Peter Crawford

Peter Crawford

UNVERIFIED PROFILE

Are you Peter Crawford?   Register this Author

Register author
Peter Crawford

Peter Crawford

Publications by authors named "Peter Crawford"

Are you Peter Crawford?   Register this Author

49Publications

912Reads

42Profile Views

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.

Cell Metab 2019 Jun;29(6):1236-1238

Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2019.05.013DOI Listing
June 2019

Hepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.

Cell Metab 2019 Feb 15;29(2):383-398.e7. Epub 2018 Nov 15.

Division of Molecular Medicine, Department of Medicine, University of Minnesota, 401 East River Parkway, MMC 194, Minneapolis, MN 55455, USA; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15504131183064
Publisher Site
http://dx.doi.org/10.1016/j.cmet.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559243PMC
February 2019

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.

JCI Insight 2019 Feb 21;4(4). Epub 2019 Feb 21.

Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona (SBP-LN), Orlando, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.124079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478419PMC
February 2019

Application of Stable Isotope Labels for Metabolomics in Studies in Fatty Liver Disease.

Methods Mol Biol 2019 ;1996:259-272

Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9488-5_20DOI Listing
January 2019

Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure.

Anal Chim Acta 2018 Dec 30;1037:87-96. Epub 2017 Nov 30.

Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78229, USA; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, TX 78229, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00032670173133
Publisher Site
http://dx.doi.org/10.1016/j.aca.2017.11.052DOI Listing
December 2018

Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments.

iScience 2018 Nov 2;9:298-313. Epub 2018 Nov 2.

Division of Molecular Medicine, Department of Medicine, University of Minnesota, 401 East River Parkway, MMC 194, Minneapolis, MN 55455, USA; Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S25890042183018
Publisher Site
http://dx.doi.org/10.1016/j.isci.2018.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240706PMC
November 2018

Refueling the Failing Heart: A Case for Sodium-Glucose Cotransporter 2 Inhibition in Cardiac Energy Homeostasis.

Authors:
Peter A Crawford

JACC Basic Transl Sci 2018 Oct 26;3(5):588-590. Epub 2018 Aug 26.

Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S2452302X183022
Publisher Site
http://dx.doi.org/10.1016/j.jacbts.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234513PMC
October 2018

Ketone bodies as epigenetic modifiers.

Curr Opin Clin Nutr Metab Care 2018 07;21(4):260-266

Division of Molecular Medicine, Department of Medicine.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCO.0000000000000475DOI Listing
July 2018

Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome.

JCI Insight 2018 06 21;3(12). Epub 2018 Jun 21.

Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.99762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124396PMC
June 2018

Intra- and inter-subject variability for increases in serum ketone bodies in patients with type 2 diabetes treated with the sodium glucose co-transporter 2 inhibitor canagliflozin.

Diabetes Obes Metab 2018 05 14;20(5):1321-1326. Epub 2018 Feb 14.

Departments of Medicine, and Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947648PMC
May 2018

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.

Cell Metab 2017 02;25(2):262-284

Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30655-
Web Search
http://dx.doi.org/10.1016/j.cmet.2016.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313038PMC
February 2017

Comprehensive and Quantitative Analysis of Polyphosphoinositide Species by Shotgun Lipidomics Revealed Their Alterations in db/db Mouse Brain.

Anal Chem 2016 12 1;88(24):12137-12144. Epub 2016 Dec 1.

Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute , Orlando, Florida 32827, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b02947DOI Listing
December 2016

Lactate metabolism is associated with mammalian mitochondria.

Nat Chem Biol 2016 Nov 12;12(11):937-943. Epub 2016 Sep 12.

Department of Chemistry, Washington University, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069139PMC
http://dx.doi.org/10.1038/nchembio.2172DOI Listing
November 2016

The Failing Heart Relies on Ketone Bodies as a Fuel.

Circulation 2016 Feb 27;133(8):698-705. Epub 2016 Jan 27.

