Peter A Jones

Peter A Jones

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Peter A Jones

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Epigenetic therapy in immune-oncology.

Nat Rev Cancer 2019 03;19(3):151-161

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41568-019-0109-9DOI Listing
March 2019

Mother-child transmission of epigenetic information by tunable polymorphic imprinting.

Proc Natl Acad Sci U S A 2018 12 3;115(51):E11970-E11977. Epub 2018 Dec 3.

Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503;

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http://dx.doi.org/10.1073/pnas.1815005115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304996PMC
December 2018

Vitamin C - A new player in regulation of the cancer epigenome.

Semin Cancer Biol 2018 08 2;51:59-67. Epub 2017 Nov 2.

Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Biotech Research and Innovation Centre (BRIC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.11.001DOI Listing
August 2018

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses.

Genome Res 2018 08 3;28(8):1147-1157. Epub 2018 Jul 3.

Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

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http://dx.doi.org/10.1101/gr.234229.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071641PMC
August 2018

Nucleosome Occupancy and Methylome Sequencing (NOMe-seq).

Methods Mol Biol 2018 ;1708:267-284

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7481-8_14DOI Listing
July 2018

Epigenetic landscape change analysis during human EMT sheds light on a key EMT mediator TRIM29.

Oncotarget 2017 Nov 9;8(58):98322-98335. Epub 2017 Oct 9.

Department of Biochemistry, School of Medicine, Konkuk University, Seoul, Korea.

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http://dx.doi.org/10.18632/oncotarget.21681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716732PMC
November 2017

Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells.

Cancer Lett 2017 08 6;401:11-19. Epub 2017 May 6.

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645058PMC
August 2017

Nucleosome Positioning and NDR Structure at RNA Polymerase III Promoters.

Sci Rep 2017 02 8;7:41947. Epub 2017 Feb 8.

Department of Hematology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.

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http://dx.doi.org/10.1038/srep41947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296907PMC
February 2017

Epigenetic Determinants of Cancer.

Cold Spring Harb Perspect Biol 2016 Sep 1;8(9). Epub 2016 Sep 1.

Van Andel Research Institute, Grand Rapids, Michigan 49503.

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http://dx.doi.org/10.1101/cshperspect.a019505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008069PMC
September 2016

Targeting the cancer epigenome for therapy.

Nat Rev Genet 2016 09;17(10):630-41

Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

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http://dx.doi.org/10.1038/nrg.2016.93DOI Listing
September 2016

Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers.

Mol Cell 2016 05;62(3):422-431

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Biochemistry & Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Van Andel Research Institute, Grand Rapids, MI 49503, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765163001
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http://dx.doi.org/10.1016/j.molcel.2016.03.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859934PMC
May 2016

DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells.

Nat Commun 2016 04 28;7:11453. Epub 2016 Apr 28.

Department of Urology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.

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http://www.nature.com/articles/ncomms11453
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http://dx.doi.org/10.1038/ncomms11453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853477PMC
April 2016

The role of DNA methylation in directing the functional organization of the cancer epigenome.

Genome Res 2015 Apr 6;25(4):467-77. Epub 2015 Mar 6.

USC Epigenome Center, University of Southern California, Los Angeles, California 90033, USA; Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA

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http://dx.doi.org/10.1101/gr.183368.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381519PMC
April 2015

Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines.

Genom Data 2015 Mar 8;3:94-6. Epub 2014 Dec 8.

Epigenetics Research Program, Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia ; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales Australia, Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.gdata.2014.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535833PMC
March 2015

Gene body methylation can alter gene expression and is a therapeutic target in cancer.

Cancer Cell 2014 Oct 25;26(4):577-90. Epub 2014 Sep 25.

Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224113PMC
October 2014

Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer.

Genome Res 2014 Sep 10;24(9):1421-32. Epub 2014 Jun 10.

Departments of Biochemistry and Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA; Van Andel Research Institute, Grand Rapids, Michigan 49503, USA

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http://dx.doi.org/10.1101/gr.163485.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158760PMC
September 2014

Reprogramming of the human intestinal epigenome by surgical tissue transposition.

Genome Res 2014 Apr 10;24(4):545-53. Epub 2014 Feb 10.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA;

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http://dx.doi.org/10.1101/gr.166439.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975055PMC
April 2014

A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence.

Clin Cancer Res 2014 Apr;20(7):1978-89

Authors' Affiliations: Departments of Urology and Preventive Medicine; Program in Genetic, Molecular, and Cellular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles; and Department of Urology, School of Medicine, University of Stanford, Stanford, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2637DOI Listing
April 2014

Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression.

