Publications by authors named "Peter Elsner"

382 Publications

Prevalence of contact allergies in the population compared to a tertiary referral patch test clinic in Jena/Germany.

Contact Dermatitis 2021 Jun 28. Epub 2021 Jun 28.

Department of Dermatology, University Hospital Jena, Jena, Germany.

Background: The contact allergy prevalences in patch tested patients are usually higher than those in the population, owing to morbidity-driven selection.

Objectives: To examine the differences between two samples, one from the population, one from the patch test clinic, in one area of Germany (Jena, Thuringia).

Methods: Between August 2008 and October 2011, 519 participants of the population-based EDEN fragrance study were patch tested in Jena using a TRUE Test baseline series extended with some pet.-based (fragrance) allergen preparations. Between 2007 and 2012 (inclusive), 1906 routine patients were patch tested for suspected ACD in the Jena University Hospital Department, of these 1694 (83.2%) with the German baseline series using pet./aq.-based, investigator-loaded allergens.

Results: In the population (clinical) sample, 19.6% (41.1%) were sensitised to at least one of the allergens considered. The most common baseline series allergens in the population/clinical sample were nickel (10.5%/13.2%), fragrance mix (FM) II (2.9%/6.7%), FM I (2.3%/8.3%), and cobalt (1.6%/5%). The clinical sample was slightly older (71.5% vs. 55.9% age 40+) and included less males (36% vs. 49.3%).

Conclusions: Results are quite similar, although prevalences are usually higher in the clinical setting, with the exception of p-tert-butylphenol formaldehyde resin. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1111/cod.13923DOI Listing
June 2021

Die (neue) Berufskrankheit Nr. 5101: „Schwere oder wiederholt rückfällige Hauterkrankungen“.

J Dtsch Dermatol Ges 2021 May;19(5):720-742

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

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http://dx.doi.org/10.1111/ddg.14537_gDOI Listing
May 2021

Aufhebung des Unterlassungszwangs bei der Berufskrankheit Haut: Hintergründe und Perspektiven.

Authors:
Peter Elsner

J Dtsch Dermatol Ges 2021 May;19(5):679-684

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

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http://dx.doi.org/10.1111/ddg.14337_gDOI Listing
May 2021

The (new) occupational disease no. 5101: "Severe or recurrent skin diseases".

J Dtsch Dermatol Ges 2021 05 3;19(5):720-741. Epub 2021 May 3.

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

Occupational dermatoses are among the most common occupational diseases, with BK 5101 accounting for the largest proportion. Historically, the latter was also the most frequently reported group of occupational diseases within the working age population. More than 80,000 suspected cases of occupational diseases were notified in 2019, of which 19,883 related to BK 5101. In Germany, work-related hand eczema accounts for 90 % of all BK 5101 diseases, and consists mainly of contact eczema. Especially young people working in the hairdressing sector, health care, metal, food or construction industries belong to the high-risk group. Diagnosis, therapy and prevention of BK 5101 play an important role, since advanced skin diseases are usually accompanied by a poor prognosis and long periods of inability to work, which can have considerable socio-economic consequences. On January 1 , 2021, with the "Seventh Act amending the Fourth Book of the German Social Code (SGB) and other Laws", an amendment to the Occupational Diseases Law came into force, with which the obligation to cease work was abolished, thereby fulfilling a decades-long requirement for recognition of BK 5101. As of this year, only the "severe or repeated recurrences" of a skin disease remain as a criterion for the occurrence of an insured event, which will likely result in an increased number of notifications and acknowledged cases of occupational skin diseases.
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http://dx.doi.org/10.1111/ddg.14537DOI Listing
May 2021

Doppelblinde, randomisierte repetitive In-vivo-Wirksamkeitsstudie zu kommerziellen Hautschutzprodukten gegen Natriumlaurylsulfat (SLS).

J Dtsch Dermatol Ges 2021 Apr;19(4):545-553

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

Hintergrund: In der Primär- und Sekundärprävention von Berufsdermatosen werden Hautschutzprodukte eingesetzt, die eine präexpositionelle Schutzwirkung aufweisen sollen. Insbesondere finden sich auf dem Markt zahlreiche Produkte, die zum Einsatz bei Feuchtarbeit ausgelobt werden. Eine objektive Qualitätsbeurteilung dieser Produkte für Anwender ist auf Grund fehlender vergleichender Wirksamkeitsstudien oft nicht möglich.

