Publications by authors named "Peng Yu"

1,221 Publications

  • Page 1 of 1

Extracellular Matrix-based Conductive Interpenetrating Network Hydrogels with Enhanced Neurovascular Regeneration Properties for Diabetic Wounds Repair.

Adv Healthc Mater 2021 Oct 14:e2101556. Epub 2021 Oct 14.

School of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China.

The critical effects that impair diabetic wound healing are characterized by poor vascularization and severe peripheral neuropathy. Current management strategies for diabetic wound healing are unsatisfactory, due to the paucity of neurovascular regeneration at the wound site. Importantly, conductivity in skin tissue has been reported to be essential for modulating myriad biological processes especially vascular and nerve regeneration. Herein, we synthesized an extracellular matrix (ECM)-based conductive dressing from an interpenetrating polymer network hydrogel composed of gelatin methacryloyl (GM), oxidized chondroitin sulfate (OCS), and OCS-polypyrrole (OCS-P) conductive nanoparticles that could promote diabetic wound repairing by enhancing local neurovascular regeneration. The conductive hydrogels combined the advantageous features of water-swollen hydrogels with conductive polymers (CPs) to provide tissue-matching electrical conductivity and mechanical properties for neurovascular regeneration. In vitro and in vivo studies showed that the conductive hydrogel can promote neurovascular regeneration by increasing intracellular Ca concentration, which subsequently promoted phosphorylation of proteins in the PI3K/AKT and MEK/ERK pathways. Furthermore, our conductive hydrogel stimulated full-thickness diabetic wound repair on day 14 by promoting local neurovascular regeneration and collagen deposition. These findings corroborated that our ECM-based conductive interpenetrating network hydrogel dressing significantly promoted wound repairing due to its neurovascular regeneration properties, suggesting that they are suitable candidates for diabetic wound repair. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adhm.202101556DOI Listing
October 2021

Predicting Blood Concentration of Tacrolimus in Patients With Autoimmune Diseases Using Machine Learning Techniques Based on Real-World Evidence.

Front Pharmacol 2021 24;12:727245. Epub 2021 Sep 24.

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Tacrolimus is a widely used immunosuppressive drug in patients with autoimmune diseases. It has a narrow therapeutic window, thus requiring therapeutic drug monitoring (TDM) to guide the clinical regimen. This study included 193 cases of tacrolimus TDM data in patients with autoimmune diseases at Southern Medical University Nanfang Hospital from June 7, 2018, to December 31, 2020. The study identified nine important variables for tacrolimus concentration using sequential forward selection, including height, tacrolimus daily dose, other immunosuppressants, low-density lipoprotein cholesterol, mean corpuscular volume, mean corpuscular hemoglobin, white blood cell count, direct bilirubin, and hematocrit. The prediction abilities of 14 models based on regression analysis or machine learning algorithms were compared. Ultimately, a prediction model of tacrolimus concentration was established through eXtreme Gradient Boosting (XGBoost) algorithm with the best predictive ability ( = 0.54, mean absolute error = 0.25, and root mean square error = 0.33). Then, SHapley Additive exPlanations was used to visually interpret the variable's impacts on tacrolimus concentration. In conclusion, the XGBoost model for predicting blood concentration of tacrolimus on the basis of real-world evidence has good predictive performance, providing guidance for the adjustment of regimen in clinical practice.
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http://dx.doi.org/10.3389/fphar.2021.727245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497784PMC
September 2021

DHFR silence alleviated the development of liver fibrosis by affecting the crosstalk between hepatic stellate cells and macrophages.

J Cell Mol Med 2021 Oct 9. Epub 2021 Oct 9.

Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Liver fibrogenesis is a dynamic cellular and tissue process which has the potential to progress into cirrhosis of even liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis. Besides, hepatic macrophages have been proposed as potential targets in combatting fibrosis. As for the relationship between HSCs and hepatic macrophages in liver fibrosis, it is generally considered that macrophages promoted liver fibrosis via activating HSCs. However, whether activated HSCs could in turn affect macrophage polarization has rarely been studied. In this study, mRNAs with significant differences were explored using exosomal RNA-sequencing of activated Lx-2 cells and normal RNA-sequencing of DHFR loss-of-function Lx-2 cell models. Cell functional experiments in both Lx-2 cells and macrophages animal model experiments were performed. The results basically confirmed exosomes secreted from activated HSCs could promote M1 polarization of macrophages further. Exosome harbouring DHFR played an important role in this process. DHFR silence in HSCs could decrease Lx-2 activation and M1 polarization of M0 macrophages and then alleviate the development of liver fibrosis both in vitro and vivo. Our work brought a new insight that exosomal DHFR derived from HSCs had a crucial role in crosstalk between HSCs activation and macrophage polarization, which may be a potential therapeutic target in liver fibrosis.
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http://dx.doi.org/10.1111/jcmm.16935DOI Listing
October 2021

Four new fatty acid derivatives from sp. T24, an endophytic fungus isolated from .

J Asian Nat Prod Res 2021 Oct 8:1-14. Epub 2021 Oct 8.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Pekin Union Medical College, Beijing 100050, China.

The endophytic fungus sp. is known to contain many secondary metabolites, but fatty acid derivatives have rarely been found. In this study, four new fatty acid derivatives (-), together with four known compounds (-), were isolated from sp., which was obtained from the stem of . The absolute configurations of the new compounds - were deduced based on spectroscopic technique and -based coupling constant analysis. Moreover, compound exhibited cytotoxic activities against HCT-8 and MCF-7 cancer cells, and compounds and showed modest selectivity for HCT-8 cells by MTT assay.
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http://dx.doi.org/10.1080/10286020.2021.1962309DOI Listing
October 2021

[Development of the curriculum of "Human Anatomy and Physiology" for special education major].

Sheng Wu Gong Cheng Xue Bao 2021 Sep;37(9):3368-3375

College of Life Sciences, Northwest Normal University, Lanzhou 730070, Gansu, China.