Nucleic Acids Res 2014 Feb 27;42(4):2245-56. Epub 2013 Nov 27.

Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 406-840, Republic of Korea, Departments of Urology and Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA, Department of Biochemistry, School of Medicine, Konkuk University, Seoul 143-701, Republic of Korea and Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9176, USA.

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http://dx.doi.org/10.1093/nar/gkt1236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936730PMC
February 2014

At the tipping point for epigenetic therapies in cancer.

Authors:
Peter A Jones

J Clin Invest 2014 Jan 2;124(1):14-6. Epub 2014 Jan 2.

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http://dx.doi.org/10.1172/JCI74145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871262PMC
January 2014

How long will I be blue? Prolonged skin staining following sentinel lymph node biopsy using intradermal patent blue dye.

Breast Care (Basel) 2013 Jun;8(3):199-202

Department of Radiology, Maidstone Hospital, Hermitage Lane, Maidstone, United Kingdom.

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http://dx.doi.org/10.1159/000352092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728719PMC
June 2013

Functional DNA demethylation is accompanied by chromatin accessibility.

Nucleic Acids Res 2013 Apr 13;41(7):3973-85. Epub 2013 Feb 13.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 USA.

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http://dx.doi.org/10.1093/nar/gkt077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627572PMC
April 2013

SNF5 is an essential executor of epigenetic regulation during differentiation.

PLoS Genet 2013 Apr 25;9(4):e1003459. Epub 2013 Apr 25.

Departments of Urology and Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636213PMC
April 2013

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules.

Genome Res 2012 Dec 7;22(12):2497-506. Epub 2012 Sep 7.

Department of Urology, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.143008.112
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http://dx.doi.org/10.1101/gr.143008.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514679PMC
December 2012

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

Cancer Res 2012 Dec 27;72(24):6319-24. Epub 2012 Nov 27.

Research Department of Cancer Biology, University College London Cancer Institute, University College London, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-3658DOI Listing
December 2012

Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions.

PLoS Genet 2012 29;8(3):e1002604. Epub 2012 Mar 29.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315468PMC
September 2012

Preoperative needle biopsy of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced ultrasound in patients with breast cancer.

AJR Am J Roentgenol 2012 Aug;199(2):465-70

Department of Radiology, Maidstone Hospital, Hermitage Ln, Maidstone ME16 9QQ, United Kingdom.

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http://dx.doi.org/10.2214/AJR.11.7702DOI Listing
August 2012

Cancer genetics and epigenetics: two sides of the same coin?

Cancer Cell 2012 Jul;22(1):9-20

Department of Urology, USC Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108120025
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http://dx.doi.org/10.1016/j.ccr.2012.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396881PMC
July 2012

DNA methylation screening identifies driver epigenetic events of cancer cell survival.

Cancer Cell 2012 May;21(5):655-67

Department of Urology, Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.03.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395886PMC
May 2012

Functions of DNA methylation: islands, start sites, gene bodies and beyond.

Authors:
Peter A Jones

Nat Rev Genet 2012 May 29;13(7):484-92. Epub 2012 May 29.

USC Norris Comprehensive Cancer Center, Keck School of Medicine of University of Southern California, Los Angeles, California 90089-99176, USA.

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http://dx.doi.org/10.1038/nrg3230DOI Listing
May 2012

Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells.

Epigenetics Chromatin 2012 Jan 27;5(1). Epub 2012 Jan 27.

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1186/1756-8935-5-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292817PMC
January 2012

Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells.

Mol Cell Biol 2011 Dec 3;31(23):4648-62. Epub 2011 Oct 3.

Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.05934-11
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http://dx.doi.org/10.1128/MCB.05934-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232925PMC
December 2011

Polycomb-repressed genes have permissive enhancers that initiate reprogramming.

Cell 2011 Dec;147(6):1283-94

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.cell.2011.10.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240866PMC
December 2011

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter.

Hum Mol Genet 2011 Nov 11;20(22):4299-310. Epub 2011 Aug 11.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1093/hmg/ddr356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196883PMC
November 2011

A decade of exploring the cancer epigenome - biological and translational implications.

Nat Rev Cancer 2011 Sep 23;11(10):726-34. Epub 2011 Sep 23.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://www.nature.com/articles/nrc3130
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http://dx.doi.org/10.1038/nrc3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307543PMC
September 2011

OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes.

Proc Natl Acad Sci U S A 2011 Aug 15;108(35):14497-502. Epub 2011 Aug 15.

