Peter Carmeliet

Peter Carmeliet

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Peter Carmeliet

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Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.

Arterioscler Thromb Vasc Biol 2020 Feb 12;40(2):350-364. Epub 2019 Dec 12.

From the Division of Nephrology, Department of Internal Medicine (G.W., G.L.T., W.M.P.J.S., B.M.v.d.B., T.J.R.), The Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, the Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.119.313399DOI Listing
February 2020

Single-Cell Transcriptome Atlas of Murine Endothelial Cells.

Cell 2020 Feb 13;180(4):764-779.e20. Epub 2020 Feb 13.

Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, and Department of Oncology and Leuven Cancer Institute (LKI), VIB and KU Leuven, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.01.015DOI Listing
February 2020

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.

Nat Commun 2020 Jan 10;11(1):174. Epub 2020 Jan 10.

Department Health Sciences and Technology, Laboratory of Exercise and Health, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41467-019-13889-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954236PMC
January 2020

Matrix deformations around angiogenic sprouts correlate to sprout dynamics and suggest pulling activity.

Angiogenesis 2020 Jan 29. Epub 2020 Jan 29.

Biomechanics Section (BMe), Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10456-020-09708-yDOI Listing
January 2020

Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics.

Methods Mol Biol 2019 ;1978:259-268

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, Leuven, Belgium.

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http://link.springer.com/10.1007/978-1-4939-9236-2_16
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http://dx.doi.org/10.1007/978-1-4939-9236-2_16DOI Listing
November 2019

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.

Stem Cell Reports 2019 11 31;13(5):803-816. Epub 2019 Oct 31.

The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895683PMC
November 2019

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.

Cell Metab 2019 Oct 8;30(4):824-832.e3. Epub 2019 Aug 8.

Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA, USA; Department of Systems Biology, Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.006DOI Listing
October 2019

PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production.

Sci Rep 2019 Oct 21;9(1):15022. Epub 2019 Oct 21.

Vascular Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC). Melchor Fernández Almagro 3, 28029, Madrid, Spain.

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http://dx.doi.org/10.1038/s41598-019-50866-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803685PMC
October 2019

Hallmarks of Endothelial Cell Metabolism in Health and Disease.

Cell Metab 2019 Sep;30(3):414-433

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven B-3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven B-3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.08.011DOI Listing
September 2019

Adult Pgf mice behaviour and neuroanatomy are altered by neonatal treatment with recombinant placental growth factor.

Sci Rep 2019 Jun 26;9(1):9285. Epub 2019 Jun 26.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, K7L 3N6, Canada.

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http://dx.doi.org/10.1038/s41598-019-45824-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594955PMC
June 2019

Gas6 is dispensable for pubertal mammary gland development.

PLoS One 2018 11;13(12):e0208550. Epub 2018 Dec 11.

Department of Biochemistry and Molecular Biology, Tulane Cancer Center, Tulane School of Medicine, New Orleans, LA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208550PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289431PMC
May 2019

[New non-metabolic role for glutamine synthetase in angiogenesis].

Med Sci (Paris) 2019 May 22;35(5):407-409. Epub 2019 May 22.

Laboratory of angiogenesis and vascular metabolism, University of Leuven, center for cancer biology, VIB, campus Gasthuisberg, O&N4, Herestraat 49-B912, B-3000, Leuven, Belgique.

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http://dx.doi.org/10.1051/medsci/2019083DOI Listing
May 2019

Stromal Gas6 promotes the progression of premalignant mammary cells.

Oncogene 2019 04 7;38(14):2437-2450. Epub 2018 Dec 7.

Department of Biochemistry and Molecular Biology, Tulane Cancer Center, Tulane School of Medicine, New Orleans, LA, USA.

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http://www.nature.com/articles/s41388-018-0593-5
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http://dx.doi.org/10.1038/s41388-018-0593-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450766PMC
April 2019

How glucose, glutamine and fatty acid metabolism shape blood and lymph vessel development.

Dev Biol 2019 03 7;447(1):90-102. Epub 2017 Dec 7.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven B-3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven B-3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.12.001DOI Listing
March 2019

Metabolic Pathways Fueling the Endothelial Cell Drive.

Annu Rev Physiol 2019 Feb;81:483-503

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; email: ,

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http://dx.doi.org/10.1146/annurev-physiol-020518-114731DOI Listing
February 2019

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

Nature 2019 01 16;565(7740):511-515. Epub 2019 Jan 16.

