Publications by authors named "Per Svenningsson"

99Publications

Hyperkinesias and Echolalia in Primary Familial Brain Calcification.

Ann Neurol 2020 Nov 10. Epub 2020 Nov 10.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.25955DOI Listing
November 2020

A Novel Duplication in ATXN2 as Modifier for Spinocerebellar Ataxia 3 (SCA3) and C9ORF72-ALS.

Mov Disord 2020 Oct 15. Epub 2020 Oct 15.

Department of Clinical Neuroscience (CNS), Neuro Svenningsson, J5:20 Bioclinicum, Karolinska Universitetssjukhuset, Stockholm, Sweden.

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http://dx.doi.org/10.1002/mds.28334DOI Listing
October 2020

P11 deficiency increases stress reactivity along with HPA axis and autonomic hyperresponsiveness.

Mol Psychiatry 2020 Oct 1. Epub 2020 Oct 1.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41380-020-00887-0DOI Listing
October 2020

Simplified quantification of [F]FE-PE2I PET in Parkinson's disease: Discriminative power, test-retest reliability and longitudinal validity during early peak and late pseudo-equilibrium.

J Cereb Blood Flow Metab 2020 Sep 21:271678X20958755. Epub 2020 Sep 21.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm, Sweden.

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http://dx.doi.org/10.1177/0271678X20958755DOI Listing
September 2020

Reduction of spontaneous cortical beta bursts in Parkinson's disease is linked to symptom severity.

Brain Commun 2020 28;2(1):fcaa052. Epub 2020 Apr 28.

Department of Clinical Neuroscience, NatMEG, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/braincomms/fcaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425382PMC
April 2020

Reduction of spontaneous cortical beta bursts in Parkinson's disease is linked to symptom severity.

Brain Commun 2020 28;2(1):fcaa052. Epub 2020 Apr 28.

Department of Clinical Neuroscience, NatMEG, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1093/braincomms/fcaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425382PMC
April 2020

Automated brainstem volumetry can aid in the diagnostics of parkinsonian disorders.

Parkinsonism Relat Disord 2020 Aug 13;79:18-25. Epub 2020 Aug 13.

Department of Clinical Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden; Center for Neurology, Academic Specialist Center, 113 65, Stockholm, Sweden; Department of Neurology, Karolinska University Hospital, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.parkreldis.2020.08.004DOI Listing
August 2020

Repurposing GLP1 agonists for neurodegenerative diseases.

Int Rev Neurobiol 2020 11;155:91-112. Epub 2020 Aug 11.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center of Neurology, Academic Specialist Center, Stockholm, Sweden; Department of Neurology, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2020.02.007DOI Listing
August 2020

Reliability of dopamine transporter PET measurements with [F]FE-PE2I in patients with Parkinson's disease.

EJNMMI Res 2020 Aug 14;10(1):95. Epub 2020 Aug 14.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Region Stockholm, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13550-020-00676-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427674PMC
August 2020

variant associated with hemiplegic migraine and acetazolamide-responsive MRS changes.

Neurol Genet 2020 Aug 7;6(4):e474. Epub 2020 Jul 7.

Department of Neurology (M.P., E.W., P.S.), Karolinska University Hospital; Department of Clinical Neuroscience (M.P., T.G., E.W., P.S.), Karolinska Institutet; Department of Neuroradiology (T.G.), Karolinska University Hospital; Department of Molecular Medicine and Surgery (K.L.-R.), Karolinska Institutet; Department of Clinical Genetics (K.L.-R.); Medical Radiation Physics and Nuclear Medicine (S.P., L.N.), Karolinska University Hospital; and Division of Clinical Geriatrics (L.N.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXG.0000000000000474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357413PMC
August 2020

Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds.

J Am Soc Mass Spectrom 2020 Jul 21. Epub 2020 Jul 21.

Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 75124, Sweden.

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http://dx.doi.org/10.1021/jasms.0c00166DOI Listing
July 2020

A randomized placebo-controlled PET study of ketamine´s effect on serotonin receptor binding in patients with SSRI-resistant depression.

