Per I Arvidsson

Per I Arvidsson

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Per I Arvidsson

Per I Arvidsson

Publications by authors named "Per I Arvidsson"

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The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.

Xenobiotica 2018 Sep 13;48(9):938-944. Epub 2017 Oct 13.

a Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban , South Africa.

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http://dx.doi.org/10.1080/00498254.2017.1375168DOI Listing
September 2018

Clofazimine protects against Mycobacterium tuberculosis dissemination in the central nervous system following aerosol challenge in a murine model.

Int J Antimicrob Agents 2018 Jan 24;51(1):77-81. Epub 2017 Aug 24.

Catalysis and Peptide Research Unit, School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Westville Campus, Durban, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2017.08.020DOI Listing
January 2018

Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.

Biomed Chromatogr 2017 Dec 13;31(12). Epub 2017 Jul 13.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.

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http://dx.doi.org/10.1002/bmc.4035DOI Listing
December 2017

Synthetic approaches to radiochemical probes for imaging of bacterial infections.

Eur J Med Chem 2017 Jun 29;133:287-308. Epub 2017 Mar 29.

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.060DOI Listing
June 2017

Institutional profile: the national Swedish academic drug discovery & development platform at SciLifeLab.

Future Sci OA 2017 Jun 7;3(2):FSO176. Epub 2017 Apr 7.

KellSa s.a.s., Str. Campo e Zampe 12, I-13900 Biella, BI, Italy.

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http://dx.doi.org/10.4155/fsoa-2017-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481862PMC
June 2017

On the bridge over the translational valley of death: interview with Per I Arvidsson.

Authors:
Per I Arvidsson

Future Sci OA 2017 Jun 10;3(2):FSO183. Epub 2017 Apr 10.

Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4155/fsoa-2017-0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481854PMC
June 2017

Sulfonimidamides in Medicinal and Agricultural Chemistry.

Angew Chem Int Ed Engl 2017 04 23;56(15):4100-4109. Epub 2017 Feb 23.

Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, 4001, South Africa.

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http://dx.doi.org/10.1002/anie.201610456DOI Listing
April 2017

A Synthesis of "Dual Warhead" β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams.

Org Lett 2017 02 11;19(3):480-483. Epub 2017 Jan 11.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, South Africa.

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http://dx.doi.org/10.1021/acs.orglett.6b03634DOI Listing
February 2017

Open for collaboration: an academic platform for drug discovery and development at SciLifeLab.

Drug Discov Today 2016 10 29;21(10):1690-1698. Epub 2016 Jun 29.

Science for Life Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.drudis.2016.06.026DOI Listing
October 2016

Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

J Mol Histol 2016 Aug 21;47(4):429-35. Epub 2016 Jun 21.

Catalysis and Peptide Research Unit, University of KwaZulu-Natal, E-Block, 6th Floor, Room E1-06-016, Westville Campus, Durban, South Africa.

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http://dx.doi.org/10.1007/s10735-016-9685-0DOI Listing
August 2016

Enantioselective Organocatalyzed Transformations of β-Ketoesters.

Chem Rev 2016 08 27;116(16):9375-437. Epub 2016 Jul 27.

Catalysis and Peptide Research Unit, University of KwaZulu Natal , Durban, 4001, South Africa.

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http://dx.doi.org/10.1021/acs.chemrev.6b00156DOI Listing
August 2016

On-Water Synthesis of Biaryl Sulfonyl Fluorides.

J Org Chem 2016 Mar 29;81(6):2618-23. Epub 2016 Feb 29.

Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , SE-171 21 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.joc.5b02770DOI Listing
March 2016

The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study.

Org Biomol Chem 2015 Oct;13(39):9993-10006

Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.

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http://www.rsc.org/suppdata/c5/ob/c5ob01565k/c5ob01565k3.pdf
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http://xlink.rsc.org/?DOI=C5OB01565K
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http://dx.doi.org/10.1039/c5ob01565kDOI Listing
October 2015

NOTA: a potent metallo-β-lactamase inhibitor.

J Antimicrob Chemother 2015 May 6;70(5):1594-6. Epub 2015 Jan 6.

Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

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http://dx.doi.org/10.1093/jac/dku538DOI Listing
May 2015

Preclinical characterization of acyl sulfonimidamides: potential carboxylic acid bioisosteres with tunable properties.

ChemMedChem 2015 Mar 28;10(3):455-60. Epub 2015 Jan 28.

Department of Medicinal Chemistry, Division of Organic Pharmaceutical Chemistry, Biomedical Center, Uppsala University, P.O. Box 574, 751 23 Uppsala (Sweden).

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http://dx.doi.org/10.1002/cmdc.201402497DOI Listing
March 2015

Proline N-oxides: modulators of the 3D conformation of linear peptides through "NO-turns".

Org Biomol Chem 2014 Jul;12(25):4479-90

Catalysis and Peptide Research Unit, School of Health Sciences, University of Kwazulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1039/c4ob00433gDOI Listing
July 2014

Organocatalyzed stereospecific C-C bond formation of β-lactams.

Org Biomol Chem 2013 Dec 11;11(48):8294-7. Epub 2013 Nov 11.

Catalysis and Peptide Research Unit, University of KwaZulu Natal, Durban, South Africa.

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http://dx.doi.org/10.1039/c3ob41858hDOI Listing
December 2013

Synthesis of novel aryl and heteroaryl acyl sulfonimidamides via Pd-catalyzed carbonylation using a nongaseous precursor.

Org Lett 2013 Mar 8;15(5):1056-9. Epub 2013 Feb 8.

Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.

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http://dx.doi.org/10.1021/ol400049mDOI Listing
March 2013

Novel bioactivation mechanism of reactive metabolite formation from phenyl methyl-isoxazoles.

Drug Metab Dispos 2012 Nov 20;40(11):2185-91. Epub 2012 Aug 20.

Drug Metabolism and Pharmacokinetics, CNS & Pain (CNSP) iMed Science, AstraZeneca R&D, Innovative Medicines, Södertälje, Sweden.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.112.047431
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http://dx.doi.org/10.1124/dmd.112.047431DOI Listing
November 2012

Imidazopyridine-based inhibitors of glycogen synthase kinase 3: synthesis and evaluation of amide isostere replacements of the carboxamide scaffold.

Chem Biodivers 2012 Nov;9(11):2442-52

Medicinal Chemistry, iScience, CNSP iMed, AstraZeneca R&D Södertälje, SE-151 85 Södertälje, Sweden.

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http://doi.wiley.com/10.1002/cbdv.201200308
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http://dx.doi.org/10.1002/cbdv.201200308DOI Listing
November 2012

Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.

J Nanosci Nanotechnol 2012 Mar;12(3):2179-84

School of Chemistry, University of KwaZulu Natal, Durban 4001, South Africa.

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March 2012

Phenyl isoxazole voltage-gated sodium channel blockers: structure and activity relationship.

Bioorg Med Chem Lett 2011 Jul 18;21(13):3871-6. Epub 2011 May 18.

Medicinal Chemistry, CNSP iMed Science, AstraZeneca R&D, Innovative Medicines, SE-15185 Södertälje, Sweden.

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http://dx.doi.org/10.1016/j.bmcl.2011.05.041DOI Listing
July 2011

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease.

Bioorg Med Chem Lett 2011 Apr 1;21(8):2274-7. Epub 2011 Mar 1.

School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2011.02.105DOI Listing
April 2011

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation.

Bioorg Med Chem 2010 Aug 1;18(16):5896-902. Epub 2010 Jul 1.

Department of Biochemistry & Organic Chemistry, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.bmc.2010.06.087DOI Listing
August 2010

Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells.

Biopolymers 2010 ;94(3):323-30

School of Biochemistry, University of KwaZulu Natal, South Africa.

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http://dx.doi.org/10.1002/bip.21370DOI Listing
June 2010

Synthesis and NMR elucidation of novel pentacycloundecane-based peptides.

Magn Reson Chem 2010 Jun;48(6):435-42

School of Chemistry, University of KwaZulu-Natal, Durban 4001, South Africa.

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http://dx.doi.org/10.1002/mrc.2598DOI Listing
June 2010

Effects of Congo red on aβ(1-40) fibril formation process and morphology.

