Publications by authors named "Peter B Dirks"

97Publications

Three-Dimensional Computed Tomography Reconstruction Unmasks Shunt Disconnection in a Child.

Can J Neurol Sci 2020 Nov 4;47(6):826-827. Epub 2020 Jun 4.

Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/cjn.2020.110DOI Listing
November 2020

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.

Cell 2020 Jun 22;181(6):1329-1345.e24. Epub 2020 May 22.

The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.047DOI Listing
June 2020

Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2 Granule Neuron Precursor.

Cell Rep 2020 04;31(2):107511

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.03.075DOI Listing
April 2020

Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma.

Clin Cancer Res 2020 Jun 14;26(11):2457-2460. Epub 2020 Feb 14.

Departments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269826PMC
June 2020

Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer.

Sci Adv 2019 12 11;5(12):eaax8898. Epub 2019 Dec 11.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1126/sciadv.aax8898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905862PMC
December 2019

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.

Cell 2019 11 21;179(6):1330-1341.e13. Epub 2019 Nov 21.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241652PMC
November 2019

Locations, associations and temporal evolution of intracranial arterial infundibular dilatations in children.

J Neurointerv Surg 2020 May 7;12(5):495-498. Epub 2019 Nov 7.

Department of Diagnostic Imaging & Image Guided Therapy, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1136/neurintsurg-2019-015433DOI Listing
May 2020

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Making a commitment: neurons refuse cancer's advances.

Authors:
Peter B Dirks

Nat Neurosci 2019 04;22(4):507-508

Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41593-019-0373-8DOI Listing
April 2019

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.

Dev Cell 2019 01 13;48(2):167-183.e5. Epub 2018 Dec 13.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Joint Institute of Genetics and Genomic Medicine, Zhejiang University and University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183093
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http://dx.doi.org/10.1016/j.devcel.2018.11.015DOI Listing
January 2019

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.

Neuron 2018 11 18;100(4):799-815.e7. Epub 2018 Oct 18.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.09.046DOI Listing
November 2018

Delayed Chronic Subdural Hematoma after Total Cranial Vault Reconstruction for Sagittal Synostosis.

Pediatr Neurosurg 2018 19;53(3):200-204. Epub 2018 Apr 19.

Division of Neurosurgery, The Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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https://www.karger.com/Article/FullText/487809
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http://dx.doi.org/10.1159/000487809DOI Listing
September 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Cell Stem Cell 2017 08 14;21(2):209-224.e7. Epub 2017 Jul 14.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.06.004DOI Listing
August 2017

Brain Tumor Stem Cells Remain in Play.

J Clin Oncol 2017 07 22;35(21):2428-2431. Epub 2017 Jun 22.

Luis F. Parada, Memorial Sloan Kettering Cancer Center, New York, NY; Peter B. Dirks, University of Toronto, Toronto, Ontario, Canada; and Robert J. Wechsler-Reya, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.

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http://dx.doi.org/10.1200/JCO.2017.73.9540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516484PMC
July 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:
Florence M G Cavalli Marc Remke Ladislav Rampasek John Peacock David J H Shih Betty Luu Livia Garzia Jonathon Torchia Carolina Nor A Sorana Morrissy Sameer Agnihotri Yuan Yao Thompson Claudia M Kuzan-Fischer Hamza Farooq Keren Isaev Craig Daniels Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Ji Yeoun Lee Wieslawa A Grajkowska Marta Perek-Polnik Alexandre Vasiljevic Cecile Faure-Conter Anne Jouvet Caterina Giannini Amulya A Nageswara Rao Kay Ka Wai Li Ho-Keung Ng Charles G Eberhart Ian F Pollack Ronald L Hamilton G Yancey Gillespie James M Olson Sarah Leary William A Weiss Boleslaw Lach Lola B Chambless Reid C Thompson Michael K Cooper Rajeev Vibhakar Peter Hauser Marie-Lise C van Veelen Johan M Kros Pim J French Young Shin Ra Toshihiro Kumabe Enrique López-Aguilar Karel Zitterbart Jaroslav Sterba Gaetano Finocchiaro Maura Massimino Erwin G Van Meir Satoru Osuka Tomoko Shofuda Almos Klekner Massimo Zollo Jeffrey R Leonard Joshua B Rubin Nada Jabado Steffen Albrecht Jaume Mora Timothy E Van Meter Shin Jung Andrew S Moore Andrew R Hallahan Jennifer A Chan Daniela P C Tirapelli Carlos G Carlotti Maryam Fouladi José Pimentel Claudia C Faria Ali G Saad Luca Massimi Linda M Liau Helen Wheeler Hideo Nakamura Samer K Elbabaa Mario Perezpeña-Diazconti Fernando Chico Ponce de León Shenandoah Robinson Michal Zapotocky Alvaro Lassaletta Annie Huang Cynthia E Hawkins Uri Tabori Eric Bouffet Ute Bartels Peter B Dirks James T Rutka Gary D Bader Jüri Reimand Anna Goldenberg Vijay Ramaswamy Michael D Taylor

Cancer Cell 2017 06;31(6):737-754.e6

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163053PMC
June 2017

Unilateral Postoperative Deep Cerebral Venous Thrombosis with Complete Recovery: A Report of 2 Cases.

