Publications by authors named "Peng Qu"

160 Publications

Atomic heterojunction-induced accelerated charge transfer for boosted photocatalytic hydrogen evolution over 1D CdS nanorod/2D ZnInS nanosheet composites.

J Colloid Interface Sci 2021 Jul 10;604:500-507. Epub 2021 Jul 10.

School of Engineering, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia. Electronic address:

Design of highly efficient heterojunctions for photocatalytic hydrogen evolution is of significant importance to address the energy shortage and environmental crisis. Nevertheless, the smart design of semiconductor-based heterojunctions at the atomic scale still remains a significant challenge hitherto. Herein, we report novel atomic CdS/ZnInS heterojunctions by in-situ epitaxially growing 2D ZnInS nanosheets onto the surface of 1D defective CdS nanorods. The strong electronic coupling between defective CdS and ZnInS is confirmed by transient photocurrent response measurements, •O and •OH radicals experiments, and PL results, leading to accelerated interfacial charge separation and transfer. Additionally, the elevated charge transfer and electronic coupling are further confirmed by theoretical calculations. Consequently, CdS/ZnInS hybrids exhibit superior photocatalytic hydrogen generation activity to pristine CdS. Our findings offer a new paradigm for designing atomic 1D/2D heterojunctions for efficient solar-driven energy conversion.
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http://dx.doi.org/10.1016/j.jcis.2021.07.041DOI Listing
July 2021

Association between plasma endothelial microparticles and contrast-induced nephropathy in patients underwent coronary angiography.

Medicine (Baltimore) 2021 Jul;100(28):e24004

Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Abstract: We aim to investigate the association between plasma endothelial microparticles (EMPs) and contrast-induced nephropathy of patients underwent coronary angiography.The patients were divided into normal renal function group and renal dysfunction group based on the estimated glomerular filtration rate (eGFR). Among the 180 cases, 117 received determination of EMP and serum creatinine after percutaneous coronary intervention (PCI) and/or coronary angiography. The patients were divided into contrast-induced-nephropathy (CIN) group and non-CIN group. EMPs collection and determination were performed, together with biochemical analysis and digital subtraction angiography (DSA) analysis.Spearman correlation showed that the expression of EMP was negatively correlated with eGFR (r = -0.201, P < .01). The serum hypersensitive C-reactive protein (hs-CRP), cystatin C (Cys-C), uric acid (UA) were significantly higher in CIN group than that in the non CIN group. Spearman correlation showed that the expression of EMP was positively correlated with serum interleukin-6 (IL-6, r = 0.393, P < .01). The expression of EMP was positively correlated with serum hs-CRP (r = 0.360, P < .01). Logistic regression analysis showed that the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), eGFR, UA, and Cys-C were correlated with the incidence of contrast induced nephropathy.In patients with contrast-induced-nephropathy, the plasma EMPs were significantly increased after coronary angiography. The expression of plasma EMPs may play a role in the occurrence of contrast-induced-nephropathy.
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http://dx.doi.org/10.1097/MD.0000000000024004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284766PMC
July 2021

Evaluation of genetic diversity and population structure of Fragaria nilgerrensis using EST-SSR markers.

Gene 2021 Sep 25;796-797:145791. Epub 2021 Jun 25.

School of Agriculture, Yunnan University, Kunming 650091, China. Electronic address:

Fragaria nilgerrensis is a diploid wild strawberry widely distributed in Southwest China. Its white color and "peach-like" fragrance of fruits are valuable characters for the genetic improvement of cultivated strawberry plants. Its strong biotic and abiotic resistance and tolerance also enable it to survive in different habitats in the field. In this study, we evaluated the level of genetic variation within and between 16 populations with 169 individuals of F. nilgerrensis using 16 newly developed EST-SSR (expressed sequence tag-simple sequence repeats) markers. The results show that the genetic diversity of this species was high, based on Nei's genetic diversity (0.26) and polymorphic loci (0.41), although it is self-compatible and has clonal propagation. Significant genetic differentiation among populations was also detected by AMOVA analysis (Fst = 0.34), which could be indicative of little gene flow (Nm = 0.43) in F. nilgerrensis. The phylogenetic tree indicates that most of individuals from the same population have clustered together. These populations were not grouped based on the geographical distance, consistent with the Mantel test result (R = 0.0063, P > 0.05). All the populations were assigned into two ancestral groups, with some individuals admixed, suggesting ancestral gene flow had occurred between these two groups. Our developed EST-SSR markers as well as the genetic diversity and population structure analysis of F. nilgerrensis are important for genetic improvement in the breeding process. Moreover, the populations that contain high genetic diversity would be a priority for collection and conservation.
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http://dx.doi.org/10.1016/j.gene.2021.145791DOI Listing
September 2021

PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway.

Exp Anim 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiology, 2nd Affiliated Hospital of Dalian Medical University.

PI3K is a downstream target of multiple cell-surface receptors, which acts as a crucial modulator of both cell polarization and survival. PI3K/AKT signaling pathway is commonly involved in cancer, atherosclerosis, and other diseases. However, its role in cardiovascular diseases, especially in atherosclerosis, remains to be further investigated. To determine the effect of PI3K/AKT signaling pathway on cellular inflammatory response and oxidative stress, PI3K inhibitor (GDC0941) and AKT inhibitor (MK2206) were used. First, THP-1 cells were incubated with ox-LDL (100 µg/ml) to establish an in vitro atherosclerosis model. The inflammatory factors and foam cell formation were then evaluated to ascertain and compare the effects of PI3K and AKT inhibition. ApoE mice fed a high-fat diet were used to assess the roles of PI3K and AKT in aortic plaque formation. Our results showed that the inhibition of PI3K or AKT could suppress the activation of NLRP3, decreased the expression levels of p-p65/p65 and reduced the production of MitoROS in THP-1 cells. Inhibition of PI3K or AKT could also reduced atherosclerosis lesion and plaque area, and decreased the levels of NLRP3 and IL-1β in ApoE mice. The effect of PI3K inhibition was more significant than AKT. Therefore, PI3K inhibition can retard the progress of atherosclerosis. Besides, there may be other AKT-independent pathways that regulate the formation of atherosclerosis.
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http://dx.doi.org/10.1538/expanim.21-0002DOI Listing
June 2021

Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.

