Peter D Kwong

Peter D Kwong

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Peter D Kwong

Peter D Kwong

Publications by authors named "Peter D Kwong"

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Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.

Sci Rep 2019 Oct 11;9(1):14696. Epub 2019 Oct 11.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, MD, USA.

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http://dx.doi.org/10.1038/s41598-019-50635-wDOI Listing
October 2019

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.

PLoS Pathog 2019 Sep 3;15(9):e1008005. Epub 2019 Sep 3.

Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.

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http://dx.doi.org/10.1371/journal.ppat.1008005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743783PMC
September 2019

Blocking αβ integrin binding to SIV does not improve virologic control.

Science 2019 09;365(6457):1033-1036

Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1126/science.aaw7765DOI Listing
September 2019

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.

Immunity 2019 03 12;50(3):677-691.e13. Epub 2019 Mar 12.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193007
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http://dx.doi.org/10.1016/j.immuni.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555550PMC
March 2019

Iterative screen optimization maximizes the efficiency of macromolecular crystallization.

Acta Crystallogr F Struct Biol Commun 2019 Feb 24;75(Pt 2):123-131. Epub 2019 Jan 24.

Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1107/S2053230X18017338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360444PMC
February 2019

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.

Structure 2019 Jan 21;27(1):196-206.e6. Epub 2018 Nov 21.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Biochemistry and Molecular Biophysics & Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126183036
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http://dx.doi.org/10.1016/j.str.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664815PMC
January 2019

CRISPro: An Automated Pipeline for Protein Conformation Stabilization by Proline.

J Chem Inf Model 2018 11 19;58(11):2189-2192. Epub 2018 Oct 19.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases , National Institutes of Health , Bethesda , Maryland 20892 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jcim.8b00592
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http://dx.doi.org/10.1021/acs.jcim.8b00592DOI Listing
November 2018

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.

PLoS Pathog 2018 07 5;14(7):e1007159. Epub 2018 Jul 5.

Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049957PMC
July 2018

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

ACS Infect Dis 2018 05 6;4(5):788-796. Epub 2018 Mar 6.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases , National Institutes of Health , 40 Convent Drive , Bethesda , Maryland 20892 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00192DOI Listing
May 2018

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure.

Immunity 2018 05;48(5):855-871

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.04.029DOI Listing
May 2018

PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine.

Bioinformatics 2018 04;34(7):1092-1098

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031027PMC
April 2018

Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.

J Am Chem Soc 2018 04 9;140(15):5202-5210. Epub 2018 Apr 9.

Genomics Research Center , Academia Sinica , 128 Academia Road, Section 2 , Nangang District, Taipei 115 , Taiwan.

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http://dx.doi.org/10.1021/jacs.8b00896DOI Listing
April 2018

What Are the Most Powerful Immunogen Design Vaccine Strategies? A Structural Biologist's Perspective.

Authors:
Peter D Kwong

Cold Spring Harb Perspect Biol 2017 Nov 1;9(11). Epub 2017 Nov 1.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1101/cshperspect.a029470DOI Listing
November 2017

Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F.

J Virol 2017 11 27;91(22). Epub 2017 Oct 27.

RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01101-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660469PMC
November 2017

Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield.

Structure 2017 10 7;25(10):1631-1639.e2. Epub 2017 Sep 7.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.07.018DOI Listing
October 2017

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.

Curr Opin HIV AIDS 2017 May;12(3):229-240

aVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland bVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1097/COH.0000000000000360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557343PMC
May 2017

Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins.

Chembiochem 2017 04 22;18(8):764-771. Epub 2017 Mar 22.

Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, 8 Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1002/cbic.201600665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557091PMC
April 2017

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

J Med Chem 2017 04 16;60(7):3124-3153. Epub 2017 Mar 16.

Laboratory of Molecular Modeling and Drug Design, Lindsey F. Kimball Research Institute, New York Blood Center , 310 E 67th Street, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00179DOI Listing
April 2017

Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.

Immunol Rev 2017 01;275(1):108-128

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/imr.12480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516196PMC
January 2017

Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

Bioconjug Chem 2016 10 22;27(10):2372-2385. Epub 2016 Sep 22.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00370DOI Listing
October 2016

SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts.

Front Immunol 2016 21;7:372. Epub 2016 Sep 21.

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA; Department of Systems Biology, Columbia University, New York, NY, USA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.3389/fimmu.2016.00372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030719PMC
September 2016

Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.

PLoS Comput Biol 2016 05 18;12(5):e1004940. Epub 2016 May 18.

Department of Biochemistry and Molecular Biophysics and Department of Systems Biology, Columbia University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871536PMC
May 2016

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.

PLoS Pathog 2016 Apr 11;12(4):e1005537. Epub 2016 Apr 11.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827850PMC
April 2016