Pediatr Neurosurg 2017 22;52(3):205-210. Epub 2017 Mar 22.

Divisions of Neurosurgery, Neuroradiology, and Neurooncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1159/000452803DOI Listing
May 2018

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Cancer Cell 2016 06;29(6):859-873

Arthur and Sonia Labatt Brain Tumor Research Center and Developmental and Stem Cell Biology, The Hospital for Sick Children (SickKids), Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, SickKids, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(16)30207-0.pd
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http://dx.doi.org/10.1016/j.ccell.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968455PMC
June 2016

Global chromatin architecture defines functional cancer hierarchies.

Cell Cycle 2016 08 31;15(16):2093-2094. Epub 2016 May 31.

b Developmental and Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/15384101.2016.1191248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993424PMC
August 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer Cell 2015 Dec 25;28(6):715-729. Epub 2015 Nov 25.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00382-7.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500382
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http://dx.doi.org/10.1016/j.ccell.2015.10.005DOI Listing
December 2015

Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma.

Mol Cancer Ther 2015 Nov 8;14(11):2560-8. Epub 2015 Sep 8.

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0282DOI Listing
November 2015

BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.

J Clin Oncol 2015 Mar 9;33(9):1015-22. Epub 2015 Feb 9.

Matthew Mistry, Nataliya Zhukova, Daniele Merico, Rahul Krishnatry, Mary Shago, James Stavropoulos, Noa Alon, Peter N. Ray, Vilma Navickiene, Joshua Mangerel, Marc Remke, Vijay Ramaswamy, Ana Guerreiro Stucklin, Martin Li, Edwin J. Young, Cindy Zhang, Pedro Castelo-Branco, Doua Bakry, Suzanne Laughlin, James T. Rutka, Peter B. Dirks, Michael D. Taylor, Mark Greenberg, David Malkin, Annie Huang, Eric Bouffet, Cynthia E. Hawkins, and Uri Tabori; The Hospital for Sick Children; Matthew Mistry, Patricia Rakopoulos, Rahul Krishnatry, Joshua Mangerel, Pawel Buczkowicz, Ana Guerreiro Stucklin, Doua Bakry, Adam Shlien, Mark Greenberg, David Malkin, Annie Huang, Eric Bouffet, Cynthia E. Hawkins, and Uri Tabori, University of Toronto; Jason D. Pole, Pediatric Oncology Group of Ontario, Toronto, Ontario; Jennifer Chan, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Pedro Castelo-Branco, Universidade do Algarve, Faro, Portugal; Keith L. Ligon, Dana-Farber/Boston Children's Cancer Center, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2014.58.3922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356711PMC
March 2015

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.

Proc Natl Acad Sci U S A 2015 Jan 5;112(3):851-6. Epub 2015 Jan 5.

Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8

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http://dx.doi.org/10.1073/pnas.1320611111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311802PMC
January 2015

Pediatric brainstem hemorrhages after traumatic brain injury.

J Neurosurg Pediatr 2014 Oct 8;14(4):421-4. Epub 2014 Aug 8.

Division of Pediatric Neurological Surgery, University of Florida Health Jacksonville, Florida; and.

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http://dx.doi.org/10.3171/2014.7.PEDS13376DOI Listing
October 2014

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Cancer Discov 2014 Oct 6;4(10):1198-213. Epub 2014 Aug 6.

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Canada. Division of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184920PMC
October 2014

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.

Cancer Cell 2014 Jul 19;26(1):33-47. Epub 2014 Jun 19.

Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, Hospital for Sick Children (HSC), Toronto, ON M5G 1L7, Canada; Program in Developmental and Stem Cell Biology, HSC, Toronto, ON M5G 1X8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441014PMC
July 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

A tumorigenic MLL-homeobox network in human glioblastoma stem cells.

Cancer Res 2013 Jan 29;73(1):417-27. Epub 2012 Oct 29.

Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada.

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http://cancerres.aacrjournals.org/content/73/1/417.full.pdf
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-1881DOI Listing
January 2013

Angioarchitectural features associated with hemorrhagic presentation in pediatric cerebral arteriovenous malformations.

