Pentti Tienari

Pentti Tienari

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Pentti Tienari

Publications by authors named "Pentti Tienari"

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Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85.

Acta Neuropathol 2019 Sep 7. Epub 2019 Sep 7.

Department of Pathology, HUSLAB, Helsinki University Hospital, University of Helsinki, P.O. Box 21, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00401-019-02071-3DOI Listing
September 2019

Hippocampal Sclerosis in the Oldest Old: A Finnish Population-Based Study.

J Alzheimers Dis 2018 ;63(1):263-272

Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.3233/JAD-171068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900558PMC
August 2019

The clinical spectrum and prognosis of idiopathic acute optic neuritis: A longitudinal study in Southern Finland.

Mult Scler Relat Disord 2019 Aug 5;35:215-220. Epub 2019 Aug 5.

Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Molecular Neurology Programme, Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.msard.2019.08.007DOI Listing
August 2019

Heritability and genetic variance of dementia with Lewy bodies.

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

Contributions of vascular and Alzheimer's disease pathology to dementia.

Alzheimers Dement 2019 Jul 11;15(7):1004-1005. Epub 2019 Jun 11.

Clinicum and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jalz.2019.04.004DOI Listing
July 2019

Multiple sclerosis in Finland 2018-Data from the national register.

Acta Neurol Scand 2019 Jul 4. Epub 2019 Jul 4.

Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1111/ane.13145DOI Listing
July 2019

Oligogenic basis of sporadic ALS: The example of p.Ala90Val mutation.

Neurol Genet 2019 Jun 23;5(3):e335. Epub 2019 Apr 23.

Department of Clinical Genetics (L.K.), Helsinki University Hospital; Department of Medical Genetics (L.K.), University of Helsinki, Helsinki, Finland; Molecular Neurology (K.K., M.V., P.J.T.), Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland; Department of Medical Genetics (S.M.), University of Helsinki, Helsinki, Finland and Turku; University Hospital (S.M.), Laboratory Division, Genetics and Saske, Department of Medical Genetics, Turku, Finland; Department of Neurology (H.L.), Helsinki University Hospital, and Molecular Neurology, Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland; Neuromuscular Research Center (M.J., B.U.), Tampere University Hospital and University of Tampere, Tampere, Finland; Division of Clinical Neurosciences (M.J.), Turku University Hospital and University of Turku, Turku, Finland; Folkhälsan Research Center (B.U.), Biomedicum, University of Helsinki, Helsinki, Finland; Institute of Biomedicine (P.P., J.S.), University of Turku; Turku University Hospital (P.P., J.S.), Laboratory Division, Genetics and Saske, Department of Medical Genetics, Turku, Finland; Department of Pathology (A.P.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Laboratory of Neurogenetics (B.J.T.), National Institute on Aging, National Institutes of Health, Bethesda, MD; Merck & Co. (D.J.S.), Inc., West Point, PA; Department of Clinical Genetics (M.P.), Helsinki University Hospital; Department of Medical Genetics (M.P.), University of Helsinki, Helsinki, Finland; Department of Neurology (P.J.T.), Helsinki University Hospital; and Department of Pathology (L.M.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1212/NXG.0000000000000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481226PMC
June 2019

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.

Ann Neurol 2019 Apr 13;85(4):470-481. Epub 2019 Mar 13.

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/ana.25431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450729PMC
April 2019

Incidence and Mimickers of Acute Idiopathic Optic Neuritis: Analysis of 291 Consecutive Patients from Southern Finland.

Ophthalmic Epidemiol 2018 Oct - Dec;25(5-6):386-391. Epub 2018 Jul 24.

b Neurology , Helsinki University Hospital and University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/09286586.2018.1500614DOI Listing
March 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

C9orf72 hexanucleotide repeat length in older population: normal variation and effects on cognition.

Neurobiol Aging 2019 Mar 11. Epub 2019 Mar 11.