Front Cardiovasc Med 2021 28;8:659643. Epub 2021 May 28.

School of Pharmaceutical, Changchun University of Chinese Medicine, Changchun, China.

Adriamycin (ADR)-based combination chemotherapy is the standard treatment for some patients with tumors in clinical, however, long-term application can cause dose-dependent cardiotoxicity. Pilose Antler, as a traditional Chinese medicine, first appeared in the Han Dynasty and has been used to treat heart disease for nearly a thousand years. Previous data revealed pilose antler polypeptide (PAP, 3.2KD) was one of its main active components with multiple biological activities for cardiomyopathy. PAP-3.2KD exerts protective effects againt myocardial fibrosis. The present study demonstrated the protective mechanism of PAP-3.2KD against Adriamycin (ADR)-induced myocardial injury through using animal model with ADR-induced myocardial injury. PAP-3.2KD markedly improved the weight increase and decreased the HW/BW index, heart rate, and ST height in ADR-induced groups. Additionally, PAP-3.2KD reversed histopathological changes (such as disordered muscle bundles, myocardial fibrosis and diffuse myocardial cellular edema) and scores of the heart tissue, ameliorated the myocardial fibrosis and collagen volume fraction through pathological examination, significantly increased the protein level of Bcl-2, and decreased the expression levels of Bax and caspase-3 in myocardial tissue by ELISA, compared to those in ADR-induced group. Furthermore, ADR stimulation induced the increased protein levels of TGF-β1 and SMAD2/3/4, the increased phosphorylation levels of SMAD2/3 and the reduced protein levels of SMAD7. The expression levels of protein above in ADR-induced group were remarkably reversed in PAP-3.2KD-treated groups. PAP-3.2KD ameliorated ADR-induced myocardial injury by regulating the TGF-β/SMAD signaling pathway. Thus, these results provide a strong rationale for the protective effects of PAP against ADR-induced myocardial injury, when ADR is used to treat cancer.
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http://dx.doi.org/10.3389/fcvm.2021.659643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194399PMC
May 2021

Constructing Zn-P charge transfer bridge over ZnFeO-black phosphorus 3D microcavity structure: Efficient photocatalyst design in visible-near-infrared region.

J Colloid Interface Sci 2021 Oct 12;600:463-472. Epub 2021 May 12.

School of Material Science and Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China. Electronic address:

Black phosphorus (BP) is one of the most promising visible-near-infrared light-driven photocatalysts with favorite photoelectric properties and unique tunable direct band gap. Nevertheless, the further development of BP is hindered by the fast carrier recombination rate and high Gibbs free energy. Herein, an innovative strategy is developed for the controllable construction of Zn-P bonds induced zinc ferrite/black phosphorus (ZnFeO-BP) three dimensions (3D) microcavity structure. The Zn-P bonds serve as an efficient channel to optimize the carrier transport and Gibbs free energy of BP simultaneously. Besides, the unique 3D core-shell microcavity structure maintains the multiple reflections of sunlight inside the catalysts, which greatly improves the sunlight utilization upon photocatalysis. An optimized photocatalytic hydrogen production rate of 560 µmol hg under near-infrared light (>820 nm) is achieved. A possible photocatalytic mechanism is proposed based on a series of experimental characterizations and theoretical calculations, this work provides a new sight to design high-quantity BP-based full-spectrum photocatalysts for solar energy conversion.
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http://dx.doi.org/10.1016/j.jcis.2021.05.043DOI Listing
October 2021

3'-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p.

Pharmgenomics Pers Med 2021 6;14:533-544. Epub 2021 May 6.

Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, People's Republic of China.

Objective: To investigate the associations of polymorphisms in the following DNA double-strand break repair (DSBR) genes with papillary thyroid carcinoma (PTC) risk (including rs11852786, rs963917, rs12516 and rs8176318, rs15869, rs2035990 and rs2440).

Materials And Methods: A matched case-control study was implemented to examine associations between PTC risk and the above polymorphisms. Subsequently, we evaluated the effects of the potential PTC susceptibility-related variant rs15869 on BRCA2 mRNA secondary structure and BRCA2 expression through bioinformatics analysis and experiment validation. Additionally, luciferase assay was used to identify whether rs15869 polymorphism can substantially affect the binding of hsa-miR-1178-3p to mRNA. Finally, Pearson correlation analysis was performed to determine the correlation between the expression of hsa-miR-1178-3p and BRCA2 mRNA and protein in thyroid tissues harboring rs15869 different genotypes.

Results: rs15869 CC genotype was associated with a higher risk of PTC than its AA genotype. Subsequently, stratified analyses came to the same conclusion in the female or age<50 population. Furthermore, we confirmed that the A-to-C substitution of rs15869 changed BRCA2 mRNA secondary structure and contributed to a decreased BRCA2 expression. Mechanistically, a significantly decreased luciferase activity verified a greater binding between hsa-miR-1178-3p and rs15869 C allele, but not the A allele, which was evidenced by the significant negative correlation between hsa-miR-1178-3p with BRCA2 mRNA and protein levels in thyroid tissues with AC and CC genotype but not AA genotype at rs15869.