Human Anatomy and Physiology is one of the basic professional courses for students majored in special education in normal colleges. It is of great importance to develop a comprehensive curriculum and improve the associated teaching approaches. In recent years, we have taken a series of approaches including optimizing the teaching content, highlighting the curriculum value, diversifying the teaching methods, and improving the evaluation methods. These approaches have received good effects and responses. Here we summarize the experiences and share our insights with colleagues.
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http://dx.doi.org/10.13345/j.cjb.200731DOI Listing
September 2021

[The Clinical Efficacy and Possible Mechanism of Combination Treatment of Cerebral Ischemic Stroke with Ginkgo Biloba Extract and Low-Frequency Repetitive Transcranial Magnetic Stimulation].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Sep;52(5):883-889

Department of Neurosurgery, Meishan Chinese Medicine Hospital, Meishan 620010, China.

Objective: To study the effect of the combination treatment of ginkgo biloba extract and low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on the oxidative stress and brain neurotransmitters of patients who had cerebral ischemic stroke (CIS).

Methods: A retrospective analysis was conducted, and 93 CIS patients admitted to the Sichuan Academy of Medical Sciences/Sichuan Provincial People's Hospital from January 2018 to January 2020 were included in the study. They were divided into three groups, the regular treatment group (31 cases), the LF-rTMS group (31 cases), and the combination treatment group (31 cases). Patients in the regular treatment group were given the conventional drug therapy and exercise regimen. The LF-rTMS group received LF-rTMS therapy (for 20-30 min each time, 1 time/d and 5 times/week) in addition to the treatment given to the regular treatment group. The combination treatment group was given ginkgo biloba extract (intravenous drips, once per day) in addition to the treatment given to the LF-rTMS group. The treatment was given continuously for 4 weeks and comparison was made at the end of the 4-week treatment regarding the clinical efficacy, oxidative stress response, cerebral oxygen metabolism, and brain neurotransmitter as shown by the three groups.

Results: The treatment efficacy in the combination treatment group (96.77%) was higher than those of the LF-rTMS group (80.65%) and the regular treatment group (54.84%). The LF-rTMS group showed higher treatment efficacy than that of the regular group. The serum superoxide dismutase (SOD) of the combination treatment group was higher than that of the LF-rTMS group and that of the routine group, while the malondialdehyde (MDA) and endothelin-1 (ET-1) of the combination treatment group were lower than those of the LF-rTMS group and the regular treatment group ( <0.05). The serum SOD of the LF-rTMS group was higher than that of the regular treatment group, while the MDA and ET-1 of the group was lower than those of the regular treatment group ( <0.05). The arterial oxygen content (CaO ), arterio-venous oxygen content difference (Ca-vO ) and cerebral extraction rate of oxygen (CERO ) in the combination treatment group were lower than those of the LF-rTMS group and the regular treatment group ( <0.05). The levels of these three indicators of the LF-rTMS group were lower than those of the regular treatment group ( <0.05). EEG frequencies of gamma-aminobutyric acid (GABA), 5-hydroxytryptamine (5-HT) and dopamine (DA) of the combination treatment group were higher than those of the LF-rTMS group and the regular treatment group, while the acetylcholine (Ach) EEG frequency of the combination treatment group was lower than that of the LF-rTMS group and regular treatment group ( <0.05). The LF-rTMS group showed higher GABA, 5-HT and DA EEG frequencies than those of the regular treatment group, while the Ach EEG frequency of the group was lower than that of the regular treatment group ( <0.05). All the patients were followed up for 6 months, and recurrence rate was lower in the combination treatment group (3.23%) than that of the LF-rTMS group (19.35%) and the regular treatment group (25.81%) ( <0.05).

Conclusion: The combination treatment of ginkgo biloba extract and LF-rTMS helped to improve the clinical outcome of CIS patients, which may be related to the inhibition of oxidative stress, improvement in cerebral oxygen metabolism, and regulation of brain neurotransmitter.
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http://dx.doi.org/10.12182/20210960202DOI Listing
September 2021

Peripheral Nerve Conduction And Sympathetic Skin Response Are Reliable Methods to Detect Diabetic Cardiac Autonomic Neuropathy.

Front Endocrinol (Lausanne) 2021 21;12:709114. Epub 2021 Sep 21.

Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.

Aim: This study aimed to investigate the role of nerve conduction studies (NCS) and sympathetic skin response (SSR) in evaluating diabetic cardiac autonomic neuropathy (DCAN).

Methods: DCAN was diagnosed using the Ewing test combined with heart rate variability analysis. NCS and SSR were assessed by electrophysiological methods. The association between NCS/SSR and DCAN was assessed multivariate regression and receiver-operating characteristic analyses.

Results: The amplitude and conduction velocity of the motor/sensory nerve were found to be significantly lower in the DCAN+ group (all < 0.05). A lower amplitude of peroneal nerve motor fiber was found to be associated with increased odds for DCAN (OR 2.77,  < 0.05). The SSR amplitude was lower while the SSR latency was longer in the DCAN+ group than in the DCAN- group. The receiver-operating characteristic analysis revealed that the optimal cutoff points of upper/lower limb amplitude of SSR to indicate DCAN were 1.40 mV (sensitivity, 61.9%; specificity, 66.3%, 0.001) and 0.85 mV (sensitivity, 66.7%; specificity, 68.5%, 0.001), respectively. The optimal cutoff points of upper/lower limb latency to indicate DCAN were 1.40 s (sensitivity, 61.9%; specificity, 62%, 0.05) and 1.81 s (sensitivity, 69.0%; specificity, 52.2%, 0.05), respectively.

Conclusions: NCS and SSR are reliable methods to detect DCAN. Abnormality in the peroneal nerve (motor nerve) is crucial in predicting DCAN. SSR may help predict DCAN.
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http://dx.doi.org/10.3389/fendo.2021.709114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490774PMC
September 2021

Resveratrol Suppresses Annulus Fibrosus Cell Apoptosis through Regulating Oxidative Stress Reaction in an Inflammatory Environment.

Biomed Res Int 2021 27;2021:9100444. Epub 2021 Sep 27.