Material Und Methodik: In einer doppelblinden, randomisierten und kontrollierten In-vivo-Studie wurden sechs kommerzielle Hautschutzexterna in einem repetitiven Irritationsmodell untersucht. Sie wurden hinsichtlich ihrer präexpositionellen Schutzwirkung vor dem durch Natriumlaurylsulfat (SLS) induzierten irritativen Kontaktekzem mittels hautphysiologischer Methoden getestet. Es wurde ein Wirkindex anhand des transepidermalen Wasserverlustes (TEWL) gemäß des Protokolls der multizentrischen Studie des Forschungsprojektes FP 275 der Deutschen Gesetzlichen Unfallversicherung DGUV berechnet.

Ergebnisse: Die untersuchten Externa zeigten eine Schutzwirkung gegen SLS im Vergleich zum unbehandelten Kontrollfeld, wiesen allerdings signifikante Wirkunterschiede auf. Die Auswertung der Nebenparameter Corneometrie und visueller Score erbrachte ebenfalls Unterschiede zwischen den Externa.

Schlussfolgerungen: Die zwischen den untersuchten Externa festgestellten Unterschiede hinsichtlich der Wirkgüte ermöglichten eine Einteilung der Produkte, welche als Grundlage für die Auswahl geeigneter Schutzpräparate dienen kann.
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http://dx.doi.org/10.1111/ddg.14359_gDOI Listing
April 2021

Therapieresistente Pityriasis rubra pilaris erfolgreich therapiert mit Adalimumab.

J Dtsch Dermatol Ges 2021 Jul;19 Suppl 1:11-13

Klinik für Hautkrankheiten des Universitätsklinikums Jena.

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http://dx.doi.org/10.1111/ddg.14472DOI Listing
July 2021

Generalized cowpox virus infection in an immunosuppressed patient.

Int J Infect Dis 2021 05 29;106:276-278. Epub 2021 Mar 29.

Robert Koch Institute, Federal Centre for Biological Threats and Special Pathogens: Highly Pathogenic Viruses (ZBS 1) & German Consultant Laboratory for Poxviruses, Berlin, Germany.

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http://dx.doi.org/10.1016/j.ijid.2021.03.076DOI Listing
May 2021

Double blind randomized repetitive efficacy test of various occupational skin protection preparations against sodium lauryl sulphate.

J Dtsch Dermatol Ges 2021 04 25;19(4):545-552. Epub 2021 Mar 25.

Department of Dermatology, Jena University Medical Center.

Background: Skin protection products, formerly named as barrier creams, are being used as primary and secondary prevention measures against occupational dermatoses. Many of these cosmetic products are claimed by manufacturers to be efficacious against wet work-induced skin barrier impairment if applied prior to exposure. However, results of validated and standardized in vivo efficacy tests allowing the comparison of different products are lacking.

Material And Methods: Efficacy of six skin protection products against sodium lauryl sulphate-induced irritant contact dermatitis was investigated in a double blind, randomized and controlled repetitive irritation study in healthy volunteers using skin physiological methods. Transepidermal water loss (TEWL) results were used to calculate an efficacy index of protection by mathematical/statistical means according to a protocol developed in a German Statutory Accident Insurance (DGUV) multicenter study (research project FP 275).

Results: All tested products had a demonstrable, protective effect against SLS compared to controls, but their relative efficacy varied significantly. Differences were also seen upon evaluation of other parameters such as corneometry and clinical irritation score (visual score).

Conclusions: Product ranking as a result of the established differences allows improved selection of appropriate skin protection products based on objective parameters, as compared to heterogenous product claims.
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http://dx.doi.org/10.1111/ddg.14359DOI Listing
April 2021

Abolition of the obligation to cease an occupation for acknowledgment of an occupational skin disease: Backgrounds and perspectives.

Authors:
Peter Elsner

J Dtsch Dermatol Ges 2021 05 25;19(5):679-683. Epub 2021 Mar 25.

Department of Dermatology, University Hospital Jena, Jena, Germany.