Molecular Neurology, Research Programs Unit, Department of Neurology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.026DOI Listing
March 2019

APOE ɛ4, rs405509, and rs440446 promoter and intron-1 polymorphisms and dementia risk in a cohort of elderly Finns-Helsinki Birth Cohort Study.

Neurobiol Aging 2019 01 12;73:230.e5-230.e8. Epub 2018 Sep 12.

Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.005DOI Listing
January 2019

Genetics of dementia in a Finnish cohort.

Eur J Hum Genet 2018 06 23;26(6):827-837. Epub 2018 Feb 23.

Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41431-018-0117-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974394PMC
June 2018

Hemophagocytic lymphohistiocytosis in 2 patients with multiple sclerosis treated with alemtuzumab.

Neurology 2018 05 30;90(18):849-851. Epub 2018 Mar 30.

From the Department of Neurology (M.S., P.J.T.), Helsinki University Hospital; Division of Clinical Neurosciences (M.S.-H., L.A.), Turku University Hospital, Finland; Department of Neurology (K.S., J.J., A.C.), Addenbrookes Hospital, University of Cambridge, UK; and Department of Neurology (J.T.S.), Vaasa Central Hospital, Finland.

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http://dx.doi.org/10.1212/WNL.0000000000005420DOI Listing
May 2018

Heterozygous TYROBP deletion (PLOSL) is not a strong risk factor for cognitive impairment.

Neurobiol Aging 2018 04 18;64:159.e1-159.e4. Epub 2017 Dec 18.

Molecular Neurology, Research Programs Unit, University of Helsinki and Department of Neurology, Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.12.008DOI Listing
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

A Novel Loss-of-Function GRN Mutation p.(Tyr229*): Clinical and Neuropathological Features.

J Alzheimers Dis 2017 ;55(3):1167-1174

Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland.

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http://dx.doi.org/10.3233/JAD-160647DOI Listing
February 2018

Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+).

Neurol Genet 2018 Feb 18;4(1):e211. Epub 2018 Jan 18.

Department of Pathology (M.M., A.E.P., M.T., L.M.), University of Helsinki, and Helsinki University Hospital, Finland; Molecular Neurology (K.K., M.V., T. Peuralinna, P.J.T.), Research Programs Unit, University of Helsinki, and Department of Neurology, Helsinki University Hospital, Finland; Institute of Neuroscience (T. Polvikoski), Newcastle University, United Kingdom; Laboratory of Neurogenetics (A.B.S., B.J.T.), National Institutes on Aging, NIH, Bethesda, MD; and Merck Research Laboratories (D.J.S.), Merck & Co., Inc., West Point, PA, USA.

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http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
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http://dx.doi.org/10.1212/NXG.0000000000000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773846PMC
February 2018

Common origin of the gelsolin gene variant in 62 Finnish AGel amyloidosis families.

Eur J Hum Genet 2018 01 22;26(1):117-123. Epub 2017 Nov 22.

Clinical Neurosciences, Neurology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41431-017-0026-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838978PMC
January 2018

"Genetic code" of brain ageing.

Duodecim 2017;133(2):201-8

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January 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

Genetic risk factors in Finnish patients with Parkinson's disease.

Parkinsonism Relat Disord 2017 Dec 29;45:39-43. Epub 2017 Sep 29.

Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland; Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812481PMC
December 2017

Magnetic Resonance Imaging of Internal Jugular Veins in Multiple Sclerosis: Interobserver Agreement and Comparison with Doppler Ultrasound Examination.

Ann Vasc Surg 2017 Jul 11;42:84-92. Epub 2017 Mar 11.

Department of Vascular Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Department of Surgery, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.avsg.2016.10.060DOI Listing
July 2017

Age-related penetrance of the C9orf72 repeat expansion.

Sci Rep 2017 05 18;7(1):2116. Epub 2017 May 18.

Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1038/s41598-017-02364-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437033PMC
May 2017

Population-based analysis of pathological correlates of dementia in the oldest old.

Ann Clin Transl Neurol 2017 03 12;4(3):154-165. Epub 2017 Feb 12.