Conclusion: rs15869 is characterized as a potential biomarker associated with PTC risk, highlighting the contribution of the hsa-miR-1178-3p via functional exploration.
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http://dx.doi.org/10.2147/PGPM.S300783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112253PMC
May 2021

Dopamine D receptor-mediated decreases in mitochondrial reactive oxygen species production are cAMP and autophagy dependent.

Hypertens Res 2021 Jun 5;44(6):628-641. Epub 2021 Apr 5.

Department of Medicine, School of Medicine & Health Sciences, George Washington University, Washington, DC, USA.

Overproduction of reactive oxygen species (ROS) plays an important role in the pathogenesis of hypertension. The dopamine D receptor (DR) is known to decrease ROS production, but the mechanism is not completely understood. In HEK293 cells overexpressing DR, fenoldopam, an agonist of the two D-like receptors, DR and DR, decreased the production of mitochondria-derived ROS (mito-ROS). The fenoldopam-mediated decrease in mito-ROS production was mimicked by Sp-cAMPS but blocked by Rp-cAMPS. In human renal proximal tubule cells with DRD1 gene silencing to eliminate the confounding effect of DR, fenoldopam still decreased mito-ROS production. By contrast, Sch23390, a DR and DR antagonist, increased mito-ROS production in the absence of DR, DR is constitutively active. The fenoldopam-mediated inhibition of mito-ROS production may have been related to autophagy because fenoldopam increased the expression of the autophagy hallmark proteins, autophagy protein 5 (ATG5), and the microtubule-associated protein 1 light chain (LC)3-II. In the presence of chloroquine or spautin-1, inhibitors of autophagy, fenoldopam further increased ATG5 and LC3-II expression, indicating an important role of DR in the positive regulation of autophagy. However, when autophagy was inhibited, fenoldopam was unable to inhibit ROS production. Indeed, the levels of these autophagy hallmark proteins were decreased in the kidney cortices of Drd5 mice. Moreover, ROS production was increased in mitochondria isolated from the kidney cortices of Drd5 mice, relative to Drd5 littermates. In conclusion, DR-mediated activation of autophagy plays a role in the DR-mediated inhibition of mito-ROS production in the kidneys.
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http://dx.doi.org/10.1038/s41440-021-00646-wDOI Listing
June 2021

Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment.

Front Cell Dev Biol 2021 4;9:635122. Epub 2021 Mar 4.

Center for Cancer Research, National Cancer Institute, Frederick, MD, United States.

The tumor microenvironment (TME) is composed of tumor cells, blood/lymphatic vessels, the tumor stroma, and tumor-infiltrating myeloid precursors (TIMPs) as a sophisticated pathological system to provide the survival environment for tumor cells and facilitate tumor metastasis. In TME, TIMPs, mainly including tumor-associated macrophage (TAM), tumor-associated dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs), play important roles in repressing the antitumor activity of T cell or other immune cells. Therefore, targeting those cells would be one novel efficient method to retard cancer progression. Numerous studies have shown that traditional Chinese medicine (TCM) has made extensive research in tumor immunotherapy. In the review, we demonstrate that Chinese herbal medicine (CHM) and its components induce tumor cell apoptosis, directly inhibiting tumor growth and invasion. Further, we discuss that TCM regulates TME to promote effective antitumor immune response, downregulates the numbers and function of TAMs/MDSCs, and enhances the antigen presentation ability of mature DCs. We also review the therapeutic effects of TCM herbs and their ingredients on TIMPs in TME and systemically analyze the regulatory mechanisms of TCM on those cells to have a deeper understanding of TCM in tumor immunotherapy. Those investigations on TCM may provide novel ideas for cancer treatment.
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http://dx.doi.org/10.3389/fcell.2021.635122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969811PMC
March 2021

Immunotherapy Targeting Myeloid-Derived Suppressor Cells (MDSCs) in Tumor Microenvironment.

Front Immunol 2020 4;11:585214. Epub 2021 Feb 4.

Center for Cancer Research, National Cancer Institute, Frederick, MD, United States.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate in tumor-bearing hosts to reduce T cells activity and promote tumor immune escape in the tumor microenvironment (TME). The immune system in the TME can be stimulated to elicit an anti-tumor immune response through immunotherapy. The main theory of immunotherapy resides on the plasticity of the immune system and its capacity to be re-educated into a potent anti-tumor response. Thus, MDSCs within the TME became one of the major targets to improve the efficacy of tumor immunotherapy, and therapeutic strategies for tumor MDSCs were developed in the last few years. In the article, we analyzed the function of tumor MDSCs and the regulatory mechanisms of agents targeting MDSCs in tumor immunotherapy, and reviewed their therapeutic effects in MDSCs within the TME. Those data focused on discussing how to promote the differentiation and maturation of MDSCs, reduce the accumulation and expansion of MDSCs, and inhibit the function, migration and recruitment of MDSCs, further preventing the growth, invasion and metastasis of tumor. Those investigations may provide new directions for cancer therapy.
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http://dx.doi.org/10.3389/fimmu.2020.585214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889583PMC
June 2021

Extracellular Vesicle-Encapsulated miR-29b-3p Released From Bone Marrow-Derived Mesenchymal Stem Cells Underpins Osteogenic Differentiation.

Front Cell Dev Biol 2020 22;8:581545. Epub 2021 Jan 22.

Department of Orthopaedics, The First Hospital of Lanzhou University, Lanzhou, China.