The occupational disease skin No. 5101 ("severe or recurrent skin diseases that have forced the patient to refrain from all activities that were or could be the cause of the development, aggravation or resurgence of the disease") is the most frequently notified occupational disease in Germany. Since 1936, the medical-objective obligation to refrain from risky work activities, which has been necessary for the recognition of this occupational disease, was intended to delimit trivial diseases, facilitate the determination of occupational causality and promote prevention. The abolition of the legal obligation to refrain from risky work activities as a criterion for the recognition of the occupational disease 5101 as of 01.01.2021 has significant effects on the occupational dermatological care and expert assessment of this occupational disease. For less severe occupational skin diseases, however, the preventive dermatologist's procedure established since 1972 will continue to apply.
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http://dx.doi.org/10.1111/ddg.14337DOI Listing
May 2021

[The "dermatologist's procedure" after the abolition of the obligation to refrain from risky work activities in occupational disease law].

Authors:
Peter Elsner

Hautarzt 2021 Jun 25;72(6):509-515. Epub 2021 Feb 25.

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

Occupational disease (German: Berufskrankheit, BK) No. 5101 was previously defined as a "serious or recurrent skin disease that has forced a person to refrain from all activities that were or could be the cause of the development, aggravation or recurrence of the disease". In a far-reaching reform of the occupational disease law, which came into force on 01 January 2021, the German legislature decided to abolish the "obligation to refrain" as a prerequisite for the recognition of an occupational disease. To avoid this "obligation to refrain" was the motivation to introduce the "dermatologist's procedure" in 1972. The prevention instruments established in this procedure (dermatological treatment, workplace sanitation, skin protection measures, health education) were successful in the majority of cases. While the abolition of the "obligation to refrain" will, on the one hand, facilitate the recognition of serious or recurrent skin diseases as occupational diseases, the "dermatologist's procedure" will, however, continue to be important for occupational skin diseases, especially cases of hand eczema, which primarily do not meet the criteria of severity and/or recurrence and which can be controlled by appropriate treatment and prevention measures. In order to avoid delays in secondary prevention when notifying an occupational disease, a supplementary dermatological report to the disease notification should provide accident insurance carriers with the information necessary for timely prevention measures and dermatological treatment. An indication for the severity of the skin disease might be the success or failure of the "dermatologist's procedure".
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http://dx.doi.org/10.1007/s00105-021-04776-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169502PMC
June 2021

Skin exposure to scented products used in daily life and fragrance contact allergy in the European general population - The EDEN Fragrance Study.

Contact Dermatitis 2021 Jun 2;84(6):385-394. Epub 2021 Mar 2.

Department of Dermatology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Background: Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization.

Objective: To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy.

Methods: A cross-sectional study on individuals from 18 to 74 years of age, who were randomly selected from the general population in five European countries. A random sample (N = 3119) was patch tested and interviewed on exposure to scented products.

Results: Female participants were strongly associated with exposure to scented products relative to male participants. Participants age 40 years and older showed an inverse association with exposure to scented products. Compared to Sweden, The Netherlands followed by Germany showed the highest overall exposure to scented products. Sensitive skin was associated with exposure to scented products and with fragrance allergy. In univariable regression analysis, exposure to leave-on products and to specific scented product subgroups was significantly associated with fragrance allergy.

Conclusion: Exposure to scented products depends primarily on sex and age. Female sex and sensitive skin are relevant indicators for developing fragrance allergy. Because aggregate exposure, especially to scented leave-on products, may enhance the prevalence of contact allergy to fragrances, further investigations into exposure amounts and frequencies is warranted.
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http://dx.doi.org/10.1111/cod.13807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247875PMC
June 2021

Teledermatology in the times of COVID-19 - a systematic review.

Authors:
Peter Elsner

J Dtsch Dermatol Ges 2020 08 27;18(8):841-845. Epub 2020 Jul 27.

Department of Dermatology, University Hospital Jena, Germany.