Department of Orthopedics, The 960 Hospital of PLA, Jinan, Shandong, China.

During disc degeneration, the increase of inflammatory cytokines and decrease of disc cell density are two prominent features. Enhanced inflammatory reaction contributes to disc annulus fibrosus (AF) cell apoptosis. In this study, we investigated whether resveratrol can suppress AF cell apoptosis in an inflammatory environment. Rat disc AF cells were cultured in medium with or without tumor necrosis factor- (TNF-). Resveratrol was added along with the culture medium supplemented with TNF-. Caspase-3 activity, cell apoptosis ratio, expression of apoptosis-associated molecules (Bcl-2, Bax, caspase-3, cleaved PARP, and cleaved caspase-3), reactive oxygen species (ROS) content, and the total superoxide dismutase (SOD) activity were measured. Our results showed that TNF- significantly increased caspase-3 activity and AF cell apoptosis ratio and upregulated gene/protein expression of Bax, caspase-3, cleaved caspase-3, and cleaved PARP, whereas it downregulated the expression of Bcl-2. Moreover, TNF- significantly increased ROS content but decreased the total SOD activity. Further analysis demonstrated that resveratrol partly attenuated the effects of TNF- on AF cell apoptosis-associated parameters, decreased ROS content, and increased the total SOD activity in the AF cells treated with TNF-. In conclusion, resveratrol attenuates inflammatory cytokine TNF--induced AF cell apoptosis through regulating oxidative stress reaction in vitro. This study sheds a new light on the protective role of resveratrol in alleviating disc degeneration.
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http://dx.doi.org/10.1155/2021/9100444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490034PMC
September 2021

Direct Probing of the Oxygen Evolution Reaction at Single NiFeO Nanocrystal Superparticles with Tunable Structures.

J Am Chem Soc 2021 Oct 6. Epub 2021 Oct 6.

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, China.

Due to the precisely controllable size, shape, and composition, self-assembled nanocrystal superlattices exhibit unique collective properties and find wide applications in catalysis and energy conversion. Identifying their intrinsic electrocatalytic activity is challenging, as their averaged properties on ensembles can hardly be dissected from binders or additives. We here report the direct measurement of the oxygen evolution reaction at single superparticles self-assembled from ∼8 nm NiFeO and/or ∼4 nm Au nanocrystals using scanning electrochemical cell microscopy. Combined with coordinated scanning electron microscopy, it is found that the turnover frequency (TOF) estimated from single NiFeO superparticles at 1.92 V vs RHE ranges from 0.2 to 11 s and is sensitive to size only when it is smaller than ∼800 nm in diameter. After the incorporation of Au nanocrystals, the TOF increases by ∼6-fold and levels off with further increasing Au content. Our study demonstrates the first direct single entity electrochemical study on individual nanocrystal superlattices with tunable structures and unravels the intrinsic structure-activity relationship that is not accessible by other methods.
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http://dx.doi.org/10.1021/jacs.1c08592DOI Listing
October 2021

Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease.

Front Immunol 2021 17;12:747076. Epub 2021 Sep 17.

Department of Rheumatology, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Objectives: To elucidate heterogeneity of IgG4-related disease (IgG4-RD) based on B cell immunophenotyping.

Methods: Immunophenotyping of 4 B-cell subsets in peripheral blood from patients with active IgG4-RD (aIgG4-RD, n=105) was performed using flow cytometry to get preliminary B-cell heterogeneity spectrum. Then 10 B-cell subsets were characterized in aIgG4-RD (n = 49), remissive IgG4-RD (rIgG4-RD, n = 49), and healthy controls (HCs, n = 47), followed by principal components analysis (PCA) and cluster analysis to distinguish B-cell immunophenotypes and classify IgG4-RD patients into subgroups.

Results: Cluster analysis identified two endotypes in 105 aIgG4-RD patients based on 4 B-cell subsets: Group1 with higher Breg and naive B cells (n = 48), and Group2 with higher plasmablasts and memory B cells (MBCs) (n = 57). PCA indicated that aIgG4-RD consisted of plasmablast-naive B cell and MBCs-Breg axes abnormalities. There was a negative relationship between naive B cells and disease activity. Both plasmablasts and MBCs were positively associated with serological biomarkers. Cluster analysis stratified aIgG4-RD patients into 3 subgroups based on 10 B-cell subsets: subgroup1 with low MBCs and normal Breg, subgroup2 with high MBCs and low Breg, and subgroup3 with high plasmablasts and low naive B cells. Patients in subroup2 and subgroup3 were more likely to be resistant to treatment.

Conclusion: Patients with aIgG4-RD can be divided into 3 subgroups based on B cell heterogeneity. The B cell immunophenotyping could help elucidate the pathogenesis of IgG4-RD, identify patients with potential refractory IgG4-RD, and provide important information for the development of new therapies.
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http://dx.doi.org/10.3389/fimmu.2021.747076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8484311PMC
September 2021

Climate change drives NDVI variations at multiple spatiotemporal levels rather than human disturbance in Northwest China.

Environ Sci Pollut Res Int 2021 Oct 1. Epub 2021 Oct 1.

Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China), National Ethnic Affairs Commission, Beijing, 100081, China.

Changes in land management and climate alter vegetation dynamics; however, the factors driving vegetation changes remain elusive at multiple spatiotemporal levels. Here, we assess the drivers of changes in greenness from 2000 to 2015 in Northwest China (NW China). We used multiple stepwise linear regression (MSLR), redundancy analysis (RDA), and 12 other models to quantify the impacts of precipitation and temperature metrics, gross domestic product (GDP), population, and grazing intensity on the normalized difference vegetation index (NDVI) at three administrative levels (county, town, and village), four temporal levels (yearly, May, July, and September), two vegetation types (woodland and grassland), and at annual precipitation gradients of <200, 200-400, and >400 mm. The results suggest that NW China underwent vegetation greening from 2000 to 2015. Precipitation and temperature were the most influential factors contributing to the NDVI change. Population was the main determinant of NDVI under the precipitation gradient of <200 mm, and the effect of GDP on NDVI was moderate. On the temporal scale, annual precipitation, precipitation before the previous year, and precipitation in the current year determined the NDVI in May, July, and September, respectively, for both woodland and grassland. At multiple scales, climate change was the primary driver of vegetation change in NW China, rather than human disturbance. These findings expand our understanding on drivers of NDVI at multiple levels over a long period. Measures to manage decreasing vegetation coverage may be more effective and could be implemented sooner based on predicted climate change in drylands worldwide.
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http://dx.doi.org/10.1007/s11356-021-16774-2DOI Listing
October 2021

Genome-Wide Characterization of Aquaporins (aqps) in Lateolabrax maculatus: Evolution and Expression Patterns During Freshwater Acclimation.

