Publications by authors named "Peter D Keightley"

84Publications

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site.

Heredity (Edinb) 2021 Jan 31;126(1):107-116. Epub 2020 Aug 31.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3FL, UK.

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January 2021

Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii.

PLoS Biol 2019 06 26;17(6):e3000192. Epub 2019 Jun 26.

Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom.

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June 2019

Understanding the Factors That Shape Patterns of Nucleotide Diversity in the House Mouse Genome.

Mol Biol Evol 2018 12;35(12):2971-2988

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom.

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December 2018

Inferring the Probability of the Derived the Ancestral Allelic State at a Polymorphic Site.

Genetics 2018 07 16;209(3):897-906. Epub 2018 May 16.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom.

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July 2018

Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes.

Evolution 2018 04 25;72(4):1000-1008. Epub 2018 Mar 25.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom.

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April 2018

Detecting positive selection in the genome.

BMC Biol 2017 10 30;15(1):98. Epub 2017 Oct 30.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3FL, UK.

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October 2017

Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.

Evolution 2017 Dec 26;71(12):2918-2929. Epub 2017 Oct 26.

Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh EH93FL, United Kingdom.

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December 2017

The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data.

Genetics 2017 09 27;207(1):297-309. Epub 2017 Jul 27.

Institute of Evolutionary Biology, University of Edinburgh, EH9 3FL, United Kingdom.

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September 2017

Inferring the Frequency Spectrum of Derived Variants to Quantify Adaptive Molecular Evolution in Protein-Coding Genes of Drosophila melanogaster.

Genetics 2016 06 20;203(2):975-84. Epub 2016 Apr 20.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom.

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June 2016

Direct Estimate of the Spontaneous Mutation Rate Uncovers the Effects of Drift and Recombination in the Chlamydomonas reinhardtii Plastid Genome.

Mol Biol Evol 2016 Mar 28;33(3):800-8. Epub 2015 Nov 28.

Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom.

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March 2016

The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses.

Genetics 2015 Dec 19;201(4):1601-13. Epub 2015 Oct 19.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, Scotland, United Kingdom.

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December 2015

Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome.

Genome Biol Evol 2015 Aug 12;7(8):2432-44. Epub 2015 Aug 12.

Institute of Evolutionary Biology, University of Edinburgh, United Kingdom.

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August 2015

Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii.

Genome Res 2015 Nov 10;25(11):1739-49. Epub 2015 Aug 10.

Institute of Evolutionary Biology, University of Edinburgh, Ashworth Labs, King's Buildings, Edinburgh EH9 3JT, Scotland.

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November 2015

Recent Evolution in Rattus norvegicus Is Shaped by Declining Effective Population Size.

Mol Biol Evol 2015 Oct 1;32(10):2547-58. Epub 2015 Jun 1.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom

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October 2015

Estimation of the spontaneous mutation rate in Heliconius melpomene.

Mol Biol Evol 2015 Jan 3;32(1):239-43. Epub 2014 Nov 3.

Department of Zoology, University of Cambridge, Cambridge, United Kingdom.

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January 2015

Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes.

Evolution 2015 Jan 9;69(1):104-16. Epub 2014 Dec 9.

Department of Biology, University of New Mexico, Albuquerque, New Mexico, 87131.

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January 2015

Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii.

Evolution 2014 09 9;68(9):2589-602. Epub 2014 Jul 9.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh, EH9 3JT, United Kingdom.

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September 2014

Faster-X adaptive protein evolution in house mice.

Genetics 2014 Apr 20;196(4):1131-43. Epub 2013 Dec 20.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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April 2014

Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib family.

Genetics 2014 Jan 8;196(1):313-20. Epub 2013 Nov 8.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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January 2014

A comparison of models to infer the distribution of fitness effects of new mutations.

Genetics 2013 Apr 22;193(4):1197-208. Epub 2013 Jan 22.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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April 2013

Nuclear gene variation in wild brown rats.