Department of Urology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1073/pnas.1111309108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167525PMC
August 2011

Preoperative sentinel node identification with ultrasound using microbubbles in patients with breast cancer.

AJR Am J Roentgenol 2011 Feb;196(2):251-6

Department of Radiology, Maidstone Hospital, Hermitage Ln., ME16 9QQ, Maidstone, United Kingdom.

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http://dx.doi.org/10.2214/AJR.10.4865DOI Listing
February 2011

Role of nucleosomes in mitotic bookmarking.

Cell Cycle 2011 Feb 1;10(3):370-1. Epub 2011 Feb 1.

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http://dx.doi.org/10.4161/cc.10.3.14734DOI Listing
February 2011

Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.

PLoS Genet 2011 Feb 3;7(2):e1001286. Epub 2011 Feb 3.

Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1001286
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http://dx.doi.org/10.1371/journal.pgen.1001286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033376PMC
February 2011

DNA methylation and cancer.

Prog Drug Res 2011 ;67:1-23

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1007/978-3-7643-8989-5_1DOI Listing
January 2011

Patch clamp recording from enteric neurons in situ.

Nat Protoc 2011 Jan;6(1):15-27

Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.1038/nprot.2010.172DOI Listing
January 2011

Targeting DNA methylation for epigenetic therapy.

Trends Pharmacol Sci 2010 Nov 16;31(11):536-46. Epub 2010 Sep 16.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.tips.2010.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967479PMC
November 2010

DNA methylation and cellular reprogramming.

Trends Cell Biol 2010 Oct 31;20(10):609-17. Epub 2010 Aug 31.

Department of Urology, University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096289241000153
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http://dx.doi.org/10.1016/j.tcb.2010.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981432PMC
October 2010

Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue.

Cancer Res 2010 Oct 14;70(20):8169-78. Epub 2010 Sep 14.

Department of Urology, USC Epigenome Center, and Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90089, USA.

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http://cancerres.aacrjournals.org/content/early/2010/10/07/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-1335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955801PMC
October 2010

Epigenetic modifications as therapeutic targets.

Nat Biotechnol 2010 Oct;28(10):1069-78

Departments of Urology and Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://www.nature.com/articles/nbt.1678
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http://dx.doi.org/10.1038/nbt.1678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022972PMC
October 2010

H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes.

Mol Cell 2010 Sep;39(6):901-11

Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947862PMC
September 2010

Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome.

PLoS One 2010 Sep 29;5(9). Epub 2010 Sep 29.

Department of Biochemistry and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012994PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947512PMC
September 2010

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth.

Mol Cancer Ther 2010 May 4;9(5):1443-50. Epub 2010 May 4.

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-1048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868087PMC
May 2010

Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer.

PLoS Genet 2010 Apr 22;6(4):e1000917. Epub 2010 Apr 22.

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1000917
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http://dx.doi.org/10.1371/journal.pgen.1000917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858672PMC
April 2010

Epigenetics in cancer.

Carcinogenesis 2010 Jan 13;31(1):27-36. Epub 2009 Sep 13.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1093/carcin/bgp220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802667PMC
January 2010

Methylation-sensitive single-molecule analysis of chromatin structure.

Curr Protoc Mol Biol 2010 Jan;Chapter 21:Unit 21.17.1-16

Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/0471142727.mb2117s89DOI Listing
January 2010

Rethinking how DNA methylation patterns are maintained.

Nat Rev Genet 2009 11 30;10(11):805-11. Epub 2009 Sep 30.

Peter A. Jones and Gangning Liang are at the Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9181, USA.

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http://dx.doi.org/10.1038/nrg2651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848124PMC
November 2009

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.

Mol Cell Biol 2009 Oct 20;29(19):5366-76. Epub 2009 Jul 20.

Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center Keck School of Medicine, University of Southern California, NOR 8302L, 9181, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1128/MCB.00484-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747980PMC
October 2009

Analysis of individual remodeled nucleosomes reveals decreased histone-DNA contacts created by hSWI/SNF.

Nucleic Acids Res 2009 Sep 30;37(16):5279-94. Epub 2009 Jun 30.

Department of Molecular Biology & Genetics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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https://nar.oxfordjournals.org/content/37/16/5279.full-text-
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkp524
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http://dx.doi.org/10.1093/nar/gkp524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760786PMC
September 2009

Emergency Department utilisation: a natural experiment.

N Z Med J 2009 Sep 11;122(1302):29-39. Epub 2009 Sep 11.