Transl Psychiatry 2020 06 1;10(1):159. Epub 2020 Jun 1.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41398-020-0844-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261801PMC
June 2020

NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism.

Neuropharmacology 2020 09 29;174:108136. Epub 2020 May 29.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2020.108136DOI Listing
September 2020

[Orthostatic tremor - a disregarded diagnosis].

Lakartidningen 2020 05 20;117. Epub 2020 May 20.

professor, överläkare, Karolinska institutet; Centrum för neurologi, Akademiskt specialistcentrum, Stockholm.

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May 2020

Modulation of Ion Channels and Receptors by p11 (S100A10).

Trends Pharmacol Sci 2020 07 14;41(7):487-497. Epub 2020 May 14.

Department of Clinical Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2020.04.004DOI Listing
July 2020

Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission.

J Pharmacol Exp Ther 2020 07 1;374(1):126-133. Epub 2020 May 1.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (K.B., M.V.d.D., V.C.S., J.T., P.S.) and Integrative Research Laboratories Sweden AB, Gothenburg, Sweden (J.T.).

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http://dx.doi.org/10.1124/jpet.119.264754DOI Listing
July 2020

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders.

Nat Rev Neurol 2020 May 22;16(5):265-284. Epub 2020 Apr 22.

Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.

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http://dx.doi.org/10.1038/s41582-020-0348-0DOI Listing
May 2020

Feasibility Aspects of Exploring Exercise-Induced Neuroplasticity in Parkinson's Disease: A Pilot Randomized Controlled Trial.

Parkinsons Dis 2020 25;2020:2410863. Epub 2020 Mar 25.

Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1155/2020/2410863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132585PMC
March 2020

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37.

Front Aging Neurosci 2020 27;12:84. Epub 2020 Mar 27.

Laboratory of Translational Neuropharmacology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fnagi.2020.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120535PMC
March 2020

Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses.

Front Pharmacol 2020 20;11:304. Epub 2020 Mar 20.

Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphar.2020.00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099513PMC
March 2020

Individually Tailored Internet-Based Cognitive-Behavioral Therapy for Daily Functioning in Patients with Parkinson's Disease: A Randomized Controlled Trial.

J Parkinsons Dis 2020 ;10(2):653-664

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JPD-191894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242852PMC
January 2020

[Recent advances in Huntington's disease].

Lakartidningen 2020 03 9;117. Epub 2020 Mar 9.

Karolinska Universitetssjukhuset - Tema Neuro Stockholm, Sweden Karolinska Universitetssjukhuset - Tema Neuro Stockholm, Sweden.

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March 2020

[Parkinson's disease - heterogeneous and complex in its clinical presentation].

Lakartidningen 2020 03 9;117. Epub 2020 Mar 9.

Karolinska Universitetssjukhuset - Tema Neuro Stockholm, Sweden - Stockholm, Sweden.

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March 2020

[Ataxia - a group of heterogeneous diseases].

Lakartidningen 2020 03 9;117. Epub 2020 Mar 9.

Karolinska Hospital - Tema Neuro och Neurofysiologi Stockholm, Sweden Karolinska Hospital - Tema Neuro och Neurofysiologi Stockholm, Sweden.

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March 2020

High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson's disease cohort.

Eur J Nucl Med Mol Imaging 2020 Sep 4;47(10):2407-2416. Epub 2020 Feb 4.

Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, RegionStockholm, Karolinska University Hospital, SE-17176, R5:02, Visionsgatan 70A, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00259-020-04683-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396398PMC
September 2020

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy.

Neurobiol Dis 2020 04 10;137:104738. Epub 2020 Jan 10.

Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, National Resource for Mass Spectrometry Imaging, Uppsala University, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2020.104738DOI Listing
April 2020

Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.

Neuropharmacology 2020 01 24;162:107829. Epub 2019 Oct 24.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.107829DOI Listing
January 2020

Progressive Ataxia with Elevated Alpha-Fetoprotein: Diagnostic Issues and Review of the Literature.

Tremor Other Hyperkinet Mov (N Y) 2019 10;9. Epub 2019 Oct 10.

Department of Neurology, Karolinska University Hospital, Stockholm, SE.