From Cardiovascular Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL (G.A., O.J.M., J.L.H., L.L., R.B.V., T.C.L., S.J.G., P.A.C., D.P.K.); Departments of Medicine, Pharmacology, and Cancer Biology, Duke University, Durham, NC (T.K., D.M.M.); CECAD Research Center, Institute for Genetics, University of Cologne, Cologne, Germany (M.K.); Departments of Pharmacology and Medicine, Case Western Reserve University, Cleveland, OH (C.L.H.); College of Medicine, University of Illinois at Chicago, Chicago, IL (E.D.L.); and Department of Medicine, Washington University School of Medicine, St. Louis, MO (P.A.C.).

View Article

Download full-text PDF

Source
http://circ.ahajournals.org/content/early/2016/01/27/CIRCULA
Web Search
http://circ.ahajournals.org/content/early/2016/01/27/CIRCULA
Web Search
http://circ.ahajournals.org/content/133/8/698.full.pdf
Web Search
http://circ.ahajournals.org/lookup/doi/10.1161/CIRCULATIONAH
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.115.017355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766035PMC
February 2016

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

Nat Med 2015 Mar 16;21(3):263-9. Epub 2015 Feb 16.

1] Section of Comparative Medicine and Program on Integrative Cell Signaling and Neurobiology of Metabolism, Yale School of Medicine, New Haven, Connecticut, USA. [2] Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nm.3804
Publisher Site
http://dx.doi.org/10.1038/nm.3804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352123PMC
March 2015

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling.

Mol Metab 2014 Oct 13;3(7):754-69. Epub 2014 Aug 13.

Department of Medicine, Center for Cardiovascular Research, Washington University, St. Louis, MO, USA ; Department of Genetics, Washington University, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2014.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209361PMC
October 2014

Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.

Am J Physiol Endocrinol Metab 2014 Jul 27;307(2):E176-85. Epub 2014 May 27.

Department of Medicine, Center for Cardiovascular Research, and Genetics, Washington University, St. Louis, Missouri

View Article

Download full-text PDF

Source
http://ajpendo.physiology.org/content/ajpendo/307/2/E176.ful
Web Search
http://ajpendo.physiology.org/cgi/doi/10.1152/ajpendo.00087.
Publisher Site
http://dx.doi.org/10.1152/ajpendo.00087.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101633PMC
July 2014

X13CMS: global tracking of isotopic labels in untargeted metabolomics.

Anal Chem 2014 Feb 24;86(3):1632-9. Epub 2014 Jan 24.

Departments of Genetics, ‡Medicine, and §Chemistry, Washington University School of Medicine , St. Louis, MO 63110, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac403384nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982964PMC
February 2014

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

Mol Metab 2013 9;2(3):194-204. Epub 2013 May 9.

Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, United States ; Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO 63110, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773825PMC
September 2013

Impact of peripheral ketolytic deficiency on hepatic ketogenesis and gluconeogenesis during the transition to birth.

J Biol Chem 2013 Jul 20;288(27):19739-49. Epub 2013 May 20.

Department of Medicine, Washington University, St Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.454868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707678PMC
July 2013

Ketone body metabolism and cardiovascular disease.

Am J Physiol Heart Circ Physiol 2013 Apr 8;304(8):H1060-76. Epub 2013 Feb 8.

Department of Medicine, Center for Cardiovascular Research, Washington University, Saint Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpheart.00646.2012
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00646.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625904PMC
April 2013

Metabolic stress in the myocardium: adaptations of gene expression.

J Mol Cell Cardiol 2013 Feb 21;55:130-8. Epub 2012 Jun 21.

Diabetic Cardiovascular Disease Center, Cardiovascular Division, Washington University School of Medicine, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2012.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474866PMC
February 2013

Altered systemic ketone body metabolism in advanced heart failure.

Tex Heart Inst J 2011 ;38(5):533-8

Division of Cardiovascular Medicine, Department of Medicine, Washington University, St Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231554PMC
November 2012

The use of a 'bleach-etch-seal' deproteinization technique on MIH affected enamel.

Int J Paediatr Dent 2012 Nov 18;22(6):427-34. Epub 2012 Jan 18.

