Biography

Primary Affiliation: Weill Cornell Medicine, Cornell University - New York, NY , United States

Specialties: Virology

Research Interests: HIV neutralization by antibodies

Education
  • 1996
    LMCB, University College London MRC research Fellow
  • 1993
    Institute of Cancer Research, London EMBO Fellow
  • 1992
    Lund Univesrity PhD
  • 1986
    Lund University MD
Relevant Experience
  • 2003
    Professor Scientist
  • 2000
    Lecturer Scientist

Publications




HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike.
J Virol 2016 Dec 14;90(23):10587-10599. Epub 2016 Nov 14.
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands


Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry.
J Biol Chem 2016 Jun 25;291(25):13088-97. Epub 2016 Apr 25.
From the Department of Pharmaceutical Sciences, College of Pharmacy, and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 and

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.
Virology 2015 Dec 1;486:116-20. Epub 2015 Oct 1.
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity.
J Virol 2015 Oct 5;89(20):10383-98. Epub 2015 Aug 5.
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA Center for HIV-1/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, California, USA



Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.
PLoS Pathog 2015 Mar 25;11(3):e1004767. Epub 2015 Mar 25.
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.





Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Science 2013 Dec 31;342(6165):1477-83. Epub 2013 Oct 31.
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.



Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers.
J Virol 2013 Sep 3;87(17):9865-72. Epub 2013 Jul 3.
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.




Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.
Proc Natl Acad Sci U S A 2013 Mar 20;110(11):4351-6. Epub 2013 Feb 20.
Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.



Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
J Virol 2012 Mar 28;86(5):2488-500. Epub 2011 Dec 28.
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, The Netherlands.





Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Proc Natl Acad Sci U S A 2011 Jul 20;108(27):11181-6. Epub 2011 Jun 20.
Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.


Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.
Virology 2011 Apr 26;413(1):47-59. Epub 2011 Feb 26.
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.



Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.
Proc Natl Acad Sci U S A 2008 Jul 22;105(30):10531-6. Epub 2008 Jul 22.
Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA.

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.
PLoS Pathog 2007 Nov;3(11):e169
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.










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