The COVID-19 pandemic restricts the care of dermatological patients in many ways. Teledermatology such as video consultation or "store-and-forward" teledermatology could at least partly compensate for this. This systematic review summarizes all published studies on teledermatology during the COVID-19 pandemic. It is based on a MEDLINE search for articles from 2020 in English and German. Two surveys among dermatologists from the USA and India showed that more than 80 % offered teledermatology. Among German dermatologists 17.5 % of 480 respondents offered online video consultation, 11.3 % offline consultation (store and forward) and 10.0 % both. Five cohort studies on teledermatology during the pandemic were identified. Three of them investigated teledermatology in chronic dermatoses (acne, inflammatory skin diseases), one dealt with the care of oncological patients with dermatological complications, and one analyzed teleconsultation in suspected COVID-19 cases. In all studies, teledermatology largely reduced the number of personal consultations. The results indicate that the limitations of personal dermatological care of patients with skin diseases during the COVID-19 pandemic can be at least partially compensated by an extension of teledermatology. Findings from the use of teledermatology during the pandemic should be employed to improve the use and acceptance of teledermatology by patients and dermatologists.
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http://dx.doi.org/10.1111/ddg.14180DOI Listing
August 2020

Patch Testing With a New Composition of the Mercapto Mix-A Multicenter Study from the International Contact Dermatitis Research Group.

Dermatitis 2021 May-Jun 01;32(3):160-163

From the Department of Occupational Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.

Background: Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing.

Objective: To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0%.

Methods: There were 7103 dermatitis patients in 12 International Contact Dermatitis Research Group dermatology departments who were patch tested with 2-mercaptobenzothiazole 2.0% petrolatum (pet.), mercapto mix 2.0% pet., and mercapto mix 3.5% pet.

Results: Contact allergy to the 3 test preparations varied among the 12 centers: 2-mercaptobenzothiazole 2.0% pet. (0-2.4%), mercapto mix 2.0% pet. (0-4.9%), and mercapto mix 3.5% pet. (0-1.4%). 2-Mercaptobenzothiazole 2.0% and mercapto mix 2.0% detected a few more positive patients compared with mercapto mix 3.5%, but the difference was statistically insignificant (mercapto mix 2.0% pet., P = 1.0; 2-mercapto-benzothiazole 2.0% pet., P = 0.66).

Conclusions: Mercapto mix 3.5% pet. is not better than 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0% by a difference that is significant. By using only 1 test preparation (mercapto mix 3.5%), an additional hapten could be tested. No cases of suspected/proven patch test sensitization were registered.
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http://dx.doi.org/10.1097/DER.0000000000000669DOI Listing
January 2021

Patch Testing With Methylchloroisothiazolinone/Methylisothiazolinone Using a New Diagnostic Mix-A Multicenter Study From the International Contact Dermatitis Research Group.

Dermatitis 2021 Jan 5;Publish Ahead of Print. Epub 2021 Jan 5.

From the Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden Dermatovenerology and Allergy Centre, Odense University Hospital, University of Southern Denmark Department of Dermatology, Jena University Hospital, Germany National Skin Centre, Singapore Department of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Portugal Department of Dermatology, University Hospital KU Leuven, Belgium Department of Dermatology and Venereology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Croatia University of Ottawa, The Ottawa Hospital, Ontario, Canada Institute of Dermatology, Bangkok, Thailand Division of Dermatology, McGill University Health Centre, Montreal General Hospital, Québec, Canada Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi.

Background: In the early 1980s, a preservative containing a mixture of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a ratio of 3:1 was introduced. This mixture (mix) has been patch tested at 100 ppm (0.01%) worldwide and at 200 ppm (0.02%) in Sweden since 1986 and also in the European baseline series since 2014.

Objective: A new aqueous mix of MCI 0.015% and MI 0.2% was compared with patch testing with the 2 aqueous baseline preparations of MCI/MI 0.02% and MI 0.2%.

Methods: Four thousand three hundred ninety-seven patients with dermatitis in 12 International Contact Dermatitis Research Group dermatology departments from 3 continents were patch tested simultaneously with the 3 preparations.

Results: The frequency of positive patch tests to the allergens varied between 0% and 26.7% in the 12 test centers. The new mixture MCI/MI 0.215% in aqua (aq) detected significantly more patients with MCI/MI allergy than both MCI/MI 0.02% aq (P < 0.001) and MI 0.2% aq (P < 0.001) alone and combined.

Conclusions: The results favor replacing the preparations MCI/MI 0.02% aq and MI 0.2% aq with the mixture MCI/MI 0.215% aq in the International Contact Dermatitis Research Group baseline series.
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http://dx.doi.org/10.1097/DER.0000000000000657DOI Listing
January 2021

[57-years old patient with bulla and striatic erythema located at the limbs].