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http://dx.doi.org/10.7916/tohm.v0.708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790008PMC
September 2020

Polyneuropathy in Gaucher disease type 1 and 3 - a descriptive case series.

Sci Rep 2019 10 25;9(1):15358. Epub 2019 Oct 25.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-019-51976-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814858PMC
October 2019

Pain in persons with mild-moderate Parkinson's disease: a cross-sectional study of pain severity and associated factors.

Int J Rehabil Res 2019 Dec;42(4):371-376

Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/MRR.0000000000000373DOI Listing
December 2019

Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging.

Nat Methods 2019 10 23;16(10):1021-1028. Epub 2019 Sep 23.

Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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http://www.nature.com/articles/s41592-019-0551-3
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http://dx.doi.org/10.1038/s41592-019-0551-3DOI Listing
October 2019

Plasma IL-6 and IL-17A Correlate with Severity of Motor and Non-Motor Symptoms in Parkinson's Disease.

J Parkinsons Dis 2019 ;9(4):705-709

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.3233/JPD-191699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839458PMC
July 2020

Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.

Int J Mol Sci 2019 Aug 30;20(17). Epub 2019 Aug 30.

Translational Neuropharmacology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, 111 22 Stockholm, Sweden.

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http://dx.doi.org/10.3390/ijms20174247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747167PMC
August 2019

Altered CSF levels of monoamines in hereditary spastic paraparesis 10: A case series.

Neurol Genet 2019 Aug 12;5(4):e344. Epub 2019 Jun 12.

Department of Neurology (M.A., K.S., G.S., M.P., P.S.), Karolinska University Hospital; Center for Neurology (M.A., P.S.), Academic Specialist Center; Department of Molecular Medicine and Surgery (K.L.-R.), Karolinska Institutet, and Department of Clinical Genetics, Karolinska University Hospital; Department of Clinical Neurophysiology (G.S.), Karolinska University Hospital, Stockholm; Department of Clinical Neuroscience (K.B.), University of Gothenburg; and Department of Clinical Neuroscience (M.A., K.S., G.S., M.P., P.S.), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXG.0000000000000344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659133PMC
August 2019

GRP78 Level Is Altered in the Brain, but Not in Plasma or Cerebrospinal Fluid in Parkinson's Disease Patients.

Front Neurosci 2019 5;13:697. Epub 2019 Jul 5.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fnins.2019.00697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624451PMC
July 2019

Vertical saccades and antisaccades: complementary markers for motor and cognitive impairment in Parkinson's disease.

NPJ Parkinsons Dis 2019 24;5:11. Epub 2019 Jun 24.

1Section of Neurology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41531-019-0083-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591173PMC
June 2019

Editorial: Update on movement disorders.

Curr Opin Neurol 2019 08;32(4):564-565

NYU School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1097/WCO.0000000000000709DOI Listing
August 2019

Involuntary movements, vocalizations and cognitive decline.

Parkinsonism Relat Disord 2019 May 29. Epub 2019 May 29.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.05.029DOI Listing
May 2019

Mutations in an Adult Patient with Parkinson's Disease, Dementia, Stroke and Elevated Levels of Methylmalonic Acid.

Int J Mol Sci 2019 May 29;20(11). Epub 2019 May 29.

Department of Neurology, Karolinska University Hospital, 141 86 Stockholm, Sweden.

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http://dx.doi.org/10.3390/ijms20112631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600349PMC
May 2019

Corticobasal degeneration: advances in clinicopathology and biomarkers.

Authors:
Per Svenningsson

Curr Opin Neurol 2019 08;32(4):597-603

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1097/WCO.0000000000000707DOI Listing
August 2019

GBA RNAi but not catalytic inhibition of glucocerebrosidase with Conduritol-β-epoxide increases levels of total α-synuclein in SH-SY5Y cells.

Neurosci Lett 2019 07 15;706:217-222. Epub 2019 May 15.

Department of Clinical Neuroscience, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.05.027DOI Listing
July 2019

Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition.

Neuropsychopharmacology 2019 11 22;44(12):2091-2098. Epub 2019 Apr 22.