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41586-019-0874-3DOI Listing
January 2019

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Cell Metab 2018 12 23;28(6):866-880.e15. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183046
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http://dx.doi.org/10.1016/j.cmet.2018.07.019DOI Listing
December 2018

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Cell Metab 2018 12 23;28(6):881-894.e13. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 51006, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.016DOI Listing
December 2018

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell Metab 2018 10 12;28(4):573-587.e13. Epub 2018 Jul 12.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.009DOI Listing
October 2018

Live imaging reveals a conserved role of fatty acid β-oxidation in early lymphatic development in zebrafish.

Biochem Biophys Res Commun 2018 09 19;503(1):26-31. Epub 2018 Jun 19.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, B-3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven, B-3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.04.233DOI Listing
September 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.

Development 2018 07 2;145(13). Epub 2018 Jul 2.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden

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http://dx.doi.org/10.1242/dev.161182DOI Listing
July 2018

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.

Nat Commun 2018 07 2;9(1):2557. Epub 2018 Jul 2.

Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41467-018-04679-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028485PMC
July 2018

Blockade of Myeloid-Derived Suppressor Cell Expansion with All- Retinoic Acid Increases the Efficacy of Antiangiogenic Therapy.

Cancer Res 2018 06 19;78(12):3220-3232. Epub 2018 Apr 19.

Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3415DOI Listing
June 2018

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.

Cell Rep 2018 06;23(11):3300-3311

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581793PMC
June 2018

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Cell Rep 2018 05;23(5):1476-1490

Montreal Clinical Research Institute (IRCM), Montréal, QC H2W 1R7, Canada; Molecular Biology Programs, Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada; Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 0C7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.019DOI Listing
May 2018

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.

Cell Stem Cell 2018 05;22(5):769-778.e4

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940005PMC
May 2018

Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development.

Dev Cell 2018 05;45(3):289-301

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute, KU Leuven, Herestraat 49 - B912, Leuven 3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.03.021DOI Listing
May 2018

Endothelial Cell Metabolism in Health and Disease.

Trends Cell Biol 2018 03 16;28(3):224-236. Epub 2017 Nov 16.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.10.010DOI Listing
March 2018

Targeting angiogenic metabolism in disease.

Science 2018 Mar;359(6382):1335-1336

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, People's Republic of China.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aar5557
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http://dx.doi.org/10.1126/science.aar5557DOI Listing
March 2018

Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease.

Nat Rev Nephrol 2018 02 18;14(2):75-76. Epub 2017 Dec 18.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Vesalius Research Center, VIB; and the Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Campus Gasthuisberg Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrneph.2017.173DOI Listing
February 2018

Endothelial Cell Metabolism.

Physiol Rev 2018 01;98(1):3-58

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium; and Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.

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http://www.physiology.org/doi/10.1152/physrev.00001.2017
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http://dx.doi.org/10.1152/physrev.00001.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866357PMC
January 2018

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation.

Nat Commun 2018 01 23;9(1):295. Epub 2018 Jan 23.

MRC Centre for Reproductive Health, The Queen's Medical Research Centre, The University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland.

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http://www.nature.com/articles/s41467-017-02375-6
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http://dx.doi.org/10.1038/s41467-017-02375-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780386PMC
January 2018

Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes.

Neurobiol Dis 2017 Dec 23;108:13-28. Epub 2017 Jul 23.

Instituto de Investigaciones en Medicina Traslacional (IIMT), Universidad Austral-CONICET, B1629AHJ, Pilar, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.07.010DOI Listing
December 2017

PP2A Inactivation Mediated by Haploinsufficiency Promotes Cancer Development.

Cancer Res 2017 12 18;77(24):6825-6837. Epub 2017 Oct 18.

Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2911DOI Listing
December 2017

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism.

Open Biol 2017 12;7(12)

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven 3000, Belgium

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http://dx.doi.org/10.1098/rsob.170219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746547PMC
December 2017

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors.

Front Immunol 2017 11;8:1750. Epub 2017 Dec 11.

Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Leuven, Belgium.

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http://dx.doi.org/10.3389/fimmu.2017.01750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732229PMC
December 2017

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.

Angiogenesis 2017 Nov 5;20(4):599-613. Epub 2017 Sep 5.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10456-017-9573-6DOI Listing
November 2017

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.

J Leukoc Biol 2017 10 17;102(4):1115-1126. Epub 2017 Jul 17.

Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium;

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http://dx.doi.org/10.1189/jlb.3A0916-405RDOI Listing
October 2017

Influences of placental growth factor on mouse retinal vascular development.

Dev Dyn 2017 09 24;246(9):700-712. Epub 2017 Jul 24.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1002/dvdy.24540DOI Listing
September 2017

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.

Circulation 2017 Aug 13;136(8):747-761. Epub 2017 Jun 13.

From Center for Molecular and Vascular Research, Leuven, Belgium (W.H., A.P., S.D., Pa.C., P.P., A.S.W., S.J., S.H.); Center for Heart Failure Research, Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands (W.H., A.P., S.D., Pa.C., W.V., R.v.L., B.S., M.v.B., S.H.); Cardiovascular Research Center, OLV Hospital, Aalst, Belgium (W.H.); Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Department of Oncology, Leuven, Belgium (A.Q., G.E., S.S., S.V., Pe.C.); Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Leuven, Belgium (A.Q., G.E., S.S., S.V., Pe.C.); Amsterdam Medical Center, Amsterdam University, The Netherlands (S.A., I.E., Y.P.); Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences (R.G., C.V.D.H.), Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences (R.G., C.V.D.H.), Leuven Viral Vector Core, Belgium (R.G., C.V.D.H.); and Klinik für Innere Medezin III, Universitätsklinikum des Saarlandes, Homburg, Germany (A.N., C.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024171DOI Listing
August 2017

Endothelial cell metabolism in health and disease: impact of hypoxia.

EMBO J 2017 08 21;36(15):2187-2203. Epub 2017 Jun 21.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.15252/embj.201696150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538796PMC
August 2017

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity.

Cell Rep 2017 Aug;20(9):2144-2155

Laboratory of Neural Plasticity, Faculty of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583518PMC
August 2017

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.

Nat Commun 2017 06 19;8:15889. Epub 2017 Jun 19.

Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.

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http://www.nature.com/doifinder/10.1038/ncomms15889
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http://dx.doi.org/10.1038/ncomms15889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481839PMC
June 2017

Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia.

Clin Cancer Res 2017 May 17;23(9):2289-2300. Epub 2016 Nov 17.

Department of Hematology and Oncology with Sections BMT and Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1930DOI Listing
May 2017

Endothelial cell metabolism: an update anno 2017.

Curr Opin Hematol 2017 May;24(3):240-247

aLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium bLaboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Center for Cancer Biology (CCB), VIB, Leuven, Belgium cGZA Hospitals Sint-Augustinus, Wilrijk and Center for Oncological Research, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1097/MOH.0000000000000335DOI Listing
May 2017

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

EMBO J 2017 05 17;36(9):1199-1214. Epub 2017 Mar 17.

Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

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http://dx.doi.org/10.15252/embj.201695988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412813PMC
May 2017

Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling.

Pflugers Arch 2017 04 24;469(3-4):473-483. Epub 2017 Feb 24.

Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1007/s00424-017-1946-6DOI Listing
April 2017

How to Cross the Lymphatic Fence: Lessons From Solute Transport.

Circ Res 2017 04;120(9):1376-1378

From the Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Leuven Cancer Institute (LKI), KU Leuven, Belgium (J.K., L.-A.T., V.G., P.C.); Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Vesalius Research Center, Leuven, Belgium (J.K., L.-A.T., V.G., P.C.); GZA Hospitals Sint-Augustinus, Wilrijk, Belgium (L.-A.T.); and Center for Oncological Research, University of Antwerp, Belgium (L.-A.T.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310916DOI Listing
April 2017

Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex.

Cell Stem Cell 2017 03 23;20(3):360-373.e7. Epub 2016 Nov 23.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.020DOI Listing
March 2017

Vessel pruning or healing: endothelial metabolism as a novel target?

Expert Opin Ther Targets 2017 Mar 27;21(3):239-247. Epub 2017 Jan 27.

a Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology , KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/14728222.2017.1282465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526136PMC
March 2017

Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective.

Vascul Pharmacol 2017 03 7;90:8-18. Epub 2017 Jan 7.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.vph.2017.01.001DOI Listing
March 2017

Central Role of Metabolism in Endothelial Cell Function and Vascular Disease.

Physiology (Bethesda) 2017 03;32(2):126-140

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, Leuven, Belgium; and

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http://dx.doi.org/10.1152/physiol.00031.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337830PMC
March 2017

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells.

Cell Rep 2017 03;18(12):3005-3017

Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium; Department of Pulmonary Medicine, ErasmusMC, 3015 Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379012PMC
March 2017

CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions.