Mar Biotechnol (NY) 2021 Sep 30. Epub 2021 Sep 30.

School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China.

Aquaporin (aqp) proteins are a group of small integral membrane proteins that play crucial roles as pore channels for the transport of water and other small solutes across the cell membrane. In our study, we identified 17 aqp genes from the spotted sea bass (Lateolabrax maculatus) genomic database. Gene organization, motif distribution, and selection pressure analyses were performed to investigate their evolutionary characteristics. The aqp mRNA displayed tissue-specific expression pattern in ten selected tissues of healthy spotted sea bass. To investigate the potential involvement of spotted sea bass aqps in osmoregulation, the expression profiles of aqp genes in gills were examined during freshwater (FW) acclimation using qRT-PCR. The mRNA level of aqp3a was dramatically induced during 1-3 day of the FW transition period (77-fold and 15-fold upregulated on 1 day and 3 day than in the control group), indicating that aqp3a may play an important hypo-osmoregulatory role in spotted sea bass. In addition, the expression levels of aqp1aa, aqp1ab, aqp3b, aqp7, and aqp9b increased to various degrees at 1 day after transferring to FW, suggesting their potential involvement in the FW acclimation process. Our study provides a valuable foundation for future studies aimed at uncovering the specific roles of aqp genes during salinity acclimation in spotted sea bass and other teleost species.
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http://dx.doi.org/10.1007/s10126-021-10057-0DOI Listing
September 2021

Precise Simulation of Heat-Flow Coupling of Pipe Cooling in Mass Concrete.

Materials (Basel) 2021 Sep 8;14(18). Epub 2021 Sep 8.

State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072, China.

For a long time, temperature control and crack prevention of mass concrete is a difficult job in engineering. For temperature control and crack prevention, the most effective and common-used method is to embed cooling pipe in mass concrete. At present, there still exists some challenges in the precise simulation of pipe cooling in mass concrete, which is a complex heat-flow coupling problem. Numerical simulation is faced with the problem of over-simplification and inaccuracy. In this study, precise simulation of heat-flow coupling of pipe cooling in mass concrete is carried out based on finite element software COMSOL Multiphysics 5.4. Simulation results are comprehensively verified with results from theoretical solutions and equivalent algorithms, which prove the correctness and feasibility of precise simulation. Compared with an equivalent algorithm, precise simulation of pipe cooling in mass concrete can characterize the sharp temperature gradient around cooling pipe and the temperature rise of cooling water along pipeline more realistically. In addition, the cooling effects and local temperature gradient under different water flow (0.60 m/h, 1.20 m/h, and 1.80 m/h) and water temperature (5 °C, 10 °C, and 15 °C) are comprehensively studied and related engineering suggestions are given.
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http://dx.doi.org/10.3390/ma14185142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465369PMC
September 2021

Characteristics of Soy Protein Prepared Using an Aqueous Ethanol Washing Process.

Foods 2021 Sep 18;10(9). Epub 2021 Sep 18.

Food Process Engineering Group, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands.

Currently, the predominant process for soy protein concentrate (SPC) production is aqueous ethanol washing of hexane-extracted soy meal. However, the use of hexane is less desired, which explains the increased interest in cold pressing for oil removal. In this study, cold-pressed soy meal was used as the starting material, and a range of water/ethanol ratios was applied for the washing process to produce SPCs. Washing enriched the protein content for the SPCs, regardless of the solvent used. However, we conclude that washing with water (0% ethanol) or solvents with a high water/ethanol ratio (60% and above) can be more advantageous. Washing with a high water/ethanol ratio resulted in the highest yield, and SPCs with the highest protein solubility and water holding capacity. The water-only washed SPC showed the highest viscosity, and formed gels with the highest gel strength and hardness among all the SPCs at a similar protein concentration. The variations in the functionality among the SPCs were attributed to protein changes, although the effects of non-protein constituents such as sugar and oil might also be important. Overall, the aqueous ethanol washing process combined with cold-pressed soy meal created SPCs comparable to commercial SPC in terms of composition, but with varied functionalities that are relevant for novel soy-food developments.
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http://dx.doi.org/10.3390/foods10092222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469348PMC
September 2021

Local Control of Supercurrent Density in Epitaxial Planar Josephson Junctions.

Nano Lett 2021 Oct 27;21(19):8274-8280. Epub 2021 Sep 27.

Department of Physics, New York University, New York, New York 10003, United States.

The critical current response to an applied out-of-plane magnetic field in a Josephson junction provides insight into the uniformity of its current distribution. In Josephson junctions with semiconducting weak links, the carrier density, and therefore the overall current distribution, can be modified electrostatically via metallic gates. Here, we show local control of the current distribution in an epitaxial Al-InAs Josephson junction equipped with five minigates. We demonstrate that not only can the junction width be electrostatically defined but also the current profile can be locally adjusted to form superconducting quantum interference devices. Our studies show enhanced edge conduction in such long junctions, which can be eliminated by minigates to create a uniform current distribution.
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http://dx.doi.org/10.1021/acs.nanolett.1c02771DOI Listing
October 2021

High-Curie Temperature Multilayered Hybrid Double Perovskite Photoferroelectrics Induced by Aromatic Cation Alloying.