Objective: Mesenchymal stem cells (MSCs) confer therapeutic benefits in various pathologies and cancers by releasing extracellular vesicles (EVs) loaded with bioactive compounds. Herein, we identified bone marrow MSC (BMSC)-derived EVs harboring microRNA (miR)-29b-3p to regulate osteogenic differentiation through effects on the suppressor of cytokine signaling 1 (SOCS1)/nuclear factor (NF)-κB pathway targeting of lysine demethylase 5A (KDM5A) in osteoporosis.

Methods: We quantified the miR-29b-3p in BMSC-derived EVs from bone marrow specimens of osteoporotic patients and non-osteoporotic patients during total hip arthroplasty (THA). miR-29b-3p targeting KDM5A was confirmed by promoter luciferase assay, and enrichment of KDM5A in the promoter region of SOCS1 was analyzed by chromatin immunoprecipitation (ChIP). The expression and translocation of NF-κB to the nucleus were detected by western blot analysis and immunofluorescence staining, respectively. An ovariectomized (OVX) osteoporosis mouse model was established to further confirm the findings.

Results: BMSC-derived EVs of osteoporotic patients exhibited downregulated miR-29b-3p. EV-encapsulated miR-29b-3p from BMSCs potentiated osteogenic differentiation by specifically inhibiting KDM5A. KDM5A inhibited osteogenic differentiation by the regulation of H3K4me3 and H3K27ac of SOCS1. SOCS1 potentiated osteogenic differentiation by inhibiting NF-κB pathway.

Conclusion: EV-encapsulated miR-29b-3p derived from BMSCs potentiated osteogenic differentiation through blockade of the SOCS1/NF-κB pathway by inhibition of KDM5A.
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http://dx.doi.org/10.3389/fcell.2020.581545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862561PMC
January 2021

Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment.

Drug Deliv 2021 Dec;28(1):319-324

Department of Orthopaedics, The First Hospital of Lanzhou University, Lanzhou, China.

The present work aims to examine the effect of gelatin on the stabilization of silver nanoparticles (AgNPs) and their use in healing the bone fracture. AgNPs-loaded Gel hydrogels (AgNPs/Gel) were fabricated under sunlight using gelatin (Gel) as stabilizing agent. The characterization of the synthesized hydrogels was performed with the help of techniques such as UV-visible spectroscopy (UV-Vis) and high-resolution transmission electron microscopy (HR-TEM). Furthermore, the results of cell cytotoxicity confirmed that the AgNPs/Gel hydrogels are nonhazardous to osteoblasts. The outcome of cell fixation with AgNPs/Gel hydrogels after an incubation period of five days exposed the improved survival and spreading of osteoblasts cells on the prepared AgNPs/Gel hydrogels. Moreover, the AgNPs/Gel hydrogel nanostructures displayed their ability in modulating bone fracture healing, which suggests their potential use in nursing care.
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http://dx.doi.org/10.1080/10717544.2020.1869865DOI Listing
December 2021

[Current quality standards of Andrographis Herba of different countries and regions].

Zhongguo Zhong Yao Za Zhi 2020 Dec;45(24):5890-5897

Guangxi Botanical Garden of Medicinal Plants Nanning 530023, China.

Andrographis Herba is a commonly used plant medicine, and has been recorded in pharmacopeias of different countries. However, there are some differences in the quality standards. Based on this, this paper compare the quality standards of Andrographis Herba between Chinese Pharmacopoeia, Hong Kong Chinese Materia Medica Standards, United States Pharmacopoeia, European Pharmacopoeia and Indian Pharmacopoeia, including origin, botanical characteristics, identification(microscopic identification and chromatographic identification), content determination, specific test(such as impurities, loss on drying, extractives, pesticides, heavy metals, mycotoxins, and other items) and storage requirements, so as to provide a reference for studying international quality standards of Andrographis.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200901.601DOI Listing
December 2020

Bisphenol A at a human exposed level can promote epithelial-mesenchymal transition in papillary thyroid carcinoma harbouring BRAF mutation.

J Cell Mol Med 2021 Feb 19;25(3):1739-1749. Epub 2021 Jan 19.

Department of Toxicology, School of Public health, China Medical University, Shenyang, China.

Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, alters the function of endocrine system and enhances the susceptibility to tumorigenesis in several hormone-dependent tumours as thyroid carcinoma. About 50% of papillary thyroid cancers (PTC), the most common type of thyroid malignancy, harbours the BRAF mutation. This study aimed to investigate a potential combined effect of BPA exposure and BRAF mutation on epithelial-mesenchymal transition (EMT) in PTC. Firstly, the level of BPA in plasma, the evaluation of BRAF mutation and the level of EMT-related proteins in PTC samples were individually determined. Additionally, the migration, invasion, colony formation capacity and the expression of EMT-related proteins after exposure to BPA were precisely analysed in vitro thyroid cells genetically modified by the introduction of BRAF mutation. Moreover, ERK-Cox2 signalling pathway was also introduced to explore the possible mechanism in PTC development. As expected, whether the clinical investigation or cultured thyroid cells demonstrated that BPA at a concentration compatible with human exposed levels (10  M) synergized with the BRAF mutation promoted EMT via the activation of ERK-Cox2 signalling pathway. Our findings offer some evidence that BPA as an environmental risk factor can facilitate the progression of PTC harbouring BRAF mutation.
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http://dx.doi.org/10.1111/jcmm.16279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875916PMC
February 2021

A more secure and effective method for throat swab collection: The importance of adequate exposure of oral cavity in COVID-19 specimen collection.

Am J Otolaryngol 2021 Mar-Apr;42(2):102896. Epub 2021 Jan 4.

