Peter Arvan

Peter Arvan

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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.

Transl Res 2019 Nov 9;213:90-99. Epub 2019 Aug 9.

Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana; The Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana; Roudebush VA Medical Center, Indianapolis, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2019.08.001DOI Listing
November 2019

Lessons from animal models of endocrine disorders caused by defects of protein folding in the secretory pathway.

Mol Cell Endocrinol 2019 Oct 9;499:110613. Epub 2019 Oct 9.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan School of Medicine, Brehm Tower Room 5112, 1000, Wall St., Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2019.110613DOI Listing
October 2019

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

Mol Cell 2019 Aug 5;75(3):442-456.e4. Epub 2019 Jun 5.

Department of Cell & Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3043, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688957PMC
August 2019

The role of thyroglobulin in thyroid hormonogenesis.

Nat Rev Endocrinol 2019 06;15(6):323-338

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41574-019-0184-8DOI Listing
June 2019

Preservation of circadian rhythms by the protein folding chaperone, BiP.

FASEB J 2019 Jun 19;33(6):7479-7489. Epub 2019 Mar 19.

Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1096/fj.201802366RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529331PMC
June 2019

Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress.

Cell Death Differ 2019 Mar 23;26(3):487-501. Epub 2018 May 23.

Department of Molecular, Cellular & Developmental Biology, University of Michigan, 830N University, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1038/s41418-018-0133-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370866PMC
March 2019

Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes.

Cell Rep 2019 Mar;26(11):3132-3144.e7

Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573026PMC
March 2019

Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells.

Mol Cell Endocrinol 2018 09 8;472:10-17. Epub 2018 Jun 8.

Lund University Diabetes Center, Malmoe, Lund University, Sweden; Department of Cell Physiology and Metabolism, University Medical Center. Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.mce.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6559235PMC
September 2018

Biosynthesis, structure, and folding of the insulin precursor protein.

Diabetes Obes Metab 2018 09;20 Suppl 2:28-50

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, Michigan.

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http://doi.wiley.com/10.1111/dom.13378
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http://dx.doi.org/10.1111/dom.13378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463291PMC
September 2018

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Cell Rep 2018 07;24(1):181-196

Diabetes Discovery Research and Gender Medicine Laboratory, Department of Medicine, Section of Endocrinology and Metabolism, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA; Southeast Louisiana Veterans Healthcare System Medical Center, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092934PMC
July 2018

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.

Ann N Y Acad Sci 2018 04 28;1418(1):5-19. Epub 2018 Jan 28.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1111/nyas.13531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934315PMC
April 2018

Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.

J Biol Chem 2018 03 12;293(13):4860-4869. Epub 2018 Feb 12.

From the Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105,

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http://dx.doi.org/10.1074/jbc.RA118.001786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880145PMC
March 2018

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

J Clin Invest 2018 03 19;128(3):1125-1140. Epub 2018 Feb 19.

Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1172/JCI96420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824855PMC
March 2018

Positive charge in the n-region of the signal peptide contributes to efficient post-translational translocation of small secretory preproteins.

J Biol Chem 2018 02 11;293(6):1899-1907. Epub 2017 Dec 11.

From the Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China,

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http://dx.doi.org/10.1074/jbc.RA117.000922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808753PMC
February 2018

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.

J Clin Invest 2017 10 18;127(10):3897-3912. Epub 2017 Sep 18.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1172/JCI94771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617659PMC
October 2017

triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone.

J Biol Chem 2017 09 25;292(37):15434-15444. Epub 2017 Jul 25.

From the Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M117.784447
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http://dx.doi.org/10.1074/jbc.M117.784447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602401PMC
September 2017

Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.

Cell Metab 2017 Sep;26(3):568-575.e3

Department of Pathology, Immunology, and Laboratory Medicine, The University of Florida Diabetes Institute, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679224PMC
September 2017

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation.

