Peng-Cheng Lv

Peng-Cheng Lv

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Peng-Cheng Lv

Publications by authors named "Peng-Cheng Lv"

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58Publications

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Recent Progress in the Development of Small Molecule c-Met Inhibitors.

Curr Top Med Chem 2019 ;19(15):1276-1288

Department of Chemistry, Purdue University, West Lafayette, Indiana, IN 47907, United States.

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http://dx.doi.org/10.2174/1568026619666190712205353DOI Listing
October 2019

Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase.

Bioorg Med Chem 2019 04 21;27(8):1509-1516. Epub 2019 Feb 21.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.02.043DOI Listing
April 2019

FAK inhibitors in Cancer, a patent review.

Expert Opin Ther Pat 2018 02 13;28(2):139-145. Epub 2017 Dec 13.

a State Key Laboratory of Pharmaceutical Biotechnology , Nanjing University , Nanjing P. R. China.

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https://www.tandfonline.com/doi/full/10.1080/13543776.2018.1
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http://dx.doi.org/10.1080/13543776.2018.1414183DOI Listing
February 2018

Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors.

Biochem Pharmacol 2017 08 27;137:10-28. Epub 2017 Apr 27.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.04.026DOI Listing
August 2017

Synthesis and Biological Evaluation of Glycyrrhetic Acid Derivatives as Potential VEGFR2 Inhibitors.

ChemMedChem 2017 07 27;12(13):1087-1096. Epub 2017 Jun 27.

Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing, 210042, P.R. China.

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http://dx.doi.org/10.1002/cmdc.201700271DOI Listing
July 2017

Tyrosyl-tRNA synthetase inhibitors: a patent review.

Expert Opin Ther Pat 2017 May 9;27(5):557-564. Epub 2017 Jan 9.

a State Key Laboratory of Pharmaceutical Biotechnology , Nanjing University , Nanjing , PR China.

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http://dx.doi.org/10.1080/13543776.2017.1273350DOI Listing
May 2017

Recent Advances in the Design and Synthesis of c-Met Inhibitors as Anticancer Agents (2014-Present).

Curr Med Chem 2017 ;24(1):57-64

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.2174/0929867323666161028161441DOI Listing
April 2017

Recent Developments of Metal and Metal Oxide Nanocatalysts in Organic Synthesis.

Mini Rev Med Chem 2016 ;16(16):1303-1320

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.

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http://dx.doi.org/10.2174/1389557516666160823143243DOI Listing
March 2017

Evaluation of Nonpeptidic Ligand Conjugates for the Treatment of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers.

Mol Cancer Ther 2017 03 15;16(3):453-460. Epub 2016 Dec 15.

Institute for Drug Discovery, Purdue University, West Lafayette, Indiana.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0537DOI Listing
March 2017

Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.

Curr Top Med Chem 2017 ;17(2):120-137

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China.

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http://dx.doi.org/10.2174/1568026616666160530154812DOI Listing
February 2017

Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers.

Bioconjug Chem 2016 Jul 7;27(7):1762-9. Epub 2016 Jul 7.

Institute for Drug Discovery and ‡Department of Chemistry, Purdue University , West Lafayette, Indiana 47907 United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343514PMC
July 2016

Evaluation of a Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence-Guided Surgery of Hypoxic Tumors.

Mol Pharm 2016 05 4;13(5):1618-25. Epub 2016 Apr 4.

Center for Drug Discovery and ‡Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358012PMC
May 2016

Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).

J Med Chem 2016 05 20;59(10):4890-9. Epub 2016 Apr 20.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States .

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http://dx.doi.org/10.1021/acs.jmedchem.6b00220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317102PMC
May 2016

Discovery of new 4-alkoxyquinazoline-based derivatives as potent VEGFR2 inhibitors.

Chem Biol Drug Des 2015 Nov 23;86(5):1323-9. Epub 2015 Jun 23.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.

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http://dx.doi.org/10.1111/cbdd.12596DOI Listing
November 2015

Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: Design, synthesis, inhibitory activity and 3D-QSAR analysis.

Bioorg Med Chem Lett 2015 Oct 14;25(20):4664-71. Epub 2015 Aug 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150086
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http://dx.doi.org/10.1016/j.bmcl.2015.08.026DOI Listing
October 2015

Recent advances of p53-MDM2 small molecule inhibitors (2011-present).

Curr Med Chem 2015 ;22(5):618-26

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.2174/0929867322666141128162557DOI Listing
September 2015

Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors.

Sci Rep 2015 Sep 9;5:13934. Epub 2015 Sep 9.

School of Life Sciences, Shandong University of Technology, Zibo, China.

