Mar 20;108(5):537-43. Epub 2011 Jan 20.

DVM, 150 College St, Fitzgerald Bldg, Rm 68, Toronto, Ontario, Canada M5S 3E2.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.229112DOI Listing
March 2011

Dissection of the voltage-activated potassium outward currents in adult mouse ventricular myocytes: I(to,f), I(to,s), I(K,slow1), I(K,slow2), and I(ss).

Basic Res Cardiol 2011 Mar 21;106(2):189-204. Epub 2011 Jan 21.

Department of Physiology, University of Toronto, 150 College St., Toronto, ON M5S 3E2, Canada.

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http://dx.doi.org/10.1007/s00395-010-0134-zDOI Listing
March 2011

Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy.

Cardiovasc Res 2011 Feb 9;89(3):623-33. Epub 2010 Nov 9.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/cvr/cvq351DOI Listing
February 2011

Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats.

Free Radic Biol Med 2010 Nov 2;49(8):1306-14. Epub 2010 Aug 2.

Physiology and Experimental Medicine Program, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.07.021DOI Listing
November 2010

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

Circ Res 2010 Nov 16;107(10):1275-89. Epub 2010 Sep 16.

Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.229054DOI Listing
November 2010

The role of thin filament cooperativity in cardiac length-dependent calcium activation.

Biophys J 2010 Nov;99(9):2978-86

Center for Cardiovascular Research, Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1016/j.bpj.2010.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965940PMC
November 2010

P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.

PLoS One 2009 Nov 5;4(11):e7712. Epub 2009 Nov 5.

Department of Physiology, Heart and Stroke/Richard Lewar Centre, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007712PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766643PMC
November 2009

Regulation of proliferation and membrane potential by chloride currents in rat pulmonary artery smooth muscle cells.

Hypertension 2009 Aug 6;54(2):286-93. Epub 2009 Jul 6.

Heart and Stroke/Richard Lewar Centre, 150 College St, Toronto, Ontario, Canada M5S 3E2.

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.109.
Publisher Site
http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.130138DOI Listing
August 2009

Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro.

Stem Cells 2008 Nov 7;26(11):2884-92. Epub 2008 Aug 7.

Department of Physiology, Heart and Stroke/Richard Lewar Centre, University Health Network, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1634/stemcells.2008-0329DOI Listing
November 2008

Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning.

Circ Res 2008 Sep 7;103(6):643-53. Epub 2008 Aug 7.

Department of Medicine and Physiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.175018DOI Listing
September 2008

RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.

Circ Res 2008 Aug 24;103(5):527-35. Epub 2008 Jul 24.

Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.180984DOI Listing
August 2008

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.

Cardiovasc Res 2008 Jun 15;78(3):505-14. Epub 2008 Feb 15.

Division of Cardiology, Department of Medicine, Rm 7326, Medical Sciences Building, One King's College Circle, University of Toronto, Toronto, Canada M5S 1A8.

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http://dx.doi.org/10.1093/cvr/cvn041DOI Listing
June 2008

2-hydroxyoleic acid affects cardiomyocyte [Ca2+]i transient and contractility in a region-dependent manner.

Am J Physiol Heart Circ Physiol 2008 Apr 22;294(4):H1948-55. Epub 2008 Feb 22.

University of the Balearic Islands, Palma de Mallorca, Spain.

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http://dx.doi.org/10.1152/ajpheart.01209.2007DOI Listing
April 2008

Tbx5-dependent pathway regulating diastolic function in congenital heart disease.

Proc Natl Acad Sci U S A 2008 Apr 31;105(14):5519-24. Epub 2008 Mar 31.

Programme in Developmental and Stem Cell Biology, Division of Cardiology and Labatt Family Heart Centre, Programme in Physiology and Experimental Medicine, and Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1073/pnas.0801779105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291114PMC
April 2008

Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway.

J Pharmacol Exp Ther 2008 Jan 10;324(1):160-9. Epub 2007 Oct 10.

Departments of Physiology and Medicine, Heart and Stroke/Richard Lewar Centre of Excellence, Room 71, FitzGerald Bldg. 150 College St., Toronto, ON M5S 3E2, Canada.

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http://dx.doi.org/10.1124/jpet.107.125773DOI Listing
January 2008

Adrenomedullary catecholamine, pressor and chronotropic responses to human coagulation beta-FXIIa mediated by endogenous kinins.

J Hypertens 2008 Jan;26(1):61-9

University Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, Canada.

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http://dx.doi.org/10.1097/HJH.0b013e3282f190cfDOI Listing
January 2008

Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-gamma.

Circ Res 2007 Dec 1;101(12):1274-82. Epub 2007 Nov 1.

Department of Physiology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.158428DOI Listing
December 2007

Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families.

J Hypertens 2007 Oct;25(10):2074-81

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada.

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http://dx.doi.org/10.1097/HJH.0b013e3282a9be1bDOI Listing
October 2007

Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.

Am J Pathol 2007 Aug 28;171(2):438-51. Epub 2007 Jun 28.

Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2353/ajpath.2007.060977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934545PMC
August 2007

PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.

Circ Res 2007 Aug 5;101(4):400-8. Epub 2007 Jul 5.

Department of Physiology, the Heart & Stroke Richard Lewar Centre, and the Division of Cardiology at the University Health Network, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.107.156422DOI Listing
August 2007

I(Ks) block by HMR 1556 lowers ventricular defibrillation threshold and reverses the repolarization shortening by isoproterenol without rate-dependence in rabbits.

J Cardiovasc Electrophysiol 2007 Jul;18(7):750-6

Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/j.1540-8167.2007.00812.xDOI Listing
July 2007

Role of phosphatidylinositol-3 kinase-gamma in the actions of glucagon-like peptide-2 on the murine small intestine.

Am J Physiol Endocrinol Metab 2007 Jun 6;292(6):E1599-606. Epub 2007 Feb 6.

Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8 Canada.

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http://www.physiology.org/doi/10.1152/ajpendo.00429.2006
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http://dx.doi.org/10.1152/ajpendo.00429.2006DOI Listing
June 2007

Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits.

J Biol Chem 2006 Dec 23;281(50):38498-506. Epub 2006 Oct 23.

Departments of Physiology and Medicine, Heart and Stroke/Richard Lewar Centre of Excellence, University Health Network, University of Toronto, 150 College Street, Toronto, Ontario M5S 3E2, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M607774200
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http://dx.doi.org/10.1074/jbc.M607774200DOI Listing
December 2006