Trends Cell Biol 2017 06 9;27(6):430-440. Epub 2017 Feb 9.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA; Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI 48105, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09628924163021
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http://dx.doi.org/10.1016/j.tcb.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440201PMC
June 2017

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Diabetes 2017 03 27;66(3):741-753. Epub 2016 Dec 27.

Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

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http://dx.doi.org/10.2337/db16-1338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319713PMC
March 2017

86th Annual Meeting of the American Thyroid Association.

Thyroid 2016 09 17;26(9):1154-5. Epub 2016 Aug 17.

2 Department of Endocrinology, Memorial Sloan Kettering Cancer Center , New York, New York.

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http://dx.doi.org/10.1089/thy.2016.29024.ataDOI Listing
September 2016

Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates.

J Biol Chem 2016 08 16;291(32):16553-66. Epub 2016 Jun 16.

From the Institut de Génomique Fonctionnelle de Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France,

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http://dx.doi.org/10.1074/jbc.M116.719047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974371PMC
August 2016

Autophagy is a major regulator of beta cell insulin homeostasis.

Diabetologia 2016 07 30;59(7):1480-1491. Epub 2016 Jan 30.

Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem, 91120, Israel.

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http://dx.doi.org/10.1007/s00125-016-3868-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912938PMC
July 2016

Erratum to: Autophagy is a major regulator of beta cell insulin homeostasis.

Diabetologia 2016 07;59(7):1575-1576

Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, PO Box 12000, Jerusalem, 91120, Israel.

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http://link.springer.com/10.1007/s00125-016-3986-4
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http://dx.doi.org/10.1007/s00125-016-3986-4DOI Listing
July 2016

Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?

Clin Diabetes Endocrinol 2016 2;2:11. Epub 2016 May 2.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, MI USA.

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http://dx.doi.org/10.1186/s40842-016-0029-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471666PMC
May 2016

Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.

Diabetes 2016 04 28;65(4):1050-60. Epub 2016 Jan 28.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, MI

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http://dx.doi.org/10.2337/db15-1345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806660PMC
April 2016

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.

Diabetes 2016 Feb 25;65(2):438-50. Epub 2015 Aug 25.

Kovler Diabetes Center, Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, Chicago, IL

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http://dx.doi.org/10.2337/db15-0792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747460PMC
February 2016

Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology.

Endocr Rev 2016 Feb 23;37(1):2-36. Epub 2015 Nov 23.

Laboratorio di Patologia Generale (B.D.J.), Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, 73100 Lecce, Italy; and Division of Metabolism, Endocrinology, and Diabetes (P.A.), University of Michigan Medical School, Ann Arbor, Michigan 48105.

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http://dx.doi.org/10.1210/er.2015-1090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740344PMC
February 2016

Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure.

Cell Rep 2015 Dec 8;13(11):2527-2538. Epub 2015 Dec 8.

Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI 48109-0678, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI 48109-0678, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839001PMC
December 2015

Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos.

J Biol Chem 2015 Nov 7;290(47):28131-40. Epub 2015 Oct 7.

From the Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China, the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105,

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http://dx.doi.org/10.1074/jbc.M115.692350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653672PMC
November 2015

PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.

Mol Biol Cell 2015 Oct 12;26(19):3413-23. Epub 2015 Aug 12.

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI 48109

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http://dx.doi.org/10.1091/mbc.E15-01-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591687PMC
October 2015

Better care for people with diabetes and endocrine diseases.

Clin Diabetes Endocrinol 2015 4;1. Epub 2015 Jun 4.

Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48104 USA.

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http://dx.doi.org/10.1186/s40842-015-0003-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469198PMC
June 2015

Sox17 regulates insulin secretion in the normal and pathologic mouse β cell.

PLoS One 2014 21;9(8):e104675. Epub 2014 Aug 21.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104675PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140688PMC
May 2015

INS-gene mutations: from genetics and beta cell biology to clinical disease.

Mol Aspects Med 2015 Apr 24;42:3-18. Epub 2014 Dec 24.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI, 48105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404187PMC
April 2015

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.