Department of Urology, Tianjin Third Central Hospital, Tianjin 300170, China. Electronic address:

Objectives: This study aims to propose a novel and effective throat swab collection method for coronavirus disease 2019 (COVID-19).

Methods: The subjects were randomly divided into two groups. The subjects were asked to open their mouth to make "ah" sound (traditional method) or simulate yawn (improved method) for throat swab collection. The usage of tongue depressor, collection time, adverse reactions and subjective discomfort (VAS score) were compared. The collection time, comprehensive indicators of adverse reactions and VAS score were also compared among three collectors.

Results: The tongue depressor was less used in the improved group (χ = 40.186, P < 0.01). The average collection time of the traditional group was 5.44 ± 2.97 and that of the improved group was 4.00 ± 2.31 (P < 0.01). The subjects in the improved group had fewer and milder adverse reactions. The VAS score of subjects in the improved group was lower than that in the traditional group (P < 0.01). Among different collectors, the collection time, comprehensive indicators of adverse reactions and VAS were the same as the overall trend.

Conclusion: Simulating yawn is a safer and faster throat swab collection method.
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http://dx.doi.org/10.1016/j.amjoto.2020.102896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834219PMC
March 2021

Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria.

Front Microbiol 2020 22;11:610070. Epub 2020 Dec 22.

College of Pharmacy Changchun University of Chinese Medicine, Changchun, China.

Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.
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http://dx.doi.org/10.3389/fmicb.2020.610070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782309PMC
December 2020

Mode locking of a coherent random fiber laser with selectable repetition rates.

Opt Express 2020 Nov;28(24):36380-36388

Controlling emission of light in random structures/disordered systems, e.g., implementing mode-locked pulses in a laser system with a random structures/disordered systems, is a complex task. Usually, the generation of laser pulse by mode locking needs a stable fixed-length cavity that determines a specific repetition rate of the mode-locked pulses. Here, mode-locking laser pulses with selectable repetition rates are achieved in a typical one-dimensional disordered laser by passive mode locking. The laser includes disordered reflectors to provide multiple resonant modes associated with different cavity length. The regular pulses with adjustable repetition rates can be generated and selected by a nonlinear polarization rotator and a semiconductor saturable absorber mirror. The proposed work utilizing the advantages of multiple resonances in random lasers could pave a new way for regulating emission of light in the random structures/disordered system. And it displays an effective and realistic technical route to study ultrafast pulses generation and optical soliton dynamics in random structures/disordered systems.
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http://dx.doi.org/10.1364/OE.409974DOI Listing
November 2020

Crystal Facet-Dependent CO Photoreduction over Porous ZnO Nanocatalysts.

ACS Appl Mater Interfaces 2020 Dec 2;12(50):56039-56048. Epub 2020 Dec 2.

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.

Crystal facet engineering provides a promising approach to tailor the performance of catalysts because of the close relationship between the photocatalytic activity and the surface atomic and electronic structures. An in-depth understanding mechanism of crystal facet-dependent CO photoreduction is still an open question. Herein, two different types of porous ZnO nanocatalysts are used as model photocatalysts for the investigation, which are, respectively, with exposed {110} and {001} facets. The porous ZnO with an exposed {110} facet exhibits superior photocatalytic activity to the one with the {001} facet. Various influencing factors have been thoroughly studied both theoretically and/or experimentally, including light harvesting (i.e., band gap), reduction capability (potential of conduction band), crystallinity, CO adsorption ability, CO activation, and charge separation. The major influencing factors are eventually figured out based on the experimental and calculation results. The product selectivity and the influence of the hole scavenger can be explained too. Our work may pave a way for directing the future rational design of efficient photocatalysts for CO reduction.
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http://dx.doi.org/10.1021/acsami.0c17596DOI Listing
December 2020

No obviously adverse pregnancy complications and outcomes of the recovered pregnant women from COVID-19.

Reprod Toxicol 2021 03 26;100:163-166. Epub 2020 Nov 26.

Institute of Reproductive and Child Health, Peking University, Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, 100191, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, PR China. Electronic address:

The effects of SARS-COV-2 infection on the pregnant women and their fetus growth have attracted worldwide concern. Our case study aimed to investigate the neonatal clinical outcomes of the recovered pregnant women from COVID-19 in China, expecting to provide the clinical references of urgent need for other countries. Our study recruited a total of 12 recovered pregnant women from COVID-19 prior to pregnancy termination. The maternal and neonatal clinical characteristics were recorded. Of them, the placental pathological characteristics of five participants were evaluated following the standard guidelines. Two of them chose induced labour due to being worry about the potential adverse effects of medical treatment for COVID-19 by themselves. For the others, 8 gave birth by cesarean section with certain indications and 2 by vaginal delivery. Their neonates were all live birth with ≥ 37 gestational weeks and high Apgar scores of 9 ∼ 10. For the neonate related biological samples, they all have negative results of RNA test, including nasopharyngeal swab, umbilical cord blood, amniotic fluid, vaginal fluid, placenta, or umbilical cord. Most of other pathological indicators of placental examination suggested no abnormal syndromes. Overall, we did not find any abnormal pregnancy complications and neonatal outcomes among them. We concluded that excess adverse effect on the fetus development due to COVID-19 in the recovered pregnant women should be less influential, especially, induce abortion due to the anxiety of COVID-19 treatment should be not advisable.
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http://dx.doi.org/10.1016/j.reprotox.2020.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689303PMC
March 2021

Hierarchically porous hydrangea-like InS/InO heterostructures for enhanced photocatalytic hydrogen evolution.

J Colloid Interface Sci 2021 Apr 13;587:876-882. Epub 2020 Nov 13.