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http://dx.doi.org/10.1038/srep13934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563558PMC
September 2015

Nitroimidazole derivatives: a patent review of US 2014/0141084 A1.

Expert Opin Ther Pat 2015 Apr 1;25(4):489-92. Epub 2015 Feb 1.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093 , PR, China . +86 25 8359 2672 ; +86 25 8359 2672 ; ;

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http://dx.doi.org/10.1517/13543776.2015.1008448DOI Listing
April 2015

6,7-Dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives as selective inhibitors of PI3Kα.

Bioorg Med Chem 2015 Mar 7;23(6):1231-40. Epub 2015 Feb 7.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896150007
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http://dx.doi.org/10.1016/j.bmc.2015.01.052DOI Listing
March 2015

Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents.

Eur J Med Chem 2015 Mar 14;93:291-9. Epub 2015 Feb 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.02.018DOI Listing
March 2015

Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAF(V⁶⁰⁰E) inhibitors.

Bioorg Med Chem 2015 Jan 26;23(1):46-54. Epub 2014 Nov 26.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896140081
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http://dx.doi.org/10.1016/j.bmc.2014.11.029DOI Listing
January 2015

Discovery and synthesis of a novel series of potent, selective inhibitors of the PI3Kα: 2-alkyl-chromeno[4,3-c]pyrazol-4(2H)-one derivatives.

Org Biomol Chem 2014 Dec;12(45):9157-65

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1039/c4ob01589dDOI Listing
December 2014

EGFR-binding peptide: a patent evaluation of WO2014002836.

Expert Opin Ther Pat 2014 Dec;24(12):1409-11

Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology , Nanjing 210093 , People's Republic of China +86 25 8359 2672 ; +86 25 8359 2672 ; ;

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http://dx.doi.org/10.1517/13543776.2014.964686DOI Listing
December 2014

Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAF(V600E) inhibitors.

Bioorg Med Chem 2014 Nov 6;22(21):6201-8. Epub 2014 Sep 6.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.08.029DOI Listing
November 2014

Synthesis, molecular docking and biological evaluation of coumarin derivatives containing piperazine skeleton as potential antibacterial agents.

Bioorg Med Chem 2014 Nov 30;22(21):5727-37. Epub 2014 Sep 30.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.09.048DOI Listing
November 2014

Design, synthesis and biological evaluation of (E)-3-(3,4-dihydroxyphenyl)acrylylpiperazine derivatives as a new class of tubulin polymerization inhibitors.

Bioorg Med Chem 2014 Aug 21;22(15):4285-92. Epub 2014 May 21.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896140037
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http://dx.doi.org/10.1016/j.bmc.2014.05.029DOI Listing
August 2014

Aromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors.

Eur J Med Chem 2014 Jun 9;81:420-6. Epub 2014 May 9.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China; School of Life Sciences, Shandong University of Technology, Shandong 255049, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234140044
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http://dx.doi.org/10.1016/j.ejmech.2014.05.026DOI Listing
June 2014

Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors.

J Med Chem 2014 May 6;57(10):4324-36. Epub 2014 May 6.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm500294aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033654PMC
May 2014

Synthesis and biological evaluation of novel N, N'-disubstituted urea and thiourea derivatives as potential anti-melanoma agents.

J Enzyme Inhib Med Chem 2012 Oct 10;27(5):708-14. Epub 2011 Oct 10.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.3109/14756366.2011.608665DOI Listing
October 2012

Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors.

Bioorg Med Chem 2011 Oct 1;19(20):5948-54. Epub 2011 Sep 1.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896110069
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http://dx.doi.org/10.1016/j.bmc.2011.08.063DOI Listing
October 2011

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents.

Bioorg Med Chem Lett 2011 Sep 14;21(18):5374-7. Epub 2011 Jul 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://ac.els-cdn.com/S0960894X11009486/1-s2.0-S0960894X1100
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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1100948
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http://dx.doi.org/10.1016/j.bmcl.2011.07.010DOI Listing
September 2011

The combination of 4-anilinoquinazoline and cinnamic acid: a novel mode of binding to the epidermal growth factor receptor tyrosine kinase.

Bioorg Med Chem 2011 Aug 21;19(16):5012-22. Epub 2011 Jun 21.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmc.2011.06.044DOI Listing
August 2011

4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation.

Bioorg Med Chem 2011 Jul 27;19(13):3884-91. Epub 2011 May 27.

College of Chemistry & Chemical Engineering, and Key Laboratory of Hunan Forest Products and Chemical Industry Engineering, Jishou University, Jishou, PR China.

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http://dx.doi.org/10.1016/j.bmc.2011.05.042DOI Listing
July 2011

Synthesis, biological evaluation of chrysin derivatives as potential immunosuppressive agents.