G3 (Bethesda) 2012 Dec 1;2(12):1661-4. Epub 2012 Dec 1.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom.

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December 2012

The maintenance of obligate sex in finite, structured populations subject to recurrent beneficial and deleterious mutation.

Evolution 2012 Dec 25;66(12):3658-69. Epub 2012 Jul 25.

Laboratoire MIVEGEC (UMR CNRS 5290, UR IRD 224, UM1, UM2), 911 avenue Agropolis, B. P. 64501, 34394 Montpellier Cedex 5, France.

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December 2012

Estimate of the spontaneous mutation rate in Chlamydomonas reinhardtii.

Genetics 2012 Dec 10;192(4):1447-54. Epub 2012 Oct 10.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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December 2012

Current hypotheses for the evolution of sex and recombination.

Integr Zool 2012 Jun;7(2):192-209

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.

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June 2012

A resolution of the mutation load paradox in humans.

Genetics 2012 Aug 1;191(4):1321-30. Epub 2012 Jun 1.

School of Life Sciences, University of Sussex, Brighton BN1 9QG, United Kingdom.

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August 2012

The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.

Genome Biol Evol 2012 21;4(5):658-67. Epub 2012 Mar 21.

School of Life Sciences, University of Sussex, Brighton, United Kingdom.

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August 2012

Rates and fitness consequences of new mutations in humans.

Genetics 2012 Feb;190(2):295-304

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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February 2012

Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small.

J Mol Evol 2012 Feb 12;74(1-2):61-8. Epub 2012 Feb 12.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK.

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February 2012

A method for inferring the rate of occurrence and fitness effects of advantageous mutations.

Genetics 2011 Dec 27;189(4):1427-37. Epub 2011 Sep 27.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK.

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December 2011

Inference of site frequency spectra from high-throughput sequence data: quantification of selection on nonsynonymous and synonymous sites in humans.

Genetics 2011 Aug 19;188(4):931-40. Epub 2011 May 19.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK.

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August 2011

Positive and negative selection in murine ultraconserved noncoding elements.

Mol Biol Evol 2011 Sep 8;28(9):2651-60. Epub 2011 Apr 8.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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September 2011

Inference of mutation parameters and selective constraint in mammalian coding sequences by approximate Bayesian computation.

Genetics 2011 Apr 1;187(4):1153-61. Epub 2011 Feb 1.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom.

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April 2011

Positive and negative selection on noncoding DNA close to protein-coding genes in wild house mice.

Mol Biol Evol 2011 Mar 8;28(3):1183-91. Epub 2010 Nov 8.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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March 2011

What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

Philos Trans R Soc Lond B Biol Sci 2010 Apr;365(1544):1187-93

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, , West Mains Road, Edinburgh EH9 3JT, UK.

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April 2010

The role of advantageous mutations in enhancing the evolution of a recombination modifier.

Genetics 2010 Apr 5;184(4):1153-64. Epub 2010 Feb 5.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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April 2010

Evidence for pervasive adaptive protein evolution in wild mice.

PLoS Genet 2010 Jan 22;6(1):e1000825. Epub 2010 Jan 22.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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January 2010

Patterns of DNA-sequence divergence between Drosophila miranda and D. pseudoobscura.

J Mol Evol 2009 Dec 27;69(6):601-11. Epub 2009 Oct 27.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.

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December 2009

Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.

Mol Biol Evol 2010 Jan;27(1):177-92

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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January 2010

Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.

Mol Biol Evol 2009 Sep 17;26(9):2097-108. Epub 2009 Jun 17.

Centre for the Study of Evolution and School of Life Sciences, University of Sussex, Brighton, United Kingdom.

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September 2009

Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines.

Genome Res 2009 Jul 13;19(7):1195-201. Epub 2009 May 13.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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July 2009

Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals.

BMC Evol Biol 2008 Sep 30;8:265. Epub 2008 Sep 30.