Department of Pathology Huslab Helsinki University Hospital and Medicum University of Helsinki Helsinki Finland.

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http://dx.doi.org/10.1002/acn3.389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338150PMC
March 2017

A novel class of somatic mutations in blood detected preferentially in CD8+ cells.

Clin Immunol 2017 02 5;175:75-81. Epub 2016 Dec 5.

Molecular Neurology, Research Programs Unit, University of Helsinki, Department of Neurology, Helsinki University Hospital, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2016.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341785PMC
February 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

APOE and aging-related cognitive change in a longitudinal cohort of men.

Neurobiol Aging 2016 08 10;44:151-158. Epub 2016 May 10.

Institute of Behavioral Sciences, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.04.024DOI Listing
August 2016

Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion.

Dement Geriatr Cogn Dis Extra 2016 Jan-Apr;6(1):142-9. Epub 2016 Apr 16.

Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

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http://dx.doi.org/10.1159/000444788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868946PMC
May 2016

The Phenotype of the C9ORF72 Expansion Carriers According to Revised Criteria for bvFTD.

PLoS One 2015 6;10(7):e0131817. Epub 2015 Jul 6.

Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131817PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493025PMC
April 2016

Exome and regulatory element sequencing of neuromyelitis optica patients.

J Neuroimmunol 2015 Dec 3;289:139-42. Epub 2015 Nov 3.

Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland; Molecular Neurology Programme, Research Program Unit, Biomedicum, University of Helsinki, Helsinki, Finland; University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jneuroim.2015.11.002DOI Listing
December 2015

The APP A673T frequency differs between Nordic countries.

Neurobiol Aging 2015 Oct 11;36(10):2909.e1-4. Epub 2015 Jul 11.

The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography Unit, Department of Public Health, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562869PMC
October 2015

Genome-wide association study of neocortical Lewy-related pathology.

Ann Clin Transl Neurol 2015 Sep 18;2(9):920-31. Epub 2015 Aug 18.

Molecular Neurology, Research Program Unit, Biomedicum, University of Helsinki Helsinki, Finland ; Department of Neurology, Helsinki University Central Hospital Helsinki, Finland.

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http://dx.doi.org/10.1002/acn3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574809PMC
September 2015

Suspected YF-AND after yellow fever vaccination in Finland.

J Clin Virol 2014 Nov 3;61(3):444-7. Epub 2014 Sep 3.

HUSLAB, Department of Virology and Immunology, Helsinki University Central Hospital, Finland; Haartman Institute, Department of Virology, University of Helsinki, Finland; Faculty of Veterinary Medicine, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jcv.2014.08.022DOI Listing
November 2014

Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.

Neurobiol Aging 2014 Sep 26;35(9):2180.e1-5. Epub 2014 Mar 26.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.024DOI Listing
September 2014

Genome-wide analysis of the heritability of amyotrophic lateral sclerosis.

JAMA Neurol 2014 Sep;71(9):1123-34

Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1001/jamaneurol.2014.1184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566960PMC
September 2014

C9ORF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation.

Neurobiol Aging 2014 Jul 5;35(7):1780.e13-7. Epub 2014 Feb 5.

Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland; Department of Neurology, Kuopio University Hospital, Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580140017
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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.149DOI Listing
July 2014

Neuromyelitis optica and aquaporin-4 (AQP4) autoantibodies in consecutive optic neuritis patients in Southern Finland.

Acta Ophthalmol 2014 Jun 15;92(4):387-91. Epub 2013 Jun 15.

Department of Ophthalmology, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandDepartment of Neurology, Helsinki University Central Hospital and University of Helsinki, Helsinki, FinlandMolecular Neurology Programme, Research Program Unit, Biomedicum, University of Helsinki, Helsinki, FinlandDepartment of Virology and Immunology, HUSLAB, Helsinki University Central Hospital, Helsinki, FinlandDepartment of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/aos.12187DOI Listing
June 2014

Shingles and statin treatment: confounding by cholesterol or APOE4 status?