Mol Aspects Med 2015 Apr 8;42:105-18. Epub 2015 Jan 8.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan, Ann Arbor, MI 48105, USA; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404191PMC
April 2015

Molecular aspects of pancreatic beta cell failure and diabetes.

Mol Aspects Med 2015 Apr 14;42:1-2. Epub 2015 Jan 14.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1016/j.mam.2015.01.002DOI Listing
April 2015

Proinsulin entry and transit through the endoplasmic reticulum in pancreatic beta cells.

Vitam Horm 2014 ;95:35-62

Division of Metabolism, Endocrinology & Diabetes, The University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-800174-5.00002-8DOI Listing
February 2015

Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.

Endocrinology 2014 Jul 14;155(7):2391-401. Epub 2014 May 14.

Department of Anatomy and Neurobiology (Y.P., E.H.B., J.R.P., I.L.), University of Maryland-Baltimore, Baltimore, Maryland 21201; Division of Endocrinology, Metabolism, and Diabetes (M.L., P.A.), University of Michigan, Michigan 48105; and Department of Cell and Molecular Biology (M.C.W., N.G.), The Scripps Research Institute, San Diego, California 92037.

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http://dx.doi.org/10.1210/en.2013-1985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060179PMC
July 2014

Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.

J Biol Chem 2014 Jun 25;289(23):16290-302. Epub 2014 Apr 25.

From the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105, the Division of Metabolism, Tianjin Medical University General Hospital, Tianjin, China 300052,

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http://dx.doi.org/10.1074/jbc.M114.562355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047398PMC
June 2014

Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum.

J Biol Chem 2014 Apr 5;289(16):11488-96. Epub 2014 Mar 5.

From the Laboratorio di Patologia Generale, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, 73100 Lecce, Italy.

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http://dx.doi.org/10.1074/jbc.M113.520767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036284PMC
April 2014

A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

Dis Model Mech 2013 Nov 12;6(6):1414-25. Epub 2013 Sep 12.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1242/dmm.013342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820264PMC
November 2013

Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.

J Biol Chem 2013 Oct 10;288(43):31010-8. Epub 2013 Sep 10.

From the Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105.

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http://dx.doi.org/10.1074/jbc.M113.510065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829414PMC
October 2013

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum.

Mol Biol Cell 2013 Sep 17;24(17):2597-608. Epub 2013 Jul 17.

Department of Biological Chemistry and Medical Scientist Training Program, University of Michigan Medical School, Ann Arbor, MI 48109-1621, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e13-02-0101
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http://dx.doi.org/10.1091/mbc.E13-02-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756913PMC
September 2013

Neuroendocrinology: regulated secretory cells go to the BAR for a bud.

Nat Rev Endocrinol 2013 Aug 25;9(8):443-4. Epub 2013 Jun 25.

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http://dx.doi.org/10.1038/nrendo.2013.121DOI Listing
August 2013

Dominant protein interactions that influence the pathogenesis of conformational diseases.

J Clin Invest 2013 Jul 3;123(7):3124-34. Epub 2013 Jun 3.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1172/JCI67260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696544PMC
July 2013

Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells.

J Biol Chem 2013 Jan 6;288(3):1896-906. Epub 2012 Dec 6.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA.

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http://dx.doi.org/10.1074/jbc.M112.420018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548498PMC
January 2013

Islet autoantigens: structure, function, localization, and regulation.

Cold Spring Harb Perspect Med 2012 Aug 1;2(8). Epub 2012 Aug 1.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, MI 48105, USA.

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http://dx.doi.org/10.1101/cshperspect.a007658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405822PMC
August 2012

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes.

Diabetes 2012 Apr 22;61(4):828-37. Epub 2012 Feb 22.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, MI, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db11-08
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http://dx.doi.org/10.2337/db11-0878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314357PMC
April 2012

Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

J Biol Chem 2012 Jan 21;287(1):43-7. Epub 2011 Nov 21.

Division of Metabolism, Endocrinology and Diabetes and the Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Michigan 48105-51714, USA.