Department of Child Dental Health, University of Bristol, Bristol Dental Hospital, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-263X.2011.01212.xDOI Listing
November 2012

Low-carbohydrate ketogenic diets, glucose homeostasis, and nonalcoholic fatty liver disease.

Curr Opin Clin Nutr Metab Care 2012 Jul;15(4):374-80

Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/co-clinicalnutrition/2012/07000
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/MCO.0b013e3283547157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679496PMC
July 2012

Amelogenesis imperfecta: genotype-phenotype studies in 71 families.

Cells Tissues Organs 2011 19;194(2-4):279-83. Epub 2011 May 19.

Department of Pediatric Dentistry, School of Dentistry, The University of North Carolina, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000324339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178091PMC
December 2011

Obligate role for ketone body oxidation in neonatal metabolic homeostasis.

J Biol Chem 2011 Mar 5;286(9):6902-10. Epub 2011 Jan 5.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.192369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044945PMC
March 2011

Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.

J Mol Cell Cardiol 2010 Dec 20;49(6):931-40. Epub 2010 Aug 20.

Center for Cardiovascular Research, John Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2010.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975863PMC
December 2010

Coordinated regulation of the metabolome and lipidome at the host-microbial interface.

Biochim Biophys Acta 2010 Mar 24;1801(3):240-5. Epub 2009 Sep 24.

Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory and Department of Molecular and Clinical Medicine, University of Gothenburg, S-413 45 Gothenburg, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2009.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823845PMC
March 2010

Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation.

Proc Natl Acad Sci U S A 2009 Jul 22;106(27):11276-81. Epub 2009 Jun 22.

Center for Genome Sciences and Department of Medicine, Washington University School of Medicine, St. Louis, MO 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0902366106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700149PMC
July 2009

DEAD-box protein-103 (DP103, Ddx20) is essential for early embryonic development and modulates ovarian morphology and function.

Endocrinology 2008 May 7;149(5):2168-75. Epub 2008 Feb 7.

Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2007-1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329271PMC
May 2008

Maternal dental history, child's birth outcome and early cognitive development.

Paediatr Perinat Epidemiol 2007 Sep;21(5):448-57

Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-3016.2007.00819.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659800PMC
September 2007

Amelogenesis imperfecta.

Orphanet J Rare Dis 2007 Apr 4;2:17. Epub 2007 Apr 4.

Paediatric Dentistry, Division of Child Dental Health, Dental School, Lower Maudlin St,, Bristol BS1 2LY, UK.

View Article

Download full-text PDF

Source
https://ojrd.biomedcentral.com/articles/10.1186/1750-1172-2-
Publisher Site
http://dx.doi.org/10.1186/1750-1172-2-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853073PMC
April 2007

Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor.

Proc Natl Acad Sci U S A 2007 Jan 3;104(2):606-11. Epub 2007 Jan 3.

Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0605957104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761863PMC
January 2007

Long-term outcome of skull base surgery with microvascular reconstruction for malignant disease.

Plast Reconstr Surg 2006 Oct;118(5):1151-8; discussion 1159-60

Department of Otolaryngology, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.prs.0000236895.28858.4aDOI Listing
October 2006

A study of the prescription of radiographs for children by a group of general dental practitioners in the South West of England.

Prim Dent Care 2006 Jan;13(1):20-30

Division of Oral and Maxillofacial Surgery, Dental School, Bristol, UK.

View Article

Download full-text PDF

Source
http://www.ingentaselect.com/rpsv/cgi-bin/cgi?ini=xref&b
Publisher Site
http://dx.doi.org/10.1308/135576106775194012DOI Listing
January 2006

Microbial regulation of intestinal radiosensitivity.

Proc Natl Acad Sci U S A 2005 Sep 29;102(37):13254-9. Epub 2005 Aug 29.

Center for Genome Sciences and Department of Molecular Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0504830102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1193536PMC
September 2005

A case study of hemispatial neglect using finite element analysis and positron emission tomography.

J Neuroimaging 2002 Oct;12(4):360-7

Academic Neurosurgery Unit, Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Department of Engineering, University of Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
October 2002