Department of Pharmaceutical Biosciences, Medical Mass Spectrometry Imaging, National Resource for Mass Spectrometry Imaging, Science for Life Laboratory, Uppsala University, Box 591, Uppsala, SE-75124, Sweden.

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http://dx.doi.org/10.1038/s41386-019-0397-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887892PMC
November 2019

Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.

Acta Neuropathol 2019 07 11;138(1):23-47. Epub 2019 Apr 11.

Department of Clinical Pathology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

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http://dx.doi.org/10.1007/s00401-019-02007-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570706PMC
July 2019

First Clinicogenetic Description of Parkinson's Disease Related to Mutation S107L.

Mov Disord Clin Pract 2019 Mar 7;6(3):254-258. Epub 2019 Mar 7.

Section of Neurology, Department of Clinical Neuroscience Karolinska Institute Stockholm Sweden.

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http://dx.doi.org/10.1002/mdc3.12743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417758PMC
March 2019

SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation.

Stem Cell Reports 2019 04 28;12(4):696-711. Epub 2019 Feb 28.

Max Planck Institute Biology of Ageing - Karolinska Institutet Laboratory, Karolinska Institutet, 171 65 Stockholm, Sweden; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden; Centre for Inherited Metabolic Diseases, Karolinska University Hospital, 171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449840PMC
April 2019

Decreased Cerebrospinal Fluid Aβ42 in Patients with Idiopathic Parkinson's Disease and White Matter Lesions.

J Parkinsons Dis 2019 ;9(2):361-367

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JPD-181486DOI Listing
April 2020

Novel Treatment Opportunities Against Cognitive Impairment in Parkinson's Disease with an Emphasis on Diabetes-Related Pathways.

CNS Drugs 2019 02;33(2):143-160

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King´s College London, London, UK.

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http://dx.doi.org/10.1007/s40263-018-0601-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373401PMC
February 2019

On the fluxes of side-chain oxidized oxysterols across blood-brain and blood-CSF barriers and origin of these steroids in CSF (Review).

J Steroid Biochem Mol Biol 2019 04 23;188:86-89. Epub 2018 Dec 23.

Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jsbmb.2018.12.009DOI Listing
April 2019

Variant ataxia-telangiectasia with prominent camptocormia.

Parkinsonism Relat Disord 2019 05 17;62:253-255. Epub 2018 Dec 17.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S13538020183055
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http://dx.doi.org/10.1016/j.parkreldis.2018.12.017DOI Listing
May 2019

Safety and tolerability of IRL790 in Parkinson's disease with levodopa-induced dyskinesia-a phase 1b trial.

NPJ Parkinsons Dis 2018 6;4:35. Epub 2018 Dec 6.

1Department of Clinical Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41531-018-0071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283839PMC
December 2018

WITHDRAWN: Novel Xp21.1 deletion associated with unusual features in a large McLeod syndrome kindred.

Parkinsonism Relat Disord 2018 Oct 8. Epub 2018 Oct 8.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13538020183039
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http://dx.doi.org/10.1016/j.parkreldis.2018.09.014DOI Listing
October 2018

Eye movements during reading in Parkinson's disease: A pilot study.

Mov Disord 2018 10 8;33(10):1661-1662. Epub 2018 Oct 8.

Section of Neurology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/mds.105DOI Listing
October 2018

Novel Imaging Biomarkers for Huntington's Disease and Other Hereditary Choreas.

Curr Neurol Neurosci Rep 2018 10 5;18(12):85. Epub 2018 Oct 5.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s11910-018-0890-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182636PMC
October 2018

PET imaging of [C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding.

Eur J Nucl Med Mol Imaging 2019 02 1;46(2):367-375. Epub 2018 Oct 1.

Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, R5:02 Karolinska University Hospital, SE-17176, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00259-018-4161-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333720PMC
February 2019

Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool.

Neuropharmacology 2018 12 14;143:38-48. Epub 2018 Sep 14.

Translational Neuropharmacology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuropharm.2018.09.021DOI Listing
December 2018

Chorea, psychosis, acanthocytosis, and prolonged survival associated with mutations.

