Peter A Gottlieb

Peter A Gottlieb

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Peter A Gottlieb

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Clinical trial data validate the C-peptide estimate model in type 1 diabetes.

Diabetologia 2020 Jan 26. Epub 2020 Jan 26.

Department of Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1007/s00125-020-05088-6DOI Listing
January 2020

Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes.

Diabetes 2019 Sep 7;68(9):1830-1840. Epub 2019 Jun 7.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO

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http://dx.doi.org/10.2337/db19-0128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702640PMC
September 2019

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.

N Engl J Med 2019 08 9;381(7):603-613. Epub 2019 Jun 9.

From the Departments of Immunobiology and Internal Medicine, Yale University, New Haven, CT (K.C.H.); the Departments of Epidemiology and Pediatrics, University of South Florida, Tampa (B.N.B., J.P.K., H.R.), the Department of Medicine, University of Miami, Miami (J.B.M., J.S.S.), and the Department of Pediatrics, University of Florida, Gainesville (D.S.) - all in Florida; Benaroya Research Institute, Seattle (S.A.L., M.J.D., P.S.L., C.J.G.); the Diabetes Center, University of California at San Francisco, San Francisco (J.A.B., S.E.G.); the Department of Pediatrics, Indiana University, Indianapolis (L.A.D.); the Barbara Davis Diabetes Center, University of Colorado, Anschultz (P.A.G.); Children's Mercy Hospital, Kansas City, MO (W.M.); the Department of Pediatrics, University of Minnesota, Minneapolis (A.M.); the Department of Pediatrics and Cell and Developmental Biology, Vanderbilt University, Nashville (W.E.R.); the Department of Pediatrics, University of Iowa, Iowa City (E.T.); the Hospital for Sick Children, University of Toronto, Toronto (D.K.W.); and Forschergruppe Diabetes, Technical University Munich, at Klinikum rechts der Isar, Munich, Germany (A.-G.Z.).

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http://dx.doi.org/10.1056/NEJMoa1902226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776880PMC
August 2019

Biomarker discovery in pre-Type 1 Diabetes; Th40 cells as a predictive risk factor.

J Clin Endocrinol Metab 2019 May 7. Epub 2019 May 7.

Webb-Waring Center, University of Colorado Anschutz Medical Campus, E Montview Boulevard, Aurora, CO, USA.

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http://dx.doi.org/10.1210/jc.2019-00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685715PMC
May 2019

Rationally designed small molecules to prevent type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2019 04;26(2):90-95

Departments of Pediatrics and Medicine, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1097/MED.0000000000000470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764771PMC
April 2019

Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1172/jci.insight.123384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413793PMC
February 2019

Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes.

Diabetes Care 2018 10 12;41(10):2178-2186. Epub 2018 Aug 12.

The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia

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http://dx.doi.org/10.2337/dc18-0777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150433PMC
October 2018

Learning From Past Failures of Oral Insulin Trials.

Diabetes 2018 07;67(7):1211-1215

Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO.

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http://dx.doi.org/10.2337/dbi17-0043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014551PMC
July 2018

Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.

J Autoimmun 2018 05 9;89:82-89. Epub 2017 Dec 9.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902436PMC
May 2018

Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.

Diabetes 2018 04 17;67(4):697-703. Epub 2018 Jan 17.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO

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http://dx.doi.org/10.2337/db17-0937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860860PMC
April 2018

Predominance of DR3 in Somali children with type 1 diabetes in the twin cities, Minnesota.

Pediatr Diabetes 2017 03 8;18(2):136-142. Epub 2016 Feb 8.

Department of Pediatric Endocrinology, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.

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http://dx.doi.org/10.1111/pedi.12369DOI Listing
March 2017

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function.

J Vis Exp 2017 02 16(120). Epub 2017 Feb 16.

Department of Immunology and Microbiology, University of Colorado School of Medicine; Department of Biomedical Research, National Jewish Health;

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http://dx.doi.org/10.3791/55382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409333PMC
February 2017

Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes.

Curr Diab Rep 2016 10;16(10):97

Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s11892-016-0793-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733031PMC
October 2016

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes.

Diabetes 2015 Oct 11;64(10):3510-20. Epub 2015 Jun 11.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO

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http://dx.doi.org/10.2337/db14-1847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587635PMC
October 2015

Screening and Monitoring for Infectious Complications When Immunosuppressive Agents Are Studied in the Treatment of Autoimmune Disorders.

J Pediatric Infect Dis Soc 2015 Sep 26;4(3):198-204. Epub 2014 Jun 26.

Brigham and Women's Hospital/Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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https://academic.oup.com/jpids/article-lookup/doi/10.1093/jp
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http://dx.doi.org/10.1093/jpids/piu055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554203PMC
September 2015

What defines disease in an age of genetics and biomarkers?

Authors:
Peter A Gottlieb

Curr Opin Endocrinol Diabetes Obes 2015 Aug;22(4):296-9

Pediatrics and Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA.