Clin Infect Dis 2014 Apr 14;58(7):1042-3. Epub 2014 Jan 14.

Department of Medicine, Geriatric Clinic, University of Helsinki and University Central Hospital.

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http://dx.doi.org/10.1093/cid/ciu030DOI Listing
April 2014

Familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma.

Neurobiol Aging 2014 Feb 27;35(2):444.e11-4. Epub 2013 Sep 27.

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Institute of Neurology, University College London, Queen Square, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01974580130035
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http://dx.doi.org/10.1016/j.neurobiolaging.2013.08.021DOI Listing
February 2014

Homozygosity analysis in amyotrophic lateral sclerosis.

Eur J Hum Genet 2013 Dec 24;21(12):1429-35. Epub 2013 Apr 24.

Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, and Department of Clinical Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1038/ejhg.2013.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829775PMC
December 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

TNFRSF1A in multiple sclerosis: a tale of soluble receptors and signaling cascades.

Neurology 2013 Nov 30;81(22):1886-8. Epub 2013 Oct 30.

From the Department of Neurology (P.J.T.), Biomedicum, Research Programs Unit, Molecular Neurology, Helsinki University Central Hospital and University of Helsinki, Finland; and the Institute of Clinical Neuroimmunology (R.H.), Ludwig Maximilians University, Munich, and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Munich, Germany.

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http://dx.doi.org/10.1212/01.wnl.0000436624.56026.ebDOI Listing
November 2013

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.

Neuron 2013 Oct;80(2):415-28

Department of Neurology, Johns Hopkins University, 855 N Wolfe Street, Rangos 2-270, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University, 855 N Wolfe Street, Rangos 2-270, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuron.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098943PMC
October 2013

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population.

Neurobiol Aging 2013 May 24;34(5):1518.e1-3. Epub 2012 Oct 24.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.09.017DOI Listing
May 2013

Month of birth is associated with multiple sclerosis but not with HLA-DR15 in Finland.

Mult Scler 2012 May 31;18(5):563-8. Epub 2011 Oct 31.