School of Engineering, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia. Electronic address:

Semiconductor-based photocatalytic hydrogen evolution is considered to be a promising and cost-effective approach to address the environmental issues and energy crisis. It still remains a great challenge to design highly-efficient semiconductor photocatalysts via a facile method. Herein, hierarchically porous hydrangea-like InS/InO heterostructures are successfully synthesized via a simple in situ oxidization process. The formed InS/InO heterostructures exhibit superior photocatalytic activity to the counterpart InS and InO. The boosted photocatalytic performance is ascribed to the formed heterostructures, which greatly facilitate the interfacial charge transfer. Moreover, the formation of hierarchically porous heterostructures increases the number of active sites and improves the permeability, and thus significantly promotes the photocatalytic H evolution activity. This work may provide a new insight for designing InS-based heterostructures for efficient solar light conversion.
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http://dx.doi.org/10.1016/j.jcis.2020.11.048DOI Listing
April 2021

Excessive Se on RuSe nanocrystals to accelerate water dissociation for the enhanced electrocatalytic hydrogen evolution reaction.

Nanoscale 2020 Dec;12(46):23740-23747

Henan Engineering Center of New Energy Battery Materials, Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, Henan, China.

Selenium-enriched RuSe2 (RuxSe) nanocrystals as electrocatalysts for the HER in basic media have been synthesized via a facile hydrothermal method followed by a calcination process. The catalytic activity of the obtained RuxSe nanocrystals is greatly dependent on calcination temperatures. The nanocrystals obtained at 400 °C (RuxSe-400) demonstrate the highest HER activity with a low overpotential of 45 mV to deliver a current density of 10 mA cm-2 and a small Tafel slope of 31.4 mV dec-1. The enhanced catalytic HER performance of RuxSe-400 could be attributed to the excessive Se on the RuSe2 nanocrystal surface. Density functional theory (DFT) calculations reveal that the excessive Se would lower the energy barrier for water dissociation and lessen the dependence on the Ru sites for OH* adsorption but have a negligible effect on hydrogen adsorption energy, leading to an accelerated HER process. Furthermore, the excessive Se on the nanocrystal surface further endows the catalyst with promoted charge-transfer kinetics, ensuring a more efficient catalytic reaction. The strategy herein for the design of highly efficient HER catalysts by engineering the separation of different intermediate (H* and OH*) adsorption sites is expected to be extended to other electrocatalysts for high-efficiency energy conversion.
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http://dx.doi.org/10.1039/d0nr07111kDOI Listing
December 2020

The role of non-coding RNA network in atherosclerosis.

Life Sci 2021 Jan 13;265:118756. Epub 2020 Nov 13.

Institute of Heart and Vessel Diseases, The Second Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian 116023, People's Republic of China; Department of Cardiology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, People's Republic of China. Electronic address:

Atherosclerosis is the primary culprit of cardiovascular and cerebrovascular diseases. Also, atherogenesis and the development of atherosclerosis involve endothelial cells, monocytes/macrophages, smooth myocytes, and others. Increasingly, studies have found that non-coding RNA (ncRNA) which can regulate apoptosis, pyroptosis, autophagy, proliferation, and monocyte migration participates in atherogenesis and progress of atherosclerosis by the above. The ncRNA networks may be essential in regulating the complicated process of atherosclerosis. Accordingly, this review delves into the regulatory roles of ncRNA, which were introduced previously. The answer above is particularly crucial to explain further the regulatory mechanism of ncRNA in cardiovascular disorders. Furthermore, we discuss the possibility and related research of ncRNAs as a biomarker and therapeutic target for the prevention, diagnosis, and treatment of atherosclerosis.
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http://dx.doi.org/10.1016/j.lfs.2020.118756DOI Listing
January 2021

Spatial genetic and epigenetic structure of Thlaspi arvense (field pennycress) in China.

Genes Genet Syst 2021 Feb 11;95(5):225-234. Epub 2020 Nov 11.

Institute of Ecology and Geobotany, School of Ecology and Environmental Sciences, Yunnan University.

Thlaspi arvense (field pennycress) is widespread in temperate regions of the northern hemisphere. We estimated the genetic and epigenetic structure of eight T. arvense populations (131 individuals) in China using amplified fragment length polymorphism and methylation-sensitive amplified polymorphism molecular-marker techniques. We detected low diversity at both genetic (mean = 0.03; total = 0.07) and epigenetic (mean = 0.04; total = 0.07) levels, while significant genetic (F = 0.42, P < 0.001) and epigenetic (F = 0.32, P < 0.001) divergence was found across the distribution range. Using Mantel testing, we found spatial genetic and epigenetic differentiation, consistent with isolation-by-distance models. We also identified a strong correlation between genetic and epigenetic differentiation (r = 0.7438, P < 0.001), suggesting genetic control of the epigenetic variation. Our results indicate that mating system, natural selection and gene flow events jointly structure spatial patterns of genetic and epigenetic variation. Moreover, epigenetic variation may serve as a basis of natural selection and ecological evolution to enable species to adapt to heterogeneous habitats. Our study provides novel clues for the adaptation of T. arvense.
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http://dx.doi.org/10.1266/ggs.20-00025DOI Listing
February 2021

Natural Killer Cell Transcript 4 promotes the development of Sjӧgren's syndrome via activation of Rap1 on B cells.

J Autoimmun 2021 01 19;116:102559. Epub 2020 Oct 19.