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http://dx.doi.org/10.1097/MED.0000000000000172DOI Listing
August 2015

α1-Antitrypsin therapy downregulates toll-like receptor-induced IL-1β responses in monocytes and myeloid dendritic cells and may improve islet function in recently diagnosed patients with type 1 diabetes.

J Clin Endocrinol Metab 2014 Aug 14;99(8):E1418-26. Epub 2014 Feb 14.

Barbara Davis Center for Childhood Diabetes (P.A.G., A.K.A., A.W.M., D.Z.) and Division of Infectious Diseases (C.A.D.), University of Colorado Denver, Aurora, Colorado 80045; Department of Clinical Biochemistry and Pharmacology (E.C.L.), Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105 Beer-Sheva, Israel; and Department of Medicine (L.S.), Division of Infectious Diseases, Veterans Affairs Medical Center and University of Colorado Denver, Denver, Colorado 80202.

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http://dx.doi.org/10.1210/jc.2013-3864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121034PMC
August 2014

Chromogranin A is a T cell antigen in human type 1 diabetes.

J Autoimmun 2014 May 13;50:38-41. Epub 2013 Nov 13.

Integrated Department of Immunology, University of Colorado at Denver School of Medicine and National Jewish Health, 1400 Jackson Street, Denver, CO 80205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2013.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995825PMC
May 2014

Dysregulated Toll-like receptor-induced interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes.

Diabetes 2012 Oct 29;61(10):2525-33. Epub 2012 Jun 29.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.2337/db12-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447890PMC
October 2012

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

J Immunol 2011 Dec 31;187(11):5921-30. Epub 2011 Oct 31.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.4049/jimmunol.1100746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221928PMC
December 2011

Dominant suppression of Addison's disease associated with HLA-B15.

J Clin Endocrinol Metab 2011 Jul 11;96(7):2154-62. Epub 2011 May 11.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045-6511, USA.

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http://dx.doi.org/10.1210/jc.2010-2964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135206PMC
July 2011

Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.

J Immunol 2011 May 6;186(10):6056-63. Epub 2011 Apr 6.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.4049/jimmunol.1003815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088514PMC
May 2011

Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes.

Diabetes Care 2011 Feb 26;34(2):454-8. Epub 2010 Oct 26.

Colorado School of Public Health, University of Colorado, Denver, Colorado, USA.

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http://dx.doi.org/10.2337/dc10-0757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024366PMC
February 2011

Altered Toll-like receptor signaling pathways in human type 1 diabetes.

J Mol Med (Berl) 2010 Dec 20;88(12):1221-31. Epub 2010 Aug 20.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct., Mail Stop B-140, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1007/s00109-010-0666-6DOI Listing
December 2010

Editorial: cystic fibrosis.

Authors:
Peter A Gottlieb

Curr Opin Endocrinol Diabetes Obes 2010 Aug;17(4):313

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http://dx.doi.org/10.1097/MED.0b013e32833c2ffdDOI Listing
August 2010

Autoimmune polyglandular syndromes.

Nat Rev Endocrinol 2010 May 23;6(5):270-7. Epub 2010 Mar 23.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Court, MS B140, PO Box 6511, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1038/nrendo.2010.40DOI Listing
May 2010

Time lag characterization of two continuous glucose monitoring systems.

Diabetes Res Clin Pract 2010 Mar;87(3):348-53

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, School of Medicine, Aurora, CO 80045, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S016882270900485
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http://dx.doi.org/10.1016/j.diabres.2009.11.014DOI Listing
March 2010

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells.

J Immunol 2009 Oct 11;183(7):4432-9. Epub 2009 Sep 11.

Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.jimmunol.org/content/183/7/4432.full.pdf
Web Search
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0900576
Publisher Site
http://dx.doi.org/10.4049/jimmunol.0900576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770506PMC
October 2009

Comparison of accuracy and safety of the SEVEN and the Navigator continuous glucose monitoring systems.

Diabetes Technol Ther 2009 Feb;11(2):65-72

Barbara Davis Center for Childhood Diabetes, School of Medicine, University of Colorado at Denver, Aurora, Colorado 80045, USA.

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http://www.liebertpub.com/doi/10.1089/dia.2008.0109
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http://dx.doi.org/10.1089/dia.2008.0109DOI Listing
February 2009

Improved glycemic control in intensively treated adult subjects with type 1 diabetes using insulin guidance software.

Diabetes Technol Ther 2008 Oct;10(5):369-75

Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1089/dia.2007.0303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979335PMC
October 2008

Continuous home monitoring of glucose: improved glycemic control with real-life use of continuous glucose sensors in adult subjects with type 1 diabetes.

Diabetes Care 2007 Dec 11;30(12):3023-5. Epub 2007 Sep 11.

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado, USA.

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http://care.diabetesjournals.org/cgi/doi/10.2337/dc07-1436
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http://dx.doi.org/10.2337/dc07-1436DOI Listing
December 2007

Type 1 diabetes intervention trials 2007: where are we and where are we going?