J Am Chem Soc 2021 Oct 27;143(39):15900-15906. Epub 2021 Sep 27.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China.

Due to the breakthrough development of layered hybrid perovskites, the multilayered hybrid double perovskites have emerged as outstanding semiconducting materials owing to their environmental friendliness and superior stability. Despite recent booming advances, the realization of above-room temperature ferroelectricity in this fascinating family remains a huge challenge. Herein, when the molecular design strategy of aromatic cation alloying is applied, an above-room temperature "green" bilayered hybrid double perovskite photoferroelectric, (CHCHNH)CsAgBiBr (), is successfully developed with a notable saturation polarization of 10.5 μC·cm and high-Curie temperature ( ∼ 483 K). Strikingly, such a achieves a new record in multilayered hybrid perovskite ferroelectrics, which extends the ferroelectric working temperature to a high level. Further computational investigation reveals that the high- originated from the high phase-transition energy barrier switched by the rotation of the aromatic cation in the confined environment of the inorganic layers. In addition, benefiting from the attractive polarization and remarkable photoelectric properties, a bulk photovoltaic effect (BPVE) with a prominent zero-bias photocurrent (2.5 μA·cm) is achieved. As far as we know, such a high- multilayered hybrid double perovskite ferroelectric is unprecedented, which sheds light on the rational design of an environmental photoferroelectric for high performance photoelectric devices.
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http://dx.doi.org/10.1021/jacs.1c05108DOI Listing
October 2021

Intravoxel Incoherent Motion Diffusion-Weighted Imaging for Predicting and Monitoring the Response of Anti-Angiogenic Treatment in the Orthotopic Nude Mouse Model of Lung Adenocarcinoma.

J Magn Reson Imaging 2021 Sep 27. Epub 2021 Sep 27.

Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: The treatment efficacy of angiogenesis inhibitor could be underestimated at an early stage based on tumor volume changes. Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can quantitatively assess tumors at the cellular level, but it is unclear whether it can provide useful information for assessing treatment response of anti-angiogenic treatment for lung adenocarcinoma.

Purpose: To determine the use of IVIM-DWI for non-invasive monitoring of the early response to anti-angiogenic treatment in the orthotopic transplantation of lung adenocarcinoma model.

Study Type: Prospective.

Population: Thirty-seven nude mice were randomized into two groups: treatment group (received bevacizumab + cisplatin, N = 20) and control group (received saline, N = 17).

Field Strength/sequence: Single-shot turbo spin-echo (TSE) IVIM-DWI, TSE T2-weighted imaging at 3.0 T.

Assessment: Tumor volume, IVIM parameters (apparent diffusion coefficient [ADC], diffusivity [D], perfusion fraction [f], and pseudo-diffusion coefficient [D*]) were measured before and 2 hours, 3, 7, 10 and 14 days after treatment. Regions of interest were manually drawn along the inner edge of the tumor by two radiologists with 5 and 10-year experience in magnetic resonance imaging. Pathological examinations (hematoxylin and eosin stain, cluster of differentiation 34) were performed.

Statistical Tests: Kolmogorov-Smirnov test, repeated-measure two-way analysis of variance test, Mann-Whitney U test, Pearson correlation analysis, receiver operating characteristic curve. P < 0.05 was considered statistically significant.

Results: The tumor volume of the two groups was significantly different only on day 14 (control group vs. treatment group, 43.15 ± 18.28 mm vs. 28.41 ± 1.71 mm ). ADC , ADC , D , D , D , and D were significantly higher, while f and f were significantly lower in the treatment group compared to those of the control group. Both the △ADC (r = -0.631) and △D (r = -0.700) showed moderate correlations with the relative tumor volume on day 14.

Data Conclusion: IVIM has the potential to predict and monitor the early response to anti-angiogenic treatment, earlier than size changes, for lung adenocarcinoma.

Level Of Evidence: 2 TECHNICAL EFFICACY: Stage 4.
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http://dx.doi.org/10.1002/jmri.27920DOI Listing
September 2021

Case Report: Good Prognosis of Mixed Alien Hand Syndrome by Verbal-Cue Rehabilitation Exercise.

Front Neurol 2021 8;12:718706. Epub 2021 Sep 8.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Mixed alien hand syndrome is a rare disease reported in the literature. The mixed callosal-frontal variant of alien hand syndrome is associated with uncoordinated hand movements, and patients may present with an involuntary grasp reflex and intermanual conflict. There are few videos in the existing literature on the comparison of patients' condition before and after recovery of the symptoms of mixed alien hand syndrome. We presented the prognosis of mixed alien hand syndrome in the form of a video. In addition, we have included some videos on the comparison of the condition of patients before and after recovery of the symptoms of mixed alien hand syndrome. A 57-year-old woman presented with left-handed intermanual conflict and right-handed involuntary grasp reflex due to infarction of the frontal lobe and corpus callosum. She was diagnosed with a mixed callosal-frontal variant of alien hand syndrome. Her left hand counteracted the purposeful movements of the right hand. However, the intermanual conflict disappeared after 3 months of therapy, including drug treatment and verbal-cue rehabilitation, and she regained normal coordination of her hand movements. Her prognosis was good despite the large corpus callosum lesions. The uncoordinated hand movements of the patient affected her daily life and caused psychological problems. Initiating rehabilitation early was important and necessary for her to regain coordination. It is possible that the verbal-cue training method played an important role in the recovery of the patient. Therefore, this method of rehabilitation deserves consideration and can be adopted in larger cohort studies as we presented only a single case. The possible mechanisms behind the verbal-cue exercise require further studies, and this patient had a good prognosis despite severe corpus callosum injury, which may merit further investigation.
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http://dx.doi.org/10.3389/fneur.2021.718706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455835PMC
September 2021

Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study.

Front Public Health 2021 7;9:710504. Epub 2021 Sep 7.

Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with albuminuria. This study aimed to investigate the association between circulating levels of ANGPTL8 and kidney function in the general population. The subjects were patients with renal dysfunction [estimated glomerular filtration rate (eGFR) <60/min/1.73 m] from Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (the REACTION study). Each case was matched by age, sex, and body mass index (BMI) with one control whose eGFR was ≥ 90 ml/min/1.73 m. The case and control groups were compared using a paired -test. Binary logistic regression analysis was used to calculate the odds ratio (OR) of renal dysfunction (RD). Among 135 case-control pairs, circulating ANGPTL8 levels were elevated in patients with RD compared to control subjects [799.96 (410.12-1086.44) vs. 609.58 (365.13-740.06) pg/ml, < 0.05]. Partial correlations showed that ANGPTL8 levels were negatively correlated with eGFR (r = -0.26, < 0.05). Multivariable-adjusted binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with an increased risk of RD (OR in quartile 4 vs. 1, 3.80; 95% CI, 1.71-8.41). Interestingly, the association between ANGPTL8 levels and RD was consistent with the overall findings in both nondiabetic individuals (OR, 1.44; 95% CI, 1.09 to 1.91) and diabetic patients (OR, 2.71; 95% CI, 1.13-6.49) in the subgroup analyses. Furthermore, the estimates for this association were also significant in females (OR, 2.12; 95% CI, 1.33-3.37), individuals aged > 60 years (OR, 1.55; 95% CI, 1.16-2.07), individuals with a BMI <24 (OR, 1.66; 95% CI, 1.16-2.39), and individuals without hyperlipidaemia (OR, 1.61; 95% CI, 1.16-2.23) (all -values <0.05). Elevated circulating ANGPTL8 levels were associated with increased risk of RD in the general population, especially among females, individuals aged > 60 years, individuals with a BMI < 24, individuals without diabetes mellitus, individuals with diabetes mellitus (DM), and individuals without hyperlipidaemia. This finding implies that ANGPTL8 may play a role in the pathological process of RD.
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http://dx.doi.org/10.3389/fpubh.2021.710504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452901PMC
September 2021

The complete mitochondrial genome of (Lepidoptera: Notodontidae) and phylogenetic analysis.

Mitochondrial DNA B Resour 2021 17;6(10):2964-2966. Epub 2021 Sep 17.

College of Life Science, Northwest Normal University, Lanzhou, China.

is an important lepidopteran pest widely distributed in tropical and subtropical zones of Asia. In this paper, the complete mitochondrial genome (mitogenome) of was determined by next-generation sequencing. The mitogenome was 15,806 bp in length, comprising 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, and an AT-rich control region (D-loop). The gene arrangement of this mitogenome was identical to that of the previous studies of Notodontidae moths. Almost all the PCGs initiated with typical ATN codons, except for with CGA. Among them, nine PCGs terminated with TAA or TAG, while other four PCGs (, , , and ) with incomplete stop codon T. All the 22 tRNAs had the typical cloverleaf structure, except for , whose dihydrouridine (DHU) arm forms a simple loop. Phylogenetic analysis based on the concatenated nucleotide sequences of 13 PCGs indicated that was more closely related to other species of family Notodontidae, forming a monophyletic group, with well-resolved relationships among five family of Noctuoidea.
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http://dx.doi.org/10.1080/23802359.2021.1973921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451694PMC
September 2021

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism.

Aging (Albany NY) 2021 Sep 21;13(18):22375-22389. Epub 2021 Sep 21.

Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang 050024, Hebei Province, China.

Sevoflurane (Sev) is a commonly used anesthetic in hospitals that can cause neurotoxicity. Postoperative cognitive dysfunction (POCD) is a common clinical problem induced by some anesthetics. However, the exact mechanism of neurotoxicity induced by Sev is unclear. Here we studied a new mechanism of POCD induced by Sev. We treated 15-month-old mice with 2% Sev for 6 hours, and we had found that Sev causes POCD. Using isobaric tags for relative and absolute quantitation (iTRAQ), we found that the transporter and the metabolism of carbohydrates and inorganic ions were involved in the cognitive impairment induced by Sev. Using synchrotron radiation micro-X-ray fluorescence (μ-XRF), we showed that Sev caused the iron overload in the brain of 15-month-old mice. Subsequently, excessive iron led to oxidative stress and impaired mitochondrial function that further led to glucose metabolism disorder and reduced ATP production by regulating the expression of key enzyme genes or proteins including G6Pase, Pck1, and Cs. Meanwhile, Sev also inhibited the oxygen consumption rate and glucose absorption by downregulating the expression of glucose transporter 1 in cerebral vascular endothelial cells. The cross-dysfunction of iron and glucose metabolism caused the apoptosis in the cortex and hippocampus through Bcl2/Bax pathway. In conclusion, the data here showed a new mechanism that Sev caused apoptosis by cross-dysregulation of iron and glucose metabolism and induced energy stress in mice. Maintaining iron and glucose metabolism homeostasis may play an important role in cognitive impairment induced by Sev.
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http://dx.doi.org/10.18632/aging.203544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507282PMC
September 2021

PD-L1 is prognostic and a negative predictor of response to immunotherapy in gastric cancer.

Mol Ther 2021 Sep 18. Epub 2021 Sep 18.

Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China; School of Medicine, Chongqing University, Chongqing 400030, China. Electronic address:

Cancer cells evade immune detection via programmed cell death 1/programmed cell death-ligand 1 (PD-1/PD-L1) interactions which inactivate T cells. PD-1/PD-L1 blockade has become an important therapy in the anti-cancer armamentarium. However, some patients do not benefit from PD-1/PD-L1 blockade despite expressing PD-L1. Here, we screened 101 gastric cancer (GC) patients at diagnosis and 141 healthy controls and reported one such segment of GC patients with rs17718883 polymorphism in PD-L1, resulting in a nonsense P146R mutation. We detected rs17718883 in 44% of healthy controls, and rs17718883 was associated with a low susceptibility to GC and better prognosis in GC patients. Structural analysis suggests the mutation weakens the PD-1:PD-L1 interaction. This was supported by co-culture experiments of T cells with GC cells showing that the P146R substitution results in INF-γ secretion by T cells and enables T cells to suppress GC cell growth. Similar results with animal gastric tumor models were obtained in vivo. PD-1 monoclonal antibody treatment did not enhance the inhibitory effect of T cells on GC expressing PD-L1in vitro or in vivo. This study suggests that rs17718883 is common and may be used as a biomarker for exclusion from PD-1/PD-L1 blockade therapy.
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http://dx.doi.org/10.1016/j.ymthe.2021.09.013DOI Listing
September 2021

Chiral Optofluidics with a Plasmonic Metasurface Using the Photothermal Effect.