Center for Cancer Research, National Cancer Institute, USA. Electronic address:

Autoimmune disorders are the third most common diseases in the United States, and affect the daily lives of millions of people. In this study, we analyzed patient samples, utilized a transgenic mouse model and human B cells to reveal Natural Killer Cell Transcript 4 (NK4) as a novel regulator that promotes the development of autoimmune disorders. NK4 was significantly elevated in samples from patients with Sjӧgren's Syndrome (SS). SS patients show elevated NK4 levels. There is a strong and positive correlation between the increased levels of NK4 and the duration of SS. Interestingly, transgenic expression of NK4 in a mouse model led to the development of autoantibodies and lymphocytic infiltration in salivary glands similar to those in SS patients. Those phenotypes were associated with increased B1a cells in the peritoneum, plasma cells in the spleen, and increased IgM, IgA, and IgG2a in serum of the NK4 transgenic mice. The autoimmune phenotypes became more severe in older mice. Moreover, after NK4 transfection, human naïve B cells were activated and memory B cells differentiation into IgG and IgA-plasmablasts, resulting in an increased production of autoantibodies.NK4 regulated the differentiation and activation of B cells through activating Rap1 activity. NK4 also promoted B cell migration in a paracrine fashion through an induction of CXCL13 in endothelial cells. Collectively, these findings identify NK4 as a promoter of the development of autoimmune disorders through its roles on B cells. Therefore, NK4 may be a novel therapeutic target for the treatment of autoimmune diseases.
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http://dx.doi.org/10.1016/j.jaut.2020.102559DOI Listing
January 2021

A system hierarchy for brain-inspired computing.

Nature 2020 10 14;586(7829):378-384. Epub 2020 Oct 14.

Center for Brain-Inspired Computing Research (CBICR), Tsinghua University, Beijing, China.

Neuromorphic computing draws inspiration from the brain to provide computing technology and architecture with the potential to drive the next wave of computer engineering. Such brain-inspired computing also provides a promising platform for the development of artificial general intelligence. However, unlike conventional computing systems, which have a well established computer hierarchy built around the concept of Turing completeness and the von Neumann architecture, there is currently no generalized system hierarchy or understanding of completeness for brain-inspired computing. This affects the compatibility between software and hardware, impairing the programming flexibility and development productivity of brain-inspired computing. Here we propose 'neuromorphic completeness', which relaxes the requirement for hardware completeness, and a corresponding system hierarchy, which consists of a Turing-complete software-abstraction model and a versatile abstract neuromorphic architecture. Using this hierarchy, various programs can be described as uniform representations and transformed into the equivalent executable on any neuromorphic complete hardware-that is, it ensures programming-language portability, hardware completeness and compilation feasibility. We implement toolchain software to support the execution of different types of program on various typical hardware platforms, demonstrating the advantage of our system hierarchy, including a new system-design dimension introduced by the neuromorphic completeness. We expect that our study will enable efficient and compatible progress in all aspects of brain-inspired computing systems, facilitating the development of various applications, including artificial general intelligence.
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http://dx.doi.org/10.1038/s41586-020-2782-yDOI Listing
October 2020

Effectiveness of Levoamlodipine Maleate for Hypertension Compared with Amlodipine Besylate: a Pragmatic Comparative Effectiveness Study.

Cardiovasc Drugs Ther 2021 02 11;35(1):41-50. Epub 2020 Sep 11.

National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Department of Biostatistics, School of Public Health, Southern Medical University, Guangzhou, 510515, China.

Purpose: Antihypertensive treatment is the most important method to reduce the risk of cardiovascular events in hypertensive patients. However, there is scant evidence of the benefits of levoamlodipine maleate for antihypertensive treatment using a head-to-head comparison in the real-world. This study aims to examine the effectiveness of levoamlodipine maleate used to treat outpatients with primary hypertension compared with amlodipine besylate in a real-world setting.

Methods: This was a pragmatic comparative effectiveness study carried out at 110 centers across China in outpatients with primary hypertension treated with levoamlodipine maleate or amlodipine besylate, with 24 months of follow-up. The primary outcomes used for evaluating the effectiveness were composite major cardiovascular and cerebrovascular events (MACCE), adverse reactions, and cost-effectiveness.

Results: Among the included 10,031 patients, there were 482 MACCE, 223 (4.4%) in the levoamlodipine maleate group (n = 5018) and 259 (5.2%) in the amlodipine besylate group (n = 5013) (adjusted hazard ratio = 0.90, 95%CI: 0.75-1.08, P = 0.252). The levoamlodipine maleate group had lower overall incidences of any adverse reactions (6.0% vs. 8.4%, P < 0.001), lower extremity edema (1.1% vs. 3.0%, P < 0.001) and headache (0.7% vs. 1.1%, P = 0.045). There was a nearly 100% chance of the levoamlodipine maleate being cost-effective at a willingness to pay threshold of 150,000 Yuan per quality-adjusted life years (QALYs) gained, resulting in more QALYs (incremental QALYs: 0.00392) and cost savings (saving 2725 Yuan or 28.8% reduction in overall costs) per patient.

Conclusion: In conclusion, levoamlodipine maleate could reduce cost by 29% with a similar MACCE incidence rate and lower occurrence of adverse reactions (especially edema and headache) compared with amlodipine besylate.

Trial Registration: Clinicaltrials.gov NCT01844570 registered at May 1, 2013.
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http://dx.doi.org/10.1007/s10557-020-07054-1DOI Listing
February 2021

Applicability of bedside ultrasonography for the diagnosis of deep venous thrombosis in patients with COVID-19 and treatment with low molecular weight heparin.

J Clin Ultrasound 2020 Nov 5;48(9):522-526. Epub 2020 Aug 5.

Department of Ultrasound, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Purpose: The aim of this study was to evaluate the applicability of bedside ultrasonography for the diagnosis of deep venous thrombosis (DVT) in patients infected with corona virus disease 2019 (COVID-19) with and without treatment with low molecular weight heparin (LMWH).

