Peter E Czabotar

Peter E Czabotar

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Peter E Czabotar

Peter E Czabotar

Publications by authors named "Peter E Czabotar"

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Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma.

Br J Haematol 2019 Sep 24;186(6):e188-e191. Epub 2019 Jun 24.

Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1111/bjh.16069DOI Listing
September 2019

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins.

Cold Spring Harb Perspect Biol 2019 Sep 30. Epub 2019 Sep 30.

Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1101/cshperspect.a036319DOI Listing
September 2019

The Structural Basis of Necroptotic Cell Death Signaling.

Trends Biochem Sci 2019 01 30;44(1):53-63. Epub 2018 Nov 30.

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2018.11.002DOI Listing
January 2019

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

J Allergy Clin Immunol 2018 12 17;142(6):1956-1967.e6. Epub 2018 May 17.

Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia; Immunology Laboratory, Guangzhou Institute of Paediatrics, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183071
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http://dx.doi.org/10.1016/j.jaci.2018.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281029PMC
December 2018

Ensemble Properties of Bax Determine Its Function.

Structure 2018 10 16;26(10):1346-1359.e5. Epub 2018 Aug 16.

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.07.006DOI Listing
October 2018

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P position of PEXEL peptidomimetics.

Eur J Med Chem 2018 Jun 18;154:182-198. Epub 2018 May 18.

The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183042
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http://dx.doi.org/10.1016/j.ejmech.2018.05.022DOI Listing
June 2018

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.

Cell 2018 05;173(5):1217-1230.e17

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.04.036DOI Listing
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Preparing Samples for Crystallization of Bcl-2 Family Complexes.

Methods Mol Biol 2016 ;1419:213-29

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1007/978-1-4939-3581-9_16DOI Listing
December 2017

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation.

Semin Cell Dev Biol 2017 12 8;72:152-162. Epub 2017 Apr 8.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.04.001DOI Listing
December 2017

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.

Mol Cell 2017 Nov;68(4):659-672.e9

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.11.001DOI Listing
November 2017

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Genes Dev 2016 05 19;30(10):1240-50. Epub 2016 May 19.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia; Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Victoria 3084, Australia.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.279414.116
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http://dx.doi.org/10.1101/gad.279414.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888843PMC
May 2016

Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes.

J Biol Chem 2016 Apr 28;291(14):7703-15. Epub 2016 Jan 28.

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, the Department of Medical Biology, University of Melbourne, Melbourne, Australia,

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http://dx.doi.org/10.1074/jbc.M115.698282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817195PMC
April 2016

The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration.

Biochem J 2016 Mar 5;473(6):733-42. Epub 2016 Jan 5.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia

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http://dx.doi.org/10.1042/BJ20151049DOI Listing
March 2016

A tale of two domains - a structural perspective of the pseudokinase, MLKL.

FEBS J 2015 Nov 25;282(22):4268-78. Epub 2015 Sep 25.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic., Australia.

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http://dx.doi.org/10.1111/febs.13504DOI Listing
November 2015

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.

Nat Struct Mol Biol 2015 Aug 27;22(8):590-6. Epub 2015 Jul 27.

1] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

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http://www.nature.com/articles/nsmb.3061
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http://dx.doi.org/10.1038/nsmb.3061DOI Listing
August 2015

Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly.

Cell Rep 2015 May 14;11(8):1184-92. Epub 2015 May 14.

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:

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http://www.cell.com/cms/attachment/2032431634/2048991268/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471500462
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http://dx.doi.org/10.1016/j.celrep.2015.04.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449314PMC
May 2015

The merozoite surface protein 1 complex is a platform for binding to human erythrocytes by Plasmodium falciparum.

J Biol Chem 2014 Sep 29;289(37):25655-69. Epub 2014 Jul 29.

From the The Walter and Eliza Hall Institute of Medical Research, Melbourne 3052, Australia, Department of Medical Biology, The University of Melbourne, Melbourne 3010, Australia,

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http://dx.doi.org/10.1074/jbc.M114.586495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162169PMC
September 2014

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Mol Cell 2014 Sep 28;55(6):938-946. Epub 2014 Aug 28.

Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, Victoria 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.07.016DOI Listing
September 2014

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.

Proc Natl Acad Sci U S A 2014 Sep 16;111(39):E4076-85. Epub 2014 Sep 16.

Molecular Genetics of Cancer Division, Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia; and

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http://dx.doi.org/10.1073/pnas.1415142111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191798PMC
September 2014

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

Arch Biochem Biophys 2014 Mar 13;545:33-43. Epub 2014 Jan 13.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2014.01.003DOI Listing
March 2014

Further insights into the effects of pre-organizing the BimBH3 helix.

ACS Chem Biol 2014 Mar 18;9(3):838-9. Epub 2014 Feb 18.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/cb400638pDOI Listing
March 2014

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.

J Med Chem 2014 Feb 5;57(4):1323-43. Epub 2014 Feb 5.

The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/jm401948bDOI Listing
February 2014

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

Arch Biochem Biophys 2014 Mar 13;545:33-43. Epub 2014 Jan 13.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2014.01.003DOI Listing
March 2014

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.

Immunity 2013 Sep 5;39(3):443-53. Epub 2013 Sep 5.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.06.018DOI Listing
September 2013

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.

Plant Mol Biol 2013 Mar 26;81(4-5):431-46. Epub 2013 Jan 26.

Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.

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http://link.springer.com/10.1007/s11103-013-0014-7
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http://dx.doi.org/10.1007/s11103-013-0014-7DOI Listing
March 2013

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.

ACS Chem Biol 2013 Feb 10;8(2):297-302. Epub 2012 Dec 10.

The Walter and Eliza Hall Institute of Medical Research , 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1021/cb3005403DOI Listing
February 2013

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus.

Arch Biochem Biophys 2011 Aug 16;512(2):167-74. Epub 2011 Jun 16.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.abb.2011.06.006DOI Listing
August 2011

Molecular biology of Bax and Bak activation and action.

Biochim Biophys Acta 2011 Apr 30;1813(4):521-31. Epub 2010 Dec 30.

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http://dx.doi.org/10.1016/j.bbamcr.2010.12.019DOI Listing
April 2011

Bcl-2 family proteins as therapeutic targets.

Curr Pharm Des 2010 ;16(28):3132-48

The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria, Australia.

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http://dx.doi.org/10.2174/138161210793292429DOI Listing
March 2011

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.

J Biol Chem 2011 Mar 3;286(9):7123-31. Epub 2011 Jan 3.

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1074/jbc.M110.161281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044969PMC
March 2011

Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.

J Biol Chem 2009 Oct 2;284(44):30508-17. Epub 2009 Sep 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1074/jbc.M109.040725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781605PMC
October 2009

High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.

Angew Chem Int Ed Engl 2009 ;48(24):4318-22

Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1002/anie.200805761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843084PMC
September 2009

BCL-2 family antagonists for cancer therapy.

Nat Rev Drug Discov 2008 Dec;7(12):989-1000

Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nrd2658DOI Listing
December 2008

Structural plasticity underpins promiscuous binding of the prosurvival protein A1.

Structure 2008 May;16(5):818-29

Biochemistry Department, University of Otago, Dunedin 9054, New Zealand.

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http://dx.doi.org/10.1016/j.str.2008.02.009DOI Listing
May 2008

Structural insights into the degradation of Mcl-1 induced by BH3 domains.

Proc Natl Acad Sci U S A 2007 Apr 27;104(15):6217-22. Epub 2007 Mar 27.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0701297104
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http://dx.doi.org/10.1073/pnas.0701297104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851040PMC
April 2007

Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence.

Virus Res 2004 Jan;99(1):57-61

National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.virusres.2003.10.004DOI Listing
January 2004

A model for the cytoplasmic domain of the influenza A virus M2 channel by analogy to the HIV-1 Vpu protein.

Protein Pept Lett 2002 Dec;9(6):495-502

Divisions of Mathematical Biology, NIMR, Mill Hill, London, NW7 1AA, UK.

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http://dx.doi.org/10.2174/0929866023408418DOI Listing
December 2002