Percio S Gulko

Percio S Gulko

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Percio S Gulko

Percio S Gulko

Publications by authors named "Percio S Gulko"

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Computational deconvolution of synovial tissue cellular composition: presence of adipocytes in synovial tissue decreased during arthritis pathogenesis and progression.

Physiol Genomics 2019 06 17;51(6):241-253. Epub 2019 May 17.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai , New York, New York.

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http://dx.doi.org/10.1152/physiolgenomics.00009.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620645PMC
June 2019

TRPV2 suppresses Rac1 and RhoA activation and invasion in rheumatoid arthritis fibroblast-like synoviocytes.

Int Immunopharmacol 2019 May 6;70:268-273. Epub 2019 Mar 6.

Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2019.02.051DOI Listing
May 2019

Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling.

Ann Rheum Dis 2018 11 26;77(11):1627-1635. Epub 2018 Jul 26.

Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.

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http://dx.doi.org/10.1136/annrheumdis-2018-213498DOI Listing
November 2018

Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis.

J Pharmacol Exp Ther 2018 05 16;365(2):227-236. Epub 2018 Feb 16.

Department of Molecular Physiology and Biophysics (M.R.T., B.H.C., R.H., E.J.G., C.B.), Interdepartmental Graduate Program in Translational Biology and Molecular Medicine (M.R.T.), and Biology of Inflammation Center and Center for Drug Discovery (C.B.), Baylor College of Medicine, Houston, Texas; Peptides International Inc., Louisville, Kentucky (M.W.P.); and Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York (T.L., P.S.G.)

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http://dx.doi.org/10.1124/jpet.117.245118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878672PMC
May 2018

Gastrin-releasing peptide and its receptor increase arthritis fibroblast-like synoviocytes invasiveness through activating the PI3K/AKT pathway.

Peptides 2017 Sep 18;95:57-61. Epub 2017 Jul 18.

Departamento de Medicina, Universidade Federal do Rio Grande do Sul,Jerônimo de Ornellas Avenue, 721, 90040-001, Porto Alegre, RS, Brazil; Laboratório de Doenças Autoimunes, Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Ramiro Barcellos Sreet, 2350, Room 645, 90035-003, Porto Alegre, RS, Brazil.

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http://dx.doi.org/10.1016/j.peptides.2017.07.008DOI Listing
September 2017

KCa1.1 channels regulate β-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.

FASEB J 2017 08 20;31(8):3309-3320. Epub 2017 Apr 20.

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA;

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http://dx.doi.org/10.1096/fj.201601097RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503717PMC
August 2017

Short-term low-magnesium diet reduces autoimmune arthritis severity and synovial tissue gene expression.

Physiol Genomics 2017 Apr 3;49(4):238-242. Epub 2017 Mar 3.

Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York

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http://dx.doi.org/10.1152/physiolgenomics.00003.2017DOI Listing
April 2017

Disease modifying anti-rheumatic activity of the alkaloid montanine on experimental arthritis and fibroblast-like synoviocytes.

Eur J Pharmacol 2017 Mar 10;799:180-187. Epub 2017 Feb 10.

Serviço de Reumatologia, Laboratório de Doenças Autoimunes, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Departamento de Medicina Interna, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.02.013DOI Listing
March 2017

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes.

Arthritis Res Ther 2016 Jun 1;18(1):122. Epub 2016 Jun 1.

Department of Molecular Physiology and Biophysics, Mail Stop BCM335, Room S409A, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13075-016-1024-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890255PMC
June 2016

Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes.

Arthritis Res Ther 2016 05 10;18(1):103. Epub 2016 May 10.

Department of Molecular Physiology and Biophysics, Mail Stop BCM335, Room S409A, Baylor College of Medicine, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13075-016-1003-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863321PMC
May 2016

Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways.

J Leukoc Biol 2015 Dec 12;98(6):1061-70. Epub 2015 Aug 12.

*Department of Pathology and Laboratory Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; and Division of Rheumatology, Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA

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http://dx.doi.org/10.1189/jlb.3A0315-102RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661038PMC
December 2015

The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion.

Clin Immunol 2015 Jun 11;158(2):183-92. Epub 2015 Apr 11.

Division of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617367PMC
June 2015

Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity.

