Publications by authors named "Per Johan Klasse"

79Publications

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure.

Immunity 2017 04;46(4):690-702

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, International AIDS Vaccine Initiative Neutralizing Antibody Center and Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400778PMC
April 2017

Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664.

Proteins 2017 05 11;85(5):843-851. Epub 2017 Mar 11.

Department of Biochemistry and Molecular Biology, Drexel University, Philadelphia, Pennsylvania, 19102.

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http://dx.doi.org/10.1002/prot.25238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389922PMC
May 2017

HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike.

J Virol 2016 Dec 14;90(23):10587-10599. Epub 2016 Nov 14.

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands

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http://dx.doi.org/10.1128/JVI.01616-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110188PMC
December 2016

Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry.

J Biol Chem 2016 Jun 25;291(25):13088-97. Epub 2016 Apr 25.

From the Department of Pharmaceutical Sciences, College of Pharmacy, and Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 and

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http://dx.doi.org/10.1074/jbc.M116.729210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933225PMC
June 2016

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.

Virology 2015 Dec 1;486:116-20. Epub 2015 Oct 1.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712445PMC
December 2015

Predicting first traversal times for virions and nanoparticles in mucus with slowed diffusion.

Biophys J 2015 Jul;109(1):164-72

School of Mathematics and Statistics, UNSW Australia, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572576PMC
July 2015

Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein.

AIDS Res Hum Retroviruses 2015 Nov 20;31(11):1160-5. Epub 2015 Jul 20.

1 Department of Microbiology and Immunology, Weill Cornell Medical College , Cornell University, New York, New York.

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http://dx.doi.org/10.1089/AID.2015.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651053PMC
November 2015

What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?

J Virol 2015 Jun 25;89(11):5981-95. Epub 2015 Mar 25.

Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, New York, USA

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http://dx.doi.org/10.1128/JVI.00320-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442429PMC
June 2015

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.

PLoS Pathog 2015 Mar 25;11(3):e1004767. Epub 2015 Mar 25.

Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373910PMC
March 2015

Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.

Science 2013 Dec 31;342(6165):1484-90. Epub 2013 Oct 31.

National Resource for Automated Molecular Microscopy, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1245627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954647PMC
December 2013

Crystal structure of a soluble cleaved HIV-1 envelope trimer.

Science 2013 Dec 31;342(6165):1477-83. Epub 2013 Oct 31.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1245625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886632PMC
December 2013

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers.

J Virol 2013 Sep 3;87(17):9865-72. Epub 2013 Jul 3.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1128/JVI.01222-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754114PMC
September 2013

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

Proc Natl Acad Sci U S A 2013 Mar 20;110(11):4351-6. Epub 2013 Feb 20.

Department of Integrative Structural and Computational Biology, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1217537110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600498PMC
March 2013

Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.

J Virol 2013 Mar 26;87(5):2401-11. Epub 2012 Dec 26.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/JVI.02964-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571396PMC
March 2013

Potent induction of antibody-secreting B cells by human dermal-derived CD14+ dendritic cells triggered by dual TLR ligation.

J Immunol 2012 Dec 16;189(12):5729-44. Epub 2012 Nov 16.

Department of Microbiology and Immunology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1200601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951118PMC
December 2012

Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques.

J Antimicrob Chemother 2013 Mar 30;68(3):678-83. Epub 2012 Oct 30.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.

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http://dx.doi.org/10.1093/jac/dks422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566668PMC
March 2013

HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.

J Immunol 2012 Dec 24;189(11):5257-65. Epub 2012 Oct 24.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1201905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504132PMC
December 2012

Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines.

Retrovirology 2012 Oct 1;9:80. Epub 2012 Oct 1.

Department of Microbiology and Immunology, Weill Cornell Medical College, Cornel University, 1300 York Avenue, Box 62, New York, NY 10065-4896, USA.

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http://dx.doi.org/10.1186/1742-4690-9-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484039PMC
October 2012

Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.

Proc Natl Acad Sci U S A 2012 May 14;109(22):8694-8. Epub 2012 May 14.

Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1203183109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365197PMC
May 2012

The molecular basis of HIV entry.

Authors:
Per Johan Klasse

Cell Microbiol 2012 Aug 5;14(8):1183-92. Epub 2012 Jun 5.

Department of Microbiology and Immunology, Cornell University, Weill Cornell Medical College, 1300 York Avenue, Box 62, New York, NY 10065-4896, USA.

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http://dx.doi.org/10.1111/j.1462-5822.2012.01812.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417324PMC
August 2012

Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance.

Virology 2012 Jul 19;428(2):86-97. Epub 2012 Apr 19.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2012.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353024PMC
July 2012

V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc.

Virology 2012 Jun 16;427(2):158-65. Epub 2012 Mar 16.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2012.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320651PMC
June 2012

Animal models for microbicide studies.