Neurology 2018 10 14;91(15):710-712. Epub 2018 Sep 14.

From Karolinska University Hospital (M.P., A.P., C.F., M.D., J.L.-M., H.S., K.L., I.S., A. Wedell, A. Wredenberg, P.S.); Karolinska Institutet (M.P., A.P., C.F., Å.B., K.L., A. Wedell, A. Wredenberg, P.S.), Stockholm, Sweden; James J. Peters Veterans Medical Affair Center (R.H.W.), Bronx; and Mount Sinai School of Medicine (R.H.W.), New York, NY.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177277PMC
October 2018

Pathological Study of a Premutation Carrier With Progressive Supranuclear Palsy.

Front Genet 2018 15;9:317. Epub 2018 Aug 15.

Department of Neurology and Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fgene.2018.00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103471PMC
August 2018

mutation and long-term follow-up of the first hyperekplexia family.

Neurol Genet 2018 Aug 7;4(4):e259. Epub 2018 Aug 7.

Section of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXG.0000000000000259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089692PMC
August 2018

Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease.

J Med Chem 2018 06 15;61(12):5269-5278. Epub 2018 Jun 15.

Science for Life Laboratory, Department of Cell and Molecular Biology , Uppsala University , BMC Box 596, SE-751 24 Uppsala , Sweden.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716773PMC
June 2018

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine.

Front Pharmacol 2018 1;9:166. Epub 2018 Mar 1.

Section of Translational Neuropharmacology, Department of Clinical Neuroscience, Center for Molecular Medicine L8:01, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fphar.2018.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837966PMC
March 2018

Nigrostriatal dopamine transporter availability in early Parkinson's disease.

Mov Disord 2018 04 13;33(4):592-599. Epub 2018 Feb 13.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1002/mds.27316DOI Listing
April 2018

A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability.

Neuroimage 2018 05 10;172:808-816. Epub 2018 Jan 10.

Biomolecular Mass Spectrometry Imaging, National Resource for Mass Spectrometry Imaging, Science for Life Laboratory, Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-75124, Uppsala, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2018.01.013DOI Listing
May 2018

Paroxysmal Kinesigenic Dyskinesia.

Tremor Other Hyperkinet Mov (N Y) 2017 12;7:529. Epub 2017 Dec 12.

Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.7916/D8R79N2FDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740227PMC
September 2018

Patient-driven N-of-1 in Parkinson's Disease. Lessons Learned from a Placebo-controlled Study of the Effect of Nicotine on Dyskinesia.

Methods Inf Med 2017 Oct 24;56(99):e123-e128. Epub 2017 Oct 24.

Sara Riggare, Health Informatics Centre, Karolinska Institutet, 171 77 Stockholm, Sweden, E-mail:

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http://dx.doi.org/10.3414/ME16-02-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291823PMC
October 2017

Quantitative susceptibility mapping differentiates between parkinsonian disorders.

Parkinsonism Relat Disord 2017 Nov 1;44:51-57. Epub 2017 Sep 1.

Department of Clinical Neuroscience, K8, CMM L8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Neurology, R54, Karolinska University Hospital, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.08.029DOI Listing
November 2017

Correlations Between Methionine Cycle Metabolism, COMT Genotype, and Polyneuropathy in L-Dopa Treated Parkinson's Disease: A Preliminary Cross-Sectional Study.

J Parkinsons Dis 2017 ;7(4):619-628

Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.3233/JPD-171127DOI Listing
June 2018

In vivo retention of F-AV-1451 in corticobasal syndrome.

Neurology 2017 Aug 28;89(8):845-853. Epub 2017 Jul 28.

From the Departments of Neurology (R.S., H.W., C.N.), Clinical Neurophysiology (D.H.), Radiation Physics (T.O.), and Clinical Physiology and Nuclear Medicine (J.J.), Skåne University Hospital (D.v.W.), Lund; Clinical Memory Research Unit (R.S., M.S., C.N., O.H.), Department of Clinical Sciences (D.v.W.), and Department of Diagnostic Radiology (D.v.W.), Lund University, Malmö; Wallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry (M.S.), University of Gothenburg; Department of Clinical Neuroscience (P.S.), CMM L8:01, Stockholm; and Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580862PMC
August 2017

Saccadic Impairments in Patients with the Norrbottnian Form of Gaucher's Disease Type 3.