Sci Rep 2017 03 23;7:44810. Epub 2017 Mar 23.

Departments of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/srep44810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363086PMC
March 2017

Nogo-A regulates vascular network architecture in the postnatal brain.

J Cereb Blood Flow Metab 2017 Feb 13;37(2):614-631. Epub 2016 Nov 13.

10 Institute for Regenerative Medicine and Clinic for Cardiovascular Surgery, University Hospital Zurich.

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http://dx.doi.org/10.1177/0271678X16675182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381465PMC
February 2017

The Link Between Angiogenesis and Endothelial Metabolism.

Annu Rev Physiol 2017 02 15;79:43-66. Epub 2016 Dec 15.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1146/annurev-physiol-021115-105134DOI Listing
February 2017

Vascular Endothelial Growth Factor Up-regulation in Human Amniotic Fluid Stem Cell Enhances Nephroprotection After Ischemia-Reperfusion Injury in the Rat.

Crit Care Med 2017 Jan;45(1):e86-e96

1Department of Development and Regeneration, Organ System Cluster, Fetal Therapy group, Group Biomedical Sciences, KU Leuven, Leuven, Belgium. 2Experimental Veterinary Surgery Laboratory, Department of Small Animals, Universidade Federal de Santa Maria, Santa Maria, Brazil. 3Department of Pharmaceutical and Pharmacological Sciences, Molecular Virology and Gene Therapy, Group Biomedical Sciences, KU Leuven, Leuven, Belgium. 4Department of Development and Regeneration, Organ System Cluster, Laboratory of Pediatric Nephrology, Group Biomedical Sciences, KU Leuven, Leuven, Belgium. 5Department of Urology, University Hospitals Leuven, Leuven, Belgium. 6Department of Clinical and Experimental Medicine, Clinical and Experimental Endocrinology, Leuven, Belgium. 7Department of Oncology, Vesalius Research Center, Laboratory of Angiogenesis and Vascular Metabolism, VIB, KU Leuven, Leuven, Belgium. 8Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium. 9Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/CCM.0000000000002020DOI Listing
January 2017

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.

Cell Metab 2016 11 20;24(5):701-715. Epub 2016 Oct 20.

Lab of Tumor Inflammation and Angiogenesis, VIB, 3000 Leuven, Belgium; Lab of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.008DOI Listing
November 2016

Endothelial cell metabolism: A novel player in atherosclerosis? Basic principles and therapeutic opportunities.

Atherosclerosis 2016 10 20;253:247-257. Epub 2016 Aug 20.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, B-3000, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Leuven, B-3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.08.011DOI Listing
October 2016

Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.

EMBO Mol Med 2016 10 4;8(10):1134-1142. Epub 2016 Oct 4.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Leuven, Belgium

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http://dx.doi.org/10.15252/emmm.201606798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048364PMC
October 2016

Vascular endothelial growth factor: a neurovascular target in neurological diseases.

Nat Rev Neurol 2016 08 1;12(8):439-54. Epub 2016 Jul 1.

Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Department of Oncology (KU Leuven) and Vesalius Research Center (VIB), Campus Gasthuisberg O&N4, Herestraat 49 - 912, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1038/nrneurol.2016.88DOI Listing
August 2016

Manipulating Angiogenesis by Targeting Endothelial Metabolism: Hitting the Engine Rather than the Drivers-A New Perspective?

Pharmacol Rev 2016 07;68(3):872-87

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, University of Leuven, and Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Vlaams Instituut voor Biotechnologie, Leuven, Belgium

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http://dx.doi.org/10.1124/pr.116.012492DOI Listing
July 2016

Glycolytic regulation of cell rearrangement in angiogenesis.

Nat Commun 2016 07 20;7:12240. Epub 2016 Jul 20.

Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism, KU Leuven, Herestraat 49 box 912, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/ncomms12240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961802PMC
July 2016

Stem Cell-Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy.

Invest Ophthalmol Vis Sci 2016 06;57(7):3509-20

Technische Universität Dresden CRTD - Center for Regenerative Therapies Dresden, Dresden, Germany.

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http://dx.doi.org/10.1167/iovs.16-19087DOI Listing
June 2016

Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature.

Mol Cell Oncol 2016 Jan 9;3(1):e970097. Epub 2015 Dec 9.

Department Cellular and Molecular Medicine; Laboratory of Cell Death and Therapy ; KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.4161/23723548.2014.970097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845249PMC
January 2016