Department of Neurology, Helsinki University Central Hospital and Program for Molecular Neurology, Biomedicum-Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1177/1352458511426814DOI Listing
May 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
Stephen Sawcer Garrett Hellenthal Matti Pirinen Chris C A Spencer Nikolaos A Patsopoulos Loukas Moutsianas Alexander Dilthey Zhan Su Colin Freeman Sarah E Hunt Sarah Edkins Emma Gray David R Booth Simon C Potter An Goris Gavin Band Annette Bang Oturai Amy Strange Janna Saarela Céline Bellenguez Bertrand Fontaine Matthew Gillman Bernhard Hemmer Rhian Gwilliam Frauke Zipp Alagurevathi Jayakumar Roland Martin Stephen Leslie Stanley Hawkins Eleni Giannoulatou Sandra D'alfonso Hannah Blackburn Filippo Martinelli Boneschi Jennifer Liddle Hanne F Harbo Marc L Perez Anne Spurkland Matthew J Waller Marcin P Mycko Michelle Ricketts Manuel Comabella Naomi Hammond Ingrid Kockum Owen T McCann Maria Ban Pamela Whittaker Anu Kemppinen Paul Weston Clive Hawkins Sara Widaa John Zajicek Serge Dronov Neil Robertson Suzannah J Bumpstead Lisa F Barcellos Rathi Ravindrarajah Roby Abraham Lars Alfredsson Kristin Ardlie Cristin Aubin Amie Baker Katharine Baker Sergio E Baranzini Laura Bergamaschi Roberto Bergamaschi Allan Bernstein Achim Berthele Mike Boggild Jonathan P Bradfield David Brassat Simon A Broadley Dorothea Buck Helmut Butzkueven Ruggero Capra William M Carroll Paola Cavalla Elisabeth G Celius Sabine Cepok Rosetta Chiavacci Françoise Clerget-Darpoux Katleen Clysters Giancarlo Comi Mark Cossburn Isabelle Cournu-Rebeix Mathew B Cox Wendy Cozen Bruce A C Cree Anne H Cross Daniele Cusi Mark J Daly Emma Davis Paul I W de Bakker Marc Debouverie Marie Beatrice D'hooghe Katherine Dixon Rita Dobosi Bénédicte Dubois David Ellinghaus Irina Elovaara Federica Esposito Claire Fontenille Simon Foote Andre Franke Daniela Galimberti Angelo Ghezzi Joseph Glessner Refujia Gomez Olivier Gout Colin Graham Struan F A Grant Franca Rosa Guerini Hakon Hakonarson Per Hall Anders Hamsten Hans-Peter Hartung Rob N Heard Simon Heath Jeremy Hobart Muna Hoshi Carmen Infante-Duarte Gillian Ingram Wendy Ingram Talat Islam Maja Jagodic Michael Kabesch Allan G Kermode Trevor J Kilpatrick Cecilia Kim Norman Klopp Keijo Koivisto Malin Larsson Mark Lathrop Jeannette S Lechner-Scott Maurizio A Leone Virpi Leppä Ulrika Liljedahl Izaura Lima Bomfim Robin R Lincoln Jenny Link Jianjun Liu Aslaug R Lorentzen Sara Lupoli Fabio Macciardi Thomas Mack Mark Marriott Vittorio Martinelli Deborah Mason Jacob L McCauley Frank Mentch Inger-Lise Mero Tania Mihalova Xavier Montalban John Mottershead Kjell-Morten Myhr Paola Naldi William Ollier Alison Page Aarno Palotie Jean Pelletier Laura Piccio Trevor Pickersgill Fredrik Piehl Susan Pobywajlo Hong L Quach Patricia P Ramsay Mauri Reunanen Richard Reynolds John D Rioux Mariaemma Rodegher Sabine Roesner Justin P Rubio Ina-Maria Rückert Marco Salvetti Erika Salvi Adam Santaniello Catherine A Schaefer Stefan Schreiber Christian Schulze Rodney J Scott Finn Sellebjerg Krzysztof W Selmaj David Sexton Ling Shen Brigid Simms-Acuna Sheila Skidmore Patrick M A Sleiman Cathrine Smestad Per Soelberg Sørensen Helle Bach Søndergaard Jim Stankovich Richard C Strange Anna-Maija Sulonen Emilie Sundqvist Ann-Christine Syvänen Francesca Taddeo Bruce Taylor Jenefer M Blackwell Pentti Tienari Elvira Bramon Ayman Tourbah Matthew A Brown Ewa Tronczynska Juan P Casas Niall Tubridy Aiden Corvin Jane Vickery Janusz Jankowski Pablo Villoslada Hugh S Markus Kai Wang Christopher G Mathew James Wason Colin N A Palmer H-Erich Wichmann Robert Plomin Ernest Willoughby Anna Rautanen Juliane Winkelmann Michael Wittig Richard C Trembath Jacqueline Yaouanq Ananth C Viswanathan Haitao Zhang Nicholas W Wood Rebecca Zuvich Panos Deloukas Cordelia Langford Audrey Duncanson Jorge R Oksenberg Margaret A Pericak-Vance Jonathan L Haines Tomas Olsson Jan Hillert Adrian J Ivinson Philip L De Jager Leena Peltonen Graeme J Stewart David A Hafler Stephen L Hauser Gil McVean Peter Donnelly Alastair Compston

Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/nature10251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

No evidence for shorter leukocyte telomere length in Parkinson's disease patients.

J Gerontol A Biol Sci Med Sci 2010 Nov 16;65(11):1181-4. Epub 2010 Jul 16.

Research Program of Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.

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http://dx.doi.org/10.1093/gerona/glq125DOI Listing
November 2010

POLG1 polyglutamine tract variants associated with Parkinson's disease.

Neurosci Lett 2010 Jun 24;477(1):1-5. Epub 2010 Apr 24.