Dtsch Med Wochenschr 2020 12 30;145(24):1795-1798. Epub 2020 Nov 30.

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

History: A female patient aged 57 presented at the emergency room with painful skin lesions after repeated gardening days. Bullae and striate erythema were ovserved in light exposed areas. The patient was transferred to the Dermatology Department at the University hospital Jena, Germany.

Findings And Diagnosis: Blood test showed raised levels of inflammation parameters. The general body examination showed no abnormalities. Dermatits bullosa pratensis (grass dermatitis), was diagnosed, based on the patient case history, the examination results and the typical skin lesions.

Therapy And Course: Treatment with intravenous corticosteroids, followed by topical steroids and sterile punctures of blisters was prescribed.

Conclusions: Dermatits bullosa pratensis, is a skin condition appearing during the summer season in Germany. It belongs to the photo phytotoxic dermatitis types and is induced by phytochemicals in combination with UV-light. It is therefore important to take appropriate skin protective safety measures when touching plant containing phytochemicals in sunlight. In this way dermatitis bullosa pratensis can be easily avoided.
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http://dx.doi.org/10.1055/a-1275-3835DOI Listing
December 2020

Patterns of care and follow-up care of patients with uveal melanoma in German-speaking countries: a multinational survey of the German Dermatologic Cooperative Oncology Group (DeCOG).

J Cancer Res Clin Oncol 2021 Jun 21;147(6):1763-1771. Epub 2020 Nov 21.

Department of Dermatology and Venerology, University of Cologne, Cologne, Germany.

Purpose: Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting.

Methods: A questionnaire addressing the patterns of care and surveillance in the management of patients with uveal melanoma was distributed to 70 skin cancer centers in Austria, Germany and Switzerland. Frequency distributions of responses for each item of the questionnaire were calculated.

Results: 44 of 70 (62.9%) skin cancer centers completed the questionnaire. Thirty-nine hospitals were located in Germany (88.6%), three in Switzerland (6.8%) and two in Austria (4.5%). The majority (68.2%) represented university hospitals. Most patients with metastatic disease were treated in certified skin cancer centers (70.7%, 29/41). Besides, the majority of patients with UM were referred to the respective skin cancer center by ophthalmologists (87.2%, 34/39). Treatment and organization of follow-up of patients varied across the different centers. 35.1% (14/37) of the centers stated to not perform any screening measures.

Conclusion: Treatment patterns of patients with uveal melanoma in Germany, Austria and Switzerland remain extremely heterogeneous. A guideline for the treatment and surveillance is urgently needed.
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http://dx.doi.org/10.1007/s00432-020-03450-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076157PMC
June 2021

How irritant are n-propanol and isopropanol? - A systematic review.

Contact Dermatitis 2021 Jan 11;84(1):1-14. Epub 2020 Nov 11.

Department of Dermatology, University Hospital Jena, Jena, Germany.

Background: The use of alcoholic-based hand rubs (ABHRs) is an important tool for hand hygiene, especially in times of the COVID-19 pandemic. Possible irritant effects of ABHR may prevent their use by persons at risk of infection.

Methods: This systematic review is based on a PubMed search of articles published between January 2000 and September 2019 in English and German, and a manual search, related to the irritation potential of alcohol-based disinfectants restricted to n-propanol (1-propanol) and its structural isomer isopropanol (isopropyl alcohol, 2-propanol).

Results: The majority of the included studies show a low irritation potential of n-propanol alone. However, recent studies provide evidence for significant barrier damage effects of repeated exposure to 60% n-propanol in healthy, as well as atopic skin in vivo. The synergistic response of combined irritants, (ie, a combination of n-propanol or isopropanol with detergents such as sodium lauryl sulfate) is greater, compared with a quantitatively identical application of the same irritant alone.

Conclusion: While recent studies indicate a higher risk of skin irritation for n-propanol and isopropanol than reported in the past, this risk still seems to be lower than that for frequent handwashing with detergents, as recommended by some to prevent COVID-19 infections.
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http://dx.doi.org/10.1111/cod.13722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675697PMC
January 2021

[38-years-old patient with papules on hands and genitals - infectious or harmless?]