ACS Chem Neurosci 2010 Apr 3;1(4):315-24. Epub 2010 Feb 3.

Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, S-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1021/cn900041xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368672PMC
April 2010

Design and study of peptide-based inhibitors of amylin cytotoxicity.

Bioorg Med Chem Lett 2010 Feb 11;20(4):1360-2. Epub 2010 Jan 11.

Department of Biochemistry, University of KwaZulu Natal, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.004DOI Listing
February 2010

Design and synthesis of glycosylated beta3-peptides capable of folding into the 3(14)-helical conformation in water.

J Org Chem 2008 Jul 25;73(14):5272-8. Epub 2008 Jun 25.

Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, S-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1021/jo8003265DOI Listing
July 2008

Glycosylated foldamers: synthesis of carbohydrate-modified beta3hSer and incorporation into beta-peptides.

J Pept Sci 2007 Nov;13(11):717-27

Department of Biochemistry & Organic Chemistry, Uppsala University, S-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1002/psc.832DOI Listing
November 2007

Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.

J Med Chem 2007 Oct 21;50(21):5238-42. Epub 2007 Sep 21.

Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden.

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http://dx.doi.org/10.1021/jm070148uDOI Listing
October 2007

Biomolecular recognition of glycosylated beta(3)-peptides by GalNAc specific lectins.

J Mol Recognit 2007 Mar-Apr;20(2):132-8

Department of Biochemistry and Organic Chemistry, Uppsala University, Sweden.

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http://doi.wiley.com/10.1002/jmr.821
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http://dx.doi.org/10.1002/jmr.821DOI Listing
August 2007

Tetrazolic acid functionalized dihydroindol: rational design of a highly selective cyclopropanation organocatalyst.

J Org Chem 2007 Jul 22;72(15):5874-7. Epub 2007 Jun 22.

Department of Biochemistry and Organic Chemistry, Uppsala University, SE-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1021/jo070519eDOI Listing
July 2007

Beta2-amino acids in the design of conformationally homogeneous cyclo-peptide scaffolds.

J Org Chem 2006 Sep;71(18):6814-21

Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-75123 Uppsala, Sweden.

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http://dx.doi.org/10.1021/jo060854nDOI Listing
September 2006

Synthesis and circular dichroism spectroscopic investigations of oligomeric beta-peptoids with alpha-chiral side chains.

Org Lett 2006 Sep;8(20):4533-6

Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden.

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http://dx.doi.org/10.1021/ol061717fDOI Listing
September 2006

Poly-N-methylated alpha-peptides: synthesis and X-ray structure determination of beta-strand forming foldamers.

Chem Commun (Camb) 2006 Feb 20(5):497-9. Epub 2005 Dec 20.

Department of Chemistry, Organic Chemistry, Uppsala University, S-75124, Uppsala, Sweden.

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http://dx.doi.org/10.1039/b513277kDOI Listing
February 2006

An improved synthesis of Fmoc-N-methyl-alpha-amino acids.

J Org Chem 2005 Aug;70(17):6918-20

Department of Chemistry, Organic Chemistry, Uppsala University Box 599, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1021/jo050916uDOI Listing
August 2005

Functionalized foldamers: synthesis and characterization of a glycosylated beta-peptide 314-helix conveying the TN-antigen.

Org Biomol Chem 2005 Apr 16;3(8):1359-61. Epub 2005 Mar 16.

Department of Chemistry, Organic Chemistry, Uppsala University, Sweden.

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http://dx.doi.org/10.1039/b503237gDOI Listing
April 2005

Antibiotic and hemolytic activity of a beta2/beta3 peptide capable of folding into a 12/10-helical secondary structure.

Chembiochem 2003 Dec;4(12):1345-7

Uppsala University, Institute of Chemistry, Department of Organic Chemistry, Box 599, 75124 Uppsala, Sweden.

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http://dx.doi.org/10.1002/cbic.200300698DOI Listing
December 2003

Cinchona alkaloid derived ligands in catalytic asymmetric transfer hydrogenation.

Org Biomol Chem 2003 Jul;1(14):2522-6

Department of Organic Chemistry, Institute of Chemistry, Uppsala University, Box 599, SE-751 24 Uppsala, Sweden.

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July 2003