Peter C Scacheri

Peter C Scacheri

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Peter C Scacheri

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Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.

Hum Genet 2019 Jul;138(7):789-791

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s00439-019-02030-8DOI Listing
July 2019

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.

Hum Genet 2019 Apr 28;138(4):307-326. Epub 2019 Feb 28.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s00439-019-01989-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483948PMC
April 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41588-018-0286-6
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http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Enhancers: bridging the gap between gene control and human disease.

Hum Mol Genet 2018 08;27(R2):R219-R227

Department of Genetics and Genome Sciences, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1093/hmg/ddy167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061867PMC
August 2018

Targeting Epigenetics to Prevent Obesity Promoted Cancers.

Cancer Prev Res (Phila) 2018 03 23;11(3):125-128. Epub 2018 Feb 23.

Department of Genetics & Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio.

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0043DOI Listing
March 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

iPSC Reprogramming Is Not Just an Open and Shut Case.

Cell Stem Cell 2017 Dec;21(6):711-712

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.stem.2017.11.017DOI Listing
December 2017

Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry.

Nat Genet 2016 11 19;48(11):1313-1320. Epub 2016 Sep 19.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083135PMC
http://dx.doi.org/10.1038/ng.3674DOI Listing
November 2016

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.

Neoplasia 2016 Oct 28;18(11):699-710. Epub 2016 Oct 28.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Ethos Discovery in Washington DC and Ethos Veterinary Health, Wolburn MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094383PMC
October 2016

12th International CHARGE syndrome conference proceedings.

Am J Med Genet A 2016 Apr 11;170A(4):856-69. Epub 2016 Jan 11.

Saint Louis University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1002/ajmg.a.37544DOI Listing
April 2016

Mutations in the noncoding genome.

Curr Opin Pediatr 2015 Dec;27(6):659-64

aCourtagen Life Sciences, 12 Gill St, Ste. 3700, Woburn, MA 01801 bDepartment of Genetics and Genome Sciences, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine; Cleveland, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084913PMC
http://dx.doi.org/10.1097/MOP.0000000000000283DOI Listing
December 2015

"PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.

Cancer Discov 2015 Oct;5(10):1018-20

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608252PMC
October 2015

Long ncRNA expression associates with tissue-specific enhancers.

Cell Cycle 2015 ;14(2):253-60

a Noncoding RNA Research Group; Max Planck Institute for Molecular Genetics ; Berlin , Germany.

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http://dx.doi.org/10.4161/15384101.2014.977641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614992PMC
September 2015

ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters.

Nat Commun 2015 Feb 3;2:6186. Epub 2015 Feb 3.

1] The Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario, Canada M5G 1L7 [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 1L7 [3] Ontario Institute for Cancer Research, Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1038/ncomms7186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431651PMC
February 2015

Enhancer variants: evaluating functions in common disease.

Genome Med 2014 28;6(10):85. Epub 2014 Oct 28.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44122 USA ; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106 USA.

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http://dx.doi.org/10.1186/s13073-014-0085-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254432PMC
December 2014

Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency.

Cell Stem Cell 2014 Jun;14(6):854-63

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; National Center for Regenerative Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(14)00192-1
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http://www.cell.com/cms/attachment/2024866441/2044539278/mmc
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S193459091400192
Publisher Site
http://dx.doi.org/10.1016/j.stem.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149284PMC
June 2014

Genomic characterization of the mouse ribosomal DNA locus.

G3 (Bethesda) 2014 Feb 19;4(2):243-54. Epub 2014 Feb 19.

Department of Genetics and Genome Sciences, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106.

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http://dx.doi.org/10.1534/g3.113.009290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931559PMC
February 2014

Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.

Dev Biol 2013 Oct 3;382(1):57-69. Epub 2013 Aug 3.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.ydbio.2013.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816111PMC
October 2013

Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification.

Development 2012 Dec 24;139(23):4428-38. Epub 2012 Oct 24.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1242/dev.081679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509735PMC
December 2012

Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene.

PLoS One 2012 23;7(4):e34944. Epub 2012 Apr 23.

Department of Otolaryngology-Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034944PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335168PMC
September 2012

The chromatin fingerprint of gene enhancer elements.

J Biol Chem 2012 Sep 5;287(37):30888-96. Epub 2012 Sep 5.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1074/jbc.R111.296491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438921PMC
September 2012

Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.

Mol Cell Biol 2012 Jun 9;32(12):2323-34. Epub 2012 Apr 9.

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1128/MCB.06392-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372260PMC
June 2012

Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells.

Nat Methods 2011 Sep 25;8(11):957-62. Epub 2011 Sep 25.

Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nmeth.1712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400969PMC
September 2011

Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functions.

Genome Res 2011 Aug 1;21(8):1273-83. Epub 2011 Jun 1.

Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1101/gr.122382.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149494PMC
August 2011

Integrative genomic analysis of human ribosomal DNA.

Nucleic Acids Res 2011 Jul 25;39(12):4949-60. Epub 2011 Feb 25.

Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1093/nar/gkq1326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130253PMC
July 2011

Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development.

Development 2010 Dec 27;137(23):3973-84. Epub 2010 Oct 27.

Department of Biology, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.056473
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http://dx.doi.org/10.1242/dev.056473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976281PMC
December 2010

Mutations in the CHD7 gene: the experience of a commercial laboratory.

Genet Test Mol Biomarkers 2010 Dec;14(6):881-91

Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44016, USA.

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http://dx.doi.org/10.1089/gtmb.2010.0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001831PMC
December 2010

Functional studies of menin through genetic manipulation of the Men1 homolog in mice.

Adv Exp Med Biol 2009 ;668:105-15

Department of Genetics, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1007/978-1-4419-1664-8_11DOI Listing
April 2010

Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.

Am J Med Genet A 2010 Mar;152A(3):674-86

Department of Genetics, Case Western Reserve University, Cleveland, Ohio, USA.

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http://doi.wiley.com/10.1002/ajmg.a.33323
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http://dx.doi.org/10.1002/ajmg.a.33323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918278PMC
March 2010

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

Curr Biol 2009 Aug 9;19(15):1255-63. Epub 2009 Jul 9.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1016/j.cub.2009.06.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741418PMC
August 2009

Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies.

Nat Methods 2008 Feb 6;5(2):163-5. Epub 2008 Jan 6.

Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1038/nmeth1170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435063PMC
February 2008

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.

Neoplasia 2007 Feb;9(2):101-7

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1802, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1813935PMC
http://dx.doi.org/10.1593/neo.06706DOI Listing
February 2007

Statistics for ChIP-chip and DNase hypersensitivity experiments on NimbleGen arrays.

Methods Enzymol 2006 ;411:270-82

Department of Genetics, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)11014-9DOI Listing
December 2006

DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays.

Nat Methods 2006 Jul;3(7):503-9

National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nmeth888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698431PMC
July 2006

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

PLoS Genet 2006 Apr 7;2(4):e51. Epub 2006 Apr 7.

Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pgen.0020051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1428788PMC
April 2006

Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.

Mamm Genome 2004 Nov;15(11):872-7

National Human Genome Research Institute, National Institutes of Health, Bldg 31, Room 4B09, 31 Center Drive, Bethesda, Maryland 20892, USA.

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November 2004