Eur J Med Chem 2011 Jan 10;46(1):393-8. Epub 2010 Nov 10.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejmech.2010.10.034DOI Listing
January 2011

Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents.

Bioorg Med Chem 2010 Dec 29;18(23):8218-25. Epub 2010 Oct 29.

Nanjing University, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmc.2010.10.008DOI Listing
December 2010

Novel depsides as potential anti-inflammatory agents with potent inhibitory activity against Escherichia coli-induced interleukin-8 production.

J Enzyme Inhib Med Chem 2010 Aug;25(4):590-5

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.3109/14756360903357551DOI Listing
August 2010

Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors.

Bioorg Med Chem Lett 2010 Aug 8;20(15):4657-60. Epub 2010 Jun 8.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmcl.2010.05.105DOI Listing
August 2010

Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line.

Eur J Med Chem 2010 Jul 1;45(7):3184-90. Epub 2010 Mar 1.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2010.02.056DOI Listing
July 2010

Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents.

Bioorg Med Chem 2010 Jul 20;18(13):4606-14. Epub 2010 May 20.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmc.2010.05.034DOI Listing
July 2010

Design, synthesis, and pharmacological investigation of iodined salicylimines, new prototypes of antimicrobial drug candidates.

Arch Pharm (Weinheim) 2010 May;343(5):282-90

Key Laboratory of Anhai Educational Department, Anhai University of Technology, Maanshan, P.R. China.

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http://dx.doi.org/10.1002/ardp.200900129DOI Listing
May 2010

Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents.

Bioorg Med Chem Lett 2010 Mar 20;20(6):2025-8. Epub 2010 Jan 20.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.032DOI Listing
March 2010

Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents.

Bioorg Med Chem 2010 Feb 24;18(3):1117-23. Epub 2009 Dec 24.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmc.2009.12.048DOI Listing
February 2010

Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors.

Bioorg Med Chem 2010 Jan 30;18(1):314-9. Epub 2009 Oct 30.

State Key Laboratory of Pollution Control and Resource Reuse, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.1016/j.bmc.2009.10.051DOI Listing
January 2010

Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors.

Bioorg Med Chem Lett 2009 Dec 2;19(23):6750-4. Epub 2009 Oct 2.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.111DOI Listing
December 2009

Synthesis, molecular docking and biological evaluation of metronidazole derivatives as potent Helicobacter pylori urease inhibitors.

Bioorg Med Chem 2009 Nov 15;17(21):7531-6. Epub 2009 Sep 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmc.2009.09.018DOI Listing
November 2009

Novel 2,4,5-trisubstituted oxazole derivatives: synthesis and antiproliferative activity.

Eur J Med Chem 2009 Oct 17;44(10):3930-5. Epub 2009 Apr 17.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2009.04.019DOI Listing
October 2009

Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents.

Eur J Med Chem 2009 Oct 14;44(10):3903-8. Epub 2009 Apr 14.

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejmech.2009.04.014DOI Listing
October 2009

Synthesis, crystal structure and immunosuppressive activity of acylamide derivatives containing 1,4-benzodioxan.

ChemMedChem 2009 Sep;4(9):1421-4

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Hankou Road 22th, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1002/cmdc.200900167DOI Listing
September 2009

Amines and oximes derived from deoxybenzoins as Helicobacter pylori urease inhibitors.

Eur J Med Chem 2009 May 11;44(5):2246-51. Epub 2008 Jun 11.

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.1016/j.ejmech.2008.06.001DOI Listing
May 2009

Urea derivatives as anticancer agents.

Anticancer Agents Med Chem 2009 May;9(4):471-80

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.2174/1871520610909040471DOI Listing
May 2009

Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials.

Eur J Med Chem 2009 Apr 4;44(4):1779-87. Epub 2008 May 4.

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejmech.2008.04.019DOI Listing
April 2009

Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents.

Eur J Med Chem 2009 Feb 25;44(2):908-14. Epub 2008 Jan 25.

Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejmech.2008.01.013DOI Listing
February 2009

Synthesis, antiproliferative evaluation, and structure-activity relationships of 3-arylquinolines.

ChemMedChem 2008 Oct;3(10):1516-9

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China.

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http://dx.doi.org/10.1002/cmdc.200800160DOI Listing
October 2008

Synthesis, antiproliferative activity, and structure-activity relationships of 3-aryl-1H-quinolin-4-ones.

ChemMedChem 2008 Jul;3(7):1077-82

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.R. China.

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http://dx.doi.org/10.1002/cmdc.200800057DOI Listing
July 2008