Dtsch Med Wochenschr 2020 09 24;145(19):1367-1368. Epub 2020 Sep 24.

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

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http://dx.doi.org/10.1055/a-1185-3185DOI Listing
September 2020

[Ulcerated plaque on the lower leg of a 14-year-old girl].

Hautarzt 2021 Mar;72(3):271-274

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

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http://dx.doi.org/10.1007/s00105-020-04688-yDOI Listing
March 2021

Teledermatologie in den Zeiten von COVID‐19 – ein systematisches Review.

Authors:
Peter Elsner

J Dtsch Dermatol Ges 2020 Aug;18(8):841-847

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

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http://dx.doi.org/10.1111/ddg.14180_gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461179PMC
August 2020

Indian Trichophyton mentagrophytes squalene epoxidase erg1 double mutants show high proportion of combined fluconazole and terbinafine resistance.

Mycoses 2020 Jul 29. Epub 2020 Jul 29.

Department of Dermatology, University Hospital Jena, Jena, Germany.

Background: The Indian ITS genotype VIII Trichophyton mentagrophytes population shows a high amount of different erg1 (ergosterol) mutants encoding for squalene epoxidase, which catalyses the first step of ergosterol biosynthesis.

Objectives: Illumination of the implication of point mutations at position Ala448Thr in single and double erg1 T mentagrophytes mutants because mutants of this type were abundantly found within the Indian fungal population.

Methods: Growth in fluconazole or terbinafine containing medium was analysed using a microplate-laser-nephelometry (MLN)-based growth assay.

Results: Ala 448 Thr erg1 single mutants were terbinafine sensitive, but about 50% of isolates showed an increased fluconazole resistance, whereas 95% of the double mutants (Phe 397 Leu, Ala 448Thr) demonstrated combined terbinafine and increased fluconazole resistance.

Conclusion: The new Indian T mentagrophytes populations show several point mutations in erg1. Point mutations at position 397 were previously described and cause terbinafine resistance. A large part of the double mutants exhibit resistance to terbinafine and fluconazole, demonstrating a selective advantage of the combination of both mutations.
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http://dx.doi.org/10.1111/myc.13150DOI Listing
July 2020

[Occupational Trichophyton verrucosum infection in a cattle farmer].

Hautarzt 2020 Nov;71(11):899-902

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

Ringworm in cattle may cause an occupational skin disease in humans. Trichophyton verrucosum lead to a highly inflammatory fungal skin infection that is often misdiagnosed as bacterial disease and consequently mistreated with antibiotics. To establish the correct diagnosis, it is necessary to collect skin scales; in addition, a skin biopsy can be helpful. Deep dermatophyte infections by Trichophyton verrucosum can be treated effectively with oral terbinafine. In addition, it is necessary to pay careful attention to use suitable hygiene measures in the stables to protect against reinfection.
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http://dx.doi.org/10.1007/s00105-020-04655-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653785PMC
November 2020

Uncharakteristische erythematöse Plaques.

J Dtsch Dermatol Ges 2020 Jul;18(7):761-763

Klinik für Hautkrankheiten, Universitätsklinikum, Jena.

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http://dx.doi.org/10.1111/ddg.14054_gDOI Listing
July 2020

Dermatological recommendations on hand hygiene in schools during the COVID-19 pandemic.

J Dtsch Dermatol Ges 2020 08 12;18(8):892-894. Epub 2020 Jul 12.

Klinik für Hautkrankheiten, Universitätsklinikum Jena.

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http://dx.doi.org/10.1111/ddg.14170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404656PMC
August 2020

[Rare cause of eruptively occurring ulcerating abscesses : Intralesional and perilesional postsurgical pathergy phenomenon in a misdiagnosed case].

Chirurg 2020 Dec;91(12):1062-1065

Klinik für Hautkrankheiten, Universitätsklinikum Jena, Erfurter Str. 35, 07743, Jena, Deutschland.

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http://dx.doi.org/10.1007/s00104-020-01215-6DOI Listing
December 2020

Uncharacteristic erythematous plaques.

J Dtsch Dermatol Ges 2020 Jul 20;18(7):761-763. Epub 2020 Apr 20.

Department of Dermatology, University Hospital, Jena, Germany.

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http://dx.doi.org/10.1111/ddg.14054DOI Listing
July 2020
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