ACS Nano 2021 Sep 21. Epub 2021 Sep 21.

Institute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, Chengdu 610054, China.

Plasmonic metasurfaces with the photothermal effect have been increasingly investigated for optofluidics. Meanwhile, along with the expanding application of circularly polarized light, a growing number of investigations on chiral plasmonic metasurfaces have been conducted. However, few studies have explored the chirality and the thermal-induced convection of such systems simultaneously. This paper aims to theoretically investigate the dynamics of the thermally induced fluid convection of a chiral plasmonic metasurface. The proposed metasurface exhibits giant circular dichroism in absorption and thus leads to a strong photothermal effect. On the basis of the multiphysical analysis, including optics, thermodynamics, and hydrodynamics, we propose a concept of chiral spectroscopy termed optofluidic circular dichroism. Our results show that different fluid velocities of thermally induced convection appear around a chiral plasmonic metasurface under different circularly polarized excitation. The chiral fluid convection is induced by an asymmetric heat distribution generated by absorbed photons in the plasmonic heater. This concept can be potentially used to induce chiral fluid convection utilizing the chiral photothermal effect. Our proposed structure can potentially be used in various optofluidics applications related to biochemistry, clinical biology, and so on.
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http://dx.doi.org/10.1021/acsnano.1c05658DOI Listing
September 2021

Chitosan hydrogel/3D-printed poly(ε-caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment.

Biomaterials 2021 Sep 15;278:121131. Epub 2021 Sep 15.

School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China; Institute of Orthopedics, Chinese PLA General Hospital, Beijing Key Laboratory of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing, 100853, People's Republic of China. Electronic address:

Articular cartilage (AC) injury repair has always been a difficult problem for clinicians and researchers. Recently, a promising therapy based on mesenchymal stem cells (MSCs) has been developed for the regeneration of cartilage defects. As endogenous articular stem cells, synovial MSCs (SMSCs) possess strong chondrogenic differentiation ability and articular specificity. In this study, a cartilage regenerative system was developed based on a chitosan (CS) hydrogel/3D-printed poly(ε-caprolactone) (PCL) hybrid containing SMSCs and recruiting tetrahedral framework nucleic acid (TFNA) injected into the articular cavity. TFNA, which is a promising DNA nanomaterial for improving the regenerative microenvironment, could be taken up into SMSCs and promoted the proliferation and chondrogenic differentiation of SMSCs. CS, as a cationic polysaccharide, can bind to DNA through electrostatic action and recruit free TFNA after articular cavity injection in vivo. The 3D-printed PCL scaffold provided basic mechanical support, and TFNA provided a good microenvironment for the proliferation and chondrogenic differentiation of the delivered SMSCs and promoted cartilage regeneration, thus greatly improving the repair of cartilage defects. In conclusion, this study confirmed that a CS hydrogel/3D-printed PCL hybrid scaffold containing SMSCs could be a promising strategy for cartilage regeneration based on chitosan-directed TFNA recruitment and TFNA-enhanced cell proliferation and chondrogenesis.
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http://dx.doi.org/10.1016/j.biomaterials.2021.121131DOI Listing
September 2021

Hybrid Li-Ion Capacitor Operated within an All-Climate Temperature Range from -60 to +55 °C.

ACS Appl Mater Interfaces 2021 Sep 20;13(38):45630-45638. Epub 2021 Sep 20.

Department of Chemistry, Fudan University, Shanghai 200433, China.

Lithium-ion capacitors (LICs) have been considered as an advanced energy storage system owing to their high energy and power densities. However, their application in a wide temperature range is still a great challenge due to the reduced ionic conductivity of the electrolyte and the poor electric conductivity of the battery-type transition metal oxide electrodes. Herein, an all-climate LIC is well-fabricated with [email protected] graphite as the anode and activated carbon as the cathode in an optimized electrolyte, which can be operated within a wide temperature range from -60 to +55 °C. Benefitting from the synergetic effect of the improved electrode and electrolyte, the LIC exhibits an outstanding energy density of 119 W h kg and a power density of 5110 W kg based on the total mass of both negative and positive electrodes. Moreover, it can deliver a capacity retention of as high as 42% at -60 °C and function at a superior rate capability at a high temperature of +55 °C, which exhibits an all-climate feature and the potential for wide applications under some extreme conditions.
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http://dx.doi.org/10.1021/acsami.1c14308DOI Listing
September 2021

Modified Valsalva maneuver for treatment of supraventricular tachycardias: A Meta-analysis.

Am J Emerg Med 2021 Aug 31;50:507-512. Epub 2021 Aug 31.

Department of Heart Center, The First Hospital of Lanzhou University, Medical College of Lanzhou University, Chengguan District, Lanzhou 730000, Gansu, China; Key Laboratory of Cardiovascular Diseases of Gansu Province, Medical College of Lanzhou University, Chengguan District, Lanzhou 730000, Gansu, China. Electronic address:

Backgroud: Valsalva maneuver (VM) is a simple and easy method for acute termination of supraventricular tachycardia (SVT), while a postural modification to the VM has been suggested to be superior to the standard VM (SVM). The objective of this meta-analysis is to explore the efficacy and safety of the modified VM (MVM) to terminate SVT compared with the SVM.

Methods: Extensive literature was conducted using the database such as PubMed, Embase, Web of Science, Cochrane library and included randomized controlled trials (RCTs) assessing the efficacy and safety of the MVM and SVM for SVT. Meta-analysis was performed using mean difference (MD), relative risk (RR) and 95% confidence interval (CI). Statistical analysis was performed using Review Manager 5.4.1 software. The quality of the published studies was evaluated using the Oxford quality scoring system (Jadad scale).