Curr HIV Res 2012 Jan;10(1):79-87

Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712901PMC
http://dx.doi.org/10.2174/157016212799304715DOI Listing
January 2012

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.

Proc Natl Acad Sci U S A 2011 Jul 20;108(27):11181-6. Epub 2011 Jun 20.

Department of Immunology and Microbial Science and International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1103012108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131343PMC
July 2011

How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?

AIDS Res Hum Retroviruses 2012 Jan 20;28(1):1-15. Epub 2011 May 20.

Department of Microbiology and Immunology, Cornell University, Weill Cornell Medical College, New York, New York 10065-4896, USA.

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http://dx.doi.org/10.1089/aid.2011.0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251839PMC
January 2012

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.

Virology 2011 Apr 26;413(1):47-59. Epub 2011 Feb 26.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.virol.2010.12.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070043PMC
April 2011

Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.

Proc Natl Acad Sci U S A 2009 Sep 17;106(35):14751-6. Epub 2009 Aug 17.

Department of Chemistry, University of Wisconsin, 1101 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.0902663106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736470PMC
September 2009

Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities.

Virology 2009 May 20;387(2):296-302. Epub 2009 Mar 20.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.virol.2009.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674391PMC
May 2009

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41.

Proc Natl Acad Sci U S A 2009 Mar 16;106(13):5318-23. Epub 2009 Mar 16.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0811713106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664029PMC
March 2009

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

Proc Natl Acad Sci U S A 2008 Jul 22;105(30):10531-6. Epub 2008 Jul 22.

Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA.

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http://dx.doi.org/10.1073/pnas.0802666105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492474PMC
July 2008

HIV-1 pathogenesis: the complexities of the CCR5-CCL3L1 complex.

Cell Host Microbe 2007 Nov;2(5):281-3

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10065-4896, USA.

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http://dx.doi.org/10.1016/j.chom.2007.10.005DOI Listing
November 2007

Antibodies to West Nile virus: a double-edged sword.

Cell Host Microbe 2007 Apr;1(2):87-9

Department of Microbiology and Immunology, Cornell University, Weill Medical College, 1300 York Avenue, Box 62, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.chom.2007.04.001DOI Listing
April 2007

HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells.

PLoS Pathog 2007 Nov;3(11):e169

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.0030169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048530PMC
November 2007

Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission.

Annu Rev Med 2008 ;59:455-71

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1146/annurev.med.59.061206.112737DOI Listing
May 2008

Modeling how many envelope glycoprotein trimers per virion participate in human immunodeficiency virus infectivity and its neutralization by antibody.

Authors:
Per Johan Klasse

Virology 2007 Dec 7;369(2):245-62. Epub 2007 Sep 7.

Department of Microbiology and Immunology, Cornell University, Weill Medical College, 1300 York Avenue, Box 62, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2007.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2317823PMC
December 2007

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands.

Virology 2007 Aug 10;364(2):281-90. Epub 2007 Apr 10.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2007.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151978PMC
August 2007

Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes.

Virology 2007 Aug 10;364(2):431-40. Epub 2007 Apr 10.

Dept of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2007.03.001DOI Listing
August 2007

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

PLoS Med 2006 Sep;3(9):e351

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.0030351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539095PMC
September 2006

Dominant-negative effect of hetero-oligomerization on the function of the human immunodeficiency virus type 1 envelope glycoprotein complex.

Virology 2006 Jul 17;351(1):121-32. Epub 2006 Apr 17.

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.virol.2006.03.003DOI Listing
July 2006

How do viral and host factors modulate the sexual transmission of HIV? Can transmission be blocked?

PLoS Med 2006 Feb 28;3(2):e79. Epub 2006 Feb 28.

International AIDS Vaccine Initiative, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pmed.0030079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1388058PMC
February 2006

Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.

Nat Med 2005 Dec 6;11(12):1293-4. Epub 2005 Nov 6.

Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433, USA.

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http://dx.doi.org/10.1038/nm1321DOI Listing
December 2005

V3: HIV's switch-hitter.

AIDS Res Hum Retroviruses 2005 Feb;21(2):171-89

Department of Structural Biology and Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland.

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http://dx.doi.org/10.1089/aid.2005.21.171DOI Listing
February 2005

Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses.

Virology 2004 Oct;328(1):19-29

Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.virol.2004.07.021DOI Listing
October 2004

Entry inhibitors SCH-C, RANTES, and T-20 block HIV type 1 replication in multiple cell types.

AIDS Res Hum Retroviruses 2003 Mar;19(3):177-86

Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1089/088922203763315678DOI Listing
March 2003

Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120.

Nat Med 2003 Mar 10;9(3):343-6. Epub 2003 Feb 10.

Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA.

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http://dx.doi.org/10.1038/nm833DOI Listing
March 2003