Methods: We retrospectively analyzed the records of deceased and surviving patients in whom ultrasonography detected or not a DVT, and in whom LMWH was or not prescribed.

Results: The incidence of DVT is higher in the deceased (33/35) than in the surviving (22/46) patients. LMWH was administered in a larger proportion of surviving (18/22) than of deceased (18/33) patients. D-dimer concentrations decreased in patients who received LMWH in both groups.

Conclusions: There was a high incidence of DVT in patients who succumbed to COVID-19. Bedside ultrasonography can detect the presence of DVT as early as possible and help assessing the risk of venous thromboembolism, allowing early and reasonable use of LMWH.
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http://dx.doi.org/10.1002/jcu.22898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436732PMC
November 2020

Chromosome Level Genome Assembly of .

Front Genet 2020 30;11:701. Epub 2020 Jun 30.

Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning, China.

(Chinese name: Chuanxinlian) is an annual dicotyledonous medicinal plant widely grown in China and Southeast Asia. The dried plant has a highly acclaimed usage in the traditional Chinese medicine for its antipyretic, anti-inflammatory, and analgesic effects. In order to help delineate the biosynthetic pathways of various secondary metabolites, we report in this study a high-quality reference genome for . With the help of both PacBio single molecule real time sequencing and Illumina sequencing reads for error correction, the genome was assembled into a total size of 284 Mb with a contig N50 size of 5.14 Mb. The contigs were further assembled into 24 pseudo-chromosomes by the Hi-C technique. We also analyzed the gene families (e.g., , and ) whose protein products are essential for synthesizing bioactive compounds in In conclusion, the high-quality genome assembly builds the foundation for decoding the biosynthetic pathways of various medicinal compounds.
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http://dx.doi.org/10.3389/fgene.2020.00701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340177PMC
June 2020

Macrophage polarization in innate immune responses contributing to pathogenesis of chronic kidney disease.

BMC Nephrol 2020 07 13;21(1):270. Epub 2020 Jul 13.

Kidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Chronic kidney disease (CKD) is characterized by inflammation, injury and fibrosis. Dysregulated innate immune responses mediated by macrophages play critical roles in progressive renal injury. The differentiation and polarization of macrophages into pro-inflammatory 'M1' and anti-inflammatory 'M2' states represent the two extreme maturation programs of macrophages during tissue injury. However, the effects of macrophage polarization on the pathogenesis of CKD are not fully understood. In this review, we discuss the innate immune mechanisms underlying macrophage polarization and the role of macrophage polarization in the initiation, progression, resolution and recurrence of CKD. Macrophage activation and polarization are initiated through recognition of conserved endogenous and exogenous molecular motifs by pattern recognition receptors, chiefly, Toll-like receptors (TLRs), which are located on the cell surface and in endosomes, and NLR inflammasomes, which are positioned in the cytosol. Recent data suggest that genetic variants of the innate immune molecule apolipoprotein L1 (APOL1) that are associated with increased CKD prevalence in people of African descent, mediate an atypical M1 macrophage polarization. Manipulation of macrophage polarization may offer novel strategies to address dysregulated immunometabolism and may provide a complementary approach along with current podocentric treatment for glomerular diseases.
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http://dx.doi.org/10.1186/s12882-020-01921-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358194PMC
July 2020

Extracellular vesicle-encapsulated miR-22-3p from bone marrow mesenchymal stem cell promotes osteogenic differentiation via FTO inhibition.

Stem Cell Res Ther 2020 06 10;11(1):227. Epub 2020 Jun 10.

Department of Orthopedics, The First Hospital of Lanzhou University, No. 1, Donggang West Road, Lanzhou, 730000, Gansu Province, People's Republic of China.

Background: Bone marrow mesenchymal stem cells (BMSCs) exhibit the capacity to self-renew and differentiate into multi-lineage cell types, including osteoblasts, which are crucial regulators of fracture healing. Thus, this study aims to investigate the effect of microRNA (miR)-22-3p from BMSC-derived EVs on osteogenic differentiation and its underlying mechanism.

Methods: Extracellular vesicles (EVs) were isolated from BMSCs and taken up with BMSCs. Dual-luciferase reporter gene assay was used to verify the binding relationship between miR-22-3p and FTO. Loss- and gain-of-function experiments were performed to determine the roles of EV-delivered miR-22-3p and FTO in osteogenic differentiation as well as their regulatory role in the MYC/PI3K/AKT axis. To determine the osteogenic differentiation, ALP and ARS stainings were conducted, and the levels of RUNX2, OCN, and OPN level were determined. In vivo experiment was conducted to determine the function of EV-delivered miR-22-3p and FTO in osteogenic differentiation, followed by ALP and ARS staining.

Results: miR-22-3p expression was repressed, while FTO expression was elevated in the ovariectomized mouse model. Overexpression of miR-22-3p, EV-delivered miR-22-3p, increased ALP activity and matrix mineralization of BMSCs and promoted RUNX2, OCN, and OPN expressions in BMSCs. miR-22-3p negatively targeted FTO expression. FTO silencing rescued the suppressed osteogenic differentiation by EV-delivered miR-22-3p inhibitor. FTO repression inactivated the MYC/PI3K/AKT pathway, thereby enhancing osteogenic differentiation both in vivo and in vitro.

Conclusion: In summary, miR-22-3p delivered by BMSC-derived EVs could result in the inhibition of the MYC/PI3K/AKT pathway, thereby promoting osteogenic differentiation via FTO repression.
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http://dx.doi.org/10.1186/s13287-020-01707-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285613PMC
June 2020