McGill University and Genome Québec Innovation Centre, 740 ave Dr Penfield Rm 7208, Montréal, Québec, H3A 1A4, Canada.

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September 2008

Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster.

PLoS Biol 2008 Aug;6(8):e204

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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August 2008

Analysis and implications of mutational variation.

Genetica 2009 Jun 29;136(2):359-69. Epub 2008 Jul 29.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK.

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June 2009

Evolution of genes and genomes on the Drosophila phylogeny.

Authors:
Andrew G Clark Michael B Eisen Douglas R Smith Casey M Bergman Brian Oliver Therese A Markow Thomas C Kaufman Manolis Kellis William Gelbart Venky N Iyer Daniel A Pollard Timothy B Sackton Amanda M Larracuente Nadia D Singh Jose P Abad Dawn N Abt Boris Adryan Montserrat Aguade Hiroshi Akashi Wyatt W Anderson Charles F Aquadro David H Ardell Roman Arguello Carlo G Artieri Daniel A Barbash Daniel Barker Paolo Barsanti Phil Batterham Serafim Batzoglou Dave Begun Arjun Bhutkar Enrico Blanco Stephanie A Bosak Robert K Bradley Adrianne D Brand Michael R Brent Angela N Brooks Randall H Brown Roger K Butlin Corrado Caggese Brian R Calvi A Bernardo de Carvalho Anat Caspi Sergio Castrezana Susan E Celniker Jean L Chang Charles Chapple Sourav Chatterji Asif Chinwalla Alberto Civetta Sandra W Clifton Josep M Comeron James C Costello Jerry A Coyne Jennifer Daub Robert G David Arthur L Delcher Kim Delehaunty Chuong B Do Heather Ebling Kevin Edwards Thomas Eickbush Jay D Evans Alan Filipski Sven Findeiss Eva Freyhult Lucinda Fulton Robert Fulton Ana C L Garcia Anastasia Gardiner David A Garfield Barry E Garvin Greg Gibson Don Gilbert Sante Gnerre Jennifer Godfrey Robert Good Valer Gotea Brenton Gravely Anthony J Greenberg Sam Griffiths-Jones Samuel Gross Roderic Guigo Erik A Gustafson Wilfried Haerty Matthew W Hahn Daniel L Halligan Aaron L Halpern Gillian M Halter Mira V Han Andreas Heger LaDeana Hillier Angie S Hinrichs Ian Holmes Roger A Hoskins Melissa J Hubisz Dan Hultmark Melanie A Huntley David B Jaffe Santosh Jagadeeshan William R Jeck Justin Johnson Corbin D Jones William C Jordan Gary H Karpen Eiko Kataoka Peter D Keightley Pouya Kheradpour Ewen F Kirkness Leonardo B Koerich Karsten Kristiansen Dave Kudrna Rob J Kulathinal Sudhir Kumar Roberta Kwok Eric Lander Charles H Langley Richard Lapoint Brian P Lazzaro So-Jeong Lee Lisa Levesque Ruiqiang Li Chiao-Feng Lin Michael F Lin Kerstin Lindblad-Toh Ana Llopart Manyuan Long Lloyd Low Elena Lozovsky Jian Lu Meizhong Luo Carlos A Machado Wojciech Makalowski Mar Marzo Muneo Matsuda Luciano Matzkin Bryant McAllister Carolyn S McBride Brendan McKernan Kevin McKernan Maria Mendez-Lago Patrick Minx Michael U Mollenhauer Kristi Montooth Stephen M Mount Xu Mu Eugene Myers Barbara Negre Stuart Newfeld Rasmus Nielsen Mohamed A F Noor Patrick O'Grady Lior Pachter Montserrat Papaceit Matthew J Parisi Michael Parisi Leopold Parts Jakob S Pedersen Graziano Pesole Adam M Phillippy Chris P Ponting Mihai Pop Damiano Porcelli Jeffrey R Powell Sonja Prohaska Kim Pruitt Marta Puig Hadi Quesneville Kristipati Ravi Ram David Rand Matthew D Rasmussen Laura K Reed Robert Reenan Amy Reily Karin A Remington Tania T Rieger Michael G Ritchie Charles Robin Yu-Hui Rogers Claudia Rohde Julio Rozas Marc J Rubenfield Alfredo Ruiz Susan Russo Steven L Salzberg Alejandro Sanchez-Gracia David J Saranga Hajime Sato Stephen W Schaeffer Michael C Schatz Todd Schlenke Russell Schwartz Carmen Segarra Rama S Singh Laura Sirot Marina Sirota Nicholas B Sisneros Chris D Smith Temple F Smith John Spieth Deborah E Stage Alexander Stark Wolfgang Stephan Robert L Strausberg Sebastian Strempel David Sturgill Granger Sutton Granger G Sutton Wei Tao Sarah Teichmann Yoshiko N Tobari Yoshihiko Tomimura Jason M Tsolas Vera L S Valente Eli Venter J Craig Venter Saverio Vicario Filipe G Vieira Albert J Vilella Alfredo Villasante Brian Walenz Jun Wang Marvin Wasserman Thomas Watts Derek Wilson Richard K Wilson Rod A Wing Mariana F Wolfner Alex Wong Gane Ka-Shu Wong Chung-I Wu Gabriel Wu Daisuke Yamamoto Hsiao-Pei Yang Shiaw-Pyng Yang James A Yorke Kiyohito Yoshida Evgeny Zdobnov Peili Zhang Yu Zhang Aleksey V Zimin Jennifer Baldwin Amr Abdouelleil Jamal Abdulkadir Adal Abebe Brikti Abera Justin Abreu St Christophe Acer Lynne Aftuck Allen Alexander Peter An Erica Anderson Scott Anderson Harindra Arachi Marc Azer Pasang Bachantsang Andrew Barry Tashi Bayul Aaron Berlin Daniel Bessette Toby Bloom Jason Blye Leonid Boguslavskiy Claude 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Lisa Zembek Danni Zhong Andrew Zimmer Zac Zwirko David B Jaffe Pablo Alvarez Will Brockman Jonathan Butler CheeWhye Chin Sante Gnerre Manfred Grabherr Michael Kleber Evan Mauceli Iain MacCallum