J Neurointerv Surg 2013 May 13;5(3):191-5. Epub 2012 Mar 13.

Department of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/neurintsurg-2011-010198DOI Listing
May 2013

Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy.

Glia 2011 Aug 5;59(8):1148-54. Epub 2011 May 5.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Ohio, USA.

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http://dx.doi.org/10.1002/glia.21185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107874PMC
August 2011

A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.

J Exp Med 2011 Apr 4;208(4):689-702. Epub 2011 Apr 4.

The Arthur and Sonia Labatt's Brain Tumor Research Centre, The Hospital for Sick Children's Research Institute, Toronto Western Hospital, University of Toronto, Toronto M5A 2N4, Ontario, Canada.

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http://dx.doi.org/10.1084/jem.20102099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135351PMC
April 2011

Large vascular malformation in a child presenting with vascular steal phenomenon managed with pial synangiosis.

J Neurosurg Pediatr 2011 Jan;7(1):15-21

Division of Neurosurgery, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2010.10.PEDS10388DOI Listing
January 2011

Intraoperative angiography during microsurgical removal of arteriovenous malformations in children.

J Neurosurg Pediatr 2010 Nov;6(5):435-43

Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2010.8.PEDS10134DOI Listing
November 2010

Outcome following decompressive craniectomy for malignant middle cerebral artery infarction in children.

Dev Med Child Neurol 2011 Jan 30;53(1):29-33. Epub 2010 Aug 30.

Department of Neurology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1111/j.1469-8749.2010.03775.xDOI Listing
January 2011

Brain tumor stem cells: the cancer stem cell hypothesis writ large.

Authors:
Peter B Dirks

Mol Oncol 2010 Oct 10;4(5):420-30. Epub 2010 Aug 10.

Division of Neurosurgery, Developmental and Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molonc.2010.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527933PMC
October 2010

Management of pediatric brainstem cavernous malformations: experience over 20 years at the hospital for sick children.

J Neurosurg Pediatr 2009 Nov;4(5):458-64

Division of Neurosurgery, The Hospital for Sick Children, Department of Surgery, The University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2009.6.PEDS0923DOI Listing
November 2009

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery.

Nat Rev Drug Discov 2009 Oct;8(10):806-23

Oncology Discovery, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA.

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http://dx.doi.org/10.1038/nrd2137DOI Listing
October 2009

MicroRNAs and parallel stem cell lives.

Authors:
Peter B Dirks

Cell 2009 Aug;138(3):423-4

Hospital for Sick Children, University of Toronto, Toronto M5G1X8, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740900904
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http://dx.doi.org/10.1016/j.cell.2009.07.025DOI Listing
August 2009

Neurosurgical management of intracranial epidermoid tumors in children. Clinical article.

J Neurosurg Pediatr 2009 Aug;4(2):91-6

Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/2009.4.PEDS08489DOI Listing
August 2009

Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.

J Clin Oncol 2009 Apr 16;27(11):1884-92. Epub 2009 Mar 16.

Department of Neurosurgery, Peter B Dirks, Christian Sainte-Rose, and Gilles Vassal Hôpital Necker Enfants Malades, Université Paris Descartes, France.

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http://dx.doi.org/10.1200/JCO.2007.15.4195DOI Listing
April 2009

New drugs for brain tumors? Insights from chemical probing of neural stem cells.

Med Hypotheses 2009 Jun 3;72(6):683-7. Epub 2009 Mar 3.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S03069877090006
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http://dx.doi.org/10.1016/j.mehy.2008.10.034DOI Listing
June 2009

Clinical predictors of developmental outcome in patients with cephaloceles.

J Neurosurg Pediatr 2008 Oct;2(4):254-7

Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton General Hospital/Neurosurgery, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.3171/PED.2008.2.10.254DOI Listing
October 2008

Cancer and stem cell biology: how tightly intertwined?

Cell Stem Cell 2008 Aug;3(2):147-50

Stem Cell Program, Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193459090800346
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http://dx.doi.org/10.1016/j.stem.2008.07.012DOI Listing
August 2008

Brain tumor stem cells: bringing order to the chaos of brain cancer.

Authors:
Peter B Dirks

J Clin Oncol 2008 Jun;26(17):2916-24

Arthur and Sonia Labatt Brain Tumor Research Center, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2008.17.6792DOI Listing
June 2008

Incorporation of C-1 lateral mass screws in occipitocervical and atlantoaxial fusions for children 8 years of age or younger. Technical note.

J Neurosurg 2007 Aug;107(2 Suppl):178-83

Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada.

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http://thejns.org/doi/abs/10.3171/PED-07/08/178
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http://dx.doi.org/10.3171/PED-07/08/178DOI Listing
August 2007

Cancer's source in the peripheral nervous system.