Department of Emergency Medicine, Auckland City Hospital, Auckland Mail Centre, Auckland, New Zealand.

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September 2009

MicroRNAs: critical mediators of differentiation, development and disease.

Swiss Med Wkly 2009 Aug;139(33-34):466-72

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/smw-12794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854010PMC
August 2009

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

Mol Cancer Ther 2009 Jun 9;8(6):1579-88. Epub 2009 Jun 9.

Department of Urology, USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186068PMC
June 2009

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

Cancer Res 2009 Mar 3;69(6):2623-9. Epub 2009 Mar 3.

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3114DOI Listing
March 2009

Molecular targets and targeted therapies in bladder cancer management.

World J Urol 2009 Feb 28;27(1):9-20. Epub 2008 Nov 28.

Departments of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1007/s00345-008-0357-xDOI Listing
February 2009

Chromatin, cancer and drug therapies.

Mutat Res 2008 Dec 22;647(1-2):44-51. Epub 2008 Jul 22.

Department of Urology, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2008.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631123PMC
December 2008

Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine.

J Med Chem 2008 Dec;51(23):7593-601

Department of Biochemistry, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1021/jm8005965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659950PMC
December 2008

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

Proc Natl Acad Sci U S A 2008 Sep 27;105(35):12979-84. Epub 2008 Aug 27.

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1073/pnas.0806437105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529074PMC
September 2008

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

Cancer Prev Res (Phila) 2008 Sep 19;1(4):233-40. Epub 2008 Mar 19.

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9181, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-07-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959547PMC
September 2008

DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight.

Nucleic Acids Res 2008 Aug 15;36(14):4689-98. Epub 2008 Jul 15.

Department of Surgery, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1093/nar/gkn455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504308PMC
August 2008

RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking.

Cancer Res 2008 Aug;68(15):6208-14

Department of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536768PMC
August 2008

Cancer epigenetics: modifications, screening, and therapy.

Annu Rev Med 2008 ;59:267-80

Department of Urology, Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles 90089, USA.

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http://www.med.upenn.edu/timm/documents/annurev.med.59.06160
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http://www.annualreviews.org/doi/abs/10.1146/annurev.med.59.
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http://dx.doi.org/10.1146/annurev.med.59.061606.095816DOI Listing
May 2008

DNA methylation: the nuts and bolts of repression.

J Cell Physiol 2007 Nov;213(2):384-90

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

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http://dx.doi.org/10.1002/jcp.21224DOI Listing
November 2007

Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.

Cancer Cell 2007 Nov;12(5):432-44

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657456PMC
November 2007

Epigenetic changes in cancer.

APMIS 2007 Oct;115(10):1039-59

Department of Hematology, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/j.1600-0463.2007.apm_636.xml.xDOI Listing
October 2007

Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides.

Cancer Res 2007 Jul;67(13):6400-8

Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0251DOI Listing
July 2007

Epigenetics and microRNAs.

Pediatr Res 2007 May;61(5 Pt 2):24R-29R

Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089, USA.

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http://www.nature.com/doifinder/10.1203/pdr.0b013e3180457684
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http://dx.doi.org/10.1203/pdr.0b013e3180457684DOI Listing
May 2007

The epigenomics of cancer.

Cell 2007 Feb;128(4):683-92

Department of Urology, Biochemistry, and Molecular Biology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1016/j.cell.2007.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894624PMC
February 2007

Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment.

Cancer Res 2007 Jan;67(1):346-53

Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2845DOI Listing
January 2007

Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells.

Blood 2006 Oct 20;108(7):2143-9. Epub 2006 Jun 20.

Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Rm 7341, Los Angeles, CA 90089-9181, USA.

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http://dx.doi.org/10.1182/blood-2006-01-021147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895553PMC
October 2006

Epigenetic activation of tumor suppressor microRNAs in human cancer cells.

Cell Cycle 2006 Oct 1;5(19):2220-2. Epub 2006 Oct 1.

Department of Urology, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.4161/cc.5.19.3340DOI Listing
October 2006

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.

Proc Natl Acad Sci U S A 2006 Sep 8;103(38):14080-5. Epub 2006 Sep 8.

Norris Comprehensive Cancer Center, Departments of Urology and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1073/pnas.0604602103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1599915PMC
September 2006

Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting.

PLoS Genet 2006 Sep;2(9):e160

Department of Urology, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.0020160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574359PMC
September 2006

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.

Cancer Cell 2006 Jun;9(6):435-43

Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.04.020DOI Listing
June 2006