Front Neurol 2017 22;8:295. Epub 2017 Jun 22.

Section of Neurology, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fneur.2017.00295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479920PMC
June 2017

Synaptic proteins in CSF relate to Parkinson's disease stage markers.

NPJ Parkinsons Dis 2017 8;3. Epub 2017 Feb 8.

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division for Neurogeriatrics, Karolinska Institutet, Novum, Stockholm Sweden.

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http://dx.doi.org/10.1038/s41531-017-0008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445607PMC
February 2017

Folding Underlies Bidirectional Role of GPR37/Pael-R in Parkinson Disease.

Trends Pharmacol Sci 2017 08 16;38(8):749-760. Epub 2017 Jun 16.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, SE-171 76, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.05.006DOI Listing
August 2017

Patients with Parkinson's disease display a dopamine therapy related negative bias and an enlarged range in emotional responses to facial emotional stimuli.

Neuropsychology 2017 Sep 5;31(6):605-612. Epub 2017 Jun 5.

Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute.

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http://dx.doi.org/10.1037/neu0000371DOI Listing
September 2017

Clozapine counteracts a ketamine-induced depression of hippocampal-prefrontal neuroplasticity and alters signaling pathway phosphorylation.

PLoS One 2017 4;12(5):e0177036. Epub 2017 May 4.

Laboratoire de Physiopathologie des Maladies Psychiatriques, UMR_S894 Inserm, Centre de Psychiatrie et Neurosciences, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177036PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417651PMC
September 2017

Vagotomy and Parkinson disease: A Swedish register-based matched-cohort study.

Neurology 2017 May 26;88(21):1996-2002. Epub 2017 Apr 26.

From the Departments of Medical Epidemiology and Biostatistics (B.L., F.F., N.L.P., A.T., J.F.L., K.W.), Medicine (A.E.), and Clinical Neuroscience (P.S., K.W.), Karolinska Institutet, Stockholm, Sweden; Department of Psychology (N.L.P.), University of Southern California, Los Angeles; Department of Paediatrics (J.F.L.), Örebro University Hospital, Sweden; and Department of Epidemiology and Biostatistics (H.C.), College of Human Medicine, Michigan State University, East Lansing.

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http://dx.doi.org/10.1212/WNL.0000000000003961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440238PMC
May 2017

A SLC20A2 gene mutation carrier displaying ataxia and increased levels of cerebrospinal fluid phosphate.

J Neurol Sci 2017 04 4;375:245-247. Epub 2017 Feb 4.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jns.2017.02.007DOI Listing
April 2017

Distribution and levels of 5-HT receptors in anterior cingulate cortex of patients with bipolar disorder, major depressive disorder and schizophrenia - An autoradiography study.

Eur Neuropsychopharmacol 2017 05 18;27(5):504-514. Epub 2017 Mar 18.

Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.euroneuro.2017.02.011DOI Listing
May 2017

Asymmetric dopaminergic degeneration and levodopa alter functional corticostriatal connectivity bilaterally in experimental parkinsonism.

Exp Neurol 2017 06 20;292:11-20. Epub 2017 Feb 20.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144886173004
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http://dx.doi.org/10.1016/j.expneurol.2017.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405850PMC
June 2017

Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.

Proc Natl Acad Sci U S A 2017 03 30;114(10):2735-2740. Epub 2017 Jan 30.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, SE-171 76 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1621218114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347629PMC
March 2017

Novel hyperkinetic dystonia-like manifestation and neurological disease course of Swedish Gaucher patients.

Blood Cells Mol Dis 2018 02 21;68:86-92. Epub 2016 Oct 21.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, SE-171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bcmd.2016.10.011DOI Listing
February 2018

Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain.

J Comp Neurol 2017 Mar 21;525(4):955-975. Epub 2016 Oct 21.

Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1002/cne.24113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222728PMC
March 2017