Results: Six RCTs involving 1208 patients were reviewed, including 603 patients in the MVM group and 605 patients in the SVM group. The results of the meta-analysis showed that MVM was found to significantly increase the success rate of the sinus rhythm after single VM (RR = 2.83; 95% CI = 2.19 to 3.66; P < 0.00001), sinus rhythm after multiple VM (RR = 3.83; 95% CI = 2.26 to 6.50; P < 0.00001), and single and multiple VM (RR = 2.85, 95% CI = 2.35 to 3.45; P < 0.00001). MVM also decreased the emergency anti-arrhythmic treatments (RR = 0.70; 95% CI = 0.62 to 0.79; P < 0.00001), and use of adenosine and verapamil (RR = 0.69; 95% CI = 0.61 to 0.78; P < 0.00001). There was no significant difference in adverse events (RR = 1.48; 95% CI = 0.91 to 2.42; P = 0.11) and time in emergency department (ED) (RR = 0.03; 95% CI = -0.17 to 0.23, P = 0.79) between MVM and SVM.

Conclusion: Compared with MVM, the conversion rate of SVT to sinus rhythm was more effective than SVM. MVM also reduced the use of anti-arrhythmic measures and drugs, and had no increased time in ED and adverse events.
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http://dx.doi.org/10.1016/j.ajem.2021.08.067DOI Listing
August 2021

Divergent Antiviral Mechanisms of Two Homeologs in a Recurrent Polyploid Fish.

Front Immunol 2021 31;12:702971. Epub 2021 Aug 31.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Wuhan, China.

Polyploidy and subsequent diploidization provide genomic opportunities for evolutionary innovations and adaptation. The researches on duplicated gene evolutionary fates in recurrent polyploids have seriously lagged behind that in paleopolyploids with diploidized genomes. Moreover, the antiviral mechanisms of Viperin remain largely unclear in fish. Here, we elaborate the distinct antiviral mechanisms of two homeologs ( and ) in auto-allo-hexaploid gibel carp (). First, and showed differential and biased expression patterns in gibel carp adult tissues. Subsequently, using co-immunoprecipitation (Co-IP) screening analysis, both Viperin-A and Viperin-B were found to interact with crucian carp () herpesvirus (HV) open reading frame 46 right (ORF46R) protein, a negative herpesvirus regulator of host interferon (IFN) production, and to promote the proteasomal degradation of ORF46R decreasing K63-linked ubiquitination. Additionally, Viperin-B also mediated ORF46R degradation through autophagosome pathway, which was absent in Viperin-A. Moreover, we found that the N-terminal α-helix domain was necessary for the localization of Viperin-A and Viperin-B at the endoplasmic reticulum (ER), and the C-terminal domain of Viperin-A and Viperin-B was indispensable for the interaction with degradation of ORF46R. Therefore, the current findings clarify the divergent antiviral mechanisms of the duplicated homeologs in a recurrent polyploid fish, which will shed light on the evolution of teleost duplicated genes.
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http://dx.doi.org/10.3389/fimmu.2021.702971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8438203PMC
August 2021

Monthly rather than annual climate variation determines plant diversity change in four temperate grassland nature reserves.

Environ Sci Pollut Res Int 2021 Sep 14. Epub 2021 Sep 14.

College of Life and Environmental Sciences, Minzu University of China, No. 27 Zhongguancun South Street, Haidian District, Beijing, 100081, China.

Plant diversity is changing in the world; climate variation at annual scale is believed to drive these changes; however, the effects of climate variation at month scale are still unknown. Anxi, West Ordos, Xilingol, and Tumuji grassland nature reserves, located in northern China, have been well protected from human disturbance, are ideal areas to identify the drive forces for plant diversity change. Using Landsat images from 1982 to 2017, we analyzed the evolution of month- and annual-climate variables and spectral plant diversity indices, and explored the effects of the variability of temperature and precipitation on plant diversity and their relationship. The results showed that the diversity of the four grasslands was decreasing. Climate variables, in particular temperature at month scale, significantly related to grassland plant diversity. These results enlarge our understanding in how climate change driving plant diversity during a long term. Measurements coping with plant diversity decreasing may be more effective and earlier based on monthly climate variables.
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http://dx.doi.org/10.1007/s11356-021-16473-yDOI Listing
September 2021

Comparison of pathological findings between patients with relapsed and non-relapsed immunoglobin G4-related disease.

Chin Med J (Engl) 2021 Sep 9. Epub 2021 Sep 9.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Beijing 100730, China Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

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http://dx.doi.org/10.1097/CM9.0000000000001713DOI Listing
September 2021

A Spherical Harmonics Decomposition Method (SHDM) for irregular Matrix Coils design.

IEEE Trans Biomed Eng 2021 Sep 10;PP. Epub 2021 Sep 10.

Objective: With advantages of reduced coupling and compact structure, Matrix Coils (MCs) design extension to approximate multiple target inhomogeneities is necessary to improve its performance in shimming applications.

Methods: A Spherical Harmonic Decomposition Method (SHDM) is proposed for the multi-target MCs optimization problem. The magnetic field generated by the MCs is represented in form of SHs orthogonal basis, based on which the MCs pattern is optimized to adapt to multiple SH targets.

Results: With multi-target SHs of the 1st, 3rd, and mixed 1st&2nd degrees in Halbach magnet shimming, MCs structure optimizations were successfully performed. Comparisons with regular interleaved MCs show the optimized coil structure provides better performance, including reduction of power dissipation, maximum current amplitude, and total current requirement.

Conclusion: This work proposed a simple and intuitive way of irregular MCs optimization, which is of high benefits in compact MR systems based on permanent magnets.

Significance: This methodology may also be translated into local gradient & shimming matrix coils designs for conventional magnetic resonance device.
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http://dx.doi.org/10.1109/TBME.2021.3111656DOI Listing
September 2021
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