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http://dx.doi.org/10.1074/jbc.C111.279927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249095PMC
January 2012

Maturation of thyroglobulin protein region I.

J Biol Chem 2011 Sep 4;286(38):33045-52. Epub 2011 Aug 4.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M111.281337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190886PMC
September 2011

In vivo misfolding of proinsulin below the threshold of frank diabetes.

Diabetes 2011 Aug 15;60(8):2092-101. Epub 2011 Jun 15.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.2337/db10-1671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142084PMC
August 2011

Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.

Endocrinology 2011 Jul 3;152(7):2599-608. Epub 2011 May 3.

Institute for Diabetes, Obesity, and Metabolism and Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 726, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1210/en.2010-1420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115612PMC
July 2011

Repeat motif-containing regions within thyroglobulin.

J Biol Chem 2011 Jul 2;286(30):26327-33. Epub 2011 Jun 2.

Division of Metabolism, Endocrinology, and Diabetes, the University of Michigan Medical Center, Ann Arbor, Michigan 48109-0678, USA.

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http://dx.doi.org/10.1074/jbc.M111.242099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143595PMC
July 2011

Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.

Endocrinology 2011 Jul 3;152(7):2599-608. Epub 2011 May 3.

Institute for Diabetes, Obesity, and Metabolism and Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 726, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1210/en.2010-1420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115612PMC
July 2011

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.

Trends Endocrinol Metab 2010 Nov 18;21(11):652-9. Epub 2010 Aug 18.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.tem.2010.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967602PMC
November 2010

Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible arm that is dispensable in the mature hormone.

J Biol Chem 2010 Oct 27;285(40):30989-1001. Epub 2010 Jul 27.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M110.152645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945590PMC
October 2010

Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer.

J Biol Chem 2010 Jun 30;285(23):17564-73. Epub 2010 Mar 30.

Division of Metabolism, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0678, USA.

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http://dx.doi.org/10.1074/jbc.M110.111641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878521PMC
June 2010

Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.

J Biol Chem 2010 Jan 30;285(1):685-94. Epub 2009 Oct 30.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0678, USA.

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http://dx.doi.org/10.1074/jbc.M109.038042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804216PMC
January 2010

Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity.

J Biol Chem 2009 Dec 22;284(50):35259-72. Epub 2009 Oct 22.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M109.046888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787385PMC
December 2009

Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

PLoS Genet 2009 Oct 16;5(10):e1000691. Epub 2009 Oct 16.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757901PMC
October 2009

Single-chain insulins as receptor agonists.

Mol Endocrinol 2009 May 19;23(5):679-88. Epub 2009 Feb 19.

Cell and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1210/me.2008-0349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675957PMC
May 2009

The cholinesterase-like domain, essential in thyroglobulin trafficking for thyroid hormone synthesis, is required for protein dimerization.

J Biol Chem 2009 May 9;284(19):12752-61. Epub 2009 Mar 9.

Cell and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676005PMC
May 2009

Secretory protein trafficking: genetic and biochemical analysis.

Authors:
Peter Arvan

Cell Biochem Biophys 2004 ;40(3 Suppl):169-78

Divisions of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.

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April 2009

The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone.

J Clin Invest 2008 Aug;118(8):2950-8

Division of Metabolism, Endocrinology and Diabetes and Program of Cellular and Molecular Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0678, USA.

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http://www.jci.org/articles/view/35164
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http://dx.doi.org/10.1172/JCI35164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441857PMC
August 2008

Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK.

J Biol Chem 2008 Jun 21;283(25):17020-9. Epub 2008 Apr 21.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M802466200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427336PMC
June 2008

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus.

J Clin Invest 2008 Jun;118(6):2148-56

Laboratory of Molecular Endocrinology and Metabolism, Bambino Gesù Children's Hospital, Scientific Institute and Department of Internal Medicine, University of Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1172/JCI33777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350430PMC
June 2008

Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter.