Department of Neurology, Helsinki University Central Hospital, FIN-00290 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.neulet.2010.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905783PMC
June 2010

MYO9B polymorphisms in multiple sclerosis.

Eur J Hum Genet 2009 Jun 14;17(6):840-3. Epub 2009 Jan 14.

Department of Molecular Medicine, National Public Health Institute and Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland.

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http://dx.doi.org/10.1038/ejhg.2008.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685895PMC
June 2009

A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.

J Neuroimmunol 2009 Mar 4;208(1-2):119-24. Epub 2009 Feb 4.

Molecular Neuroscience Programme, Biomedicum-Helsinki, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jneuroim.2009.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682252PMC
March 2009

No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.

J Neuroimmunol 2009 Jan 18;206(1-2):86-90. Epub 2008 Nov 18.

Finnish Institute for Molecular Medicine, FIMM, and National Public Health Institute, Biomedicum, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jneuroim.2008.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682253PMC
January 2009

Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis.

Circ Cardiovasc Genet 2008 Dec 15;1(2):107-16. Epub 2008 Oct 15.

Department of Forensic Medicine, University of Tampere Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.791764DOI Listing
December 2008

Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.

Ann Neurol 2008 Sep;64(3):348-52

Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ana.21446DOI Listing
September 2008

Geographical variation of medicated parkinsonism in Finland during 1995 to 2000.

Mov Disord 2008 May;23(7):1024-1031

Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1002/mds.22024DOI Listing
May 2008

Senile systemic amyloidosis, cerebral amyloid angiopathy, and dementia in a very old Finnish population.

Amyloid 2006 Sep;13(3):164-9

Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1080/13506120600876757DOI Listing
September 2006

Assessment of PINK1 (PARK6) polymorphisms in Finnish PD.

Neurobiol Aging 2006 Jun 19;27(6):906-7. Epub 2005 Jul 19.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35 Room 1A1000, MSC 3707, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2005.03.028DOI Listing
June 2006

The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations.

Neurosci Lett 2006 Mar 18;395(3):227-9. Epub 2005 Nov 18.

Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Building 35, Room 1A-1012, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neulet.2005.10.081DOI Listing
March 2006

Multiple sclerosis in G: genes and geography.

Clin Neurol Neurosurg 2006 Mar 18;108(3):223-6. Epub 2006 Jan 18.

Helsinki University Central Hospital, Department of Neurology and University of Helsinki, Biomedicum-Helsinki, Neuroscience Programme, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.clineuro.2005.11.004DOI Listing
March 2006

18q deletions: clinical, molecular, and brain MRI findings of 14 individuals.

Am J Med Genet A 2006 Feb;140(4):331-9

Department of Pediatric Neurology, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ajmg.a.31072DOI Listing
February 2006

Fine mapping of the multiple sclerosis susceptibility locus on 5p14-p12.

J Neuroimmunol 2005 Dec 19;170(1-2):122-33. Epub 2005 Sep 19.

Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2005.08.004DOI Listing
December 2005

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis.

Nat Genet 2005 Oct 25;37(10):1108-12. Epub 2005 Sep 25.

Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK.

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http://dx.doi.org/10.1038/ng1647DOI Listing
October 2005

Interaction of herpesviridae, APOE gene, and education in cognitive impairment.

Neurobiol Aging 2005 Jul;26(7):1001-4

Department of Medicine, Geriatric Clinic, University of Helsinki, P.O. Box 340, FIN-00029 HUS, Finland.

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http://dx.doi.org/10.1016/j.neurobiolaging.2004.09.008DOI Listing
July 2005

The tau H2 haplotype is almost exclusively Caucasian in origin.

Neurosci Lett 2004 Oct;369(3):183-5

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.05.119DOI Listing
October 2004

Paraoxonase 1 (PON1) gene polymorphisms and Parkinson's disease in a Finnish population.

Neurosci Lett 2004 Sep;367(2):168-70

Molecular Genetics Section, Laboratory of Neurogenetics, National Institutes of Health, Building 10, Room 6C103, MSC 1589, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.05.108DOI Listing
September 2004