Nature 2007 Nov;450(7167):203-18

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.

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November 2007

Patterns of selective constraints in noncoding DNA of rice.

BMC Evol Biol 2007 Nov 1;7:208. Epub 2007 Nov 1.

Institute of Crop Science & Institute of Bioinformatics, Zhejiang University, Hangzhou 310029, China.

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November 2007

Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites.

J Mol Evol 2007 Dec 25;65(6):627-39. Epub 2007 Sep 25.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.

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December 2007

The distribution of fitness effects of new mutations.

Nat Rev Genet 2007 Aug;8(8):610-8

Centre for the Study of Evolution, University of Sussex, Brighton, BN1 9QG, UK.

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August 2007

Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila.

Nature 2007 Jan;445(7123):82-5

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.

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January 2007

Genomic selective constraints in murid noncoding DNA.

PLoS Genet 2006 Nov 18;2(11):e204. Epub 2006 Oct 18.

Institute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

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November 2006

Interference among deleterious mutations favours sex and recombination in finite populations.

Nature 2006 Sep;443(7107):89-92

Institute of Evolutionary Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK.

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September 2006

MCALIGN2: faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution.

BMC Bioinformatics 2006 Jun 8;7:292. Epub 2006 Jun 8.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK.

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June 2006

Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison.

Genome Res 2006 Jul 2;16(7):875-84. Epub 2006 Jun 2.

Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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July 2006

PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice.

Genetics 2006 Jul 15;173(3):1547-53. Epub 2006 May 15.