Mol Endocrinol 2008 Feb 4;22(2):477-84. Epub 2007 Oct 4.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1210/me.2007-0183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725791PMC
February 2008

Structural features of vps35p involved in interaction with other subunits of the retromer complex.

Traffic 2007 Dec 17;8(12):1841-53. Epub 2007 Oct 17.

Division of Biological Sciences, 401 Tucker Hall, University of Missouri, Columbia, MO 65211, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2007.00659.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504507PMC
December 2007

Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.

Traffic 2007 Dec 17;8(12):1829-40. Epub 2007 Oct 17.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan, 5560 MSRB2, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA.

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http://doi.wiley.com/10.1111/j.1600-0854.2007.00658.x
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532708PMC
December 2007

Proinsulin maturation, misfolding, and proteotoxicity.

Proc Natl Acad Sci U S A 2007 Oct 26;104(40):15841-6. Epub 2007 Sep 26.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.0702697104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000385PMC
October 2007

Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.

J Biol Chem 2007 Mar 2;282(9):6183-91. Epub 2007 Jan 2.

Program in Cell and Molecular Biology and Division of Endocrinology, University of Cincinnati, Ohio 45267, USA.

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http://dx.doi.org/10.1074/jbc.M608863200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542443PMC
March 2007

A role for Lte1p (a low temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway.

J Biol Chem 2007 Jan 22;282(3):1670-8. Epub 2006 Nov 22.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M610500200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533109PMC
January 2007

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.

J Biol Chem 2006 Aug 25;281(34):24889-99. Epub 2006 May 25.

Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106-4935.

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http://dx.doi.org/10.1074/jbc.M602617200DOI Listing
August 2006

Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation.

J Cell Biol 2006 Jun;173(6):853-9

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1083/jcb.200602046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063911PMC
June 2006

Lumenal protein sorting to the constitutive secretory pathway of a regulated secretory cell.

J Cell Sci 2006 May 11;119(Pt 9):1833-42. Epub 2006 Apr 11.

Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1242/jcs.02905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547412PMC
May 2006

Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.

Mol Cell Biol 2005 Nov;25(22):9793-805

Laboratorio di Patologia Generale, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Facoltà di Scienze MFN, Università degli Studi di Lecce, Centro Ecotekne, Lecce, Italy.

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http://dx.doi.org/10.1128/MCB.25.22.9793-9805.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280251PMC
November 2005

Intracellular trafficking of thyroid peroxidase to the cell surface.

J Biol Chem 2005 Jul 24;280(30):27713-8. Epub 2005 May 24.

Division of Endocrinology and Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M503804200DOI Listing
July 2005

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum.

J Biol Chem 2005 Apr 10;280(14):13209-12. Epub 2005 Feb 10.

Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.C400475200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527538PMC
April 2005

Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.

Mol Biol Cell 2004 Apr 23;15(4):1690-701. Epub 2004 Jan 23.

Division of Endocrinology and Department of Developmental/Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1091/mbc.e03-08-0554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379267PMC
April 2004

The acetylcholinesterase homology region is essential for normal conformational maturation and secretion of thyroglobulin.

J Biol Chem 2004 Apr 5;279(17):17085-9. Epub 2004 Feb 5.

Division of Metabolism, Endocrinology, and Diabetes and the Program of Cellular and Molecular Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M314042200DOI Listing
April 2004

Sorting ourselves out: seeking consensus on trafficking in the beta-cell.

Traffic 2004 Jan;5(1):53-61

Division of Metabolism, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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January 2004

The trafficking of alpha 1-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cells.

J Biol Chem 2003 Aug 7;278(34):31486-94. Epub 2003 Jun 7.

Division of Endocrinology and Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M305690200DOI Listing
August 2003

Role of the connecting peptide in insulin biosynthesis.

J Biol Chem 2003 Apr 14;278(17):14798-805. Epub 2003 Feb 14.

Diabetes Research and Training Center and the Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M212070200DOI Listing
April 2003

Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.

J Biol Chem 2003 Feb 21;278(6):3687-93. Epub 2002 Nov 21.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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February 2003