Publications by authors named "Peter D Kwong"

100Publications

Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans.

PLoS Pathog 2020 Aug 31;16(8):e1008793. Epub 2020 Aug 31.

Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485984PMC
August 2020

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.

N Engl J Med 2020 07 28. Epub 2020 Jul 28.

From the Vaccine Research Center (K.S.C., B. Flynn, K.E.F., J.R.F., S.B.-B., A.P.W., B. Flach, S. O'Connell, A.T.N., N.D., M.M.D., N.N.N., G.S.A., D.R.F., E.L., N.A.D.-R., B.C.L., M.K.L., S. O'Dell, S.D.S., E.P., L.A.C., C.Y., J.-P.M.T., W.S., Y.Z., O.M.A., L.W., A.P., E.S.Y., K.L., T.Z., I.-T.T., A.W., I.G., L.N., R.A.G., R.J.L., J.I.M., W.-P.K., K.M.M., T.J.R., J.E.L., M.R.G., P.D.K., J.R.M., A.M., N.J.S., M.R., R.A.S., B.S.G.), the Infectious Disease Pathogenesis Section (K.W.B., M.M., B.M.N., M.G.L.), and the Biostatistics Research Branch, Division of Clinical Research (M.C.N.), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, and Bioqual (H.A., L.P., A.V.R., S.B., J.G., T.P.-T., A.S., T.-A.C., A. Cook, A.D., K.S., I.N.M.) and the Public Health Service Commissioned Corps (M.R.G.), Rockville - both in Maryland; the Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill (D.R.M., R.S.B.); Moderna, Cambridge, MA (D.K.E., G.S.-J., S.H., A. Carfi); and the Institute for Biomedical Sciences, George Washington University, Washington, DC (E.P.).

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http://dx.doi.org/10.1056/NEJMoa2024671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449230PMC
July 2020

Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles.

Nat Struct Mol Biol 2020 Aug 29;27(8):726-734. Epub 2020 Jun 29.

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1038/s41594-020-0452-2DOI Listing
August 2020

The covalent SNAP tag for protein display quantification and low-pH protein engineering.

J Biotechnol 2020 Aug 16;320:50-56. Epub 2020 Jun 16.

Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USA; Department of Chemical & Petroleum Engineering, The University of Kansas, Lawrence, Kansas, USA; Kansas Vaccine Institute, The University of Kansas, Lawrence, Kansas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2020.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434562PMC
August 2020

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies.

Cell Rep 2020 Apr;31(4):107583

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.107583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196886PMC
April 2020

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.

Cell Rep 2020 Apr;31(1):107488

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.052DOI Listing
April 2020

Next-generation sequencing of the intrahepatic antibody repertoire delineates a unique B-cell response in HBV-associated acute liver failure.

J Viral Hepat 2020 Aug 3;27(8):847-851. Epub 2020 Apr 3.

Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/jvh.13290DOI Listing
August 2020

Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates.

PLoS One 2020 11;15(2):e0228572. Epub 2020 Feb 11.

RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012412PMC
April 2020

cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence.

Front Immunol 2019 9;10:2365. Epub 2019 Oct 9.

Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794461PMC
October 2019

Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.

Sci Rep 2019 10 11;9(1):14696. Epub 2019 Oct 11.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, MD, USA.

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http://dx.doi.org/10.1038/s41598-019-50635-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789020PMC
October 2019

Blocking αβ integrin binding to SIV does not improve virologic control.

Science 2019 09;365(6457):1033-1036

Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

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http://dx.doi.org/10.1126/science.aaw7765DOI Listing
September 2019

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.

PLoS Pathog 2019 09 3;15(9):e1008005. Epub 2019 Sep 3.

Centre for HIV and STIs, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.

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http://dx.doi.org/10.1371/journal.ppat.1008005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743783PMC
September 2019

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.

Immunity 2019 03 12;50(3):677-691.e13. Epub 2019 Mar 12.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193007
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http://dx.doi.org/10.1016/j.immuni.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555550PMC
March 2019

Iterative screen optimization maximizes the efficiency of macromolecular crystallization.

Acta Crystallogr F Struct Biol Commun 2019 Feb 24;75(Pt 2):123-131. Epub 2019 Jan 24.

Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1107/S2053230X18017338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360444PMC
February 2019

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition.

Structure 2019 01 21;27(1):196-206.e6. Epub 2018 Nov 21.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Biochemistry and Molecular Biophysics & Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09692126183036
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http://dx.doi.org/10.1016/j.str.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664815PMC
January 2019

CRISPro: An Automated Pipeline for Protein Conformation Stabilization by Proline.

J Chem Inf Model 2018 11 19;58(11):2189-2192. Epub 2018 Oct 19.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases , National Institutes of Health , Bethesda , Maryland 20892 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jcim.8b00592
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http://dx.doi.org/10.1021/acs.jcim.8b00592DOI Listing
November 2018

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.

PLoS Pathog 2018 07 5;14(7):e1007159. Epub 2018 Jul 5.

Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049957PMC
July 2018

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure.

Immunity 2018 05;48(5):855-871

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.04.029DOI Listing
May 2018

Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.

J Am Chem Soc 2018 04 9;140(15):5202-5210. Epub 2018 Apr 9.

Genomics Research Center , Academia Sinica , 128 Academia Road, Section 2 , Nangang District, Taipei 115 , Taiwan.

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http://dx.doi.org/10.1021/jacs.8b00896DOI Listing
April 2018

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

ACS Infect Dis 2018 05 6;4(5):788-796. Epub 2018 Mar 6.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases , National Institutes of Health , 40 Convent Drive , Bethesda , Maryland 20892 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00192DOI Listing
May 2018

PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine.

Bioinformatics 2018 04;34(7):1092-1098

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1093/bioinformatics/btx662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031027PMC
April 2018

Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield.

Structure 2017 10 7;25(10):1631-1639.e2. Epub 2017 Sep 7.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.07.018DOI Listing
October 2017

Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F.

J Virol 2017 11 27;91(22). Epub 2017 Oct 27.

RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/JVI.01101-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660469PMC
November 2017

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.

Curr Opin HIV AIDS 2017 May;12(3):229-240

aVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland bVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1097/COH.0000000000000360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557343PMC
May 2017

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

J Med Chem 2017 04 16;60(7):3124-3153. Epub 2017 Mar 16.

Laboratory of Molecular Modeling and Drug Design, Lindsey F. Kimball Research Institute, New York Blood Center , 310 E 67th Street, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00179DOI Listing
April 2017

Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins.

Chembiochem 2017 04 22;18(8):764-771. Epub 2017 Mar 22.

Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, 8 Center Drive, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1002/cbic.201600665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557091PMC
April 2017

What Are the Most Powerful Immunogen Design Vaccine Strategies? A Structural Biologist's Perspective.

Authors:
Peter D Kwong

Cold Spring Harb Perspect Biol 2017 Nov 1;9(11). Epub 2017 Nov 1.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1101/cshperspect.a029470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666634PMC
November 2017

Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.

Immunol Rev 2017 01;275(1):108-128

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/imr.12480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516196PMC
January 2017