Authors:
Peter B Dirks

Nat Med 2008 Apr;14(4):373-5

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http://dx.doi.org/10.1038/nm0408-373DOI Listing
April 2008

Cancer stem cells: at the headwaters of tumor development.

Annu Rev Pathol 2007 ;2:175-89

Program in Developmental Biology, Division of Neurosurgery, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1146/annurev.pathol.2.010506.091847DOI Listing
August 2008

The history of neurosurgery at the Hospital for Sick Children in Toronto.

Neurosurgery 2007 Sep;61(3):612-24; discussion 624-5

Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto Faculty of Medicine, Toronto, Canada.

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http://dx.doi.org/10.1227/01.NEU.0000290910.32600.7EDOI Listing
September 2007

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat Chem Biol 2007 May 8;3(5):268-73. Epub 2007 Apr 8.

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nchembio873DOI Listing
May 2007

Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells.

Authors:
Peter B Dirks

Philos Trans R Soc Lond B Biol Sci 2008 Jan;363(1489):139-52

Division of Neurosurgery and Program in Developmental Biology, University of Toronto, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
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http://dx.doi.org/10.1098/rstb.2006.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605491PMC
January 2008

Brain tumor stem cells: identification and concepts.

Neurosurg Clin N Am 2007 Jan;18(1):31-8, viii

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Suite 1503, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.nec.2006.10.014DOI Listing
January 2007

Cancer: stem cells and brain tumours.

Authors:
Peter B Dirks

Nature 2006 Dec;444(7120):687-8

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http://dx.doi.org/10.1038/444687aDOI Listing
December 2006

IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme.

Cancer Res 2006 Sep;66(18):9074-82

Institut National de la Santé et de la Recherche Médicale EMI 0104, Département de Réponse et Dynamique Cellulaires, CEA Grenoble, Grenoble, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0761DOI Listing
September 2006

Gelfoam obstruction of endoscopic third ventriculostomy. Case illustration.

J Neurosurg 2006 Aug;105(2 Suppl):154

Department of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.3171/ped.2006.105.2.154DOI Listing
August 2006

[Clinical diagnosis and treatment of pediatric head trauma].

No Shinkei Geka 2006 Feb;34(2):135-46

Division of Neurosurgery, The Hospital for Sick Children.

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February 2006

Measuring the health status of children with hydrocephalus by using a new outcome measure.

J Neurosurg 2004 Nov;101(2 Suppl):141-6

Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Canada.

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http://dx.doi.org/10.3171/ped.2004.101.2.0141DOI Listing
November 2004

Brain tumor stem cells.

Authors:
Peter B Dirks

Biol Blood Marrow Transplant 2005 Feb;11(2 Suppl 2):12-3

Labatt Brain Tumor Research Centre, Division of Neurosurgery and Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

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http://linkinghub.elsevier.com/retrieve/pii/S108387910400564
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http://dx.doi.org/10.1016/j.bbmt.2004.11.004DOI Listing
February 2005

Identification of human brain tumour initiating cells.

Nature 2004 Nov;432(7015):396-401

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nature03128DOI Listing
November 2004

Cancer stem cells in nervous system tumors.

Oncogene 2004 Sep;23(43):7267-73

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.

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http://www.nature.com/articles/1207946
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http://dx.doi.org/10.1038/sj.onc.1207946DOI Listing
September 2004

Patients with primary brain tumors as organ donors: case report and review of the literature.

Pediatr Blood Cancer 2004 Jul;43(1):73-7

Pediatric Brain Tumor Program, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20039DOI Listing
July 2004

Slow-flow spinal epidural AVF with venous ectasias: two pediatric case reports.

AJNR Am J Neuroradiol 2003 Oct;24(9):1901-5

Division of Neuroradiology, Department of Diagnostic Imaging, Toronto Western Hospital, Toronto, Canada.

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http://www.ajnr.org/content/24/9/1901.full.pdf
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October 2003

Identification of a cancer stem cell in human brain tumors.

Cancer Res 2003 Sep;63(18):5821-8

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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September 2003

p16(ink4a) and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG-A astrocytoma cells.

Glia 2002 Oct;40(1):85-94

Arthur and Sonia Labatt Brain Tumour Research Centre, and Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/glia.10127DOI Listing
October 2002

Avulsion transverse ligament injuries in children: successful treatment with nonoperative management. Report of three cases.

J Neurosurg 2002 Apr;96(3 Suppl):338-42

Division of Neurosurgery, Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.3171/spi.2002.96.3.0338DOI Listing
April 2002

Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children.

Acta Neuropathol 2002 Jan;103(1):1-10

Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s004010100419DOI Listing
January 2002