Curr Opin Endocrinol Diabetes Obes 2007 Aug;14(4):283-7

Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1097/MED.0b013e32825a673bDOI Listing
August 2007

Autoantibody "subspecificity" in type 1 diabetes: risk for organ-specific autoimmunity clusters in distinct groups.

Diabetes Care 2005 Apr;28(4):850-5

Barbara Davis Center, University of Colorado Health Sciences Center, 4200 E. 9th Ave., B140, Denver, CO 80262, USA.

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http://dx.doi.org/10.2337/diacare.28.4.850DOI Listing
April 2005

In vitro and in vivo approaches to prevention and cure of T1D.

Authors:
Peter A Gottlieb

Curr Diab Rep 2005 Apr;5(2):77-8

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA.

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http://dx.doi.org/10.1007/s11892-005-0030-3DOI Listing
April 2005

Optimizing insulin therapy in pregnant women with type 1 diabetes mellitus.

Treat Endocrinol 2002 ;1(4):235-40

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.2165/00024677-200201040-00005DOI Listing
April 2005

Inflammatory markers and diabetic retinopathy in type 1 diabetes.

Diabetes Care 2005 Mar;28(3):714-5

Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Ave., Box B-140, Denver, CO, USA.

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http://dx.doi.org/10.2337/diacare.28.3.714DOI Listing
March 2005

Secondary attack rate of type 1 diabetes in Colorado families.

Diabetes Care 2005 Feb;28(2):296-300

Barbara Davis Center for Childhood Diabetes University of Colorado Health Sciences Center, 4200 East 9th Ave., Box B-140, Denver, CO 80262, USA.

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http://dx.doi.org/10.2337/diacare.28.2.296DOI Listing
February 2005

CD4+CD25high regulatory T cells in human autoimmune diabetes.

J Autoimmun 2005 Feb 12;24(1):55-62. Epub 2005 Jan 12.

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO, USA.

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http://dx.doi.org/10.1016/j.jaut.2004.11.004DOI Listing
February 2005

Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population.

J Clin Endocrinol Metab 2005 Jan 13;90(1):128-34. Epub 2004 Oct 13.

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B-140, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1210/jc.2004-0874DOI Listing
January 2005

Reduced severe hypoglycemia with insulin glargine in intensively treated adults with type 1 diabetes.

Diabetes Technol Ther 2004 Oct;6(5):589-95

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://www.liebertpub.com/doi/10.1089/dia.2004.6.589
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http://dx.doi.org/10.1089/dia.2004.6.589DOI Listing
October 2004

Insulin lispro therapy in pregnancies complicated by type 1 diabetes: glycemic control and maternal and fetal outcomes.

Endocr Pract 2003 May-Jun;9(3):187-93

Department of Medicine, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.

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http://dx.doi.org/10.4158/EP.9.3.187DOI Listing
May 2004

Autoimmune polyendocrine syndromes.

N Engl J Med 2004 May;350(20):2068-79

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://www.nejm.org/doi/abs/10.1056/NEJMra030158
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http://dx.doi.org/10.1056/NEJMra030158DOI Listing
May 2004

HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

J Immunol 2004 Mar;172(6):3955-62

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B-140, Denver, CO 80262, USA.

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http://dx.doi.org/10.4049/jimmunol.172.6.3955DOI Listing
March 2004

Prediabetes: prediction and prevention trials.

Endocrinol Metab Clin North Am 2004 Mar;33(1):75-92, ix

Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B-140, Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/j.ecl.2003.12.006DOI Listing
March 2004

Type 1 diabetes.

Authors:
Peter A Gottlieb

Endocrinol Metab Clin North Am 2004 Mar;33(1):xiii-xiv

Departments of Pediatrics and Medicine, Barbara Davis Center for Childhood Diseases, University of Colorado Health Science Center, 4200 East 9th Avenue, Box B-140, Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/j.ecl.2003.12.002DOI Listing
March 2004

Glycemic parameters with multiple daily injections using insulin glargine versus insulin pump.

Diabetes Technol Ther 2004 Feb;6(1):9-15

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://www.liebertpub.com/doi/10.1089/152091504322783350
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http://dx.doi.org/10.1089/152091504322783350DOI Listing
February 2004

Testing the NKT cell hypothesis of human IDDM pathogenesis.

J Clin Invest 2002 Sep;110(6):793-800

Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1172/JCI15832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151131PMC
September 2002

The genetics of autoimmune polyendocrine syndrome type II.

Endocrinol Metab Clin North Am 2002 Jun;31(2):353-68, vi-vii

Medical Scientist Training Program, Department of Immunology, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave., Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/s0889-8529(01)00015-9DOI Listing
June 2002

Cytokine and immunosuppressive therapies of type 1 diabetes mellitus.

Endocrinol Metab Clin North Am 2002 Jun;31(2):477-95

Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave., Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/s0889-8529(01)00020-2DOI Listing
June 2002

Insulin-specific tolerance in diabetes.

Clin Immunol 2002 Jan;102(1):2-11

Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1006/clim.2001.5142DOI Listing
January 2002