University of Edinburgh Institute of Evolutionary Biology, School of Biological Sciences, United Kingdom.

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July 2006

Evolutionary constraints in conserved nongenic sequences of mammals.

Genome Res 2005 Oct;15(10):1373-8

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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October 2005

The scale of mutational variation in the murid genome.

Genome Res 2005 Aug 15;15(8):1086-94. Epub 2005 Jul 15.

Institute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom.

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August 2005

Regulatory variation at glypican-3 underlies a major growth QTL in mice.

PLoS Biol 2005 May 5;3(5):e135. Epub 2005 Apr 5.

University of Edinburgh, Institute of Evolutionary Biology, School of Biological Sciences, Edinburgh, United Kingdom.

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May 2005

Intron size and exon evolution in Drosophila.

Genetics 2005 May 21;170(1):481-5. Epub 2005 Mar 21.

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, UK.

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May 2005

Evidence for widespread degradation of gene control regions in hominid genomes.

PLoS Biol 2005 Feb 25;3(2):e42. Epub 2005 Jan 25.

School of Biological Sciences, University of Edinburgh, United Kingdom.

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February 2005

Genetic instability of C. elegans comes naturally.

Trends Genet 2005 Feb;21(2):67-70

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK.

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February 2005

Behavioural genetics: finding genes that cause complex trait variation.

Curr Biol 2005 Jan;15(1):R19-21

Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK.

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January 2005

DNA sequence error rates in Genbank records estimated using the mouse genome as a reference.

DNA Seq 2004 Oct-Dec;15(5-6):362-4

University of Edinburgh, School of Biological Sciences, Ashworth Laboratories, UK.

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June 2005

Rates of molecular evolution in nuclear genes of east Mediterranean scorpions.

Evolution 2004 Nov;58(11):2486-97

School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom.

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November 2004

Unexpected conserved non-coding DNA blocks in mammals.

Trends Genet 2004 Aug;20(8):332-7

Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom.

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August 2004

Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL.

Mamm Genome 2004 Jun;15(6):482-91

Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh, EH9 3JT, UK.

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June 2004

MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution.

Genome Res 2004 Mar;14(3):442-50

University of Edinburgh, School of Biological Sciences, Ashworth Laboratories, Edinburgh EH9 3JT, UK. Peter.Keightley_at_ed.ac.uk

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March 2004

Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila.

Genome Res 2004 Feb;14(2):273-9

University of Edinburgh, School of Biological Sciences, Edinburgh EH9 3JT, UK.

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February 2004

Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents.

Proc Natl Acad Sci U S A 2003 Nov 3;100(23):13402-6. Epub 2003 Nov 3.

Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom.

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November 2003

Toward a realistic model of mutations affecting fitness.

Evolution 2003 Mar;57(3):683-5; discussion 686-9

University of Edinburgh, Institute of Cell, Animal and Population Biology, West Mains Road, Edinburgh EH9 3JT, United Kingdom.

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March 2003

Characterization of a QTL affecting skeletal size in mice.

Mamm Genome 2003 Mar;14(3):175-83

Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, UK.

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March 2003

How many lethal alleles?

Trends Genet 2003 Feb;19(2):57-9

Institute of Cell, Animal and Population Biology, University of Edinburgh, EH9 3JT, Edinburgh, UK.

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February 2003

Quantifying the slightly deleterious mutation model of molecular evolution.

Mol Biol Evol 2002 Dec;19(12):2142-9

Centre for the Study of Evolution & School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK.

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December 2002

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

Science 2002 Jul;297(5580):403-5

Wellcome Trust Centre for Cell Biology, The King's Buildings, Edinburgh University, Edinburgh EH9 3JR, UK.

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July 2002

Genetic architecture: dissecting the genetic basis of phenotypic variation.

Curr Biol 2002 Jun;12(12):R415-6

Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, UK.

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June 2002