Physiol Genomics 2013 Nov 17;45(22):1109-22. Epub 2013 Sep 17.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset New York;

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http://dx.doi.org/10.1152/physiolgenomics.00108.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841791PMC
November 2013

Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1β, and NF-κB activators' expression in pristane-induced arthritis.

Physiol Genomics 2013 Jul 21;45(13):552-64. Epub 2013 May 21.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00029.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727023PMC
July 2013

The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis.

BMC Genomics 2012 Dec 19;13:710. Epub 2012 Dec 19.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive Room 1240, Manhasset, NY 11030, USA.

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http://dx.doi.org/10.1186/1471-2164-13-710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548698PMC
December 2012

Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10.

Mol Med 2012 Sep 7;18:1009-17. Epub 2012 Sep 7.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York 11030, United States of America.

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http://dx.doi.org/10.2119/molmed.2012.00173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459482PMC
September 2012

The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology.

Mol Med 2012 Mar 27;18:194-200. Epub 2012 Mar 27.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, United States of America.

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http://dx.doi.org/10.2119/molmed.2011.00410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320133PMC
March 2012

CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis.

Arthritis Rheum 2011 Nov;63(11):3274-83

Feinstein Institute for Medical Research, Manhasset, New York, USA.

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http://dx.doi.org/10.1002/art.30573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205193PMC
November 2011

Increased synovial expression of nuclear receptors correlates with protection in pristane-induced arthritis: a possible novel genetically regulated homeostatic mechanism.

Arthritis Rheum 2011 Oct;63(10):2918-29

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research and Elmezzi Graduate School of Molecular Medicine, Manhasset, New York 11030, USA.

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http://dx.doi.org/10.1002/art.30507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183331PMC
October 2011

mTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis.

Mol Med 2010 Sep-Oct;16(9-10):352-8. Epub 2010 May 27.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.

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http://dx.doi.org/10.2119/molmed.2010.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935948PMC
December 2010

Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature.

Arthritis Res Ther 2008 15;10(4):R92. Epub 2008 Aug 15.

Laboratory of Experimental Rheumatology, Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.

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http://dx.doi.org/10.1186/ar2476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575606PMC
February 2009

The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.

Mol Med 2007 May-Jun;13(5-6):297-304

Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, New York 11030, USA.

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http://dx.doi.org/10.2119/2007–00025.ChanDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906689PMC
September 2007

Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat.

Mol Med 2007 May-Jun;13(5-6):277-87

Laboratory of Experimental Rheumatology, The Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.

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http://dx.doi.org/10.2119/2007–00003.BrennerDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936230PMC
September 2007

Cia25 on rat chromosome 12 regulates severity of autoimmune arthritis induced with pristane and with collagen.

Ann Rheum Dis 2007 Jul 28;66(7):952-7. Epub 2007 Feb 28.

Laboratory of Experimental Rheumatology, The Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, 350 Community Drive, Room 139, Manhasset, NY 11030, USA.

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http://ard.bmj.com/cgi/doi/10.1136/ard.2006.066225
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http://dx.doi.org/10.1136/ard.2006.066225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955106PMC
July 2007

The arthritis severity quantitative trait loci Cia4 and Cia6 regulate neutrophil migration into inflammatory sites and levels of TNF-alpha and nitric oxide.

J Immunol 2007 Feb;178(4):2344-51

Laboratory of Experimental Rheumatology, Robert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY, USA.

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http://dx.doi.org/10.4049/jimmunol.178.4.2344DOI Listing
February 2007

The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis.

J Immunol 2005 Jun;174(12):7894-903

Laboratory of Experimental Rheumatology, Robert S. Boas Center for Genomics and Human Genetics and Graduate School of Molecular Medicine, North Shore-Long Island Jewish (LIJ) Research Institute, Manhasset, NY 11030, USA.

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http://dx.doi.org/10.4049/jimmunol.174.12.7894DOI Listing
June 2005

The non-major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage.

Arthritis Rheum 2005 Jan;52(1):322-32

Laboratory of Experimental Rheumatology, R.S. Boas Center for Genomics and Human Genetics, North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA.

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http://dx.doi.org/10.1002/art.20782DOI Listing
January 2005